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Kidney disease
Focal segmental glomerulosclerosis (FSGS) is a histopathologic finding of scarring (sclerosis) of glomeruli and damage to renal podocytes. This process
Focal segmental glomerulosclerosis
Focal_segmental_glomerulosclerosis
Term for several kidney diseases
progress to chronic kidney disease. Focal segmental glomerulosclerosis is characterised by a sclerosis of segments of some glomeruli. It is likely to present
Glomerulonephritis
Medical condition
type of glomerulosclerosis and is most commonly caused by diabetes. Focal segmental glomerulosclerosis (FSGS) is another type of glomerulosclerosis and can
Glomerulosclerosis
Protein-coding gene in the species Homo sapiens
shown to increase the risk of developing diseases such as Focal Segmental Glomerulosclerosis(FSGS), Hypertension Attributed-End Stage Kidney Disease (ESKD)
Apolipoprotein_L1
Symptoms resulting from kidney damage
pressure. Causes include a number of kidney diseases such as focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease. It may
Nephrotic_syndrome
Kidney disease
second most common cause of nephrotic syndrome in adults, with focal segmental glomerulosclerosis (FSGS) recently becoming the most common. Most people will
Membranous_glomerulonephritis
Medication
the treatment of primary immunoglobulin A nephropathy and focal segmental glomerulosclerosis. Sparsentan is an endothelin and angiotensin II receptor antagonist
Sparsentan
Disease with unknown pathogenesis or apparently spontaneous origin
percentage of all cases has not been established—for example, focal segmental glomerulosclerosis or ankylosing spondylitis; the majority of these cases are
Idiopathic_disease
Abnormally low levels of albumin in the blood
change disease, membranoproliferative glomerulonephritis, or focal segmental glomerulosclerosis. In adults, on the other hand, nephrotic syndrome is commonly
Hypoalbuminemia
English footballer (born 1971)
June 2014, Cole suffered kidney failure after developing focal segmental glomerulosclerosis. In April 2017, he underwent a kidney transplant. His nephew
Andy_Cole
Stiffening of a tissue or anatomical feature
such as cholesterol, in the arteries which causes hardening. Focal segmental glomerulosclerosis is a disease that attacks the kidney's filtering system (glomeruli)
Sclerosis_(medicine)
American bodybuilder (1968–2022)
Prince suffered from a rare kidney-related disease called focal segmental glomerulosclerosis, caused by either hereditary causes, obesity, drug abuse,
Tom_Prince_(bodybuilder)
American bodybuilder
bodybuilding's top tier. In 1999, Wheeler discovered that he had focal segmental glomerulosclerosis, a form of kidney disease. Despite press speculation as to
Flex_Wheeler
Type of kidney cell
(November 2009). "Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis--a review". European Journal of Pediatrics. 168 (11): 1291–1304
Podocyte
Pathological conditions of the kidney, impairing the organ's ability to filter blood
kidney disease through several direct and indirect mechanisms. Focal segmental glomerulosclerosis is the most common condition arising in such cases. Discontinuation
Kidney_disease
podocin gene NPHS2 can cause nephrotic syndrome, such as focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD). Symptoms may develop
Podocin
Monoclonal antibody
for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma). It binds to and
Fresolimumab
Monosaccharide sugar
studies suggest galactose may have a role in treatment of focal segmental glomerulosclerosis (a kidney disease resulting in kidney failure and proteinuria)
Galactose
Medical condition
"classical", type of HIV-associated nephropathy is a collapsing focal segmental glomerulosclerosis (FSGS), though other forms of kidney disease may also occur
HIV-associated_nephropathy
German nephrologist (born 1971)
causative agent contributing to many kidney diseases including focal segmental glomerulosclerosis (FSGS). These studies have broad clinical significance and
