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Protein allowing tissue in the body to resume shape after stretching
Elastin is a protein encoded by the ELN gene in humans and several other animals. Elastin is a key component in the extracellular matrix of gnathostomes
Elastin
Chemical compound
uniquely in elastin, a protein found in connective tissue such as skin, lungs, and elastic arteries. Desmosine is a component of elastin and cross links
Desmosine
Type of connective tissue in animals
component of the extracellular matrix composed of bundles of proteins (elastin) which are produced by a number of different cell types including fibroblasts
Elastic_fiber
Structural support for biological cells
tissues contain high amounts of elastins. Elastins are synthesized by fibroblasts and smooth muscle cells. Elastins are highly insoluble, and tropoelastins
Extracellular_matrix
Biomolecule consisting of chains of amino acid residues
Most structural proteins are fibrous proteins; for example, collagen and elastin are critical components of connective tissue such as cartilage, and keratin
Protein
Elastin-like polypeptides (ELPs) are synthetic biopolymers with potential applications in the fields of cancer therapy, tissue scaffolding, metal recovery
Elastin-like_polypeptides
Aesthetic technique
energy to heat skin with the purpose of stimulating cutaneous collagen, elastin and hyaluronic acid production in order to reduce the appearance of fine
Radio-frequency skin tightening
Radio-frequency_skin_tightening
Chemical compound
found in elastin. Isodesmosine is an isomeric pyridinium-based amino acid resulting from the condensation of four lysine residues between elastin proteins
Isodesmosine
Protein
ganglioside substrates and other glycoconjugates. The GLB1 gene also encodes an elastin binding protein. In corn (Zea mays), Glb1 is a gene coding for the storage
GLB1
Histological stain which colors elastin
cationic, anionic and non-ionic bonds with elastin, the main constituent of elastic fiber tissue. Elastin has a strong affinity for the iron-hematoxylin
Verhoeff's_stain
Pharmaceutical compound
Hexapeptide-12 (Elastin hexapeptide) is a hexapeptide with the sequence VGVAPG, which is derived from a sequence found in the connective tissue protein elastin. At
Hexapeptide-12
American biotechnology company
American biotechnology company that develops animal-free collagen and elastin proteins by precision fermentation, engineering microbes to make recombinant
Geltor
Clade of reptiles
antibody binding) demonstrated the presence of proteins such as collagen, elastin, and laminin. Both specimens yielded collagen protein sequences that were
Dinosaur
Genetic disorder
two copies of the elastin gene. Since 98-99% of individuals with WS lack half of the 7q11.23 region of chromosome 7, where the elastin gene is located,
Williams_syndrome
Type of tissue
elastic fiber networks and collagen type II fibers. The principal protein is elastin. Elastic cartilage is histologically similar to hyaline cartilage but contains
Elastic_cartilage
Folds of throat tissues that help to create n through vocalization
vocal fold. There is a steady increase in the elastin content of the lamina propria as humans age (elastin is a yellow scleroprotein, the essential constituent
Vocal_cords
Resilient and smooth elastic tissue present in animals
of glycosaminoglycans, proteoglycans, collagen fibers and, sometimes, elastin. It usually grows quicker than bone. Because of its rigidity, cartilage
Cartilage
Inflammatory disease involving a buildup of lesions in the walls of arteries
thrombosis. The bulk of these lesions is made of excess fat, collagen, and elastin. At first, as the plaques grow, only wall thickening occurs without narrowing
Atherosclerosis
Category of diseases
elastin and collagen. Tendons, ligaments, skin, cartilage, bone, and blood vessels are all made of collagen. Skin and ligaments also contain elastin.
