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Eukaryotic protein complex that removes the 5' cap on mRNA
mRNA decapping complex is a protein complex in eukaryotic cells responsible for removal of the 5' cap. The active enzyme of the decapping complex is the
Decapping_complex
Formation on 5' ends of mRNAs
message from decapping. When translationally repressed or marked for decay by various mechanisms the 5' cap is bound by the mRNA decapping enzyme DCP2
Cap_binding_complex
Protein found in humans
mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene. DCP2 is a key component of an mRNA-decapping complex required for removal
DCP2
RNA that is read by the ribosome to produce a protein
destabilize the cap binding complex. The message is then subject to degradation by either the exosome complex or the decapping complex. In this way, translationally
Messenger_RNA
Protein found in humans
protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated
DCP1A
Specially altered nucleotide on the 5' end of pre-mRNA
processes take significant time. Decapping of a 7-methylguanylate-capped mRNA is catalyzed by the decapping complex made up of at least Dcp1 and Dcp2
Five-prime_cap
Protein-coding gene in the species Homo sapiens
Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene. EDC3 is associated with an mRNA-decapping complex required for
EDC3
Type of enzyme
hydrolase (EC 3.6.1.62, DCP2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme) is an enzyme with systematic name m7GpppN-mRNA m7GDP
M7GpppN-mRNA_hydrolase
Superfamily of hydrolytic enzymes
contains the catalytic amino acids. NUDIX hydrolases include Dcp2 of the decapping complex, ADP-ribose diphosphatase, MutT, ADPRase, Ap4A hydrolases, RppH, and
Nudix_hydrolase
Addition of adenylic acids to 3' end of mature mRNA
inhibit poly(A) tail removal. Once the poly(A) tail is removed, the decapping complex removes the 5′ cap, leading to a degradation of the RNA. Several other
Polyadenylation
Protein found in humans
mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene. DCP1B is a core component of the mRNA decapping complex, a key factor
DCP1B
Protein-coding gene in the species Homo sapiens
sapiens (human) ]". Lykke-Andersen J (2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell
UPF1
Short length polypeptides
enriches proteins associated with 5' mRNA decapping. It is thought to interact directly with Enhancer of mRNA Decapping 4 (EDC4). ELABELA (ELA) (a.k.a. APELA)
Micropeptide
Protein-coding gene in the species Homo sapiens
PMID 15231747. Lykke-Andersen J (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular
UPF2
Protein complex that degrades RNA
LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3):
Exosome_complex
Protein-coding gene in the species Homo sapiens
Izaurralde E (2005). "A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing". RNA. 11 (11): 1640–1647. doi:10
TNRC6A
Protein-coding gene in the species Homo sapiens
PMID 14527413. Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell
UPF3B
Uruguayan biochemist and molecular biologist
miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes". Genes & Development. 20 (14): 1885–1898. doi:10.1101/gad.1424106
Elisa_Izaurralde
Biomolecular condensates of mRNA and RNA binding proteins found in eukaryotic cells
proposed to be the sites of mRNA degradation in the cell and involved in decapping and digestion of mRNAs earmarked for destruction. Later work called this
P-bodies
Protein-coding gene in the species Homo sapiens
S2CID 389385. Lykke-Andersen J (2003). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell
UPF3A
American biochemist
mRNA Decapping”(1999) This paper examined promoters for decapping and how the promoters impede the translation and destruction of mRNA. “Decapping and
Roy_R._Parker
Class of enzymes; type of nuclease
normal turnover of mRNA: 5′ to 3′ exonuclease (Xrn1), which is a dependent decapping protein; 3′ to 5′ exonuclease, an independent protein; and poly(A)-specific
Exonuclease
Conversion of a gene's sequence into a mature gene product or products
bound by cap binding complex heterodimer (CBP20/CBP80), which aids in mRNA export to cytoplasm and also protect the RNA from decapping. Another modification
Gene_expression
Biomolecule
targets the RNA transcript for decay, facilitated by the non-canonical decapping enzyme, DXO. Considering the centrality of NAD in redox chemistry and
NAD+_Five-prime_cap
Protein-coding gene in the species Homo sapiens
production by destabilizing its mRNA. Mice deficient in TTP develop a complex syndrome of inflammatory diseases. ZFP36 has been shown to interact with
ZFP36
Family of viruses
(supported by its decapping proteins, D9 and D10), which forces the production of late stage genes. Intriguingly, D9 and D10 decapping proteins have also
Poxviridae
Protein-coding gene in the species Homo sapiens
Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220
LSM1
Final stage of semiconductor device fabrication
B-staging Potting (electronics) Quilt packaging Electronic packaging Decapping Rabaey, Jan (2007). Digital Integrated Circuits (2nd ed.). Prentice Hall
Integrated_circuit_packaging
