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2018 scientific and bioethical controversy
The He Jiankui affair is a scientific and bioethical controversy concerning the use of genome editing following its first use on humans by Chinese scientist
He_Jiankui_affair
Chinese scientist (born 1984)
He Jiankui (Chinese: 贺建奎; pinyin: Hè Jiànkuí [xɤ̂ tɕjɛ̂nkʰwěɪ] HUH JEE-enn KWAY; born 1984) is a Chinese biophysicist known for his controversial first
He_Jiankui
South Korean scientific misconduct scandal
documentary film King of Clones, which covered Hwang Woo-suk and this affair. He Jiankui affair Kim, Jongyoung; Park, Kibeom (2013). "Ethical Modernization: Research
Hwang_affair
Process of editing the human genome so that the changes are inherited
2018 plans to convene an intentional committee on the topic. The He Jiankui affair is a scientific and bioethical controversy concerning the use of genome
Human_germline_engineering
Genetically modified human embryo
(October 2019). "CRISPR'd babies: human germline genome editing in the 'He Jiankui affair'". Journal of Law and the Biosciences. 6 (1): 111–183. doi:10.1093/jlb/lsz010
Designer_baby
2022 American film
University. It focuses on the circumstances involving Chinese biologist He Jiankui who created the first genetically modified humans in 2018. Featured experts
Make_People_Better
Gene editing method
embryos using the CRISPR technique, as a result of the controversial He Jiankui affair. Several bioethical concerns have been raised about the prospect of
CRISPR_gene_editing
Organism altered by genetic engineering
edit the DNA of non-viable human embryos. In November 2018, He Jiankui announced that he had edited the genomes of two human embryos, in an attempt to
Genetically_modified_organism
British economist (1883–1946)
Diaghilev's Ballets Russes. In the early years of his courtship, he maintained an affair with a younger man, Sebastian Sprott, in tandem with Lopokova,
John_Maynard_Keynes
1932 dystopian novel by Aldous Huxley
novels, which became Brave New World. He wrote in a letter to Mrs. Arthur Goldsmith, an American acquaintance, that he had "been having a little fun pulling
Brave_New_World
American aviator (1902–1974)
Lindbergh. He became a U.S. Army Air Service cadet in 1924. The next year, he was hired as a U.S. Air Mail pilot in the Greater St. Louis area, where he began
Charles_Lindbergh
Efforts to avoid miscegenation, analogous to an animal breeder seeking purebred animals
(Rassenhygiene) in 1895 in his Racial Hygiene Basics (Grundlinien einer Rassenhygiene). He discussed the importance of avoiding "counterselective forces" such as war
Racial_hygiene
Type of genetic engineering
embryos using the CRISPR technique, as a result of the controversial He Jiankui affair. Genome editing was pioneered in the 1990s, before the advent of the
Genome_editing
Romanian-American Internet personality (born 1980)
articles in mock imitation of a caveman)". Nathan Robinson of Current Affairs magazine writes that BAP in Bronze Age Mindset does not attempt to make
Bronze_Age_Pervert
Philosophical movement
ISBN 978-0-262-52428-5. Management Association, Information Resources (2015). Public Affairs and Administration: Concepts, Methodologies, Tools, and Applications: Concepts
Transhumanism
embryo gene-editing intended for reproduction. The case is called the He Jiankui affair. Woo-suk Hwang (Hwang Woo-suk) (South Korea), former Professor of
List of scientific misconduct incidents
List_of_scientific_misconduct_incidents
Idea about population growth and food supply
Greater Wealth, More Resources, Healthier Environment", Economic Affairs: J. Inst. Econ. Affairs, April 1994. Fischer, R. A.; Byerlee, Eric; Edmeades, E. O
Malthusianism
American writer (1875–1950)
Moon Maid. The Mucker (1914) The Return of the Mucker (1916) The Oakdale Affair (1918) The Monster Men (1913) The Lost Continent (1916; a.k.a. Beyond Thirty)
Edgar_Rice_Burroughs
Post-World War II trial of German doctors for war crimes
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Doctors'_Trial
American political scientist, economist, and author (born 1952)
and Its Discontents, he wrote the article A Country of Their Own: Liberalism Needs the Nation, which was published in Foreign Affairs in April 2022. The
Francis_Fukuyama
American engineer, scientist, inventor, and entrepreneur
the doctoral advisor to He Jiankui, a PhD student of his from 2008 to 2010, who later became known for the 2018 He Jiankui affair surrounding the first
Michael_W._Deem
Japanese anarchist and feminist writer (1886–1971)
to steal a moment of fame in history. Exaggerated stories of their love affairs and nonconformism, once again spread by Japan's mainstream press, turned
Hiratsuka_Raichō
Multicellular diploid eukaryote in its earliest stage of development
embryos for use in IVF. Some have proposed (or even attempted—see He Jiankui affair) genetic editing of human embryos via CRISPR-Cas9 as a potential avenue
