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Protein domain
A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. The C-type designation is from their requirement for calcium for binding
C-type_lectin
Carbohydrate-binding protein
hepatitis C viral glycoproteins may attach to host-produced C-type lectins on the liver cell surface to initiate infection. Mannose-binding lectin (MBL),
Lectin
Family of cell surface receptors
The name lectin is a bit misleading because the family includes proteins with at least one C-type lectin domain (CTLD) which is a specific type of carbohydrate
Pattern_recognition_receptor
Protein-coding gene in humans
C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene. This gene encodes a member of the C-type lectin/C-type
CLEC4A
Macrophage inducible Ca2+-dependent lectin receptor, (abbreviated to Mincle), is a member of the C-type lectin superfamily encoded by the gene CLEC4E.
Mincle_receptor
Protein-coding gene in humans
C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type
CLEC7A
Protein-coding gene in humans
C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene. This gene encodes a member of the C-type lectin/C-type
CLEC12A
Polymer in bacterial cell walls
It can sense MDP and promote IL-1 secretion through binding NOD2. C-type lectins are a diverse superfamily of mainly Ca2+-dependent proteins that bind
Peptidoglycan
Protein found in humans
C-type lectin domain family 5 member A (CLEC5A), also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL-1)
CLEC5A
Protein-coding gene in humans
C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part
CLEC10A
Protein-coding gene in the species Homo sapiens
protein which in humans is encoded by the CD209 gene. DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells
DC-SIGN
Mammalian protein found in Homo sapiens
Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as
Mannan-binding_lectin
Protein-coding gene in humans
C-type lectin domain containing 6A is a protein that in humans is encoded by the CLEC6A gene. Dectin-2 is a member of the C-type lectin/C-type lectin-like
CLEC6A
Clusters of receptor proteins
protein domains and may be members of either the immunoglobulin or C-type lectin families. The extracellular domains of homologous paired receptors are
Paired_receptors
Species of virus
K, Rychlewski L (2007). "HSV-1 UL45 encodes a carbohydrate binding C-type lectin protein". Cell Cycle. 7 (2): 269–271. doi:10.4161/cc.7.2.5324. PMID 18256535
Herpes_simplex_virus
Protein-coding gene in the species Homo sapiens
C-type lectin domain family 4 member F is a protein that in humans is encoded by the CLEC4F gene. GRCh38: Ensembl release 89: ENSG00000152672 – Ensembl
C-type lectin domain family 4 member F
C-type_lectin_domain_family_4_member_F
From the N-terminus to the C-terminus, the domains are: EGF-like domain 3 Sushi domains one LCCL domain and one C-type lectin domain 2 more Sushi domains
Limulus_clotting_factor_C
Genus of snakes
The venom acts, at least in part, by binding to and activating the C-type lectin domain family 1 member B protein (also termed the CLEC1B or CLEC2 protein)
Calloselasma
Human lectin protein
CD69 (Cluster of Differentiation 69) is a human transmembrane C-type lectin protein encoded by the CD69 gene. It is an early activation marker that is
CD69
Protein-coding gene in humans
and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are
KLRB1
Protein-coding gene in humans
C-type lectin domain family 9 member A is a protein that in humans is encoded by the CLEC9A gene. CLEC9A is a group V C-type lectin-like receptor (CTLR)
CLEC9A
Low-affinity" receptor for IgE
regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils,
CD23
Protein-coding gene in humans
C-type lectin domain family 1 member B (also termed CLEC-1b, C-type lectin-like receptor 2, CLEC-2, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain
CLEC1B
Protein found in Homo sapiens
and Jenny Valladeau as a main part of Birbeck granules. Langerin is C-type lectin receptor on Langerhans cells (LCs) and in mice also on dermal interstitial
Langerin
Protein-coding gene in humans
CARD10 (CARMA3) and CARD14 (CARMA2) as a member of the CARD-CC family with a C terminal MAGUK domain (the so-called CARMA proteins). The CARD domain of proteins
CARD11
Protein-coding gene in the species Homo sapiens
in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during
REG3A
Protein-coding gene in the species Homo sapiens
low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded
OLR1
Type of cascade reaction in the complement system
The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, in
Lectin_pathway
Species of snake
secretory venom proteins and other toxins including natriuretic peptide, C-type lectin, snake venom serine proteinase (SVSP), Kunitz and venom complement-activating
Indian_cobra
Protein-coding gene in humans
C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene. This gene encodes a member of the C-type lectin/C-type
CLEC1A
Protein family
The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages, immature dendritic cells
Mannose_receptor
Soluble protein
Calreticulin and Calnexin's ability to bind carbohydrates associates them with the lectin protein family. In normal cellular function, trimming of glucose residues
Calreticulin
Protein-coding gene in humans
gene. Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion
CD248
Activation or suppression of the immune system to treat disease
cytokines (e.g., Flt3L, GM-CSF) and targeting the DCs with antibodies to C-type lectin receptors or agonistic antibodies (e.g., anti-CD40) that are conjugated