Human chromosome
polypeptide 2 (6p21.33) DHX16: DEAH-box helicase 16 (6p21.33) DOM3Z: Decapping exoribonuclease (6p21.33) DSP: Desmoplakin gene linked to cardiomyopathy
Chromosome_6
Protein-coding gene in the species Homo sapiens
mRNA strand near the premature stop codon. This event is essentially decapping the protective head group on the mRNA strand, which will cause the rest
Eukaryotic translation termination factor 1
Eukaryotic_translation_termination_factor_1
regulation of mRNA decapping, including interactions between UPF1 and other decapping activators and the DCP1/DCP2 enzyme complex. Jacobson’s research
Allan_Jacobson
American electronics company
Semiconductor, which is a joint venture co-owned by VIA. Unreleased CHA Processor Decapped CHA Processor Die shot of the CHA Processor The CHA SoC comprised eight
Centaur_Technology
Form of non-volatile memory used in computers and other electronic devices
regions are difficult to distinguish optically, which may be attempted with decapping of the ROM and a microscope. Using two levels of thickness for a gate
Read-only_memory
substrates, leaving decapped and degrading mRNAs to be bound. 5′-monophosphorylated ends sequencing (5Pseq) captures both capped and decapped sequences to allow
Translatomics
Series of CPUs by AMD
silicon must be defect free. These size requirements necessitate a more complex fabrication process, which further adds to the production of fewer functional
Athlon_64_X2
Manual assembly of ammunition
of either set performs the sizing and decapping operation, except in some cases in the 3-die set, where decapping may be done by the second die. The middle
Handloading
Protein family
in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability". BMC Genomics. 5 (1): 45. doi:10.1186/1471-2164-5-45
YjeF N terminal protein domain
YjeF_N_terminal_protein_domain
nucleotidyltransferases (which add tails to transcripts), 5'-end capping and decapping enzymes and assorted RNA-binding proteins that help to model RNA for presentation
Degradosome
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
molecules found in stress granules are stalled translation pre-initiation complexes associated with 40S ribosomal subunits, translation initiation factors
Stress_granule
Pre-assembled firearm ammunition
sporting ammunition uses Berdan primers. Removing the spent primer from (decapping) these cases requires the use of a special tool because the primer anvil
Cartridge_(firearms)
Protein-coding gene in the species Homo sapiens
bond hydrolysis, exonucleolytic rhythmic process deadenylation-dependent decapping of nuclear-transcribed mRNA mRNA processing transcription by RNA polymerase
Nocturnin
Protein-coding gene in the species Homo sapiens
transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex. The protein
CNOT7
Protein-coding gene in the species Homo sapiens
Katada T (2004). "Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein". J. Biol. Chem. 279 (2): 1383–91
PAN3
Protein-coding gene in the species Homo sapiens
Shyu AB (December 2005). "Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover". Nature Structural & Molecular Biology
USP52
allows for researchers to easily measure the kinetic activity of NAD-RNA decapping enzymes. Affinity capillary electrophoresis (ACE) refers to a number of
Affinity_electrophoresis
Protein-coding gene in the species Homo sapiens
by the DOM3Z gene. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product
DOM3Z
exonucleases, and promote translation in the cytoplasm. Mature mRNAs can also be decapped. 5' untranslated region (5'-UTR) 5-bromodeoxyuridine See bromodeoxyuridine
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
attributed to the activity of decapping enzymes and Xrn1. Transcripts that enter the cytoplasm can be targeted by the Dcp1-Dcp2 complex which removes the 5′ cap
Cryptic_unstable_transcript
Protein-coding gene in the species Homo sapiens
LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87
Exosome_component_4
Protein-coding gene in the species Homo sapiens
LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. 12 (3): 675–87
Exosome_component_10
Protein-coding gene in the species Homo sapiens
(Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3):
Pyruvate dehydrogenase phosphatase
Pyruvate_dehydrogenase_phosphatase
American virologist
; Van Wynsberghe, P. M.; Ahlquist, P.; Díez, J. (2013). "The Cellular Decapping Activators LSm1, Pat1, and Dhh1 Control the Ratio of Subgenomic to Genomic
Paul_Ahlquist
Protein-coding gene in the species Homo sapiens
processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell. 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915
DDX6
American geneticist (born 1978)
Taverniti, Valerio; et al. (2015-06-01). "Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular
Bruno_Reversade
DECAPPING COMPLEX
DECAPPING COMPLEX
Surname or Lastname
English
English : nickname from Middle English gulle ‘gull’ or gul(le) (Old Norse gulr) ‘yellow’, ‘pale’ (of hair or complexion).Swiss German : nickname for an irascible or unreliable person, from an Alemannic form of Latin gallus ‘rooster’. See also Guell.
