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Class of enzymes
DNA primase is an enzyme involved in the replication of DNA and is a type of RNA polymerase. Primase catalyzes the synthesis of a short RNA (or DNA in
Primase
helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated
Helicase–primase_complex
Biological process
helix. The preinitiation complex also loads α-primase and other DNA polymerases onto the DNA. After α-primase synthesizes the first primers, the primer-template
DNA_replication
Parts of lagging strand in DNA replication
creating what is known as the DNA replication fork. Following this fork, DNA primase and DNA polymerase begin to act in order to create a new complementary
Okazaki_fragments
Bacterial DNA primase
DnaG is a bacterial DNA primase and is encoded by the dnaG gene. The enzyme DnaG, and any other DNA primase, synthesizes short strands of RNA known as
DnaG
Family of protein complexes
α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits
DNA_polymerase_alpha
Chemical compound
(herpes zoster). It acts as an inhibitor of the zoster virus's helicase–primase complex. Amenamevir was approved in Japan for the treatment of shingles
Amenamevir
Protein-coding gene in the species Homo sapiens
DNA primase small subunit is in humans is encoded by the PRIM1 gene and is part of the enzyme DNA polymerase alpha. The replication of DNA in eukaryotic
PRIM1
Chemical compound
inhibition of the viral helicase primase complex, encoded by the UL5 (helicase), UL8 (scaffold protein) and UL52 (primase) genes, which is essential for
Pritelivir
Enzymes that catalyze DNA formation
α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits
DNA_polymerase
Antiherpes drug candidate
2 clinical testing for recurrent genital herpes. IM-250 is a helicase-primase inhibitor, which interferes with viral DNA replication. In January 2026
IM-250
Chemical compound
been found to cause a conformational change in Escherichia coli enzyme Primase. In this experiment Mg(OAc)2, MnCl2, CaCl2, NaOAc, LiCl, MgSO4 and MgCl2
Magnesium_acetate
Protein-coding gene in the species Homo sapiens
humans. PrimPol is a eukaryotic protein with both DNA polymerase and DNA Primase activities involved in translesion DNA synthesis. It is the first eukaryotic
PrimPol
Class of enzymes which synthesize nucleic acid chains or polymers
different superfamily (InterPro: IPR043519). Primases generally don't fall into either category. Bacterial primases usually have the Toprim domain, and are
Polymerase
Molecular complex
proteins including helicase, RFC, PCNA, gyrase/topoisomerase, SSB/RPA, primase, DNA polymerase III, RNAse H, and DNA ligase. For prokaryotes, each dividing
Replisome
Class of enzymes
alpha. This gene encodes the p180 catalytic subunit of DNA polymerase α-primase. Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading
DNA polymerase alpha catalytic subunit
DNA_polymerase_alpha_catalytic_subunit
Protein-coding gene in the species Homo sapiens
DNA primase large subunit in humans is encoded by the PRIM2 gene and is part of the enzyme DNA polymerase alpha. The replication of DNA in eukaryotic
PRIM2
Class of proteins
replication fork machinery, including a two-subunit DNA polymerase, a helicase–primase complex and a single-stranded DNA-binding protein. The human herpesvirus
Single-stranded binding protein
Single-stranded_binding_protein
direction to the other dnaB-dnaC complex. After the assembly of dnaG, a primase, onto the N-terminus of dnaB, dnaC is released and dnaB will be allowed
DnaC
Science that studies the disease called herpes
Helicase-Primase Inhibitor Candidate ABI-5366". assemblybio.com. 10 June 2024. Retrieved 2 February 2025. Gege, Christian (16 June 2021). "A helicase-primase drug
Herpes_simplex_research
DNA region replicating from a single origin
Prokaryotic (initiation) Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin
Replicon_(genetics)
Class of enzymes
Prokaryotic (initiation) Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin
