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Cell type with functions of both muscular and fibrous connective tissue
A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell. Myofibroblasts are contractile
Myofibroblast
Area of fibrous tissue that replaces normal skin after an injury
contraction is the myofibroblast, which is a specialized contractile fibroblast. These cells express α-smooth muscle actin (α-SMA). The myofibroblasts are absent
Scar
Abnormal growth of scar tissue within the penis
growth factor-beta 1 (TGF-β1) — that end in fibroblast proliferation, myofibroblast differentiation, and overproduction of type I collagen. Genetic predisposition
Peyronie's_disease
Series of events that restore integrity to damaged tissue after an injury
occurs without myofibroblast involvement. Later, fibroblasts, stimulated by growth factors, differentiate into myofibroblasts. Myofibroblasts, which are similar
Wound_healing
Intense physical sensation of sexual release
becomes congested from engorged soft tissue. Elsewhere in the body, myofibroblasts of the nipple-areolar complex contract, causing erection of the nipples
Orgasm
Thin connective tissue layer of mucous membranes
and compliance, through complex coiling. It has been suggested that myofibroblasts also reside in the lamina propria of several organs. These cells have
Lamina_propria
Inflammatory disease involving a buildup of lesions in the walls of arteries
profile to resemble various other cell types, including macrophages, myofibroblasts, mesenchymal stem cells and osteochondrocytes. Importantly, genetic
Atherosclerosis
Tumour-promoting cell type
apoptosis. CAFs have been found to be abundant in a tumour stroma. Myofibroblasts and fibroblasts make up CAFs. The functions of these CAFs have been
Cancer-associated_fibroblast
Medical condition featuring permanent bending of fingers
understood. The disease is driven by over-activation of fibroblasts and myofibroblasts in response to signaling molecules including IL-1 beta, TGF-beta, EGF
Dupuytren's_contracture
Animal connective tissue cell
contribute to basal lamina components in some situations (e.g. subepithelial myofibroblasts in intestine may secrete the α-2 chain-carrying component of the laminin
Fibroblast
Group of autoimmune diseases resulting in abnormal growth of connective tissue
factors to generate myofibroblasts. Dysregulated transforming growth factor β (TGF-β) signalling in fibroblasts and myofibroblasts has been observed in
Scleroderma
Type of endocrine gland cancer
or structural tissue consisting of a range of cell types (including myofibroblasts, macrophages, lymphocytes and mast cells) and deposited material (such
Pancreatic_cancer
This is a list of cells in humans derived from the three embryonic germ layers – ectoderm, mesoderm, and endoderm. Trichocyte Keratinocyte Gonadotrope
List of human cell types derived from the germ layers
List_of_human_cell_types_derived_from_the_germ_layers
Process during wound healing
Saunders/Elsevier. ISBN 978-1-4377-0792-2. Shin D1, Minn KW. (2004). "The effect of myofibroblast on contracture of hypertrophic scar". Plast Reconstr Surg. 113 (2):
Wound_contracture
Chronic disease of the liver, characterized by fibrosis
stellate cells, which increases fibrosis through the production of myofibroblasts, and obstructs hepatic blood flow. In addition, stellate cells secrete
Cirrhosis
Muscular tissue of heart in vertebrates
infarction. Following injury, fibroblasts can become activated and turn into myofibroblasts – cells which exhibit behaviour somewhere between a fibroblast (generating
Cardiac_muscle
Protein-coding gene in the species Homo sapiens
as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation. Studies have shown that ACTA2 is associated with TGF-β pathway
ACTA2
Type of liver cell
with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver. In murine (rats, mice) liver, reelin expressed
Hepatic_stellate_cell
Chronic multi-symptomatic pain disorder
viral 'fibromyalgia-ness': Suggesting a mechanistic role for fascial myofibroblasts (Nineveh, the shadow is in the fascia)". Frontiers in Medicine. 10 952278
Fibromyalgia
Androgen-producing cell adjacent to the seminiferous tubules of the testicle
2 spermatids, 3 spermatocytes, 4 spermatogonia, 5 Sertoli cell, 6 myofibroblasts, 7 Leydig cells, 8 capillaries Identifiers MeSH D007985 FMA 72297 Anatomical
Leydig_cell
Pancreatic stellate cells (PaSCs) are classified as myofibroblast-like cells that are located in exocrine regions of the pancreas. PaSCs are mediated
Pancreatic_stellate_cell
Undifferentiated male germ cell