Connective_tissue_disease
Skin which is abnormally inelastic and hangs loosely
associated with deficient or absent elastin fibers in the extracellular matrix. This can be related to decreased elastin synthesis or structural defects in
Cutis_laxa
Medical condition
elastosis, also known as solar elastosis, is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin, or in the conjunctiva of the
Actinic_elastosis
"I steer") is a component of elastic fibers formed from deposition of elastin between oxytalan fibers. It is found in the periodontal ligament and the
Elaunin
Artery able to stretch in response to each pulse
(conducting artery or conduit artery) is an artery with many collagen and elastin filaments in the tunica media, which gives it the ability to stretch in
Elastic_artery
Structural material present in almost all organic life
Gosilin, J.M.; Aaron, B.B (1981). "Elastin as a Random-network elastomer, a mechanical and optical analysis of single elastin fibers". Biopolymers. 20 (6):
Fibril
Type of biological tissue in animals
organs to recoil; provide resistance to stretch forces Elastic microfibril, elastin, fibrillin Extracellular matrix, walls of large blood vessels, certain
Connective_tissue
Protein-coding gene in the species Homo sapiens
Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene. It is the best characterized member of the EMILIN
EMILIN1
Ligament at the back of the neck
head. The nuchal ligament is unusual in being a ligament containing more elastin, as well as collagen, allowing for stretch and recovery to its original
Nuchal_ligament
Narrowing of the aorta just above the aortic valve of the heart
hemizygous deletion of the Elastin gene. Further studies have shown that patients with less extensive deletions featuring the Elastin gene also tend to develop
Supravalvular_aortic_stenosis
Medical condition
and atrophic hair follicles, milia, dilated dermal vessels, lack of elastin or elastin in clumps. After light irradiation a tendency to increased repair
Rombo_syndrome
chemical reaction Preferential cleavage: Leu-, Met- and Phe-. Hydrolyses elastin This peptidase from trypsin family is formed by activation of proelastase
Pancreatic_elastase_II
Flexible rod-shaped structure in all chordates
vacuolated cells filled with glycoproteins, covered by two helical collagen-elastin sheaths. It lies longitudinally along the rostral-caudal (head to tail)
Notochord
Protein family
insoluble microfibrils, which appear to provide a scaffold for deposition of elastin. Marfan syndrome is a genetic disorder of the connective tissue caused
Fibrillin
Connective tissue composed of reticular collagen fibers
Tissue fluid Fibers Collagen fibers Reticular fibers COL3A1 Elastic fibers Elastin Fibrillin FBN1 FBN2 FBN3 EMILIN1 Elaunin Types Proper Loose Reticular Adipose
Reticular_connective_tissue
Infraphylum of vertebrates
appendages (pectoral and pelvic fins, limbs, wings, etc.). Other traits are elastin, horizontal semicircular canal of the inner ear, myelinated neurons, and
Gnathostomata
Bulge in the wall of a blood vessel
results in a decreased activity of the lysyl oxidase enzyme, affecting elastin, a key component in vessel walls. Copper deficiency results in vessel wall
Aneurysm
following chemical reaction Broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. This enzyme
Staphopain
Excessive enlargement of the human aorta
more common than their thoracic counterpart. One reason for this is that elastin, the principal load-bearing protein present in the wall of the aorta, is
Aortic_aneurysm
Enzyme
(peptidases) that break down proteins, specifically one that can break down elastin. In other words, the name only refers to the substrate specificity (i.e
Elastase
Collagen of bones
proteins: ossein (collagens), osseomucoid (proteoglycans) and osseoalbuminoid (elastin). Advances in molecular biology rendered these terms obsolete. When processed
Ossein
Medical condition
revealed that elastin fibers display abnormally high levels of fragmentation and clumping of microfibrils, with little amorphous elastin. Within collagen
Wrinkly_skin_syndrome
Medical condition
in patients with Reinke's edema will show lowered levels of collagen, elastin, and extracellular matrix proteins. These characteristics can be used to
Reinke's_edema
Group of genetic connective tissues disorders
Structurally, changes within the musculature in the intestine, such as increased elastin, can lead to increased frequency of herniation. Laxity of the phreno-esophageal
Ehlers–Danlos_syndrome
Connective tissue around muscle groups
fibers gives the deep fascia its strength and integrity. The amount of elastin fiber determines how much extensibility and resilience it will have. Examples
Deep_fascia
Injury to the innermost layer of the aorta
tear may occur, quite often it involves degeneration of the collagen and elastin that make up the media. This is known as cystic medial necrosis and is
Aortic_dissection
Layer of skin between the epidermis and subcutaneous tissues
composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular
Dermis
American biochemist (1911–1980)
In 1937, Stein completed his thesis on the amino acid composition of elastin, earning his Ph.D. Stein was introduced to potassium trioxalatochromate
William_Howard_Stein
Structural fibrous protein