Immunotherapy
Protein-coding gene in the species Homo sapiens
proteoglycans. The C-terminal (G3) globular domain consists of one or two Epidermal growth factor (EGF) repeats, a C-type lectin domain and complement
Versican
Protein-coding gene in humans
C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299 (cluster of
CLEC4M
Protein-coding gene in the species Homo sapiens
Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch
Mucin_7
CD94/NKG2 is a family of C-type lectin receptors which are expressed predominantly on the surface of NK cells and a subset of CD8+ T-lymphocyte. These
CD94/NKG2
Protein-coding gene in the species Homo sapiens
protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein
HCST_(gene)
Human protein
particularly the C-type lectin-like receptor 2, i.e., CLEC-2 (also termed CLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, and C-type lectin domain family
PDPN
Family of cell adhesion molecules
to C-type lectins due to a related amino terminus and calcium-dependent binding. Selectins bind to sugar moieties and so are considered to be a type of
Selectin
Protein-coding gene in humans
C-type lectin domain family 16, also known as CLEC16A, is a protein that in humans is encoded by the CLEC16A gene. Little is known regarding the function
CLEC16A
Protein-coding gene in the species Homo sapiens
that in humans is encoded by the ATRN gene. Attractin is a Group XI C-type lectin. Multiple transcript variants encoding different isoforms exist for
Attractin
Part of the innate immune system
col-lectins, (collagen-containing C-type lectins) are a part of the innate immune system. They form a sub-family of collagenous Ca2+-dependent lectins of
Collectin
Species of virus
bind "the plant lectins C-type mannose binding domain". Aminopeptidase N has the same ability to interact with plant lectins C-type mannose-binding and
Feline_coronavirus
Protein-coding gene in humans
(December 2001). "BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon
CLEC4C
Neurocan, brevican, versican, and aggrecan all share similar N-terminal and C-terminal domains. CSPGs play an active role in the neural development of postnatal
Chondroitin sulfate proteoglycan
Chondroitin_sulfate_proteoglycan
Class of echinoderms
PMID 22049097. Yoshida S, Shimada Y, Kondoh D, et al. (2007). "Hemolytic C-Type Lectin CEL-III from Sea Cucumber Expressed inTransgenic Mosquitoes Impairs
Sea_cucumber
Protein-coding gene in the species Homo sapiens
Laine A (November 1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon". The Journal
Mucin_5B
Protein-coding gene in humans
mCRC patients with KRAS wild-type tumors. In the Phase III CRYSTAL study, published in 2009, patients with the wild-type KRAS gene treated with Erbitux
KRAS
Protein-coding gene in humans
proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene
KLRC2
Protein-coding gene in humans
production compared to BMDCs expressing wild-type CARD9. In contrast, CARD9 Δ11 and CARD9 S12NΔ11, as well as the C-terminal truncated variant CARD9 V6, showed
CARD9
Protein in humans
is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion
CD93
Protein family
The asialoglycoprotein receptors (ASGPR) are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose
Asialoglycoprotein_receptor
Protein-coding gene in the species Homo sapiens
human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat
PLCG2
Protein-coding gene in the species Homo sapiens
Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann
Neurocan
Mammalian protein found in Homo sapiens
PMID 34177884. Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides
ICAM3
Type of cytotoxic lymphocyte
with a few examples to follow: Ly49 (homodimers), relatively ancient, C-type lectin family receptors, are of multigenic presence in mice, while humans have
Natural_killer_cell
Mammalian protein found in humans
to degradation by removing one of the nine mannose residues. The mannose lectin Yos-9 (OS-9 in humans) marks and sorts misfolded glycoproteins for degradation
Calnexin
Protein-coding gene in humans
C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene. This gene encodes a member of the C-type lectin superfamily
CLEC11A
Blood vessel lining
nonintegrin), LSECtin (liver and lymph node sinusoidal endothelial cell C-type lectin), Lyve-1 (lymphatic vessel endothelial hyaluronan receptor‐1), and LRP‐1
Liver sinusoidal endothelial cell
Liver_sinusoidal_endothelial_cell
Species of virus
mannose receptor is a 180-kDa transmembrane protein with eight tandem C-type lectin carbohydrate recognition domains (CRD) of which CRD4 and CRD5 are essential
Visna-maedi_virus
Protein-coding gene in humans
also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene. CD302 is a C-type lectin receptor involved
CD302
Protein-coding gene in the species Homo sapiens
ubiquitin-conjugating enzyme E2 variant 1". Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ (October 2000). "Activation of the IkappaB
UBE2V1
Protein-coding gene in humans
C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene. This gene encodes a member of the natural killer cell
CLEC2D
Protein-coding gene in the species Homo sapiens
duodenum by the same pathway that pancreatic exocrine enzymes. It has C-terminal C-type lectin domain whose binding partner is currently unknown. The PSP has
REG1A
Medical condition
short arm of chromosome 2 (2p25.3) in humans. The CL-K1 protein is a C-type lectin, and belongs to the collectin family of these proteins. Other than its
Malpuech facial clefting syndrome
Malpuech_facial_clefting_syndrome
Snake venom toxin
