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RAB5A

  • RAB5A
  • Protein-coding gene in the species Homo sapiens

    Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene. RAB5A localizes to early endosomes where it is involved in the recruitment

    RAB5A

    RAB5A

    RAB5A

  • Endosome
  • Vacuole to which materials ingested by endocytosis are delivered

    probably via budding of vesicles out of endosomes. Finally, the endosomes lose RAB5A and acquire RAB7A, making them competent for fusion with lysosomes. Fusion

    Endosome

    Endosome

    Endosome

  • C5a receptor
  • Mammalian protein found in Homo sapiens

    C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a, coupling of Gαi proteins, ERK1/2 phosphorylation, calcium mobilization

    C5a receptor

    C5a receptor

    C5a_receptor

  • Ras superfamily
  • Protein superfamily of small GTPases

    trafficking RAB1A; RAB1B; RAB2; RAB3A; RAB3B; RAB3C; RAB3D; RAB4A; RAB4B; RAB5A; RAB5B; RAB5C; RAB6A; RAB6B; RAB6C; RAB7A; RAB7B; RAB7L1; RAB8A; RAB8B;

    Ras superfamily

    Ras superfamily

    Ras_superfamily

  • Rabaptin
  • Protein family

    protein that interacts with the GTP form of the small GTPase Rab5 (see RAB5A, RAB5B, RAB5C) a potent regulator of endocytic transport. It is mainly cytosolic

    Rabaptin

    Rabaptin

    Rabaptin

  • RAB5C
  • Protein-coding gene in the species Homo sapiens

    Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells". J. Biol. Chem. 273 (51):

    RAB5C

    RAB5C

    RAB5C

  • Rab (G-protein)
  • Family of GTP-binding proteins

    RAB3A Secretory and synaptic vesicles RAB3B RAB4A Recycling endosomes RAB4B RAB5A Clathrin-coated vesicles, plasma membranes RAB5C (Vps21, RabB) Early endosomes

    Rab (G-protein)

    Rab_(G-protein)

  • Endoplasmic reticulum membrane protein complex
  • Protein family

    phosphatidylserine (PS) from the ER. EMC6 interacts with the small GTPase RAB5A and Beclin-1, regulators of autophagosome formation. This observation suggests

    Endoplasmic reticulum membrane protein complex

    Endoplasmic_reticulum_membrane_protein_complex

  • Legionella pneumophila
  • Species of bacterium

    to the LCV while preventing the recruitment of endosomal markers such as Rab5a and Rab7a. Formation and maintenance of the vacuoles are crucial for pathogenesis;

    Legionella pneumophila

    Legionella pneumophila

    Legionella_pneumophila

  • EEA1
  • Protein-coding gene in humans

    ultimately resulting in the fusion and delivery of endosomal cargo. EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is

    EEA1

    EEA1

    EEA1

  • NatB
  • Enzyme

    TNBC cells to promote cell proliferation by activating EGFR signaling via Rab5A. Knockdown of NAA20 in vivo showed a decrease in tumor growth There are

    NatB

    NatB

  • C9orf72
  • Protein-coding gene in humans

    lysosomes is not yet identified, it might feasibly be Rab7A, which along with Rab5A and Rab11A, is activated by C9ORF72-SMCR8-WDR41 functioning as a GEF. As

    C9orf72

    C9orf72

    C9orf72

  • Leishmania donovani
  • Species of intracellular parasite

    "Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494". PLOS Pathogens. 13 (6) e1006459

    Leishmania donovani

    Leishmania donovani

    Leishmania_donovani

  • ZFYVE20
  • Protein-coding gene in the species Homo sapiens

    is encoded by the ZFYVE20 gene. ZFYVE20 has been shown to interact with RAB5A. GRCh38: Ensembl release 89: ENSG00000131381 – Ensembl, May 2017 GRCm38:

    ZFYVE20

    ZFYVE20

    ZFYVE20

  • RABGEF1
  • Protein-coding gene in the species Homo sapiens

    and it serves as a specific guanine nucleotide exchange factor for RAB5(RAB5A; MIM 179512) (Horiuchi et al., 1997) [supplied by OMIM]. GRCh38: Ensembl

    RABGEF1

    RABGEF1

    RABGEF1

  • RAB11A
  • Protein-coding gene in the species Homo sapiens

    PMID 12435603. S2CID 24295732. Roosterman D, Schmidlin F, Bunnett NW (May 2003). "Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor

