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DACTOLISIB

Dactolisib

Chemical compound

Dactolisib (codenamed NVP-BEZ235 and BEZ-235, also known as RTB101) is an imidazoquinoline derivative acting as a PI3K inhibitor. It also inhibits mTOR

Dactolisib

MTOR inhibitors

Class of pharmaceutical drugs

phosphorylation of AKT Ser473 residue. Dual mTOR/PI3K inhibitors include dactolisib, voxtalisib, BGT226, SF1126, PKI-587 and many more. For example, Novartis

MTOR inhibitors

MTOR_inhibitors

Phosphoinositide 3-kinase inhibitor

Medical drug glass

1–3 previous lines of therapy. Results are expected for February 2023. Dactolisib (codenamed BEZ235, NVP-BEZ235; dual pan-class I PI3K and mTOR inhibitor)

Phosphoinositide 3-kinase inhibitor

Phosphoinositide_3-kinase_inhibitor

Non-homologous end joining

Pathway that repairs double-strand breaks in DNA

repair capacity of HLS. Also blocking both HR and NHEJ repair pathways by dactolisib (NVP-BEZ235) inhibitor showed that repair of HLS is not dependent on HR

Non-homologous end joining

Non-homologous_end_joining

Everolimus

Chemical compound

clinical trial published in 2018 showed that everolimus in combination with dactolisib decreased the rate of reported infections in an elderly population. Compared

Everolimus

MTOR

Mammalian protein found in humans

Parkinson's disease. After a short-term treatment with the mTOR inhibitors dactolisib and everolimus, in elderly (65 and older), treated subjects had a reduced

MTOR

Imidazoquinoline

derivatives and compounds are often used for antiviral and antiallergic creams. Dactolisib Imiquimod Gardiquimod Resiquimod Sumanirole Hemmi, H; Kaisho, T; Takeuchi

Imidazoquinoline

List of signaling peptide/protein receptor modulators

Umirolimus Zotarolimus; ATP-competitive / indirect: Berberine Curcumin Dactolisib EF-24 Epigallocatechin gallate HY-124798 NV-5440 Pterostilbene Quercetin

List of signaling peptide/protein receptor modulators

List_of_signaling_peptide/protein_receptor_modulators

List of investigational Parkinson's disease drugs

Investigational Parkinson's disease drugs

against α-synuclein [254] CVXL-0107 – glutamate release inhibitor [255] Dactolisib (BEZ-235; NVP-BEZ-235; NVP-BEZ235-ANA; NVP-BEZ235-NX; RTB-101) – 1-phosphatidylinositol

List of investigational Parkinson's disease drugs

List_of_investigational_Parkinson's_disease_drugs

ATM serine/threonine kinase

Mammalian protein found in Homo sapiens

5-c]quinolin-2-one scaffold. The first important representative is the inhibitor is Dactolisib (NVP-BEZ235), which was first published by Novartis as a selective mTOR/PI3K

ATM serine/threonine kinase