tetramer C-type lectin with an oligomeric structure, made up of heterodimeric subunits. Convulxin is part of the snake venom C-type lectin family, a
Convulxin
Protein-coding gene in the species Homo sapiens
PMID 20926598. Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1
Mucin_17
Mammalian protein found in Homo sapiens
retardation. PAK3 was initially cloned from a murine fibroblast cDNA library and from a murine embryo cDNA library. Like other group I PAKs, PAK3 is stimulated
PAK3
Protein-coding gene in the species Homo sapiens
797–801. doi:10.1016/S1357-2725(98)00028-4. PMID 9722984. Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM, Toribara NW (May 2004). "The complete genomic
Mucin_2
Protein-coding gene in the species Homo sapiens
novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192. Bozzacco L, Trumpfheller C, Siegal
LY75
Protein-coding gene in the species Homo sapiens
proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family
KLRC4
similar to lectins (sugar-binding proteins), and has a fold similar to that seen in C-type lectins. However, unlike other C-type lectins (those that
Major_basic_protein
Protein-coding gene in humans
Information, U.S. National Library of Medicine. "Entrez Gene: CLEC3B C-type lectin domain family 3, member B". Human CLEC3B genome location and CLEC3B
CLEC3B
Life-threatening response to infection
cytosolic. There are four families of PRRs: the toll-like receptors, the C-type lectin receptors, the NOD-like receptors, and the RIG-I-like receptors. Invariably
Sepsis
Protein-coding gene in the species Homo sapiens
calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and
S100G
Animal protein found in humans
consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through
CD72
Mammalian protein found in Homo sapiens
and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by
KLRD1
Calcium-binding protein
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calsequestrin
Protein-coding gene in the species Homo sapiens
epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is
STAB1
Protein
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calbindin
Protein-coding gene in humans
C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene. This gene encodes a member of the C-type lectin/C-type
CLEC2B
Human chromosome
chromatin assembly factor 1 subunit B CHODL: encoding chondrolectin, a C-type lectin CLDN8: encoding protein claudin-8 CLDN14: encoding protein claudin-14
Chromosome_21
Mammalian protein found in humans
member of the C-type lectin domain (CTLD) group 14 family. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant
Thrombomodulin
Protein domain
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Fibulin
Protein found in humans
Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (Sep 1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans
Brevican
Enzyme found in humans
characteristics and biological functions. In brief, 20S sub complex presents three types proteolytic activities, including caspase-like, trypsin-like, and chymotrypsin-like
PSMD7
induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins". Immunity. 22 (4): 507–517. doi:10.1016/j.immuni.2005.03.004. ISSN 1074-7613
Immunoreceptor tyrosine-based activation motif
Immunoreceptor_tyrosine-based_activation_motif
Protein-coding gene in the species Homo sapiens
116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150. Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, et al. (October
Mucin_5AC
Species of snake
range of proteins. Some of the proteins include metalloproteinase, C-type lectin/lectin-like proteins and serine proteases. A total of 44 proteins were identified
Trimeresurus_nebularis
Type of white blood cell
PRRs, such as toll-like receptors (TLRs), scavenger receptors (SRs), C-type lectin receptors, among others, recognize pathogens for phagocytosis. Macrophages
Macrophage
Human retrovirus, cause of AIDS
(DCs) by this CD4-CCR5 route, but another route using mannose-specific C-type lectin receptors such as DC-SIGN can also be used. DCs are one of the first
HIV
Protein family
association with complement B-type domains, C-type lectin domains, von Willebrand type A domains, CUB domains, discoidin lectin domains or CAP domains. It
LCCL_domain
Protein found in humans
There is no confirmed ligand for CD5 but there is evidence that CD72, a C-type lectin, may be a ligand or that CD5 may be homophilic, binding CD5 on the surface
CD5_(protein)
Part of the spleen
certain pathogens, especially encapsulated bacteria. For example, the C-type lectin SIGN-R1 receptor (present on the marginal zone macrophages), mediates
Marginal_zone
Protein-coding gene in the species Homo sapiens
immunodeficiency virus type 1". DNA and Cell Biology. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377. Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K,
EP300
Protein-coding gene in the species Homo sapiens
chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes". Diabetes. 53 (7): 1890–3. doi:10.2337/diabetes.53.7.1890. PMID 15220215
MAP3K7IP2
Mammalian protein found in Homo sapiens
L-selectin is composed of multiple structural regions: an N-terminus C-type lectin domain, an adjacent epidermal growth factor-like domain, two consensus
L-selectin
Group of cell surface receptors expressed by leukocytes
a broad range of signalling molecules. At any given time, multiple NTR types can be engaged with their receptive ligands, inducing activatory, costimulatory
Non-catalytic tyrosine-phosphorylated receptor
Non-catalytic_tyrosine-phosphorylated_receptor
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