Embryo
Manipulation of an organism's genome
enhancement can also be difficult to establish. In November 2018, He Jiankui announced that he had edited the genomes of two human embryos, to attempt to disable
Genetic_engineering
British socialist organisation founded in 1884
Fabianism and the Empire, the first statement of its views on foreign affairs, drafted by Bernard Shaw and incorporating the suggestions of 150 Fabian
Fabian_Society
Former Vermont government survey
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Eugenics_Survey_of_Vermont
Effort to improve purported human genetic quality
bashing" and Nature's Kevin Davies called it a "surprisingly pedestrian affair", while molecular biologist Lee Silver described its extreme determinism
Eugenics
Enzymes that cleave DNA in specific ways
Controversies Genetically modified food controversies GMO conspiracy theories Pusztai affair Séralini affair StarLink corn recall He Jiankui affair v t e
Transcription activator-like effector nuclease
Transcription_activator-like_effector_nuclease
Species of virus
Controversies Genetically modified food controversies GMO conspiracy theories Pusztai affair Séralini affair StarLink corn recall He Jiankui affair v t e
Genetically_modified_virus
French surgeon and biologist (1873–1944)
the United States. He was awarded the Nobel Prize in Physiology or Medicine in 1912 for pioneering vascular suturing techniques. He invented the first
Alexis_Carrel
Eugenic experiments in 19th-century United States
Francis Galton created the term "eugenics". In 1904, Galton claimed that he had first come up with the term and "deliberately changed it for eugenics
Oneida_stirpiculture
English author and Christian apologist (1874–1936)
reforms should not be made until the reasoning behind the existing state of affairs is understood. The quotation is from the 1929 Chesterton book entitled
G._K._Chesterton
Natural, artificial, or technological alteration of the human body
and will face less resistance as a pathway of radical human enhancement. He also argues that the concept of "enablement" needs to be added to the debate
Human_enhancement
Irish playwright, critic, and polemicist (1856–1950)
overcome by Jane (Jenny) Patterson, a widow some years his senior. Their affair continued, not always smoothly, for eight years. Shaw's sex life has caused
George_Bernard_Shaw
DNA molecules formed by human agency at a molecular level generating novel DNA sequences
Controversies Genetically modified food controversies GMO conspiracy theories Pusztai affair Séralini affair StarLink corn recall He Jiankui affair v t e
Recombinant_DNA
President of Peru from 1990 to 2000
(2006). "Assessing Fujimori's Peru". Georgetown Journal of International Affairs. 7 (2): 160. Fujimori's rule as a dictator lasted for nearly ten years
Alberto_Fujimori
German philosopher (born 1947)
theorist. He was a professor of philosophy and media theory at and Rector from 2001 to 2015 of the Karlsruhe University of Arts and Design. He co-hosted
Peter_Sloterdijk
1928 law in Alberta, Canada
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Sexual_Sterilization_Act
Biological elevation of emotional well-being
directly manipulating the biological roots of happiness in order to increase it. He sought to defend it on the grounds that happiness ought to be of interest
Biohappiness
Stem cell controversy "Designer baby" "Frankenstein's monster" He Jiankui affair Hwang affair Against life extension Undesirability of immortality Nikolas
United Nations Declaration on Human Cloning
United_Nations_Declaration_on_Human_Cloning
Challenges for traditional communities
its permitted varieties. If he performs any of the forbidden techniques, he is guilty, his earnings are forbidden, and he must be stopped from his morally
Religious response to assisted reproductive technology
Religious_response_to_assisted_reproductive_technology
American philanthropist (1851–1932)
include dairying, horse breeding and mining. As one of his neighbors put it, "He collects mountains as other men collect china." By the start of the 20th century
Mary_Williamson_Harriman
1945 science-fiction novel by C. S. Lewis
the heavenly beings may also cross the barrier and intervene in human affairs. Jane has two mystical experiences; the first with the Earth-bound counterpart
That_Hideous_Strength
Medical technology
self-regulation. The American Medical Association's Council on Ethical and Judicial Affairs stated that "genetic interventions to enhance traits should be considered
Gene_therapy
British eugenist, polymath, and behavioural geneticist (1822–1911)
340 papers and books. He also developed the statistical concept of correlation and widely promoted regression toward the mean. He was the first to apply
Francis_Galton
Animal that has been genetically modified
