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CUL1

  • CUL1
  • Protein-coding gene in humans

    Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination

    CUL1

    CUL1

    CUL1

  • Cullin
  • Hydrophobic scaffold protein

    complex. CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play

    Cullin

    Cullin

    Cullin

  • SCF complex
  • Type of protein

    is essential for the recognition and binding of F-box proteins. Cullin (CUL1) – Cullin forms the major structural scaffold of the SCF complex and links

    SCF complex

    SCF complex

    SCF_complex

  • RBX1
  • Protein-coding gene in the species Homo sapiens

    regulation of protein turn-over. RBX1 has been shown to interact with: CAND1, CUL1, CUL2, CUL4A, CUL5 CUL7, DCUN1D1, and P70-S6 Kinase 1. GRCh38: Ensembl release

    RBX1

    RBX1

    RBX1

  • Todd Kellett
  • British motorcycle racer

    Husqvarna CUL1 9 CUL2 11 LYN1 8 LYN2 8 CAN1 4 CAN2 13 HAW1 3 HAW2 5 DES1 4 DES2 4 5th 241 KTM BLA1 4 BLA2 1 PRD1 19 PRD2 7 FOX1 5 FOX2 3 2018 MX2 KTM CUL1 9 CUL2

    Todd Kellett

    Todd Kellett

    Todd_Kellett

  • Ning Zheng
  • American biochemist and structural biologist

    Goldenberg, S.J., Cascio, T.C., Shumway, S.D. et al. Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit

    Ning Zheng

    Ning Zheng

    Ning_Zheng

  • CAND1
  • Protein-coding gene in humans

    humans is encoded by the CAND1 gene. CAND1 has been shown to interact with: CUL1, CUL2, CUL3, CUL4A, CUL4B, DCUN1D1, and RBX1. GRCh38: Ensembl release 89:

    CAND1

    CAND1

    CAND1

  • Ubiquitin ligase
  • Protein

    (Skp1-Cullin-F-box protein complex). SCF complexes consist of four proteins: Rbx1, Cul1, Skp1, which are invariant among SCF complexes, and an F-box protein, which

    Ubiquitin ligase

    Ubiquitin ligase

    Ubiquitin_ligase

  • SCF
  • Topics referred to by the same term

    a telecommunications network Small carbonaceous fossil SCF-complex (Skp1/Cul1/F-box complex), a ubiquitin ligase Supercritical fluid Standard cubic foot

    SCF

    SCF

  • 1925 AAA Championship Car season
  • Auto racing season

    Pos Driver CUL1 FRE CHA1 INDY ALT1 LAU1 ALT2 LAU2 SAL CHA2 CUL2 Pts 1 Peter DePaolo 2 1 5 1* 1 1 DNP 2 1* 15 9 3260 2 Tommy Milton 1* 2 3 5 3 7 3 16 1

    1925 AAA Championship Car season

    1925_AAA_Championship_Car_season

  • BTRC (gene)
  • Protein-coding gene in the species Homo sapiens

    the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein), which often, but not always, recognize substrates in a

    BTRC (gene)

    BTRC (gene)

    BTRC_(gene)

  • COPS7B
  • Protein-coding gene in humans

    PMID 11285227. Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    COPS7B

    COPS7B

    COPS7B

  • Cell division control protein 4
  • control protein 4) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which acts as a mediator of ubiquitin

    Cell division control protein 4

    Cell division control protein 4

    Cell_division_control_protein_4

  • COPS6
  • Protein-coding gene in humans

    C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    COPS6

    COPS6

    COPS6

  • Ubiquitin
  • Regulatory protein found in most eukaryotic tissues

    independently. By inhibition of the ligase activity (through the making of Cul1 dominant negative thus renders ubiquitination not to occur), increased reporter

    Ubiquitin

    Ubiquitin

    Ubiquitin

  • FBXO31
  • Protein-coding gene in the species Homo sapiens

    acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box

    FBXO31

    FBXO31

    FBXO31

  • FBXW7
  • Protein-coding gene in the species Homo sapiens

    transferase activity ubiquitin binding Cellular component cytoplasm Parkin-FBXW7-Cul1 ubiquitin ligase complex SCF ubiquitin ligase complex nucleoplasm nucleolus

    FBXW7

    FBXW7

    FBXW7

  • Proteasome
  • Protein complexes which degrade ubiquitin-tagged proteins by proteolysis

    anaphase promoting complex (APC), an E3 ubiquitin ligase. The APC and the Skp1/Cul1/F-box protein complex (SCF complex) are the two key regulators of cyclin

    Proteasome

    Proteasome

    Proteasome

  • S-phase kinase-associated protein 1
  • Protein-coding gene in the species Homo sapiens

    chromosome 7. SKP1A has been shown to interact with: BTRC, CACYBP, CDCA3, CDK9, CUL1, FBXL3, FBXO4, FBXO5, FBXO7, FBXW2, FBXW7, and SKP2. GRCh38: Ensembl release

