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Protein-coding gene in humans
migration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by the DCX gene. Doublecortin (DCX) is a
Doublecortin
Birth defect in which the brain lacks surface folds
and a mutation in this gene has been reported. DCX or doublecortin encodes for the doublecortin protein which is similar to LIS1 as it encodes a microtubule
Lissencephaly
Protein-coding gene in humans
Doublecortin domain-containing protein 2 (DCDC2) is a protein that in humans is encoded by the DCDC2 gene. This gene encodes a protein with two doublecortin
DCDC2
Protein-coding gene in the species Homo sapiens
Doublecortin-like kinase protein 1 (DCLK1) is an enzyme that in humans is encoded by the DCLK1 gene. Its C-terminal domain in rats is expressed independently
DCLK1
Protein-coding gene in the species Homo sapiens
Doublecortin like kinase 3 is a protein that in humans is encoded by the DCLK3 gene. GRCh38: Ensembl release 89: ENSG00000163673 – Ensembl, May 2017 GRCm38:
Doublecortin_like_kinase_3
Birth defect of abnormally large or thick brain folds
Truncated (shortened) mutations of LIS1 tend to cause severe lissencephaly. Doublecortin (DCX or XLIS) mutations are responsible for X-linked disorders. While
Pachygyria
Reptile of Africa
Telencephalon and Cerebellar Cortex of the Nile Crocodile Revealed with Doublecortin Immunohistochemistry: ADULT NEUROGENESIS IN NILE CROCODILE". The Anatomical
Nile_crocodile
Human chromosome
bullosa, dystrophic, dominant and recessive) CRBN: Cereblon protein DCLK3: Doublecortin like kinase 3 DLEC1: encoding protein Deleted in lung and esophageal
Chromosome_3
granule cell layer (GCL), and molecular layer (ML). Cells were stained for doublecortin (DCX), a protein expressed by neuronal precursor cells and immature neurons
Subgranular_zone
Region of the hippocampus in the brain
granule cell layer (GCL), and molecular layer (ML). Cells were stained for doublecortin (DCX). (B) Closeup of subgranular zone, located between the hilus and
Dentate_gyrus
Antibody in molecular biology and neuroscience
neurons mature, typically after they have downregulated expression of Doublecortin, a marker seen in the earliest stages of neuronal development. Fox-3
NeuN
have been used in birds include NeuN, Hu, PCNA, pHH3, and DCX. DCX (doublecortin) is one of the most commonly used protein target when describing neurogenesis
Adult neurogenesis in songbirds
Adult_neurogenesis_in_songbirds
Chemical compound
unknown. Oleamide has been found to enhance PPARα-dependent increase in doublecortin, a marker of neurogenesis in the hippocampus Oleamide is rapidly metabolized
Oleamide
Region of the brain
been shown to harbor cells expressing markers of plasticity such as doublecortin and PSA-NCAM which are modulated by the noradrenergic neurotransmitter
Piriform_cortex
Abnormal stiffness of skeletal muscle
help from a specialised team or health professional.[citation needed] Doublecortin positive cells, similar to stem cells, are extremely adaptable and, when
Spasticity
Endogenous tag expressed in different cells along neurogenesis and differentiated cells
there are specific markers that label particular regions of the neuron. Doublecortin (DCX) is a microtubule-associated protein that is widely expressed in
Neuronal_lineage_marker
S. A.; Ramanujam, R; Wyche, J. H.; Anant, S; Houchen, C. W. (2009). "Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled
List of intestinal stem cell marker genes
List_of_intestinal_stem_cell_marker_genes
Topics referred to by the same term
spacecraft Digital customer experience DCX (gene), which encodes the protein doublecortin .dcx (DCX), a document image format, the Multipage PCX 610 (number) (Roman
DCX
Proteins associated with the disassembly of cell microtubules
of catastrophe without affecting the promotion of microtubule growth. Doublecortin (DCX) shows an ability to inhibit catastrophe without affecting the microtubule
Catastrophin
Microtubules in nervous tissue neurons
dendritic proteins into axons. On the other hand, DCX encodes the protein doublecortin that interacts with Lis1 on top of supporting the 13 protofilament structure
Neurotubule
Protein found in humans
1 and regulates the microtubules by also phosphorylating tau, MAP1B, doublecortin, Nudel, and CRMPs, which are all microtubule-associated proteins. A non-proper
Cyclin-dependent_kinase_5
Filament Formation
nucleation potential of centrosomes. The microtubule-binding protein doublecortin, in vitro, nucleates microtubules—acting by binding to the side rather
Microtubule_nucleation
Neurological disorder
of symptoms. The scientific classifications for these types include: Doublecortin positive cells, similar to stem cells, are extremely adaptable and, when