DNA_polymerase_epsilon
Class of enzymes
AR, Weisshart K, Grosse F, Nasheuer HP (1998). "Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity
DNA polymerase alpha subunit 2
DNA_polymerase_alpha_subunit_2
Human mitochondrial protein
is a mitochondrial protein with structural similarity to the phage T7 primase/helicase (GP4) and other hexameric ring helicases. The twinkle protein
Twinkle_(protein)
Species of virus
dUTPase, ribonucleotide reductase, DNA polymerase, DNA helicase, DNA primase, and protein kinases. The B virus genome was fully sequenced in 2003 from
B_virus
Primary oocyte Primary spermatocyte Primary structure Primary transcript Primase Primer Primosome Prion Privacy Pro Probability Probability theory Proband
Index_of_genetics_articles
Type of chromosome
helicase both unwinds the parental DNA and interacts momentarily with primase. In order for DNA replication to continue, single stranded binding proteins
Circular_chromosome
Short strand of RNA or DNA that serves as a starting point for DNA synthesis
initiation of synthesizing a strand of DNA. A class of enzymes called primases add a complementary RNA primer to the reading template de novo on both
Primer_(molecular_biology)
Topics referred to by the same term
been drinking, a medical abbreviation Helicase binding domain, of the DNA primase DnaG Hemoglobin D (HbD), a variant of hemoglobin HBD (gene), the gene encoding
HBD
Hexameric motor protein
separating (helicase) the two strands as it progresses. It is also a primase, making short stretches of RNA that initiates DNA synthesis. It forms a
T7_DNA_helicase
Enzyme
replication. In T7 system, primase domain of one subunit interacts with primase domain of adjacent subunit. This interaction between primase domains acts as a
T7_DNA_polymerase
DNA replication in eukaryotic organisms
synthesis, polymerase α (Pol α) acts as a replicative primase. Pol α is associated with an RNA primase and this complex accomplishes the priming task by synthesizing
Eukaryotic_DNA_replication
Chemical compound
compound isolated from Penicillium verrucosum that inhibits bacterial DNA primase. "KNApSAcK Metabolite Information - C00045061". www.knapsackfamily.com
Sch_642305
US scientist & fertility specialist who became the first man to clone himself
using a poly(dT) template. He and his colleagues discovered that HeLa cell primase in these cells is in a bound form and they determined the presence of multiple
Samuel_H._Wood
models of molecules as varied as RNA polymerase, an E. coli, bacterial DNA primase template suggesting very complex dynamics at the interfaces between the
Molecular_models_of_DNA
Class of enzymes
initiated by a short RNA segment, known as RNA primer, synthesized by Primase in the 5' to 3' direction. DNA synthesis then occurs by the addition of
DNA_polymerase_I
Family of viruses
important proteins for viral replication. For vaccinia these are: a helicase-primase (viral gene, D5), single-stranded DNA-binding protein (viral gene, I3)
Poxviridae
Medical condition
broad-spectrum antiviral efficacy. New herpes virus drugs include viral helicase-primase and terminase inhibitors. A promising new area of research involves therapies
Central nervous system viral disease
Central_nervous_system_viral_disease
DNA inside the nucleus of eukaryotic cells
chain of nucleotides. Therefore, replication begins as an enzyme called primase assembles an RNA primer at the origin of replication. The RNA primer consists
Nuclear_DNA
Chemistry professor
biochemistry from the University of Minnesota. He studies the enzymes primase and DnaB helicase in his search for antibiotics that inhibit them. He is
Mark_Griep
Enzyme that synthesizes RNA from DNA
centrifugation. By a DNA column. By an ion chromatography column. Alpha-amanitin Primase Werner F, Grohmann D (February 2011). "Evolution of multisubunit RNA polymerases
RNA_polymerase
Synthesis of complex molecules from simple precursors