    S-phase kinase-associated protein 1

    S-phase kinase-associated protein 1

    S-phase_kinase-associated_protein_1

  • FBXW11
  • Protein-coding gene in the species Homo sapiens

    the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein), which often, but not always, recognize substrates in a

    FBXW11

    FBXW11

    FBXW11

  • SKP2
  • Protein-coding gene in the species Homo sapiens

    has been shown to interact with: CCNA2, CDK2, CDKN1A CDKN1B CKS1B, CDT1, CUL1 E2F1, ORC1L, and SKP1A. GRCh38: Ensembl release 89: ENSG00000145604 – Ensembl

    SKP2

    SKP2

    SKP2

  • SENP8
  • Protein-coding gene in the species Homo sapiens

    603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called

    SENP8

    SENP8

    SENP8

  • FBXW10
  • Protein-coding gene in the species Homo sapiens

    acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box

    FBXW10

    FBXW10

    FBXW10

  • NEDD8
  • Protein found in the human body

    al., the best-characterized activated-NEDD8 substrates are the cullins (CUL1, 2, 3, 4A, 4B, 5, and 7 and PARC in human cells), that serve as molecular

    NEDD8

    NEDD8

    NEDD8

  • FBXO28
  • Protein-coding gene in the species Homo sapiens

    acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box

    FBXO28

    FBXO28

    FBXO28

  • CUL4A
  • Protein-coding gene in humans

    Matsumoto T, Xiong Y (Dec 2002). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases". Molecular Cell. 10

    CUL4A

    CUL4A

    CUL4A

  • RNF7
  • Protein-coding gene in the species Homo sapiens

    "The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1". Mol

    RNF7

    RNF7

    RNF7

  • DREAM complex
  • Protein complex

    promote gene expression (e.g. AURKA). During late S phase BMYB is degraded via CUL1 (SCF complex), while FOXM1 is degraded during mitosis by the APC/C. Near

    DREAM complex

    DREAM_complex

  • Wee1
  • Nuclear protein

    repeat-containing protein 1/2 (β-TrCP1/2) F-box protein-containing SKP1/Cul1/F-box protein complex "Gene: wee1 / SPCC18B5.03". PomBase. Nurse P (December

    Wee1

    Wee1

    Wee1

  • Parkin (protein)
  • Mammalian protein found in humans

    Parkin (ligase) has been shown to interact with: Alpha-synuclein, CASK, CUL1, FBXW7 and GPR37, HSPA1A, HSPA8, Multisynthetase complex auxiliary component

    Parkin (protein)

    Parkin (protein)

    Parkin_(protein)

  • UBR1
  • Mammalian protein found in Homo sapiens

    other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated

    UBR1

    UBR1

    UBR1

  • Raymond J. Deshaies
  • American biochemist and cell biologist

    of predicted metalloprotease motif of Jab1/Csn5 in cleavage of NEDD8 from CUL1. Science 298, 608-611 Verma, R., Aravind L., Oania, R., McDonald, W.H., Yates

    Raymond J. Deshaies

    Raymond_J._Deshaies

  • CUL4B
  • Protein-coding gene in humans

    Wei N, Sun H, Kobayashi R, Zhang H (2003). "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex". Mol. Cell

    CUL4B

    CUL4B

    CUL4B

  • COPS4
  • Protein-coding gene in humans

    Shevchenko A, Serino G, Tsuge T, Zhou C, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–1385.

    COPS4

    COPS4

    COPS4

  • GPS1
  • Protein-coding gene in the species Homo sapiens

    PMID 11285227. Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    GPS1

    GPS1

    GPS1

  • COPS7A
  • Protein-coding gene in humans

    Shevchenko A, Serino G, Tsuge T, Zhou C, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    COPS7A

    COPS7A

    COPS7A

  • CUL3
  • Protein-coding gene in humans

    H, Fukuda M (April 2001). "In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3". FEBS Letters. 494 (3): 181–185. doi:10.1016/S0014-5793(01)02343-2

    CUL3

    CUL3

    CUL3

  • CUL5
  • Protein-coding gene in humans

    Matsumoto T, Xiong Y (2003). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases". Mol. Cell. 10 (6):

    CUL5

    CUL5

    CUL5

  • CUL2
  • Protein-coding gene in humans

    C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    CUL2

    CUL2

    CUL2

  • COP9 signalosome complex subunit 3
  • Protein-coding gene in the species Homo sapiens

    PMID 11285227. Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    COP9 signalosome complex subunit 3

    COP9 signalosome complex subunit 3

    COP9_signalosome_complex_subunit_3

  • E2F1
  • Protein-coding gene in the species Homo sapiens

    E2F1 promoter[PAX8] => E2F1 E2F1 has been shown to interact with: ARID3A, CUL1, Cyclin A1, Cyclin A2, GTF2H1, MDM4, NCOA6, NDN, NPDC1, PURA, PHB, RB1, UDG

