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Way to propagate genes throughout a population
A gene drive is a natural process (see meiotic drive) and technology of genetic engineering that propagates a particular suite of genes throughout a population
Gene_drive
American biologist
was involved with the development of gene drive technology. He focuses on the bioethics and biosafety of gene drives. In 2016, Esvelt was named an Innovator
Kevin_M._Esvelt
Genetic segments that can enhance their own transmission at the expense of other genes
Selfish genetic elements (historically also referred to as selfish genes, ultra-selfish genes, selfish DNA, parasitic DNA and genomic outlaws) are genetic segments
Selfish_genetic_element
Species complex of mosquitos
al., 2020 (an X chromosome destroying site specific nuclease). See § Gene drive below for their applications. An. gambiae has a high degree of polymorphism
Anopheles_gambiae
Gene editing method
gene drives including molecular, reproductive, and ecological. Many recommend that immunization and reversal drives be developed in tandem with gene drives
CRISPR_gene_editing
Topics referred to by the same term
capture prey Gene drive, in genetics, a type of bias in the inheritance of a gene Drive, a computer data storage device or logical unit Disk drive, a data
Drive
2002 single by Alan Jackson
"Drive (For Daddy Gene)" is a song written and recorded by American country music singer Alan Jackson. It was released in January 2002 as the second single
Drive_(For_Daddy_Gene)
Introduced species that harms its new environment
techniques. A wider outreach network for gene drive research exists to raise awareness of the value of gene drive research for the public good. Some scientists
Invasive_species
mechanism called a gene drive. The genetically modified mosquitoes carry a trait that targets their ability to reproduce. Gene drive ensures this modification
Target_Malaria
Genus of mosquito
CRISPR-Cas9 gene drive system was proposed to eradicate Anopheles gambiae, by deleting the dsx gene, causing female sterility. Such a gene drive system has
Anopheles
Existential threat from biological sources
including viral agents. Since then, new technologies like CRISPR and gene drives have been introduced. While the ability to deliberately engineer pathogens
Biotechnology_risk
Biotechnological elimination of involuntary suffering
gene drive, called a "daisy-chain drive", intended to limit spread through wild populations. Proposed methods for limiting or reversing gene drives include
Eradication_of_suffering
Genus of insects
suggested that some Cochliomyia may be a suitable target for an extinction gene drive. In general, all Diptera have three body regions (head, thorax, and abdomen)
Cochliomyia
Mosquito-borne disease
of mosquitoes using gene drive technologies, such as CRISPR-Cas9. Through CRISPR-Cas9 gene editing, scientists can introduce genes into mosquito populations
Malaria
American R&B singer (1934–2004)
If You Try" allowed him to open a 24-hour soul food restaurant called Gene's Drive-In in Nashville. Allison continued to perform well beyond his brief period
Gene_Allison
Self-limiting gene editing
form of gene editing, or "gene drive", which, unlike CRISPR, is self-limiting. This means that any alteration made in the laboratory to a gene sequence
Daisy_chaining_DNA
Species of plant
population has developed fomesafen resistance. Gene drive technologies could provide a countermeasure: A gene drive agent could engineer A. palmeri to become
Amaranthus_palmeri
DNA-editing technology
in genetic diseases and gene drives. Cas12a's characteristics may confer advantages to Cas12a over Cas9 in the context of gene editing. For instance, the
Cas12a
Health Sciences Research Institute. His research considers the use of gene drive to eliminate malaria, and he leads Target Malaria Burkina Faso. He delivered
Abdoulaye_Diabaté_(scientist)
Type of unintended effects of genetic modification techniques
qualities of a gene drive while maintaining the endonuclease expression. In such a situation there would be an increased risk of gene flow between the
Off-target_genome_editing
