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Pneumolysin is a virulence factor of the Gram-positive bacteria Streptococcus pneumoniae. It is a pore-forming toxin of 53 kDa composed of 471 amino acids
Pneumolysin
Species of bacterium
typically when the host's immune system is suppressed. Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall
Streptococcus_pneumoniae
Toxin from bacteria that destroys or disrupts cells
pneumolysin, which is released from the cytoplasm of Streptococcus pneumoniae when the bacteria lyse. The CDCs Streptococcus pneumoniae Pneumolysin,
Exotoxin
Medical condition
host immune cells by inhibiting C3b opsonization of the bacterial cells Pneumolysin (Ply)—a 53-kDa pore-forming protein that can cause lysis of host cells
Pneumococcal_infection
Infection of the lungs by Streptococcus bacteria
Pro-inflammatory effects are exhibited by the single pneumococcal toxin, pneumolysin (Ply); use of anti-Ply antibodies result in decreased inflammation. Studies
Pneumococcal_pneumonia
Protein-produced toxins that create pores in cell membrane
proliferation, phagocytosis, and proinflammatory cytokine release. CDCs, such as pneumolysin, from S. pneumoniae, form pores as large as 260 Å (26 nm), containing
Pore-forming_toxin
Chemical compound
devoid of neurotoxicity". Mutepe, N. Daphney (2013). "Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin". v t e
Fura-2-acetoxymethyl_ester
Family of toxins from bacteria
shared by all CDCs, which essentially corresponds to the sequence of pneumolysin, the shortest member of the family. CDCs with longer sequences usually
Cholesterol-dependent cytolysin
Cholesterol-dependent_cytolysin
German-American biochemist and biophysicist
"Mucins protect against Streptococcus pneumoniae virulence by suppressing pneumolysin expression". Journal of Clinical Investigation. 134 (19) e182769. doi:10
Katharina_Ribbeck
Large group of transport proteins
HR (2005). "Structural basis of pore formation by the bacterial toxin pneumolysin". Cell. 121 (2): 247–56. doi:10.1016/j.cell.2005.02.033. PMID 15851031
MACPF
Substances toxic to individual cells
E. coli α-hemolysin, Aeromonas aerolysin) to 25–30 nm (streplysin O, pneumolysin). Depending on how the pores are formed, the pore forming cytolysins
Cytolysin
Protein-coding gene in the species Homo sapiens
Gerber J, Spreer A, Bähr M, Michel U, Nau R (2002). "Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends
MAPK11
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