involves cloning the genes into plasmids in Escherichia coli or yeast. Primase is an RNA polymerase, and it can add a primer to an existing strand awaiting
De_novo_synthesis
Species of virus
P89430 Virion maturation UL8 DNA helicase/primase complex-associated protein P10192 P89431 DNA virus helicase-primase complex-associated protein UL9 Replication
Herpes_simplex_virus
Protein complex
during DNA replication. The primosome consists of seven proteins: DnaG primase, DnaB helicase, DnaC helicase assistant, DnaT, PriA, Pri B, and PriC. At
Primosome
Realm of viruses
in replication. Ahmunviruses encode homologs of the archaeo-eukaryotic primase and DNA polymerase sliding clamp, which likely are important during replication
Adnaviria
American bioinorganic chemist
enzyme kinetics, metallo-beta-lactamase, and the mechanics of replisome and primase in DNA replication. In 2001, Valentine joined the chemistry faculty of
Ann_M._Valentine
Founder of Khuda Bakhsh Oriental Library
and commitment. He died on 3 August 1908 and was buried in the library primase. Sir Khuda Bakhsh was given the title of "Khan Bahadur" in 1881. He was
Khuda_Bakhsh
Cytosolic DNA sensor
polymerase Template-directed RNA polymerase I II III IV V ssRNAP POLRMT Primase 1 2 PrimPol RNA-dependent RNA polymerase Polyadenylation PAP PNPase Phosphorolytic
Cyclic_GMP-AMP_synthase
Species of virus
form a hairpin, which contributes to so-called self-priming that allows primase-independent synthesis of the second DNA strand. The ITRs were also shown
Adeno-associated_virus
Sequence in a genome
Prokaryotic (initiation) Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin
Origin_of_replication
EC 2.7.7.100: SAMP-activating enzyme EC 2.7.7.101: DNA primase DnaG EC 2.7.7.102: DNA primase AEP EC 2.7.7.103: L-glutamine-phosphate cytidylyltransferase
List_of_EC_numbers_(EC_2)
Class of antymetabolites for cytostatic chemotherapy
Nucleotide analogues Fludarabine inhibits multiple DNA polymerases, DNA primase, and DNA ligase I, and is S phase-specific (since these enzymes are highly
Purine_analogue
Primary enzyme complex involved in prokaryotic DNA replication
primer, complementary to part of the single-stranded DNA, is synthesized by primase (an RNA polymerase):[citation needed] ("!" for RNA, '"$" for DNA, "*" for
DNA_polymerase_III_holoenzyme
Species of coronavirus causing SARS and COVID-19
secondary structure (light blue), RNA sliding clamp for processivity and primase domain for priming (green/orange), and a helicase to unwind RNA (downstream)
SARS-related_coronavirus
Protein-coding gene in the species Homo sapiens
binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal
MCM3AP
Subviral agent
fall between ORFs. Several other homologues such as those of a helicase-primase, a packaging ATPase, an insertion sequence transposase DNA-binding subunit
Sputnik_virophage
Process where substrates are converted into more complex products in living organisms
prior to replication. DNA synthesis is initiated by the RNA polymerase primase, which makes an RNA primer with a free 3'OH. This primer is attached to
Biosynthesis
Plasmid in bacteria
by DNA polymerase I. Lagging strand synthesis is later initiated by a primase encoded by the host cell. Replication is carried out entirely by host proteins
ColE1
Species of virus
process is thought to be catalyzed by host factors. The presence of DNA primase along with polymerase activity has been noted as one method of replication
Sweet_potato_leaf_curl_virus
Informal grouping of viruses
Origin-binding protein U74 DNa helicase-primase complex U75 Tegument protein U76 DNA packaging, virion protein U77 Helicase-primase complex U79 Transcriptional activation
Human_herpesvirus_6
Species of virus
formation ORF39 – gM – envelope glycoprotein ORF40 and ORF41 – helicase and primase – DNA replication ORF42 – uncharacterized ORF45 – tegument protein, binds
Kaposi's sarcoma-associated herpesvirus
Kaposi's_sarcoma-associated_herpesvirus
