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FTH1

FTH1

Protein-coding gene in the species Homo sapiens

heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosis

FTH1

Ferritin

Iron-carrying protein

ferritin, heavy polypeptide 1 Identifiers Symbol FTH1 Alt. symbols FTHL6 NCBI gene 2495 HGNC 3976 OMIM 134770 RefSeq NM_002032 UniProt P02794 Other data

Ferritin

Iron overload

Abnormal accumulation of iron in the body

type 4 604653 ferroportin (SLC11A3/SLC40A1) Hemochromatosis type 5 615517 FTH1 BMP6-related hemochromatosis 620121 BMP6 Neonatal hemochromatosis 231100

Iron overload

Iron_overload

Hereditary haemochromatosis

Genetic condition involving iron buildup

Archived from the original on 27 January 2022. Retrieved 22 May 2021. "FTH1-related iron overload - About the Disease". Genetic and Rare Diseases Information

Hereditary haemochromatosis

Hereditary_haemochromatosis

List of genetic disorders

type 4 SLC40A1 (or HFE4) (chromosome 2) dominant Hemochromatosis type 5 FTH1 (chromosome 11) dominant Hemophilia FVIII 1:7,500 males (hemophilia A) 1:40

List of genetic disorders

List_of_genetic_disorders

Neurodegeneration with brain iron accumulation

Group of neurodegenerative disorders with associated iron accumulation in the brain

Kufor–Rakeb syndrome ATP13A2 autosomal recessive Neuroferritinopathy FTL, FTH1 autosomal dominant Aceruloplasminemia CP autosomal recessive Woodhouse–Sakati

Neurodegeneration with brain iron accumulation

Neurodegeneration_with_brain_iron_accumulation

Ferroxidase

Iron oxidizing enzyme, Fe(II) to Fe(III) conversion

encoding proteins with ferroxidase activity include: CP – Ceruloplasmin FTH1 – Ferritin heavy chain FTMT – Ferritin, mitochondrial HEPH - Hephaestin Cox

Ferroxidase

Beta-propeller protein-associated neurodegeneration

Neurodegenerative disorder with brain iron accumulation

WDR45 deficiency induces endoplasmic reticulum stress-dependent autophagy of FTH1 (ferritin heavy chain) and GPX4, which causes iron accumulation and lipid

Beta-propeller protein-associated neurodegeneration

Beta-propeller_protein-associated_neurodegeneration

Iron response element

RNA family

IRE—one with a bulged U and one without. Genes known to contain IREs include FTH1, FTL, TFRC, ALAS2, Sdhb, ACO2, Hao1, SLC11A2 (encoding DMT1), NDUFS1, SLC40A1

Iron response element

Iron_response_element

Housekeeping gene

Gene which maintains basic cellular functions

deaminase questionable: not present in very high levels at all CPNE1 ENSA (gene) FTH1 Heavy chain of Ferritin GDI2 rab/ras vesicular trafficking GUK1 Guanylate

Housekeeping gene

Housekeeping_gene

NCOA4

Protein-coding gene in the species Homo sapiens

responsible for ferritin degradation. NCOA4 binds ferritin heavy chain (FTH1) and delivers ferritin complexes to autophagosomes for lysosomal degration

NCOA4

Ferritin light chain

Protein found in humans

stress and cell death. Ferritin light chain has been shown to interact with FTH1. An oxygen molecule acts as the terminal electron acceptor during the oxidation

Ferritin light chain

Ferritin_light_chain

Smoker's macrophages

Alveolar macrophages whose characteristics have been affected by smoking

causality in cigarette iron. M1 macrophage demonstrates high TF, HAMP, and FTH1 gene activities that mediates iron uptake. M2 macrophage on the other hand

Smoker's macrophages

Smoker's_macrophages

List of human protein-coding genes 3

Q8N475 5896 FTCD HGNC:3974; O95954 5897 FTCDNL1 HGNC:48661; E5RQL4 5898 FTH1 HGNC:3976; P02794 5899 FTHL17 HGNC:3987; Q9BXU8 5900 FTL HGNC:3999; P02792

List of human protein-coding genes 3

List_of_human_protein-coding_genes_3

Topics referred to by the same term

social movement Frölunda HC, a Swedish ice hockey club Ferritin heavy chain (FTH1), an enzyme Fremont Hotel and Casino, in Las Vegas This disambiguation page

FHC

MARK2

Protein-coding gene in the species Homo sapiens

Gaudray P (1995). "Human EMK1 is located on 11q12-q13, close to COX8 and FTH1". Mamm. Genome. 6 (4): 311–2. doi:10.1007/BF00352433. PMID 7613050. S2CID 37616665

MARK2