Jochen_Reiser
American actor (1968–2010)
fork-lift operator, and Edmonia Sue, a nurse practitioner. Due to focal segmental glomerulosclerosis, a kidney disease, and the corticosteroids and other medications
Gary_Coleman
Presence of abundant hair between the eyebrows
and dysmorphic features Epilepsy-telangiectasia syndrome Focal segmental glomerulosclerosis and neurodevelopmental syndrome Fontaine progeroid syndrome
Unibrow
Presence of an excess of serum proteins in the urine
exercise Stress Benign orthostatic (postural) proteinuria Focal segmental glomerulosclerosis (FSGS) IgA nephropathy (i.e. Berger's disease) IgM nephropathy
Proteinuria
Inflammatory disease of the kidney
glomerulus can only be seen through an electron microscope. Focal segmental glomerulosclerosis: A disease in which scar tissue develops in the glomeruli
Glomerulonephrosis
American basketball player (born 1970)
from the NBA because of a life-threatening kidney disease, focal segmental glomerulosclerosis, the same problem that Sean Elliott had in 1999. Cooper asked
Alonzo_Mourning
Disease where the kidneys fail to adequately filter waste products from the blood
HIV-associated nephropathy (HIVAN), primary nonmonogenic forms of focal segmental glomerulosclerosis, and hypertension affiliated chronic kidney disease not attributed
Kidney_failure
Endogenous non-cancerous pluripotent stem cell
injected intravenously repair SCID and BALB/c mouse models of focal segmental glomerulosclerosis without added immunosuppression. Injected human Muse cells
Muse_cell
Class of drugs
nephropathy, acute renal failure (secondary to rhabdomyolysis), focal segmental glomerulosclerosis, renal cell carcinoma. Others: glucose intolerance, insulin
Anabolic_steroid
Miniaturized and simplified version of an organ
different kidney diseases, polycystic kidney disease and focal segmental glomerulosclerosis. These CRISPR-modified pluripotent stem cells were subsequently
Organoid
Protein-coding gene in humans
NPHS2 has been shown to interact with Nephrin and CD2AP. Focal segmental glomerulosclerosis GRCh38: Ensembl release 89: ENSG00000116218 – Ensembl, May
NPHS2
Chemical compound
Thus, this could in certain circumstances be the case for focal segmental glomerulosclerosis after inhalational exposure: such a glomerulopathy with noteworthy
Ochratoxin_A
Protein-coding gene in the species Homo sapiens
processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. Alpha-actinin-4 has been shown to interact with PDLIM1
Alpha-actinin-4
Protein factor that regulates the length of R-actin
of tumors. Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis (FSGS). Actin Muscle contraction Sjöblom B, Salmazo A, Djinović-Carugo
Actinin
Doctor, academic, and author
for pathologic diagnosis of kidney transplant rejection, focal segmental glomerulosclerosis, IgA nephropathy, membranoproliferative glomerulonephritis
J._Charles_Jennette
blood glucose monitoring) FSE fetal scalp electrode FSGS focal segmental glomerulosclerosis FSH follicle-stimulating hormone FSIQ full scale intelligence
List of medical abbreviations: F
List_of_medical_abbreviations:_F
Topics referred to by the same term
a railway station in Sussex, England Fluorosilicate glass Focal segmental glomerulosclerosis Free Spirit Gathering, an American Pagan and Pantheist event
FSG
Abnormal kidney structure or gradual loss of kidney function
into:[citation needed] Primary glomerular disease such as focal segmental glomerulosclerosis and IgA nephropathy (or nephritis) Secondary glomerular disease
Chronic_kidney_disease
Chemical compound used as medication
PMC 4101632. PMID 24987008. Meyrier A (2005). "Treatment of focal segmental glomerulosclerosis". Expert Opinion on Pharmacotherapy. 6 (9): 1539–1549. doi:10
Ciclosporin
Protein-coding gene in the species Homo sapiens
encircling and severing filaments. It can be associated with Focal segmental glomerulosclerosis and Charcot-Marie-Tooth Disease. GRCh38: Ensembl release 89:
INF2
American football player (born 1990)