2 spermatids, 3 spermatocytes, 4 spermatogonia, 5 Sertoli cell, 6 myofibroblasts, 7 Leydig cells, 8 capillaries Identifiers MeSH D013093 FMA 72291 Anatomical
Spermatogonium
Transmembrane protein
role in TGF-beta1 dependent fibroblast to myofibroblast differentiation. Aberrant persistence of myofibroblasts within tissues can lead to progressive tissue
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Gland between the intestinal villi that produces new cells
propria, which contains various stromal cells including fibroblasts, myofibroblasts, telocytes, vascular and lymphatic capillaries, and leukocytes. Intestinal
Intestinal_gland
Protein-coding gene in the species Homo sapiens
by keratoconus. Another study showed that ITGA11 is overexpressed in myofibroblasts in different human fibrotic diseases, including liver cirrhosis, renal
Integrin_alpha_11
can give rise to myofibroblasts, fibroblast cells with smooth muscle characteristics. Dermal cells differentiate into myofibroblasts by altering their
Dermal_fibroblast
Protein-coding gene in the species Homo sapiens
in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular
Galectin-3
Process of the restoration of health
much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the same type of actin found in smooth muscle, which enables
Healing
Regenerative therapy based on electrostimulation
"Pulsed electromagnetic fields (PEMF) promote early wound healing and myofibroblast proliferation in diabetic rats". Bioelectromagnetics. 35 (3): 161–169
V-EMF_therapy
Location in liver between hepatocyte and sinusoid
hepatic stellate cells into transdifferentiated and prolific myofibroblasts. The myofibroblasts synthesize and secrete components of the extracellular matrix
Perisinusoidal_space
Medical condition
Microscopically, IF lesions consist of proliferating, atypical fibroblasts and/or myofibroblasts. The lesions were initially regarded as non-neoplastic proliferation
Ischemic_fasciitis
Medical condition
Sharma et al. (2024) proposed a refined pathogenic framework in which myofibroblasts endure in OSF by establishing an immune-privileged niche. They identified
Oral_submucous_fibrosis
Protein-coding gene in the species Homo sapiens
negative regulation of fibroblast proliferation negative regulation of myofibroblast differentiation Sources:Amigo / QuickGO Orthologs Species Human Mouse
TP53INP1
Regrowth of lost tissues or organs
regeneration. Myofibroblasts are the fibroblast responsible for scar and in 2017 it was found that the regeneration of fat transformed myofibroblasts into adipocytes
Regeneration_in_humans
Chemical compound
appeared to reduce existing fibrosis through inducing apoptosis of myofibroblasts. Further research is required to elucidate the exact mechanisms and
Navitoclax
advanced stages of healing process a number of keratocytes transforms into myofibroblasts actively secreting ECM components; this transformation is thought to
Corneal_keratocyte
American cell biologist
as the cellular mechanisms of wound healing. Her lab determined that myofibroblasts and fibroblasts in the cornea are not "terminally differentiated". Masur
Sandra_K._Masur
Blood vessel formation, when new vessels emerge from existing vessels
new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the core to provide an
Angiogenesis
Reorganization of tissues
apoptosis, being replaced by myofibroblasts which produce large amounts of collagen. In the maturation phase, myofibroblast numbers are reduced by apoptosis
Tissue_remodeling
Benign childhood tumor
infant at birth. The cells involved in FHI include bland fibroblasts/myofibroblasts, mature fat cells, and primitive-appearing spindle-shaped and/or star-shaped
Fibrous_hamartoma_of_infancy
Medical condition
results in excessive production of scarred and fibrotic tissues from myofibroblasts, which is the activated form of fibroblast. Consequently, normal cellular
Hostile_abdomen
Abnormally increased portal venous pressure
hepatic stellate cell (HSC) activation, Kupffer cell activation, and myofibroblast activation.Normally, SECs generate nitric oxide, which has several functions
Portal_hypertension
German biophysicist
Fischbach (8 May 2020). "Collagen microarchitecture mechanically controls myofibroblast differentiation." Proceedings of the National Academy of Sciences. PMID
Claudia_Fischbach
Medical condition
restriction of movement around the injured area. This is mediated by myofibroblasts. The treatment of burn scar contracture and deformity begins upon hospitalization
Burn_scar_contracture
Medical condition
Nodular fasciitis (NF) is a benign, soft tissue tumor composed of myofibroblasts that typically occurs in subcutaneous tissue, fascia, and/or muscles.