Preferential transmission of alleles over others during meiosis
meiotic drive is when one copy of a gene is passed on to offspring more than the expected 50% of the time. According to Buckler et al., "Meiotic drive is the
Meiotic_drive
Type of genetic engineering
Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the
Genome_editing
Differential transmission of genes residing in the same genome
coadapted gene complex in Drosophila melanogaster called Segregation Distorter (SD). The main drive locus, a truncated tandem duplication of the gene RanGAP
Intragenomic_conflict
American geneticist
Doebley is an American plant geneticist whose main area of interest is how genes drive plant development and evolution. He has spent the last two decades examining
John_Doebley
American medical institution
supported by Frontiers Group awards include research on regeneration, gene drives, and human brain evolution, among many others. The Frontiers Group directs
Allen_Institute
Governmental plan for eradicating pests in New Zealand
Retrieved 17 January 2017. Regalado, Antonio (10 February 2017). "First Gene Drive in Mammals Could Aid Vast New Zealand Eradication Plan". MIT Tech Review
Predator_Free_2050
French biologist
Agricultural pest control with CRISPR‐based gene drive: time for public debate: should we use gene drive for pest control?. EMBO reports, 18(6), 878-880
Virginie_Courtier-Orgogozo
Gene in mice
leading to the death of any embryo produced from that egg. gene drive Homing endonuclease gene Clark, Frances E.; Greenberg, Naomi L.; Silva, Duilio M.
R2d2_(mouse_gene)
Organism altered by genetic engineering
male population (known as a gene drive). This approach has been taken further by using the gene drive to spread a lethal gene. In trials the populations
Genetically_modified_organism
Process that prevents the expression of a gene
Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene. Gene silencing can occur during either transcription
Gene_silencing
American food reality television series
Diners, Drive-Ins and Dives (often nicknamed Triple D and stylized as Diners, Drive-Ins, Dives) is an American food reality television series that has
Diners,_Drive-Ins_and_Dives
American radio and television personality (1917–1999)
Gene Rayburn (born Eugene Peter Jeljenic; December 22, 1917 – November 29, 1999) was an American radio and television personality. He is best known as
Gene_Rayburn
American businessman (born 1952)
Gene Francis Haas (born November 12, 1952) is the American founder, president, and sole stockholder of Haas Automation, a CNC machine tool manufacturer
Gene_Haas
American evolutionary biologist and geneticist
Gaut". scholar.google.com. Retrieved 2023-09-17. Conduct, Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible; Sciences
Brandon_Gaut
Type of pattern of inheritance
intellectual disability gene in individuals with a sufficient number of repeats. Meiotic drive CoRR Hypothesis Epigenetic inheritance Gene drive Intragenomic conflict
Non-Mendelian_inheritance
Family of flies
BBC. Kyrou, Kyros Kyrou; et al. (24 September 2018). "A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles
Mosquito
Fictional superluminal spacecraft propulsion system
A warp drive or a drive enabling space warp is a fictional superluminal (faster than the speed of light) spacecraft propulsion system in many science fiction
Warp_drive
Animal that has been genetically modified
throughout the male population (known as a gene drive). This has been taken further by swapping it for a lethal gene. In trials the populations of Aedes aegypti
Genetically_modified_animal
Species of fly
Alun L.; Scott, Maxwell J. (2023-06-20). "CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest
Drosophila_suzukii
Gene editing technique
(2021-01-07). "Engineering the Composition and Fate of Wild Populations with Gene Drive". Annual Review of Entomology. 66 (1). Annual Reviews: 407–434. doi:10
Prime_editing
American mass murderer (1940–1990)
Ronald Gene Simmons Sr. (July 15, 1940 – June 25, 1990) was an American spree mass murderer and former military serviceman who perpetrated an attack that
Ronald_Gene_Simmons
