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AMNIONLESS

Amnionless

Protein-coding gene in the species Homo sapiens

Amnionless is a protein that in humans is encoded by the AMN gene. A complex of amnionless and cubilin forms the cubam receptor. The protein encoded by

Amnionless

Cubam

Multi-ligand receptor

of amnionless (AMN), and cubilin. Cubilin is essential as a cell receptor recognizing the "vitamin B12-intrinsic factor" complex, whereas amnionless is

Cubam

Imerslund–Gräsbeck syndrome

Medical condition

located in the terminal ileum. This receptor is composed of two proteins, amnionless (AMN), and cubilin. A defect in either of these protein components can

Imerslund–Gräsbeck syndrome

Imerslund–Gräsbeck_syndrome

Cubilin

Mammalian protein found in humans

complexes by means of amnionless (AMN). Cubilinis essentially only present in the small intestine and kidneys. A complex of amnionless and cubilin forms the

Cubilin

Vitamin B12

Vitamin used in animal cell metabolism

the stomach. IF delivers the vitamin to receptor proteins cubilin and amnionless, which together form the cubam receptor in the distal ileum. The receptor

Vitamin B12

Vitamin_B12

Topics referred to by the same term

neuron (α-MNs), large lower motor neurons of the brainstem and spinal cord Amnionless, a gene for a protein necessary for efficient absorption of vitamin B12

AMN

LRP2

Mammalian protein found in Homo sapiens

transcytosis. LRP2/megalin can also form complexes with CUBAM, the cubilin and amnionless complex. Those complexes are able to reabsorb several molecules and can

LRP2

CLCN5

Mammalian protein found in humans

formation/function of the endocytic complex that also involves megalin and cubilin/amnionless receptors, the sodium-hydrogen antiporter 3 (NHE3), and the V-ATPase.

CLCN5

Lymphotoxin beta receptor

Wang X, Bornslaeger EA, Haub O, et al. (1996). "A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein". Dev

Lymphotoxin beta receptor