Protein complex formed during initiation of DNA replication
stabilize the newly formed replication bubble and interact with the DnaG primase. DnaG recruits the replicative DNA polymerase III, and replication begins
Pre-replication_complex
Virus type
products include transposase, helicase, integrase, cysteine protease, DNA primase–polymerase and DNA-packaging ATPase enzymes, major and minor capsid proteins
Zamilon_virophage
Species of virus
T7 has the simplest known DNA replisome, consisting of a helicase and primase that reside in a single polypeptide chain that forms a hexamer in the presence
T7_phage
Cellular process
from a few nucleotides to whole segments of chromosome. Recombinases and primases lay a foundation of nucleotides along the DNA sequence. One such particular
Chromosomal_crossover
Genus of archaea
more related to those in eukaryotes. These genes include DNA polymerase, primase (including two subunits), MCM, CDC6/ORC1, RPA, RPC, and PCNA. In 2004,
Sulfolobus
Protein in the Coronavirus genome
RTC indicate that nsp7 and nsp8 form an 8:8 hexadecamer which acts as a primase to initiate viral replication. While nsp12 is relatively well conserved
Nsp12
Class of enzymes
in both type II topoisomerases, type IA topoisomerases, and bacterial primase (DnaG), a central DNA-binding core (which structurally forms a heart-shaped
Type_II_topoisomerase
replication fork), elongation must occur by an indirect mechanism in which a primase enzyme synthesizes short RNA primers complementary to the template DNA
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Subfield of genetics devoted to the study of microorganisms
initiation, elongation, and termination. The primase used to synthesize a RNA primer varies than in eukaryotes. The primase by archaea is highly derived version
Microbial_genetics
DNA replication in prokaryotes
recruit the DnaB helicase, which will continue to unwind the DNA as the DnaG primase lays down an RNA primer and DNA Polymerase III holoenzyme begins elongation
Prokaryotic_DNA_replication
Protein-coding gene in humans
Prokaryotic (initiation) Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin
POLE_(gene)
Class of enzymes
enzyme. This enzyme has an associated 3′→5′ exonuclease activity along with primase activity. DNA Pol II is a high fidelity enzyme with a substitution error
DNA_polymerase_II
Brázda vydavatelství Břeclav, 2007. (in Czech) Dušan Holý: Mudrosloví primáše Jožky Kubíka, Prague: Supraphon, 1984 (in Czech) Jarek Miškeřík (ed.):
Horňácko
Chemical compound
specific sites about 100-200kb away from oriC in both directions. DNA primase (DnaG) was directly inhibited by (p)ppGpp. Unlike E. coli, B. subtilis
Guanosine_pentaphosphate
Network of circular DNA
replication proteins including an endonuclease, helicase, DNA polymerase, DNA primase, and DNA ligase, which initiate repair of remaining discontinuities in
Kinetoplast
Gene which maintains basic cellular functions
MAZ (gene) MYC also considered a transcription factor MCM3AP possibly a primase XRCC5 NM_021141 Ku80 XRCC6 NM_001469 Homo sapiens thyroid autoantigen:
Housekeeping_gene
Family of viruses
neither have complete replicative genes, since they all lack genes for primase. Neither EsV-1 nor PBCV-1 encode a complete RNA polymerase, but they produce
Phycodnaviridae
essential upstream component of oriLyt. It interacts with the viral helicase-primase complex and BMRF1, the viral polymerase accessory factor. It has been shown
BZLF1
Hungarian symphony orchestra
violin and leader) Sándor Járóka ('The Primas of kings and the king of Primases') died. At his funeral, the Roma community gathered. Musicians gathered
Budapest Gypsy Symphony Orchestra
Budapest_Gypsy_Symphony_Orchestra
Compound isolated from fungi for medicinal benefit
Sch 642305 Penicillium verrucosum and Rhizoctonia solani bacterial DNA primase inhibitor Sclerotides A-B Aspergillus sclerotiorum PT06-1 bio-active cyclic
Fungal_isolate