The spread of transformed symbionts benefits from the availability of a gene drive system to replace non-transformed symbionts present in natural vector
Paratransgenesis
Insect that has been genetically modified
Gribble, Matthew; Baker, Dean; Marois, Eric (2015-12-07). "A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles
Genetically_modified_insect
Microbial protein found in Streptococcus pyogenes M1 GAS
during elongation, silencing genes. In 2014, Esvelt, Smidler, Catteruccia, and Church suggested that Cas9-based gene drives could spread genetic modifications
Cas9
American actor (1930–2025)
to Gene Hackman. Gene Hackman at the American Film Institute Catalog Gene Hackman at IMDb Gene Hackman at the TCM Movie Database (archived) Gene Hackman
Gene_Hackman
2001 film by David Lynch
Mulholland Drive is a 2001 mystery film written and directed by David Lynch. Its narrative is characterized by surrealist and neo-noir elements, and follows
Mulholland_Drive_(film)
American serial killer
Donald Gene Miller (born December 28, 1954), known as The East Lansing Serial Killer or simply Don Miller, is an American serial killer and rapist who
Donald_Gene_Miller
Efforts to reduce damage from mosquitoes
mosquito more efficiently. A pioneering experimental demonstration of the gene drive method eradicated small populations of Anopheles gambiae. In 2020, Oxitec's
Mosquito_control
2002 studio album by Alan Jackson
10 awards winning Album of the Year for Drive and Video of the Year for the video to "Drive (For Daddy Gene)." In 2009, Rhapsody ranked the album number
Drive_(Alan_Jackson_album)
Italian microbiologist and politician
Hammond, Andrew M.; Kyrou, Kyros (24 September 2018). "A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles
Andrea_Crisanti_(scientist)
1981 studio album by Alan Vega
Bop a Lula" by Gene Vincent, Donald Graves and Bill Davis and "Ghost Rider" co-written with Martin Rev. Adapted from the Collision Drive liner notes. Valdivia
Collision_Drive
Concept from Freudian psychoanalytics
In classical psychoanalysis, the death drive (German: Todestrieb) is an aspect of libidinal energy that seeks "to lead organic life back into the inanimate
Death_drive
American nonprofit bioethics research institute
(AICC), The National Academies of Sciences, Engineering, and Medicine's Gene Drives on the Horizon report, which was produced by a committee that included
Hastings_Center_for_Bioethics
American actor, dancer, singer and director (1912–1996)
related to Gene Kelly. Wikiquote has quotations related to Gene Kelly. Gene Kelly at IMDb Gene Kelly at the TCM Movie Database (archived) Gene Kelly at
Gene_Kelly
Computer storage device with no moving parts
Etymologically, "solid-state drive" partly refers to existing data storage devices like tape drives and hard disk drives, which all use a mechanically
Solid-state_drive
Burkinabé animal nutritionist and biosecurity expert
Target Malaria project to release sterile male mosquitoes, carrying a gene drive to spread the sterility through the native population, in rural areas
Chantal_Kaboré-Zoungrana
American jazz drummer and bandleader (1909–1973)
The youngest of Anna (née Oslowski) and Bartłomiej Krupa's nine children, Gene Krupa was born in Chicago, Illinois, United States. Bartłomiej was an immigrant
Gene_Krupa
1995 film directed by Nick Gomez
"New Jersey Drive". Rotten Tomatoes. Ebert, Roger (April 19, 1995). "New Jersey Drive movie review (1995)". RogerEbert.com. Siskel, Gene (April 28, 1995)
New_Jersey_Drive
Sudden and large mutational change
that way. American biologist Michael Freeling has proposed "balanced gene drive" as a saltational mechanism in the mutationist tradition, which could
Saltation_(biology)
American fast food chain
Sonic Corporation, founded as Sonic Drive-In and more commonly known as Sonic (stylized in all caps), is an American drive-in fast-food chain owned by Inspire
Sonic_Drive-In
Decreased effectiveness of a pesticide on a pest
works faster and remains stable in a variety of conditions. Resistance to gene drive forms of population control is expected to occur and methods of slowing
Pesticide_resistance
Canadian academic