Nodular_fasciitis
Cells found in human testes which help produce sperm
2. spermatids 3. spermatocytes 4. spermatogonia 5. Sertoli cell 6. myofibroblasts 7. Leydig cells 8. capillaries Details System Reproductive system Location
Sertoli_cell
Medical condition
individual nodules being composed of bland, slender, spindle-shaped cells (myofibroblasts) in a dense, fibrous matrix.” A common microscopic finding is the presence
Fibroma_of_tendon_sheath
Phenomenon characterized by the cessation of cell division
limits fibrosis during wound closure by inducing cell cycle arrest in myofibroblasts once they have fulfilled their function. When these cells have accomplished
Cellular_senescence
Fibrosis of lungs due to unknown causes
fibroblasts accumulate in these areas of damage and differentiate into myofibroblasts that secrete collagen and other proteins. In the current classification
Idiopathic_pulmonary_fibrosis
Mouth-lining mucous membrane
is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model". Journal
Oral_mucosa
Medical condition
shows fibrosclerosis with noticeable hyalinizing collagen bundles and myofibroblast cell proliferation. Numerous distinct treatment plans have been documented
Multifocal_fibrosclerosis
Chemical compound
"5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation". Journal of Molecular and Cellular Cardiology. 53 (5):
SB-228357
Cell-surface glycoprotein
2013). "Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal
CD44
Protein-coding gene in the species Homo sapiens
its levels are highly increased in infiltrated inflammatory cells and myofibroblasts in angiogenic areas in atherosclerotic and rheumatic valvular heart
Periostin
Cells usually found in glandular epithelium
true epithelial cells positive for keratins, not to be confused with myofibroblasts which are true mesenchymal cells positive for vimentin. These cells
Myoepithelial_cell
Membrane-bound extracellular vesicles
deliver signals to surrounding cells and have been shown to regulate myofibroblast differentiation. In melanoma, tumor-derived vesicles can enter lymphatics
Exosome_(vesicle)
Process by which cells are grown under controlled conditions
PMID 20733059. Wipff PJ, Rifkin DB, Meister JJ, Hinz B (December 2007). "Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix"
Cell_culture
Medical condition
merges the appearances of fibroblasts and smooth muscle cells (see myofibroblast), occur in normal as well as tumor tissues, and in normal tissues are
Inflammatory myofibroblastic tumour
Inflammatory_myofibroblastic_tumour
Inflammation of the bronchioles and surrounding tissue in the lungs
intra-alveolar fibroproliferation. The fibroblasts differentiate into myofibroblasts and continue to form fibrosis resulting in intra-alveolar fibroinflammatory
Cryptogenic organizing pneumonia
Cryptogenic_organizing_pneumonia
Joint tissue pathology
inflammation activates fibroblasts and other cell types, turning them into myofibroblasts which create scar tissue and more inflammation. Arthrofibrosis of the
Arthrofibrosis
Nanotechnology simulation of human organ function
VIC-hydrogel. VECs are verified to restrain the differentiation of morbid VIC myofibroblast, with reinforced suppression by shear stress. Another PDMS 3D microfluidic
Organ-on-a-chip
Pharmaceutical compound
Naugle JE, Meszaros JG, Insel PA (January 2005). "Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of
Cenderitide
Mammalian protein found in Homo sapiens
Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts". International Journal
Hepatocyte_growth_factor
Protein-coding gene in the species Homo sapiens
"Hyaluronidase-2 Regulates RhoA Signaling, Myofibroblast Contractility, and Other Key Profibrotic Myofibroblast Functions". The American Journal of Pathology
HYAL2
such as ependymoma, glioblastoma and schwannoma. It may also stain myofibroblasts and smooth muscle cells. Furthermore, it may stain nodal epithelial
AE1/AE3
Asthma complication
fibrosis in airway remodelling is also associated with fibroblast-to-myofibroblast transition mediated by transforming growth factor β. Airway remodelling