edit the DNA of non-viable human embryos. In November 2018, He Jiankui announced that he had edited the genomes of two human embryos, to attempt to disable
Genetically_modified_animal
Methods used to change the DNA of organisms
disruption. The creation of HIV-resistant babies by Chinese researcher He Jiankui is perhaps the most famous example of gene disruption using this method
Genetic engineering techniques
Genetic_engineering_techniques
American white supremacist author (1883–1950)
Rising Tide of Color Against White World-Supremacy (1920). He advocated a racial hierarchy which he believed needed to be preserved through anti-miscegenation
Lothrop_Stoddard
Early British eugenics and family planning organisation (1877–1927)
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Malthusian_League
Soybean that has had DNA introduced into it using genetic engineering techniques
Controversies Genetically modified food controversies GMO conspiracy theories Pusztai affair Séralini affair StarLink corn recall He Jiankui affair v t e
Genetically_modified_soybean
Rhetorical tactic and potential fallacy
single normative understanding of human being the only possible understanding. He writes, "When we regard ourselves as 'machines whose components are biochemicals
Appeal_to_nature
Views of the British philosopher on the state and society
reflected his life at the time – his second wife Dora was openly having an affair, and would soon become pregnant by another man, but Russell was keen for
Political views of Bertrand Russell
Political_views_of_Bertrand_Russell
British physician, eugenicist, writer and social reformer (1859–1939)
affair with Margaret Sanger. According to Ellis in My Life, his friends were much amused at his being considered an expert on sex. Some knew that he reportedly
Havelock_Ellis
Five prominent Canadian women's rights advocates
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
The_Famous_Five_(Canada)
1943 book by C. S. Lewis
rational grounds. He says that there is a set of objective values that have been shared, with minor differences, by every culture, which he refers to as "the
The_Abolition_of_Man
Former sperm bank in California, US
Only Shockley remained, and even he donated only once. Paul Smith was charged with recruiting new donors, and he traveled throughout California, focusing
Repository for Germinal Choice
Repository_for_Germinal_Choice
First organisms to be modified in the laboratory
Controversies Genetically modified food controversies GMO conspiracy theories Pusztai affair Séralini affair StarLink corn recall He Jiankui affair v t e
Genetically_modified_bacteria
1883 book by Francis Galton
by Francis Galton, in which he covers a variety of psychological phenomena and their subsequent measurement. In this text he also references the idea of
Inquiries into Human Faculty and Its Development
Inquiries_into_Human_Faculty_and_Its_Development
1924 United States immigration law
immigration to the United States and Palestine, 1915–1925". East European Jewish Affairs. 47 (2–3): 150–168. doi:10.1080/13501674.2017.1400859. ISSN 1350-1674.
Immigration_Act_of_1924
American philanthropic organization
Bank, 1963–1968. Võ Tòng Xuân, 2002–2010, vice president for academic affairs, Tan Tao University, Ho Chi Minh City; former rector of An Giang University
Rockefeller_Foundation
Book by David Starr Jordan
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
The_Blood_of_the_Nation
Pro-segregation eugenics group
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
International Association for the Advancement of Ethnology and Eugenics
International_Association_for_the_Advancement_of_Ethnology_and_Eugenics
Nazi Germany eugenics program
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Lebensborn
British learned society for scholar-activism regarding genetics
proportional to economic class before the Royal Commission on Income Tax. He feared the falling birth rate of the middle-class would result in a “national
Adelphi_Genetics_Forum
1956 and 1980 volumes by Günther Anders
Stem cell controversy "Designer baby" "Frankenstein's monster" He Jiankui affair Hwang affair Against life extension Undesirability of immortality Nikolas
The Outdatedness of Human Beings
The_Outdatedness_of_Human_Beings
German völkisch organisation (est. 1894)
academic career and a brief stint as a university librarian in Göttingen, he lived from 1891 onward as a privatgelehrter in Freiburg im Breisgau, supported
Gobineau_Association
Concept of extending human lifespan
not. However, not everyone agrees. Harry R. Moody, director of academic affairs for AARP, notes that what is normal and what is disease strongly depend
Life_extension
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Heredity_Commission
20th-century global conferences
rid of and the desirables multiplied?” This concept of eugenics - a term he introduced - soon won many adherents, notably in North America and England