major capsid protein, a DNA packaging ATPase, a putative DNA polymerase/primase and a N6 adenine specific DNA methyltransferase. Yau, S.; Lauro, F. M.;
Organic_Lake_virophage
Protein-coding gene in the species Homo sapiens
Prokaryotic (initiation) Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin
POLE4
Protein-coding gene in the species Homo sapiens
Prokaryotic (initiation) Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin
POLE2
Mammalian protein found in Homo sapiens
"Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication"
PARP1
Protein
helicase, so it travels on the lagging strand. It associates with DnaG (a primase) to form the only primer for the leading strand and to add RNA primers
DnaA
which, after processing, becomes a mature mRNA ready for translation. primase Any of a class of enzymes that catalyze the synthesis of short, ~10-base
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Protein-coding gene in humans
proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested
CDK2AP1
Protein-coding gene in the species Homo sapiens
Yonezawa K, Takagi K, Sakaguchi N (Aug 2002). "MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR". Genes Cells. 7
PPP2R3C
Protein-coding gene in the species Homo sapiens
Winkler D, Kelly TJ, Fanning E (1992). "Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen". EMBO J. 11 (2):
Replication_protein_A1
Virus affecting abalone snails
include the terminase, endonuclease, exonuclease, resolvase, helicase, primase and single-stranded binding protein. Seven other proteins appear to be
Abalone shriveling syndrome-associated virus
Abalone_shriveling_syndrome-associated_virus
Chemical compound
"Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts"
Flumequine
Protein-coding gene in humans
membrane nucleoplasm perinuclear region of cytoplasm alpha DNA polymerase:primase complex MCM complex nucleus nucleolus intracellular membrane-bounded organelle
MCM3
Protein-coding gene in the species Homo sapiens
coated with replication protein A (RPA) (light pink). Polα bound to a primase, initiates lagging strand synthesis (blue line), herein an RNA primer is
POLD1
Genus of Gram-positive bacteria
tRNA preQ1(34)S-adenosylmethionine ribosyltransferase-isomerase QueA, DNA primase, FMN reductase (NADPH), UvrABC system protein C, sensor histidine kinase
Metalysinibacillus
Protein-coding gene in the species Homo sapiens
Prokaryotic (initiation) Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG Eukaryotic (preparation in G1 phase) Pre-replication complex Origin
POLD3
Species of virus
expression and replication: endonuclease, RNA polymerase, DNA polymerase, RNA primase, DNA ligase, topoisomerase, and DNA helicase. Therefore, CC31 does not
Escherichia_virus_CC31
American biochemist
coli DNA polymerase III in 1975, T4 polynucleotide kinase in 1981, T7 DNA primase in the late 1980s and early 1990s, and T7 DNA helicase in 2004. Richardson
Charles_C._Richardson
dna-directed rna polymerases MeSH D08.811.913.696.445.735.270.375 – dna primase MeSH D08.811.913.696.445.735.270.750 – rna polymerase i MeSH D08.811.913
List_of_MeSH_codes_(D08)
PRIMASE
PRIMASE
PRIMASE
PRIMASE
Boy/Male
Arabic, Muslim
Name of a Sahabi who Participated in the Battle of Badr
Girl/Female
Arabic, Muslim
Passion; Strong Emotion
Girl/Female
Tamil
Sharumathi | à®·à®°à¯à®®à®¾à®‚தீ
Full Moon
Boy/Male
Tamil
The Sun
Boy/Male
American, Australian, Danish, French, German, Hebrew
God Sees; The Lord Exists; Form of Jessica; Wealthy
Surname or Lastname
English
English : habitational name from Sharrow in Sheffield or Sharow in North Yorkshire, both named with Old English scearu ‘boundary’ + hÅh ‘hill-spur’.Americanized spelling of French Charron.
Boy/Male
Muslim
Full of qualities, Expansionist, Vast, Spacious, Man of qualities
Female
English
 Pet form of Scottish Kirstine, KIRSTY means "believer" or "follower of Christ."
Boy/Male
English American French Irish
Fair-haired.
Boy/Male
Hindu
King, Gift of God
PRIMASE
PRIMASE
PRIMASE
PRIMASE
PRIMASE