Airway_remodelling
Examines sequence information from individual cells
Zhang X, Ziegler S, Perales-Patón J, et al. (January 2021). "Decoding myofibroblast origins in human kidney fibrosis". Nature. 589 (7841): 281–286. Bibcode:2021Natur
Single-cell_sequencing
Excess deposition of extracellular matrix in the cardiac muscle
JG (March 2005). "Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol". American Journal of Physiology. Heart
Cardiac_fibrosis
Infiltration of neutrophils and macrophages, fibroplasia, scarring, fibrosis Possible role in anti-scarring Angiogenesis Wound Closure Actin cable Myofibroblasts
Scar_free_healing
German psychologist and author
biopsy-derived myofascial tissue samples are sufficient for quantification of myofibroblast density". Clinical Anatomy. 31 (3): 368–372. doi:10.1002/ca.23040. PMID 29314236
Robert_Schleip
Digestive system structure
observed. Underlying the epithelium is the lamina propria, which contains myofibroblasts, blood vessels, nerves, and several different immune cells, and the
Gastrointestinal_wall
Mammalian protein found in humans
positive regulation of collagen fibril organization negative regulation of myofibroblast differentiation cell differentiation negative regulation of cold-induced
Retinoblastoma_protein
Protein-coding gene in the species Homo sapiens
L (Nov 2002). "P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype". The Journal of Clinical Investigation. 110 (9): 1349–58
NREP
Rejection of transplanted tissue by the recipient's immune system
injury, then inflammatory lesions and recruitment of fibroblasts and myofibroblasts, which proliferate and secrete proteins forming scar tissue. A similar
Transplant_rejection
Type of molecules within cells
contributing to epithelial–mesenchymal transition, and potentially, to myofibroblast differentiation and proliferation. These discoveries suggest that DAMPs
Damage-associated molecular pattern
Damage-associated_molecular_pattern
Group of disorders
is a rare malignancy of follicular dendritic cells (FD cells). These myofibroblast-like cells are derived from the stroma (i.e. connective tissue) of lymph
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
Class of enzymes
is known to reverse fibrosis, possibly through de-differentiation of myofibroblasts back to fibroblasts.[further explanation needed] SOD is commercially
Superoxide_dismutase
Human protein
α-SMA) in their lung's interstitium, almost complete absence of lung myofibroblasts that contained ACTA2, abnormal expression of the Wilms tumor protein
PDPN
Protein-coding gene in the species Homo sapiens
Transforming Growth Factor-β1-Mediated Conversion of Fibroblasts to Myofibroblasts". Am. J. Pathol. 161 (2): 471–80. doi:10.1016/S0002-9440(10)64203-4
CLIC4
Medical condition
cause of atypical fibroxanthoma is unknown. They may originate from myofibroblasts. Ultraviolet light and sun exposure are most likely risk factors. Atypical
Atypical_fibroxanthoma
Acute form of osteomyelitis
constitutive organized phase, fibroblasts persist and are converted to myofibroblasts by these same cytokines, that begin to fibrous extracellular matrix
Osteoradionecrosis
Mammalian protein found in humans
and reduced the amount of apoptosis in cardiomyocytes and cardiac myofibroblasts. This finding was coordinate with enhanced expression of pro-survival
Catenin_beta-1
American bioengineer and academic
N Shah; Kristi S Anseth; Leslie Leinwand (24 June 2004). "Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological
Kristyn_Masters
List of immortalized cell lines overgrown by other, more aggressive cells
lymphoblastoid Drexler et al. (2003) CVCL_D870 GREF-X Virtual liver myofibroblast unknown Laboratory rat cell line CVCL_7667 HAEND liver angiosarcoma
List of contaminated cell lines
List_of_contaminated_cell_lines
Protein-coding gene in the species Homo sapiens
(COPD), asthma and bronchiolitis obliterans syndrome (BOS). Cells (myofibroblasts, macrophages and other inflammatory cells) can migrate more easily through
Versican
Protein-coding gene in the species Homo sapiens