Spastic_quadriplegia
Generating of neurons from neural stem cells in adults
promoter. For example, a recombinant plasmid may contain the promoter for doublecortin, a protein expressed predominantly by neurons, upstream of a sequence
Adult_neurogenesis
Biological process
Another protein that contributes to a lissencephaly disorder is DCX, or Doublecortin. DCX is a microtubule associated protein that is responsible for double
Development of the cerebral cortex
Development_of_the_cerebral_cortex
Protein-coding gene in the species Homo sapiens
with DYNC1H1, CLIP1, NDEL1, NDE1, PAFAH1B3, PAFAH1B2, NUDC, TUBA1A and Doublecortin. platelet-activating factor PAFAH1B2 PAFAH1B3 GRCh38: Ensembl release
PAFAH1B1
Protein-coding gene in the species Homo sapiens
treatment or JDP2 is also regulated by other kinases such as p38 MAPK and doublecortin like protein kinase. Polyubiquitination of JDP2 protein is induced by
Jun_dimerization_protein_2
American physician-scientist, professor of neurosciences and genetics
There, in the laboratory of Christopher A. Walsh, he identified the doublecortin gene as the cause for X-linked lissencephaly and double cortex syndrome
Joseph_G._Gleeson
Motor protein in humans
microtubule lattice. Three MAPs that localize within dendrites, doublecortin (DCX), doublecortin-like kinase-1 (DCLK1), and MAP9, regulate motor protein activity
KIF1A
American neurological researcher
Minnerath, Sharon R; Ross, M.Elizabeth; Walsh, Christopher A (1998). "doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double
Christopher_A._Walsh
Protein-coding gene in humans
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains that bind to microtubules and
RP1
Precursor cells of neurons and glia during embryonic development
cortical layers, Magavi showed that SVZ neural progenitors expressing Doublecortin, a critical molecule for migration of neuroblasts, migrated long distances
Neural_stem_cell
American neuroscientist
PMID 23144223. Schaar, BT; Kinoshita, K; McConnell, SK (22 January 2004). "Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase
Susan_McConnell
Protein found in humans
Oldekamp J, Eichele G (2004). "Identification of neurabin II as a novel doublecortin interacting protein". Mech. Dev. 120 (9): 1033–43. doi:10.1016/S0925-4773(03)00177-1
PPP1R9B
Dutch biologist (born 1973)
Kapitein LC, Jaworski J, Hoogenraad CC (2016). "Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites"
Casper_Hoogenraad
Protein-coding gene in the species Homo sapiens
G, Perez-Garcia CG, Gleeson JG (Nov 2002). "Selective expression of doublecortin and LIS1 in developing human cortex suggests unique modes of neuronal
NDE1
Autosomal dominant disorders that result in brain malformations
dynactin that assists in neuronal radial migration and axon extension. Doublecortin, a MAP protein also associated with lissencephaly, assists in neuronal
Tubulinopathies
Protein-coding gene in the species Homo sapiens
Kizhatil K, Wu YX, Sen A, Bennett V (September 2002). "A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain
NFASC
One path neural stem cells take to reach the olfactory bulb
or during autopsies. They discovered that cells that expressed DCX (doublecortin) and PSA-NCAM are present in the brain sections taken from infants, but
Rostral_migratory_stream
degradation of target proteins. DCLK2 Serine/threonine-protein kinase, doublecortin like kinase 2 Experimental Data, Co-Mentioned in Abstracts 0.091, 0.581
KLHL36
Space radiation effects on the brain
significantly decreased 48 hours after irradiation. Antibodies against Ki-67 and doublecortin (Dcx) were used to detect proliferating cells and immature neurons, respectively
Central nervous system effects from radiation exposure during spaceflight
Central_nervous_system_effects_from_radiation_exposure_during_spaceflight
Protein-coding gene in the species Homo sapiens
Vinet MC, Schaar BT, McConnell SK, Francis F, Chelly J (Sep 2001). "Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing
AP2M1
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Girl/Female
Assamese, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Sanskrit, Tamil, Telugu
Dark as Cloud; Goddess Kali
Male
Japanese
(三郎) Japanese name SABURO means "third son."Â
Girl/Female
Hindu, Indian
Sweet; Sugar
Boy/Male
Norse
Son of Thor.
Girl/Female
American, British, English, Irish, Swedish
Pure; Medieval English Form of the Irish Caitlin; Variant of Katherine; Holy
Boy/Male
Native American
Nez Perce name meaning flint necklace.
Girl/Female
German
Beloved; Hidden
Female
Hawaiian
 Hawaiian name KALI means "hesitation." Compare with another form of Kali.
Girl/Female
Indian
Good Nature
Girl/Female
Hindu, Indian, Marathi, Sanskrit
A Cooling Note
DOUBLECORTIN
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