decision making, ethical questions in emerging technology, such as genomics, gene drive and CRISPR-Cas9, cloning and reproductive ethics. He is also concerned
Kerry_Bowman
Fictional propulsion system
The spore drive, formally known as the displacement-activated spore hub drive, is a fictional spacecraft propulsion system introduced in the 2017 television
Spore_drive
Show rod (car) built by Gene Winfield
The Reactor is a custom car built by Gene Winfield. The low slung car featured front wheel drive and height adjustable suspension. It appeared in episodes
The_Reactor_(show_rod)
West African Christian Organization
Mother Earth Foundation website, Do Not Betray Africa on SynBio and Gene Drives, article dated Nov 20, 2018 Official website World Council of Churches
Fellowship of Christian Councils and Churches in West Africa
Fellowship_of_Christian_Councils_and_Churches_in_West_Africa
Removable disk storage medium
floppy disk drive (FDD) connected to or built into a computer or other device. The three most popular formats of floppy disks (and their drives) are the
Floppy_disk
Bodies found within starlet sea anemones
Leslie S. Babonis, Mark Q. Martindale & Joseph F. Ryan (2016). "Do novel genes drive morphological novelty? An investigation of the nematosomes in the sea
Nematosome
Treatment for blindness
Retinal gene therapy holds a promise in treating different forms of non-inherited and inherited blindness. In 2008, three independent research groups reported
Gene therapy of the human retina
Gene_therapy_of_the_human_retina
Second subphase of interphase
transcription of S-phase genes by inactivating the transcriptional repressor Whi5. Since upregulation of S-phase genes drive further suppression of Whi5
S_phase
Gene Hackman (January 30, 1930 – c. February 18, 2025) was an American actor. Considered one of the greatest actors of his generation and a paragon of
List of Gene Hackman performances
List_of_Gene_Hackman_performances
Principle in genetics
assortative mating, natural selection, sexual selection, mutation, gene flow, meiotic drive, genetic hitchhiking, population bottleneck, founder effect, inbreeding
Hardy–Weinberg_principle
Question that a research project sets out to answer
technologies which are instead best to delay. Concerning control strategies for gene drives, researchers have however cautioned that such may lead to a counterproductive
Research_question
Spanish-American physicist and biologist (born 1974)
Tzoneva, G.; et al. (2013). "Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL". Nat Med. 19 (3): 368–371. doi:10
Raúl_Rabadán
enhancers work alongside primary enhancers to drive overlapping gene expression patterns, which stabilizes gene expression against genetic and environmental
Shadow_enhancer
'home-brew' opiates." Oye et al. Nature. 521.7552 (2015): 281–283. "Regulating gene drives." Oye et al. Science. 345.6197 (2014): 626–628. “Embracing Uncertainty
Kenneth_A._Oye
Evolution of novel genes from non-genic DNA sequence
De novo gene birth is the process by which new genes evolve from non-coding DNA. De novo genes represent a subset of novel genes, and may be protein-coding
De_novo_gene_birth
Ability to move using metabolic energy
Nüsslein-Volhard, Christiane (2006). "6 Form and Form Changes". Coming to life: how genes drive development. San Diego, California: Kales Press. p. 75. ISBN 978-0-9798456-0-4
Motility
Italian professor of immunology and infectious disease
involved in the design of gene drives to force malaria-resistance genes to spread through mosquito populations, using CRISPR gene editing. In 2016 Catteruccia
Flaminia_Catteruccia
1976 film by Rod Amateau
D. (May 26, 1976). "Film Reviews: Drive-In". Variety. 26. Siskel, Gene (June 3, 1976). "'Disaster' one-ups 'Drive-In'". Chicago Tribune. Section 3, p
Drive-In_(film)
Activation of genes
Spatiotemporal gene expression is the activation of genes within specific tissues of an organism at specific times during development. Gene activation patterns
Spatiotemporal gene expression
Spatiotemporal_gene_expression
Type of drivetrain with four driven wheels
