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Chemical compound
Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide
Wortmannin
Chemical compound
potent than wortmannin, another well-known PI3 kinase inhibitor. However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly
LY294002
Class of enzymes
inhibited by the drugs wortmannin and LY294002, although certain members of the class II PI3K family show decreased sensitivity. Wortmannin shows better efficiency
Phosphoinositide_3-kinase
Chemical compound: furanosteroid
C-4 and C-6 of the steroid framework. Members of this family, including wortmannin, are known to be potent, irreversible covalent inhibitors of phosphoinositide
Viridin
Signaling glycoprotein regulating cell proliferation
edge in osteogenic differentiation. Wortmannin is a PI3K-specific inhibitor, and treatment of cells with Wortmannin in combination with PDGF resulted in
Platelet-derived growth factor
Platelet-derived_growth_factor
Human protein-coding gene
mutations. All PI 3-kinases are inhibited by the drugs wortmannin and LY294002 but wortmannin shows better efficiency than LY294002 on the hotspot mutation
P110α
Type of amino acid
activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice". FASEB Journal. 18 (15): 1894–96. doi:10
Ketogenic_amino_acid
Species of fungus
an anamorph species of fungus in the genus Penicillium which produces wortmannin. MycoBank "Straininfo of Penicillium proteolyticum". Archived from the
Penicillium_proteolyticum
Protein-coding gene in the species Homo sapiens
BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE 1e7v: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002
PIK3CG
Genus of virus
specific inhibitors were tested: cytochalasin D (depolymerizing agent), wortmannin (Wort), LY-294002 (both are inhibitors of PI3K) and EIPA (5-(N-ethyl-N-isopropyl)
Ebolavirus
Species of fungus
described in 2007. Aspergillus australensis produces aszonalenins and wortmannins. A. australensis has been cultivated on both Czapek yeast extract agar
Aspergillus_australensis
Medical drug glass
cell carcinoma and endometrial cancer. Sonolisib (codenamed PX-866; a wortmannin derivative) has undergone several phase II trials as a potential treatment
Phosphoinositide 3-kinase inhibitor
Phosphoinositide_3-kinase_inhibitor
Israeli biotech company
Special antibiotics and molecular biology reagents. Anisomycin, Thiolutin, Wortmannin, K252a, Staurosporine, K252C, Bafilomycin, Alamethicin, Leptomycin, A23187
Fermentek
Protein-coding gene in humans
prolactin cellular response to DNA damage stimulus cellular response to wortmannin mitotic cell cycle cell cycle DNA repair cell differentiation RNA splicing
CDC5L
Process by which cells absorb materials
ligand. The formation of these vesicles is sensitive to inhibition by wortmannin[citation needed] The initiation of vesicle formation can be delayed/inhibited
Receptor-mediated_endocytosis
Species of fungus
produce aszonalenins, chromanols, tryptoquivalines, tryptoquivalones, and wortmannins. Samson, R.A.; Visagie, C.M.; Houbraken, J.; Hong, S-B.; Hubka, V.; Klaassen
Aspergillus_solicola
Vitamin H (biotin) Vitamin K (naphthoquinone) Vitamin M (folic acid) Water Wortmannin Xanthophyll Xylose Yellow fluorescent protein Zearalenone Chemical compound
List_of_biomolecules
Post-translational carbohydrate modification of proteins
caused OGT to localize to the plasma membrane. Inhibition of PI3K with wortmannin reversed this effect, suggesting dependence on phosphatidylinositol(3
O-GlcNAc
Protein-coding gene in the species Homo sapiens
Meyers R, Cantley LC (February 1997). "Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase". The Journal of Biological
PI4KB
Protein-coding gene in the species Homo sapiens
of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may
PIK3C2A
Mammalian protein found in Homo sapiens
an IC50 of 0.2 mM and only a low selectivity within the PIKK family. Wortmannin is an irreversible inhibitor of ATM with no selectivity over other related
ATM_serine/threonine_kinase
Protein-coding gene in the species Homo sapiens
of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not
PIK3C2B
Species of fungus
asperpentyn, avenaciolide, glabramycin A, B, C, sartoryglabrin A, B, C, and wortmannins. A. neoglaber has been cultivated on both Czapek yeast extract agar (CYA)
Aspergillus_neoglaber
Protein-coding gene in the species Homo sapiens
of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin". J. Biol. Chem. 271 (35): 21005–1011. doi:10.1074/jbc.271.35.21005. PMID 8702863
MAP2K2
"Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine". Molecular Cell. 6
Roger_L._Williams
Protein domain
"Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine". Molecular Cell. 6
C2_domain
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