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Protein-coding gene in humans
member 7 is a protein that in humans is encoded by the SLAMF7 gene. The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant
SLAMF7
Pharmaceutical drug
targets the Signaling Lymphocytic Activation Molecule Family member 7 (SLAMF7) through two mechanisms. In May 2014, it was granted breakthrough therapy
Elotuzumab
Protein family
FimH) SLAMF3 (CD229, LY9) SLAMF4 (CD244, 2B4) SLAMF5 (CD84) SLAMF6 (CD352) SLAMF7 (CD319, CRACC) SLAMF8 (CD353) SLAMF9 SLAMFs are CD2-related surface receptors
Signaling lymphocytic activation molecule
Signaling_lymphocytic_activation_molecule
Cancer of plasma cells
disappears rapidly ex vivo. Recently, however, the surface antigen CD319 (SLAMF7) was discovered to be considerably more stable and allows robust isolation
Multiple_myeloma
White blood cell that secretes large volumes of antibodies
is expressed at high levels. Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells
Plasma_cell
Protein domain
SIGLEC7; SIGLEC8; SIGLEC9; SIRPA; SIRPB1; SIRPD; SIRPG; SISP1; SLAMF6; SLAMF7; TAPBPL; TCRA; TCRB; TIMD4; TRA@; TRAV20; TRBC1; TRBV19; TRBV3-1; TRBV5-4;
V-set_domain
Artificial stimulation of the immune system to treat cancer
targets the Signaling Lymphocytic Activation Molecule Family member 7 (SLAMF7) through two mechanisms. In May 2014, it was granted breakthrough therapy
Cancer_immunotherapy
Elgemtumab mab human ERBB3 (HER3) cancer Elotuzumab Empliciti mab humanized SLAMF7 Y multiple myeloma Elsilimomab mab mouse IL-6 Emactuzumab mab humanized
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
CDCP1 phosphorylation in tumors is currently under investigation. CD319 SLAMF7, a marker of normal plasma cells and malignant plasma cells in multiple
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Form of immunotherapy
elotuzumab Empliciti Bristol-Myers Squibb 11/30/2015 intravenous humanized SLAMF7 Multiple myeloma 761035 Link[dead link] emicizumab-kxwh Hemlibra Genentech
Monoclonal_antibody_therapy
Q9P270 14854 SLAMF1 HGNC:10903; Q13291 14855 SLAMF6 HGNC:21392; Q96DU3 14856 SLAMF7 HGNC:21394; Q9NQ25 14857 SLAMF8 HGNC:21391; Q9P0V8 14858 SLAMF9 HGNC:18430;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Overview of and topical guide to immunology
(CD48) SLAMF3 (CD229, LY9) SLAMF4 (CD244) SLAMF5 (CD84) SLAMF6 (CD352) SLAMF7 (CD319) SLAMF8 (CD353) SLAMF9 Cadherins Selectins E-selectin L-selectin
Outline_of_immunology
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