    RAB11A

    RAB11A

    RAB11A

  • Syntenin-1
  • Protein found in humans

    with: EFNB1, GRIK1, GRIK2, Interleukin 5 receptor alpha subunit, Merlin, RAB5A, SOX4, TRAF6, ULK1. and ERICH2 GRCh38: Ensembl release 89: ENSG00000137575

    Syntenin-1

    Syntenin-1

    Syntenin-1

  • GAPVD1
  • Protein-coding gene in the species Homo sapiens

    Rab GTPase guanine nucleotide exchange factor essential for activation of RAB5A during engulfment of apoptotic cells. GAPVD1 is also involved in the degradation

    GAPVD1

    GAPVD1

    GAPVD1

  • Housekeeping gene
  • Gene which maintains basic cellular functions

    RAB3GAP1 NM_012233 RAB3GAP2 NM_012414 RAB40C NM_021168 RAB4A NM_004578 RAB5A NM_004162 RAB5B NM_002865 RAB5C NM_004583 RAB6A NM_002868 RAB7A NM_004637

    Housekeeping gene

    Housekeeping_gene

  • RAB5B
  • Protein-coding gene in the species Homo sapiens

    PMID 1541686. Chiariello M, Bruni CB, Bucci C (Aug 1999). "The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro". FEBS Lett

    RAB5B

    RAB5B

    RAB5B

  • List of human protein-coding genes 6
  • Q96QF0 13268 RAB4A HGNC:9781; P20338 13269 RAB4B HGNC:9782; P61018 13270 RAB5A HGNC:9783; P20339 13271 RAB5B HGNC:9784; P61020 13272 RAB5C HGNC:9785; P51148

    List of human protein-coding genes 6

    List_of_human_protein-coding_genes_6

  • CHML (gene)
  • Protein-coding gene in humans

    syndrome type II. CHML (gene) has been shown to interact with RAB1A and RAB5A. GRCh38: Ensembl release 89: ENSG00000203668 – Ensembl, May 2017 GRCm38:

    CHML (gene)

    CHML (gene)

    CHML_(gene)

  • TBC domain
  • Protein domain

    his coworkers found a specific interaction between RUTBC3/RabGAP-5 and Rab5A that activates the GTPase activity of Rab5 isoform. Similarly other research

    TBC domain

    TBC domain

    TBC_domain

  • RAB1A
  • Protein-coding gene in the species Homo sapiens

    geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A". Proceedings of the National Academy of Sciences of the United States of

    RAB1A

    RAB1A

    RAB1A

  • STX4
  • Protein-coding gene in the species Homo sapiens

    PMID 11880646. Perskvist N, Roberg K, Kulyté A, Stendahl O (Mar 2002). "Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic

    STX4

    STX4

    STX4

  • RAB3A
  • Protein-coding gene in the species Homo sapiens

    geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 11963–7. Bibcode:1994PNAS...9111963F

    RAB3A

    RAB3A

    RAB3A

  • RABEP1
  • Protein-coding gene in the species Homo sapiens

    RABEP1 has been shown to interact with: AP1G1, GGA1, GGA2, RAB4A, and RAB5A. GRCh38: Ensembl release 89: ENSG00000029725 – Ensembl, May 2017 GRCm38:

    RABEP1

    RABEP1

    RABEP1

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Online names & meanings

  • Vanij | வநிஜ
  • Boy/Male

    Tamil

    Vanij | வநிஜ

    Lord Shiva

  • TAHLIA
  • Female

    Hebrew

    TAHLIA

    Variant spelling of Hebrew Talia, TAHLIA means "dew."

  • Rakashnda
  • Girl/Female

    Hindu

    Rakashnda

  • Chenni
  • Boy/Male

    Indian, Tamil

    Chenni

    Sweet as Sugar

  • Petronella
  • Girl/Female

    Greek Latin Swedish

    Petronella

    Rock.

  • Kanaiyya
  • Boy/Male

    Hindu

    Kanaiyya

    Lord Krishna

  • IRA
  • Male

    English

    IRA

    Anglicized form of Hebrew Iyra, IRA means "watchful of a town." In the bible, this is the name of one king David's officers and two of his warriors.

  • Moghana
  • Girl/Female

    Hindu, Indian

    Moghana

    Daughter of Emperor Mughal

  • Mastura |
  • Girl/Female

    Muslim

    Mastura |

    Protected

  • Colborn
  • Surname or Lastname

    English

    Colborn

    English : variant of Colburn.

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