Surname or Lastname
English (Midlands)
English (Midlands) : nickname for a dark-complexioned man, from Old English earp ‘swarthy’.Americanized spelling of German Erp.
Boy/Male
Tamil
Pandurang | பாஂடà¯à®°à®‚க
A deity, One with pale white complexion, Lord Vishnu
Pandurang | பாஂடà¯à®°à®‚க
Girl/Female
Tamil
Gourangi | கௌராஂகீ
Giver of happiness, One name of radhas name, Lord krishnas beloved, Fair complexioned
Gourangi | கௌராஂகீ
Girl/Female
Tamil
Fair complexioned
Boy/Male
Tamil
Krishnasai | கà¯à®°à¯€à®·à¯à®¨à®¾à®¸à®¾à®ˆ
Dark complexioned, Lord Krishna, Name of a river
Krishnasai | கà¯à®°à¯€à®·à¯à®¨à®¾à®¸à®¾à®ˆ
Surname or Lastname
English
English : nickname for someone with a complexion that was as ‘white as a lily’ (Middle English lilie).
Boy/Male
Tamil
Krishna Prabhu | கரஷà¯à®£ பà¯à®°à®ªà¯Â
Dark complexioned, Lord Krishna, Name of a river
Krishna Prabhu | கரஷà¯à®£ பà¯à®°à®ªà¯Â
Girl/Female
Tamil
Gaurangi | கௌராஂகீ
Giver of happiness, One name of radhas name, Lord krishnas beloved, Fair complexioned
Gaurangi | கௌராஂகீ
Surname or Lastname
English
English : from the popular medieval personal name Hudde, which is of complex origin. It is usually explained as a pet form of Hugh, but there was a pre-existing Old English personal name, Hūda, underlying place names such as Huddington, Worcestershire. This personal name may well still have been in use at the time of the Norman Conquest. If so, it was absorbed by the Norman Hugh and its many diminutives. Reaney adduces evidence that Hudde was also regarded as a pet form of Richard.German : from a short form of a Germanic compound personal name formed with hut ‘guard’ as the first element.Variant spelling of German Hütt (see Huett).Jewish (Ashkenazic) : metonymic occupational name from Yiddish hut, German Hut ‘hat’ (see Huth).
Surname or Lastname
English
English : from Old English dūst ‘dust’, applied as a nickname, possibly for someone with a dusty complexion or hair (as, for example, a miller), or for a worthless person.North German : possibly a Westphalian habitational name from a farm named with dost ‘bush’, ‘brush’. However, the word also means ‘fine dust’, ‘flour’ and may have been applied as an occupational nickname for a miller. Compare 1.
Girl/Female
Tamil
Dheekshitha | தீகà¯à®·à¯€à®¤à®¾Â
Fair complexioned
Dheekshitha | தீகà¯à®·à¯€à®¤à®¾Â
Girl/Female
Tamil
Anekavarna | அநேகவாரநா
One who has many complexions
Anekavarna | அநேகவாரநா
Surname or Lastname
English
English : variant of Grice.French (Grisé) : variant spelling of Griset, a nickname for someone with gray hair, a gray complexion, or perhaps one who habitually wore gray, from Old French gris ‘gray’.