A four-wheel drive, also called 4×4 ("four-by-four") or 4WD, is a two-axled vehicle drivetrain capable of providing torque to all of its wheels simultaneously
Four-wheel_drive
Genetic engineering technique
recombination to drive targeted gene replacement, although other methods using a transposon-mediated system to insert the target gene have been developed
Gene_knock-in
American ethicist (born 1950)
Jewish Thought” (Oxford University Press, 2023); “May We Make the World: Gene Drives, Malaria, and the Future of Nature” (MIT Press, 2023)and editor (with
Laurie_Zoloth
Topics referred to by the same term
(gene) or huntingtin, the IT15 gene, which codes for the huntingtin protein H.D. or Hilda Doolittle (1886–1961), American poet and novelist Hard drive
HD
Group of proteins found in phages
disease vectors, such as mosquitoes. Anti-CRISPR proteins can impede gene drive, which could create uncertain and catastrophic consequences in ecosystems
Anti-CRISPR
2001 song by Alan Jackson
Nashville 69129 Where Were You (When the World Stopped Turning) 5:05 Drive (For Daddy Gene) 4:03 The next morning, many stations already were playing Jackson's
Where Were You (When the World Stopped Turning)
Where_Were_You_(When_the_World_Stopped_Turning)
Bioinformatician at the University of Otago
understanding genes involved in possum reproduction could help New Zealand meet its predator control targets, and what social licence might be needed for gene drives
Alana_Alexander
Protein that initiates male sex determination in therian mammals
is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of
Sex-determining region Y protein
Sex-determining_region_Y_protein
English existential risk research centre
topics including cybersecurity, nuclear security, climate change, and gene drives.[non-primary source needed] CSER Public Lectures have been viewed over
Centre for the Study of Existential Risk
Centre_for_the_Study_of_Existential_Risk
1971 film by Jack Nicholson
New York Times. 49. Siskel, Gene (July 26, 1971). "Drive, He Said". Chicago Tribune. Section 2, p. 9. "Film Reviews: Drive, He Said". Variety. June 2,
Drive,_He_Said
Metabolic gene clusters or biosynthetic gene clusters (BGC) are tightly linked sets of mostly non-homologous genes participating in a common, discrete
Metabolic_gene_cluster
German cabaret artist
from the original on June 27, 2020. Retrieved May 22, 2019. "Gin and genes drive Bernie Dieter". The West Australian. January 7, 2019. Retrieved January
Bernie_Dieter
American automotive customizer (1927–2025)
Custom Car Icon Gene Winfield Just Raised $98,000". Road & Track. Retrieved November 17, 2019. Geisert, Eric (July 2003). "Profile: Gene Winfield". Street
Gene_Winfield
Spanish racing driver (born 1974)
European Grand Prix.[citation needed] Unable to obtain a quality drive for 2001, Gené opted to sign with Williams as test driver. He drove three Grands
Marc_Gené
Asteroid
MIT, where she contributed to a number of papers including Daisy-chain gene drives for the alteration of local populations. As of 2025[update] she runs
23131_Debenedictis
Topics referred to by the same term
Wiktionary, the free dictionary. Sonic or Sonics may refer to: Sonic Drive-In, an American drive-in, fast-food restaurant chain Sonic (ISP), an Internet provider
Sonic
Gene or genetic redundancy is a term used to describe the existence of multiple genes in the genome of an organism that perform the same biochemical function
Gene_redundancy
2019 documentary television series
The first season of Formula 1: Drive to Survive documents the 2018 Formula One World Championship. It ran for 10 episodes and aired on Netflix on 8 March
Formula 1: Drive to Survive season 1
Formula_1:_Drive_to_Survive_season_1
Biological cell regulation mechanisms
of lactose and absence of glucose. In multicellular organisms, gene regulation drives cellular differentiation and morphogenesis in the embryo, leading
Regulation_of_gene_expression
Inability to achieve orgasm despite adequate stimulation
is taken from public domain CDC text. Khamsi, Roxanne (8 June 2005). "Genes drive ability to orgasm". Nature. doi:10.1038/news050606-4. Anorgasmia.net
Anorgasmia
travel, tourism, insurance
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