International Eugenics Conference
International_Eugenics_Conference
British physicist (1887–1962)
director of the National Physical Laboratory (NPL) during the Second World War. He was a son of the mathematician George Darwin and a grandson of Charles Darwin
Charles_Galton_Darwin
1943 Japanese government report on racial theory and policy
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
An Investigation of Global Policy with the Yamato Race as Nucleus
An_Investigation_of_Global_Policy_with_the_Yamato_Race_as_Nucleus
Rhetorical strategy and accusation
"Climate Engineering and the Playing God Critique". Ethics & International Affairs. 31 (3): 313–333. doi:10.1017/S0892679417000223. ISSN 0892-6794. S2CID 149327407
Playing_God_(ethics)
such politicians, anthropologists, and sociologists. While still alive, he was a major influence on "Gobinism", also known as Gobineauism, an academic
Social thinking of Arthur de Gobineau
Social_thinking_of_Arthur_de_Gobineau
following experiments crossing peas. Although largely ignored for 34 years he provided the first evidence of hereditary segregation and independent assortment
History of genetic engineering
History_of_genetic_engineering
Concept of eternal life
shortened telomeres. The first and still most widely used immortal cell line is HeLa, developed from cells taken from the malignant cervical tumor of Henrietta
Immortality
German Nazi biologist, eugenicist
Also the Jew who enjoys life as a host in our country, is our enemy, even if he does not actively engage with weapons in this fight. …From the European point
Karin_Magnussen
Foods produced from organisms that have had changes introduced into their DNA
academic condemnation against the researchers such as the Pusztai affair and the Séralini affair. There are no certifications for foods that have been verified
Genetically_modified_food
American physician (1852–1943)
movement and the eugenics policies espoused by many in the Progressive Movement. He was the director of the Battle Creek Sanitarium in Battle Creek, Michigan
John_Harvey_Kellogg
Genetically modified crop
the Beijing-based DBN Group, was accused of stealing trade secrets after he was found digging in an Iowa cornfield. Genetically modified food Genetically
Genetically_modified_maize
1973 book by Konrad Lorenz
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Civilized Man's Eight Deadly Sins
Civilized_Man's_Eight_Deadly_Sins
1951 science fiction story by Cyril Kornbluth
members of an elite, intellectual upper-class who secretly govern world affairs. Both Tinny-Peete and Ryan-Ngana are members of this group. The simple-minded
The_Marching_Morons
American author, journalist and social activist (1876–1916)
journalist and activist. A pioneer of commercial fiction and American magazines, he was one of the first American authors to become an international celebrity
Jack_London
1942 United States Supreme Court case
makes no attempt to say that he who commits larceny by trespass or trick or fraud has biologically inheritable traits which he who commits embezzlement lacks
Skinner_v._Oklahoma
German psychiatrist (1856–1926)
century's end. While he proclaimed his own high clinical standards of gathering information "by means of expert analysis of individual cases", he also drew on
Emil_Kraepelin
Far-right organization
defended the Waffen-SS and has stated that he wants to create a home for "white, Christian people", as he believes they are under threat from immigration
Human_Diversity_Foundation
Eugenics research institute at Cold Spring Harbor, New York
the Carnegie Institute to establish the ERO. He was well connected to wealthy people during the time and he lobbied them to finance his vision of the ERO
Eugenics_Record_Office
Plants with human-introduced genes from other organisms
Controversies Genetically modified food controversies GMO conspiracy theories Pusztai affair Séralini affair StarLink corn recall He Jiankui affair v t e
Genetically_modified_plant
Natalist privileges awarded in the Roman Empire
take over the obligation of guardianship of a woman, legally a minor, that he would otherwise be obligated under the tutela mulierum. Women who had the
Jus_trium_liberorum
1933 compulsory sterilisation law in Nazi Germany
32–55. IBM and the Holocaust, Edwin Black, 2001 Crown / Random House, p. 96. He cites Henry Friendlander, The Origins of Nazi Genocide: From Euthanasia to
Law for the Prevention of Hereditarily Diseased Offspring
Law_for_the_Prevention_of_Hereditarily_Diseased_Offspring
Geneticist and evolutionary biologist (1892–1964)
they divorced in 1945. Later that year he married Helen Spurway, his former PhD student. He also had an affair with Angel Records founder Dorle Soria
J._B._S._Haldane
Nazi German policy of the murder of "undesirable" persons