feature a size-constrained helical shape. The connective tissue protein elastin also has a high percentage of both glycine and alanine. A preponderance
Keratin
Family of cetacean mammals
These nerves are packed into a central core area that is surrounded by elastin fibers. Opening the mouth causes the nerves to unfold, and they snap back
Rorqual
Disease of draft horses
CPL is not known, although it is suspected that a genetic disorder of elastin metabolism prevents the lymphatic vessels from functioning properly, leading
Chronic progressive lymphedema
Chronic_progressive_lymphedema
Loss of elasticity in blood vessels
to increased stiffening over time, including the disruption of lamellar elastin structures within the wall, possibly due to repeated cycles of mechanical
Arterial_stiffness
Durable and flexible material created by tanning animal skins
not damage or dissolve collagen or keratin, but should hydrolyze casein, elastin, albumin, globulin-like proteins, and nonstructural proteins that are not
Leather
Part of the female primate torso that has mammary glands
milk glands, the breast is also composed of connective tissues (collagen, elastin), white fat, and the suspensory Cooper's ligaments. Sensation in the breast
Breast
Lung disease involving long-term poor airflow
Inhaled smoke triggers the excessive release of proteases. This degrades elastin, the major component of the walls of alveoli, the small air sacs in the
Chronic obstructive pulmonary disease
Chronic_obstructive_pulmonary_disease
Type of connective tissue in animals
coils of collagen molecules. Elastic fibers: elastic fibers are made of elastin and are "stretchable." Reticular fibers: reticular fibers consist of one
Loose_connective_tissue
Medication to treat high blood pressure and alopecia
in a dose-dependent manner. In hypertensive rats, minoxidil increases elastin levels in the mesenteric, abdominal, and renal arteries by a decrease in
Minoxidil
Mechanism that maintains blood pressure between heart beats
arteries and their larger branches) contain elastic fibers, formed of elastin. These arteries distend when the blood pressure rises during systole and
Windkessel_effect
Protein-coding gene in the species Homo sapiens
MFAP2 gene. Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology
MFAP2
Class of animals
glottis. Some geckos and turtles possess true vocal cords, which have elastin-rich connective tissue. Hearing in humans relies on 3 parts of the ear;
Reptile
catalyses the following chemical reaction Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally
Pseudolysin
Abnormal yellowish skin colour caused by high level of bilirubin
has a particularly high affinity for bilirubin deposition due to high elastin content. Slight increases in serum bilirubin can, therefore, be detected
Jaundice
Extracellular non-fibrous substance
extracellular matrix (ECM) except for fibrous materials such as collagen and elastin. Ground substance is active in the development, movement, and proliferation
Ground_substance
Anatomical structure of the penis
canal of the urethra.[citation needed] It consists of approximately 5% elastin, with the remainder mostly consisting of collagen. The tunica albuginea
Tunica_albuginea_(penis)
Non-soluble proteins with elongated or sheet-like structures
Fibrous proteins consist of many families including keratin, collagen, elastin, fibrin or spidroin. Collagen is the most abundant of these proteins which
Fibrous_protein
Natural emission of light by biological structures
to autofluorescence because of the intrinsic properties of collagen and elastin. Generally, proteins containing an increased amount of the amino acids
Autofluorescence
Form of scarring
affects the dermis by preventing the fibroblasts from forming collagen and elastin fibers necessary to keep rapidly growing skin taut; this can create a lack
Stretch_marks
Pharmaceutical compound
from a sequence found in connective tissue proteins such as collagens and elastin. It stimulates endogenous biosynthesis of collagens, fibronectin and hyaluronic
Tetrapeptide-21
Organ covering the outside of the human body
follicle and blood vessel patterns; biochemically the dermal collagen and elastin content is similar in pig and human skin; and pig skin and human skin have
Human_skin
Layer found in atheromatous plaques
bundles of muscle cells, macrophages, foam cells, lymphocytes, collagen and elastin. An atheroma with a cap is termed a fibrous cap atheroma. The rupture of
Fibrous_cap
Red pigment of the bile
Jaundice leads to raised bilirubin levels that in turn negatively remove elastin-rich tissues. Jaundice may be noticeable in the sclera of the eyes at levels
Bilirubin
Medical condition
thought to cause fibroblasts to produce more elastin fibers, which are more twisted than normal elastin fibers and may lead to the degradation of the
Pinguecula
Class of enzymes
catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- > -Val- This enzyme is present in polymorphonuclear
Myeloblastin
Lowermost layer of the integumentary system in vertebrates
plants. Fibrous bands anchoring the skin to the deep fascia Collagen and elastin fibers attaching it to the dermis Fat is absent from the eyelids, clitoris
Subcutaneous_tissue
Primary organ of the respiratory system
the alveolar walls. Elastin is the key protein of the extracellular matrix and is the main component of the elastic fibres. Elastin gives the necessary