(2014). "Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor β receptor-dependent
AE_binding_protein_1
Type of angiogenesis
new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the core to provide an
Intussusceptive_angiogenesis
Medical condition
heterogeneous, poorly defined and uniform proliferation of spindle-shaped myofibroblast-like cells (i.e. cells with combine some of the microscopic appearance
Gardner_fibroma
Multi-functional cells on the outer surface of microvascular endothelial cells
revealing that they contribute to the glial scar by differentiating into myofibroblasts and depositing extracellular matrix. However, this remains controversial
Pericyte
Mammalian protein found in Homo sapiens
Ekström G, et al. (August 2016). "5-HT2B receptor antagonists attenuate myofibroblast differentiation and subsequent fibrotic responses in vitro and in vivo"
5-HT2B_receptor
Protein-coding gene in the species Homo sapiens
"NF-kappaB induced by IL-1beta inhibits elastin transcription and myofibroblast phenotype". American Journal of Physiology. Cell Physiology. 283 (1):
Transcription_factor_Sp1
Contrast agent for cancer imaging
induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts". The Journal of Cell
Ga-68-Trivehexin
American cancer biologist (born 1966)
Tuveson, D.A. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. Journal of Experimental Medicine. 214(3):579-596
David_Tuveson
Growth of fibrous or connective tissue
neoplastic origins. These scars are hypercellular with fibroblasts, myofibroblasts, and some immune cells present. The immature scars can be distinguished
Desmoplasia
Conversion of mechanical stimulus of a cell into electrochemical activity
"Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation". Arthritis and Rheumatism. 64 (5): 1653–1664. doi:10.1002/art
Mechanotransduction
Cell surface receptors
the development of hepatic fibrosis—activated HSCs transition to a myofibroblast-like phenotype and secrete large amounts of ECM. Excessive accumulation
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
"Expression of VSX1 in human corneal keratocytes during differentiation into myofibroblasts in response to wound healing". Invest. Ophthalmol. Vis. Sci. 47 (12):
VSX1
Protein-coding gene in the species Homo sapiens
regulation of smooth muscle cell apoptotic process negative regulation of myofibroblast differentiation apoptotic process positive regulation of endothelial
PDCD4
Protein found in humans
myocardial infarction. In murine trials, TLR9-deficient mice had less myofibroblast proliferation, meaning cardiac muscle recovery is connected to TLR9
Toll-like_receptor_9
Connective tissue around muscle groups
fascial remodeling. Fascia may be able to contract due to the activity of myofibroblasts which may play a role in wound healing. The deep fascia can also relax
Deep_fascia
MYOFIBROBLAST
MYOFIBROBLAST
MYOFIBROBLAST
MYOFIBROBLAST
Girl/Female
Indian
Singing a Song
Girl/Female
Australian, Greek, Hebrew
Peace
Surname or Lastname
German and Danish
German and Danish : metonymic occupational name for a salmon fisher or a seller of salmon, Middle High German lahs ‘salmon’.English (northeastern counties) and Danish : from an Old Norse nickname, Lax, meaning ‘salmon’.Jewish (Ashkenazic) : ornamental name from German Lachs ‘salmon’, Yiddish laks, one of the many Ashkenazic surnames taken from words denoting fish, birds, and animals.
Girl/Female
Arabic, Australian, Iranian, Muslim, Parsi
Creator of Joy
Male
English
Merchant
Girl/Female
Irish
Bard.
Boy/Male
Greek
Lordly.
Biblical
the Lord opening; gate of the Lord
Boy/Male
Bengali, Hindu, Indian, Kannada, Telugu
Son
Surname or Lastname
English (chiefly Bristol)
English (chiefly Bristol) : status name from the Anglo-Norman French feudal term franchomme ‘free man’ (see Free), composed of the elements franc ‘free’ (see Frank 2) + homme ‘man’ (Latin homo). The spelling has been altered as the result of folk etymological association with the common English place name endings -combe and -ham.
MYOFIBROBLAST
MYOFIBROBLAST
MYOFIBROBLAST
MYOFIBROBLAST
MYOFIBROBLAST