borrowed from Ernst Haeckel), adding that he considered Sparta to be the first "Völkisch State". He endorsed what he perceived to be an early eugenics treatment
Nazi_eugenics
British polymath (1890–1962)
active as a mathematician, statistician, biologist, geneticist, and academic. He has been described as "a genius who almost single-handedly created the foundations
Ronald_Fisher
Variety of ethical positions
Stem cell controversy "Designer baby" "Frankenstein's monster" He Jiankui affair Hwang affair Against life extension Undesirability of immortality Nikolas
Ethics_of_cloning
1911 book by Charles Davenport
program (1990–2000) Population planning in Singapore New eugenics He Jiankui affair Human genetic enhancement Religious response to assisted reproductive
Heredity in Relation to Eugenics
Heredity_in_Relation_to_Eugenics
Introduction of foreign genetic material into host cells
Controversies Genetically modified food controversies GMO conspiracy theories Pusztai affair Séralini affair StarLink corn recall He Jiankui affair v t e
Gene_delivery
French populations studies research institute
ministries in charge of population questions and health statistics (social affairs, health or employment, depending on the government in power). With the
Institut national d'études démographiques
Institut_national_d'études_démographiques
Eugenics as theorized or practiced in Spain
Ricardo Campos said, "the racial question during the Franco era is complex." He went on to say, "despite the similarities of the Franco regime with the Italian
Hispanic_eugenics
Retracted study led by Gilles-Éric Séralini
The Séralini affair was the controversy surrounding the publication, retraction, and republication of a journal article by French molecular biologist Gilles-Éric
Séralini_affair
Gene editing technique
Wang, Yanhong; Hu, Yun; Jiao, Yaoge; Zhou, Lifang; Jiang, Lurong; Li, Li; He, Xingyu; Li, Min; Yu, Yamei; Chen, Qiang; Yao, Shaohua (2022-04-20). "WT-PE:
Prime_editing
Eugenics and racial hygiene organization
Battle Creek, Michigan by John Harvey Kellogg due to his concerns about what he perceived as "race degeneracy". The foundation supported conferences (including
Race_Betterment_Foundation
travel, tourism, insurance
HE JIANKUI-AFFAIR
HE JIANKUI-AFFAIR
Male
Chinese
building the army.
Female
Egyptian
, the daughter of Piankhi II.
Boy/Male
Tamil
Janakidas | ஜாநகீதாஸ
Servant of Janki
Janakidas | ஜாநகீதாஸ
Female
Egyptian
, the granddaughter of Piankhi II.
Boy/Male
Tamil
Janakibhushan | ஜாநகீபூஷண
Ornament of Janki
Janakibhushan | ஜாநகீபூஷண
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Mythological, Oriya, Sanskrit, Sindhi, Tamil, Telugu
Another Name of Goddess Sita
Girl/Female
Indian
Another Name of Goddess Sita
Male
Chinese
building the universe.
Boy/Male
Biblical
He.
Girl/Female
Arabic, Indian, Pakistani
Combination
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu, Traditional
Ornament of Janki
Male
Chinese
building the country.
Male
Egyptian
, King of Pizattikhurunpi.
Female
Egyptian
, the mother of Pthah Taho.
Female
Egyptian
, a daughter of Pianki.
Boy/Male
Hindu
Servant of Janki
Male
Egyptian
, a priest of Apis.
Girl/Female
Hindu
Goddess Sita
Male
Egyptian
, a captain of Piankhi.
Boy/Male
Native American
Fighter.
HE JIANKUI-AFFAIR
HE JIANKUI-AFFAIR
HE JIANKUI-AFFAIR
HE JIANKUI-AFFAIR
HE JIANKUI-AFFAIR
HE JIANKUI-AFFAIR
HE JIANKUI-AFFAIR
a.
Ready; quick; expert; as, he is facile in expedients; he wields a facile pen.
n.
The faculty of overcoming obstacles; aggressive energy; as, he has push, or he has no push.
adv. & conj.
While; during or at the same time that; when; as, he trembled as he spoke.
n.
He who, or that which, abases.
v. t.
To pass or cross by wading; as, he waded /he rivers and swamps.
obj.
The man or male being (or object personified to which the masculine gender is assigned), previously designated; a pronoun of the masculine gender, usually referring to a specified subject already indicated.
obj.
Man; a male; any male person; -- in this sense used substantively.
adv.
By; beyond; as, he ran past.
obj.
Any one; the man or person; -- used indefinitely, and usually followed by a relative pronoun.
v.
To have remaining at death; hence, to bequeath; as, he left a large estate; he left a good name; he left a legacy to his niece.
n.
He who, or that which, accompanies.
prep.
Adhering; not off; as in the phrase, "He is neither on nor off," that is, he is not steady, he is irresolute.
v. i.
To occupy one's self with getting laboriously; as, he scraped and saved until he became rich.
pron., a., conj., &
As adverb: To such a degree; so; as, he was that frightened he could say nothing.
pron.
The objective case of he. See He.
n.
He who declines or rejects.
n.
He who, or that which, accommodates.
pron.
He; the one.
v. t.
To bear, carry, or manage; as he holds himself erect; he holds his head high.
n.
He who, or that which, applies.
travel, tourism, insurance