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Technology enabling rapid molecule diversification
to achieve glycorandomization/diversification have been developed: an enzyme-based strategy referred to as 'chemoenzymatic glycorandomization' and a chemoselective
Glycorandomization
Molecule in which a sugar is bound to another functional group
mustard. Carbohydrate Carbohydrate chemistry Chemical glycosylation Glycorandomization Glycosylation Natural products Brito-Arias, Marco (2007). Synthesis
Glycoside
Enzyme
anomeric kinases serve as a cornerstone for in vitro and in vivo glycorandomization. Recently, the roles of active site residues in human galactokinase
Galactokinase
non-native sugar nucleotides has enabled a process referred to as glycorandomization where these sugar nucleotide libraries serve as donors for permissive
Nucleotide_sugar
Antibiotic medication
generate libraries of differentially glycosylated analogs through glycorandomization. Both the vancomycin aglycone and the complete vancomycin molecule
Vancomycin
Chemical compound
cancer has been restricted by its narrow therapeutic index. Digitoxin glycorandomization led to the discovery of novel digitoxigenin neoglycosides which displayed
Digitoxin
Drugs to treat parasitic worms and insect pests
chemically closely related group of parasiticides. Avermectin/ivermectin glycorandomization Yoon, Y. J.; Kim, E.-S.; Hwang, Y.-S.; Choi, C.-Y. (2004). "Avermectin:
Avermectin
Class of antibiotics
to Natural Product Glycodiversification: Pathway Engineering and Glycorandomization". Comprehensive Glycoscience. pp. 373–396. doi:10.1016/B978-044451967-2/00040-4
Azalide
Biochemical process
molecule Glycation – Attachment of a sugar to a protein or lipid Glycorandomization – Technology enabling rapid molecule diversification Lima, M.; Baynes
Glycosylation
Chemical compound
phenomenon that could be exploited for sugar nucleotide synthesis and 'glycorandomization'. The structures of all four glycosyltransferases were also reported
Calicheamicin
Class of enzymes
context of drug discovery and drug development (a process known as glycorandomization). Suitable enzymes can be isolated from natural sources or produced
Glycosyltransferase
Chemical compound
disaccharide and at aa6 with a beta1-epivancosamine saccharide. Glycorandomization Teixobactin Wright, Andrew G. McArthur, Gerard D. "The Comprehensive
Chloroeremomycin
Reaction of a glycosyl donor and acceptor
series of glycosylation reactions. Glycosylation Glycosyl transferase Glycorandomization Glycation Carbohydrate chemistry Oligosaccharide Carbohydrate Boons
Chemical_glycosylation
Indian biologist (born 1968)
highly promiscuous thermostable sugar nucleotidylyltransferases for glycorandomization". The FEBS Journal. 285 (15): 2840–2855. doi:10.1111/febs.14521. PMID 29806742
Balaji_Prakash
GLYCORANDOMIZATION
GLYCORANDOMIZATION
GLYCORANDOMIZATION
GLYCORANDOMIZATION
Female
Babylonian
, the mother of gods.
Girl/Female
Indian
Popular
Girl/Female
Muslim
Hearing, Forgiveness or forgiver
Boy/Male
Muslim/Islamic
Gaining success-but the Prophet (S.A.W) has discouraged us from giving such names to our children; according to Sayyidina Jab (R.A) The Prophet (S.A.W) intended to forbid such names as Yala, Barakah,
Boy/Male
Tamil
Nagpal | நாகபால , நாகபால
Saviour of serpents
Girl/Female
Arabic, Muslim, Sindhi
Narrator of Hadith; Daughter of Ahban Al-ghifariyah
Girl/Female
Hebrew American French German
Graceful lily.
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Muslim
Self subsistent
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Greek
King of Calydon.
Boy/Male
American, Australian, German, Jamaican
Beautiful at Birth
GLYCORANDOMIZATION
GLYCORANDOMIZATION
GLYCORANDOMIZATION
GLYCORANDOMIZATION
GLYCORANDOMIZATION