    E2F1

    E2F1

    E2F1

  • F-box protein 40
  • Protein-coding gene in the species Homo sapiens

    acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box

    F-box protein 40

    F-box protein 40

    F-box_protein_40

  • KCTD7
  • Protein-coding gene in the species Homo sapiens

    domain of KCTD7. However, KCTD7 does not show any interaction cullin-1 (CUL1). Immunoprecipitation assays also shows that KCTD7 does not interact with

    KCTD7

    KCTD7

    KCTD7

  • List of human protein-coding genes 2
  • O60494 3780 CUEDC1 HGNC:31350; Q9NWM3 3781 CUEDC2 HGNC:28352; Q9H467 3782 CUL1 HGNC:2551; Q13616 3783 CUL2 HGNC:2552; Q13617 3784 CUL3 HGNC:2553; Q13618

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

  • FBXL3
  • Protein-coding gene in the species Homo sapiens

    subunits of a ubiquitin ligase complex called SKP1-CUL1-F-box-protein, which includes the proteins CUL1, SKP1, and RBX1. The FBXL3 protein plays a role in

    FBXL3

    FBXL3

    FBXL3

  • HEAT repeat
  • Protein tandem repeat

    SD, Garbutt KC, Liu J, Xiong Y, Zheng N (2004). "Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit

    HEAT repeat

    HEAT repeat

    HEAT_repeat

  • FBXO7
  • Protein-coding gene in the species Homo sapiens

    variants being determined. FBXO7 has been shown to interact with SKP1A, CUL1, CDK6, p27, PI31, Parkin, and PINK1. GRCh38: Ensembl release 89: ENSG00000100225

    FBXO7

    FBXO7

    FBXO7

  • COPS2
  • Protein-coding gene in humans

    C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    COPS2

    COPS2

    COPS2

  • DCUN1D1
  • Protein-coding gene in the species Homo sapiens

    driver in cancer cells. DCUN1D1 has been shown to interact with: CAND1, CUL1, CUL2, CUL3 and RBX1. GRCh38: Ensembl release 89: ENSG00000043093 – Ensembl

    DCUN1D1

    DCUN1D1

    DCUN1D1

  • CDC34
  • Protein-coding gene in humans

    Wu K, Chen A, Tan P, Pan ZQ (January 2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient

    CDC34

    CDC34

    CDC34

  • COP9 constitutive photomorphogenic homolog subunit 5
  • Protein-coding gene in the species Homo sapiens

    Shevchenko A, Serino G, Tsuge T, Zhou C, et al. (May 2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    COP9 constitutive photomorphogenic homolog subunit 5

    COP9 constitutive photomorphogenic homolog subunit 5

    COP9_constitutive_photomorphogenic_homolog_subunit_5

  • FBXL4
  • Protein-coding gene in the species Homo sapiens

    Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR (Sep 2011). "The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates

    FBXL4

    FBXL4

    FBXL4

  • COPS8
  • Protein-coding gene in humans

    Shevchenko A, Serino G, Tsuge T, Zhou C, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci

    COPS8

    COPS8

    COPS8

  • FBXO4
  • Protein-coding gene in the species Homo sapiens

    generates 2 transcript variants. FBXO4 has been shown to interact with: CUL1, and SKP1A. GRCh38: Ensembl release 89: ENSG00000151876 – Ensembl, May 2017

    FBXO4

    FBXO4

    FBXO4

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Online names & meanings

  • Omvati
  • Girl/Female

    Assamese, Hindu, Indian, Kannada, Marathi, Sanskrit, Sindhi, Telugu

    Omvati

    Sacred; Having the Power of Om

  • Izri
  • Girl/Female

    Biblical

    Izri

    Fasting, tribulation.

  • Garnier
  • Surname or Lastname

    French

    Garnier

    French : from a Germanic personal name, Warinhari, composed of the elements war(in) ‘guard’ + hari, heri ‘army’.English : variant of Garner 1.This name was also brought to America by the Huguenots.

  • Aadhira
  • Girl/Female

    Assamese, Hindu, Indian, Tamil

    Aadhira

    Restless; Moon

  • Gedaliah
  • Boy/Male

    Australian, Biblical, Christian, Hebrew

    Gedaliah

    God is Great

  • Biboswan | பீபோஸ்வாந
  • Boy/Male

    Tamil

    Biboswan | பீபோஸ்வாந

    Sun God

  • ELYAN
  • Male

    Arthurian

    ELYAN

    , le blanc (the white), a knight.

  • Vimo
  • Girl/Female

    Indian

    Vimo

    Goodness

  • Haviya
  • Girl/Female

    Assamese, Hindu, Indian

    Haviya

    Sun; Moon; Lord of Sun; Lord Shiva

  • te Scarlet
  • Girl/Female

    British, English

    te Scarlet

    Scarlet

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CUL1

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