Adderall. As of February 2019, Bryant is being treated for focal segmental glomerulosclerosis (FSGS), which has led to kidney failure and requires dialysis
Armonty_Bryant
American songwriter and producer (born 1983)
experiencing kidney problems. A biopsy showed he had FSGS, or focal segmental glomerulosclerosis, a relatively common form of kidney disease which decreases
Brian Kennedy (music producer)
Brian_Kennedy_(music_producer)
Medical condition
heart failure, ventricular hypertrophy, arrhythmia Kidney Focal segmental glomerulosclerosis, nephropathy Intestine Malabsorption or constipation Muscle
Diabetes_and_deafness
Medical condition
of the condition include progressive glomerulonephropathy (focal segmental glomerulosclerosis). Patients are also at increased risk of genito-urinary tumors
Frasier_syndrome
American track and field runner
of the United States Olympic Trials, he was diagnosed with focal segmental glomerulosclerosis (FSGS), although his official diagnosis didn't come about
Jon_Rankin
Gene editing method
in genes relevant to polycystic kidney disease (PKD) and focal segmental glomerulosclerosis (FSGS). These CRISPR-modified pluripotent stem cells were
CRISPR_gene_editing
Toxicity in the kidneys
drug toxicity. Heroin and Pamidronate are known to cause focal segmental glomerulosclerosis Gold salts therapy can cause membranous nephropathy Penicillamine
Nephrotoxicity
was discovered that Mourning had a chronic kidney disease: Focal segmental glomerulosclerosis. On October 16, 2000, it was announced that Alonzo would not
History_of_the_Miami_Heat
Medical procedure
kidney transplant: Club ambassador has a condition called Focal Segmental Glomerulosclerosis". The Irish Times. 7 April 2017. Retrieved 7 April 2017. "Andrew
Kidney_transplantation
effects and used to treat cancer and autoimmune diseases like focal segmental glomerulosclerosis. Naltrexone (Revia) for behavioral addiction: there is some
List of drugs known for off-label use
List_of_drugs_known_for_off-label_use
American basketball player (born 1968)
Elliott announced that he had a kidney disease known as focal segmental glomerulosclerosis, that his kidney function was worsening, and that he would
Sean_Elliott
Medical condition
nephropathy: is it closer to minimal change disease or to focal segmental glomerulosclerosis?". Journal of Nephrology. 29 (4). Springer Science and Business
IgM_nephropathy
American musician (born 1966)
second eldest, Ade, was diagnosed with a kidney disease called focal segmental glomerulosclerosis (FSGS). The disease has left Ade with just 50% function in
Michael_Franti
Structures projecting from cells
"Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis". Kidney International. 74 (12): 1568–76. doi:10.1038/ki.2008
Cellular_extensions
Medical condition
lesion: A distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum". Kidney International. 65 (5). Elsevier BV: 1690–1702
Glomerulopathy
American baseball executive
awareness for kidney diseases, including Nephrotic Syndrome and Focal Segmental Glomerulosclerosis (FSGS), conditions that his daughter was diagnosed with prior
Jim_Duquette
American hurdler (born 1985)
competition, he felt very ill and was diagnosed with collapsing focal segmental glomerulosclerosis, a rare congenital kidney disease, aggravated by a parvovirus
Aries_Merritt
Human chromosome
or Phelan-McDermid syndrome Emanuel syndrome Ewing sarcoma Focal Segmental Glomerulosclerosis Li-Fraumeni syndrome TANGO2 deficiency Metachromatic leukodystrophy
Chromosome_22
Sean Elliot's 1999 game-winning shot in Game 2 of the 1999 Western Conference Finals
the Spurs' championship run, Elliott had been playing with focal segmental glomerulosclerosis, which would require a kidney transplant, and he would likely
Memorial_Day_Miracle
Medical techniques to separate one or more components of blood
II Homozygotes with small blood volume Plasmapheresis II Focal segmental glomerulosclerosis Recurrent Plasmapheresis I Graft-versus-host disease Skin
Apheresis
Drug that inhibits activity of immune system