Lung
Internal support structure of an animal
a notochord, a flexible glycoprotein rod cross-wrapped by two collagen-elastin helices, which their body plans develop around as embryos. With the exception
Endoskeleton
Mammalian protein found in Homo sapiens
collagen and elastin precursors. These aldehydes react with unmodified lysine residues, resulting in cross-linking collagen and elastin, which is essential
Lysyl_oxidase
Veins draining blood from the pelvis and lower limbs
inflammatory response within the common iliac vein. The resulting intraluminal elastin and collagen deposition can cause intimal fibrosis and the formation of
Common_iliac_vein
Ballooning or rupturing of a blood vessel in the brain
association with the development of intracranial aneurysms, including perlecan, elastin, collagen type 1 A2, endothelial nitric oxide synthase, endothelin receptor
Intracranial_aneurysm
skin located on the bat wing is called the patagium. It is composed of elastin fibers along with connective tissue, and provides durability and flexibility
Bat_flight
Species of fish
skin, which consists of about 90% water and a meshwork of collagen and elastin, acting like an exoskeleton, with a greasy texture that may indicate it
Ocean_sunfish
and in a non-uniform manner, the skin loses elasticity as collagen and elastin decline, which leads to laxity, wrinkling, and visible aging changes. Further
Platysmaplasty
Type of tissue that connects muscle to bone
matrix components, including: 3% cartilage oligomeric matrix protein, 1–2% elastin, 1–5% proteoglycans, 0.2% inorganic components such as copper, manganese
Tendon
Medical condition
Floppy eyelid syndrome is thought to revolve around the upregulation of elastin-degrading enzymes, as well as mechanical factors. These can cause instability
Floppy_eyelid_syndrome
Skin and other protective organs
connective tissue and areolar connective tissue such as a collagen with elastin arranged in a diffusely bundled and woven pattern. The dermis has two layers:
Integumentary_system
Protein-coding gene in the species Homo sapiens
catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to
LOXL2
of S. aureus in its very broad specificity and its ability to degrade elastin. Staphopain A expressed from the gene scpA within the scp operon. The operon
Staphopain A (Staphylococcus aureus)
Staphopain_A_(Staphylococcus_aureus)
Layer of connective tissue in the body
of muscles into fascial compartments. This fascia has a high density of elastin fibre that determines its extensibility or resilience. Deep fascia was
Fascia
Soft outer covering organ of vertebrates
with blood vessels and nerves. It consists of loose connective tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (the subcutaneous
Skin
Extracellular matrix glycoprotein family
Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". Am J Med Genet C Semin Med Genet. 139
Tenascin
Mammalian protein found in humans
antitrypsin deficiency), neutrophil elastase can excessively break down elastin, leading to the loss of elasticity in the lungs. This results in respiratory
Alpha-1_antitrypsin
Order of reptiles with a shell
the larynx or glottis that vibrate to produce sound. Other species have elastin-rich vocal cords. Due to their heavy shells, turtles are slow-moving on
Turtle
Tissue in the body that is not hardened by ossification
substances inside the extracellular matrix of soft tissue are the collagen, elastin and ground substance. Normally the soft tissue is very hydrated because
Soft_tissue
Naturally occurring mineral form of calcium apatite
microspheres function as a scaffold for the endogenous production of collagen, elastin, and proteoglycans. This process is reported to lead to increases in skin
Hydroxyapatite
Anatomical structure
perineum, pelvic side wall and sacrum via attachments that include collagen, elastin, and smooth muscle. Surgery can be performed to repair pelvic floor muscles
Pelvic_floor
Sub-field of pathology
be derived from the image analysis of other fibrillar proteins such as elastin, laminins, fibronectin… For each digital pathology image, the PHN file
Digital_pathology
Genus of bacteria
down the extracellular matrix of host tissues, including collagen and elastin, is one of the organism's primary virulence factors. By doing so, the bacterium
Porphyromonas
Interstitial cells
podomeres have the same thickness as collagen fibrills, which make them impossible to be observed under light microscopy. E - elastin Scale bar - 2 mm.
Telocyte
Form of scleroderma involving isolated patches of hardened skin
border dropping into a depression with no outpouching, which, on biopsy, elastin is normal, while collagen may be thickened. Atrophoderma of Pasini and
Morphea
Hungarian biochemist
discovered the first elastase – an enzyme capable of degrading the protein elastin which gives tissues like veins their flexibility. She also contributed
Ilona_Banga
of the extracellular Matrix (ECM) e.g. collagen types I, III, IV, V VI, elastin, lamin etc. In addition to the structural proteins, fibroblasts make
Mechanobiology
changes and includes diminished or defective synthesis of collagen and elastin in the dermis.[citation needed] Extrinsic ageing of skin is a distinctive
Intrinsic and extrinsic ageing
Intrinsic_and_extrinsic_ageing
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