Boy/Male
Tamil
Panduranga | பாநà¯à®¤à¯à®°à®‚கா
A deity, One with pale white complexion, Lord Vishnu
Panduranga | பாநà¯à®¤à¯à®°à®‚கா
Surname or Lastname
Irish
Irish : reduced Anglicized form of Gaelic Ó Duinn, Ó Doinn ‘descendant of Donn’, a byname meaning ‘brown-haired’ or ‘chieftain’.English : nickname for a man with dark hair or a swarthy complexion, from Middle English dunn ‘dark-colored’.Scottish : habitational name from Dun in Angus, named with Gaelic dùn ‘fort’.Scottish : nickname from Gaelic donn ‘brown’. Compare 1.
Boy/Male
Tamil
Pandurangan | பநà¯à®¤à¯à®°à®‚கந
A deity, One with pale white complexion, Lord Vishnu
Pandurangan | பநà¯à®¤à¯à®°à®‚கந
Girl/Female
Tamil
Dheekshit | தீகà¯à®·à®¿à®¤
Fair complexioned
Dheekshit | தீகà¯à®·à®¿à®¤
Surname or Lastname
German
German : nickname from the small medieval coin known as the häller or heller because it was first minted (in 1208) at the Swabian town of (Schwäbisch) Hall. Compare Hall.Jewish (Ashkenazic) : habitational name for someone from Schwäbisch Hall.German : topographic name for someone living by a field named as ‘hell’ (see Helle 3).English : topographic name for someone living on a hill, from southeastern Middle English hell + the habitational suffix -er.Dutch : from a Germanic personal name composed of the elements hild ‘strife’ + hari, heri ‘army’.Jewish (Ashkenazic) : nickname for a person with fair hair or a light complexion, from an inflected form, used before a male personal name, of German hell ‘light’, ‘bright’, Yiddish hel.
Surname or Lastname
English
English : nickname for a person with a ruddy complexion, from an adjective derivative of Middle English mad(d)er ‘madder’, the dye plant (see Mader 1), here used in a transferred sense.
DECAPPING COMPLEX
DECAPPING COMPLEX
Surname or Lastname
English
English : nickname for a tall, scrawny person, from Middle English, Old French grue ‘crane’ (Late Latin grua, for classical Latin grus).Irish : reduced form of Mulgrew.
Boy/Male
Indian
Unique; None of Second
Boy/Male
Sikh
Auspicious
Girl/Female
Indian, Telugu
Camphor
Girl/Female
Tamil
Beloved, Another name of Lord Vishnu, Goddess Lakshmi and a name given to karmic Yoga
Boy/Male
Indian
Planner, Designer, Disposer
Boy/Male
Muslim
To be heard
Boy/Male
American, Australian, British, English, French, Greek, Irish, Latin
Son of Pierce; A Rock; Form of Piers from Peter
Boy/Male
Indian
God
Boy/Male
Danish Swedish Greek English Scandinavian
DECAPPING COMPLEX
DECAPPING COMPLEX
DECAPPING COMPLEX
DECAPPING COMPLEX
DECAPPING COMPLEX
n.
Dead or decaying grass remaining on land through the winter; -- called also foggage.
n.
A capping molding. Same as Cymatium.
p. pr. & vb. n.
of Decant
n.
The process of elutriating; a decanting or racking off by means of water, as finer particles from heavier.
a.
Affected with caries; decaying; as, a carious tooth.
p. pr. & vb. n.
of Decuple
n.
An old name for several species of Polyporus, corky fungi growing on decaying wood.
a.
Growing old; decaying with the lapse of time.
a.
Feeding or growing upon decaying animal or vegetable matter; pertaining to a saprophyte or the saprophytes.
p. pr. & vb. n.
of Decamp
p. pr. & vb. n.
of Delapse
n.
One of a tribe of beetles which feed upon decaying animal and vegetable substances; a carrion beetle.
p. pr. & vb. n.
of Decay
a.
Withering without/ falling off; fading; decaying.
n.
A brown amorphous substance found in decaying vegetation. Cf. Humin.
n.
a nontoxic base, C5H14N2, found in the putrescent matters of flesh, fish, decaying cheese, etc.
n.
A capping or crowning molding in classic architecture.
a.
Decaying; deteriorating.
p. pr. & vb. n.
of Cap