erythematosus, systemic sclerosis, scleroderma, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, ankylosing
Immunosuppressive_drug
Swiss pharmacuetical company
CKD-associated peripheral artery disease and aortic valve stenosis, focal segmental glomerulosclerosis, IgA nephropathy and cardiac surgery-associated Acute kidney
CSL_Vifor
of systemic inflammatory response syndrome (SIRS), cancer, focal segmental glomerulosclerosis, cardiovascular disease, type 2 diabetes, infectious diseases
Soluble urokinase plasminogen activator receptor
Soluble_urokinase_plasminogen_activator_receptor
Diabetes researcher
et al. (June 2011). "Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis". Science Translational Medicine. 3 (85): 85ra46. doi:10.1126/scitranslmed
Camillo_Ricordi
Class of transport proteins
have been associated with respiratory diseases along with focal segmental glomerulosclerosis in the kidneys. All TRPC channels are activated either by
Transient receptor potential channel
Transient_receptor_potential_channel
American baseball player (born 1960)
in Overland Park, Kansas, in 1992 Hearn was diagnosed with focal segmental glomerulosclerosis. Hearn immediately underwent a kidney transplant and was required
Ed_Hearn_(baseball)
Medical condition
characteristic, and the possibility of other diagnoses, particularly focal segmental glomerulosclerosis (FSGS), may be raised. Electron microscopy shows a characteristic
Alport_syndrome
Medical condition
light microscopy can vary from minimal change nephropathy to focal segmental glomerulosclerosis or diffuse mesangial sclerosis. Electron microscopy shows
Congenital_nephrotic_syndrome
Group of pharmaceuticals that modulate the renin–angiotensin system
kidney disease, chronic kidney disease, interstitial fibrosis, focal segmental glomerulosclerosis, or any conditions such as ARBs-treated but still clinically
Angiotensin II receptor blocker
Angiotensin_II_receptor_blocker
Fresolimumab mab human TGF-β idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer Frovocimab mab humanized PCSK9 hypercholesterolemia
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Adult and pediatric nephrologist
Changli, et al. “Circulating Urokinase Receptor as a Cause of Focal Segmental Glomerulosclerosis.” Nature Medicine, vol. 17, no. 8, 2011, pp. 952–960. Cited
Minnie_Sarwal
Protein-coding gene in the species Homo sapiens
or focal and segmental glomerulosclerosis. Signs and symptoms include kidney biopsies demonstrating non-specific histologic changes such as focal segmental
PLCE1
Diverse group of genetic neuromuscular disorders disrupting mitochondrial function
muscle endothelial cells. Various nephropathies, including focal segmental glomerulosclerosis and tubulointerstitial nephritis arise in MELAS patients as
Mitochondrial encephalomyopathy
Mitochondrial_encephalomyopathy
Family of transient receptor potential cation channels in animals
Ingelheim's BI 764198, a selective TRPC6 inhibitor developed for focal segmental glomerulosclerosis (FSGS, a kidney disease), achieved positive Phase II results
TRPC
Failure of the kidney(s) to develop during embryonic growth
2014. Kiprov, DD; Colvin, RB; McCluskey, RT (March 1982). "Focal and segmental glomerulosclerosis and porteinuria associated with unilateral renal agenesis"
Renal_agenesis
English footballer (born 1977)
In October 2022, Andrews opened up on his diagnosis with focal segmental glomerulosclerosis, a form of kidney disease. A. ^ The "Other" column constitutes
Wayne_Andrews_(footballer)
Protein
shown to interact with: Cbl gene, NPHS2, Nephrin, and RAB4A. Focal segmental glomerulosclerosis GRCh38: Ensembl release 89: ENSG00000198087 – Ensembl, May
CD2AP
Medical condition
membranous glomerulonephritis, minimal change disease, and focal segmental glomerulosclerosis.[citation needed] There are no laboratory tests used to diagnose
Renal_vein_thrombosis
German nephrologist and internist (born 1971)
Mundel, P., and Shaw, A. S. 2006. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin
Tobias_Huber
Protein-coding gene in humans
in a consanguineous family with histological findings of focal segmental glomerulosclerosis". Am. J. Kidney Dis. 50 (5): 855–64. doi:10.1053/j.ajkd.2007
NPHP4
Protein-coding gene in the species Homo sapiens
disease and associated with proteinuria, kidney failure, and focal segmental glomerulosclerosis. Mutations in SCARB2 have also been shown to cause Gaucher
SCARB2
Sections of the genome experiencing minimal changes across species
2006). "Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants". Nature Genetics. 38 (10): 1216–1220
Ultraconserved_element
Kidney structure which performs the first step in blood filtration
glomerulonephritis, acute crescentic glomerulonephritis, focal segmental glomerulonephritis, and diabetic glomerulosclerosis.[citation needed] Bowman's capsule is named
Bowman's_capsule
Mammalian protein found in Homo sapiens
et al. (October 2008). "MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis". Nature Genetics. 40 (10): 1175–84. doi:10.1038/ng.226. PMC 2827354
MYH9
Kidney disorder
examination of a kidney biopsy) is minimal change disease, though focal segmental glomerulosclerosis (kidney scaring) is increasingly seen. Management of the syndrome
Childhood-onset nephrotic syndrome
Childhood-onset_nephrotic_syndrome
Mammalian protein found in Homo sapiens
HMOX1 and HMOX2 belong to the heme oxygenase family. HMOX2 Focal segmental glomerulosclerosis GRCh38: Ensembl release 89: ENSG00000100292 – Ensembl, May
HMOX1
Mammalian protein found in Homo sapiens
and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis". Life Sciences. 79 (8): 757–63. doi:10.1016/j.lfs.2006.02
SYNPO
Mammalian protein found in Homo sapiens
"Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis". Clinical Immunology. 273 (1) 110459. doi:10.1016/j.clim
C5a_receptor
Chemical compound
both children and adults are minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) and membranous nephropathy (MN). These diseases are
N-Acetylmannosamine
Medical condition
needed] decrease in nephron number associated with hypertrophy focal segmental glomerulosclerosis interstitial fibrosis and tubular atrophy multicystic dysplastic
Papillorenal_syndrome
advanced/progressive = segmental glomerulosclerosis, crescent, interstitial fibrosis, tubular atrophy Immunofluorescence: Expanded mesangium with segmental lesions Mesangial
Endocapillary proliferative glomerulonephritis
Endocapillary_proliferative_glomerulonephritis
Protein and coding gene in humans
range of diseases including: Kidney diseases Proteinuria Focal segmental glomerulosclerosis Diabetic nephropathy Disorders of the nervous system Alzheimer's
TRPC6
Removal, treatment and return of blood plasma
syndrome (experimental, unproven) Pemphigus vulgaris Recurrent focal and segmental glomerulosclerosis in the transplanted kidney Refsum disease Rhabdomyolysis
Plasmapheresis
Medical condition
followed by focal and segmental necrotizing glomerulonephritis with crescents. Other abnormalities that are found include glomerulosclerosis, IgA nephropathy
Relapsing_polychondritis
Medical condition
identified in the renal and glomerular vasculature. Glomerulosclerosis is often present, either focally or globally, which is characterized by hardening
Hypertensive_kidney_disease
Medical condition
reveals the typical lesion of "hyperfiltration nephropathy" namely, focal segmental glomerular sclerosis. This finding has led to the suggestion that anemia-induced
Sickle_cell_nephropathy
Medical condition
becomes more diffuse over time, accompanied by secondary focal segmental and global glomerulosclerosis and hyalinosis, variable mesangial matrix expansion
Transplant_glomerulopathy
FN1 Glomerulosclerosis, focal segmental, 1; 603278; ACTN4 Glomerulosclerosis, focal segmental, 2; 603965; TRPC6 Glomerulosclerosis, focal segmental, 3;
List_of_OMIM_disorder_codes
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FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
FOCAL SEGMENTAL-GLOMERULOSCLEROSIS
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