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CUBAM

Cubam

Multi-ligand receptor

Cubam is the term used to refer to a multi-ligand receptor located in the terminal ileum, specializing in absorption of vitamin B12. Cubam is essentially

Cubam

Imerslund–Gräsbeck syndrome

Medical condition

familial form of vitamin B12 deficiency caused by malfunction of the "Cubam" receptor located in the terminal ileum. This receptor is composed of two

Imerslund–Gräsbeck syndrome

Imerslund–Gräsbeck_syndrome

Vitamin B12

Vitamin used in animal cell metabolism

vitamin to receptor proteins cubilin and amnionless, which together form the cubam receptor in the distal ileum. The receptor is specific to the IF-B12 complex

Vitamin B12

Vitamin_B12

LRP2

Mammalian protein found in Homo sapiens

This pathway is mediated by LRP2 and CUBAM, where Dab2 binds to the cytoplasmic tails of both LRP2 and CUBAM to initiate clathrin-coated endocytosis

LRP2

Pernicious anemia

Lack of red blood cells due to vitamin B12 deficiency

intrinsic factor-B12-complex is absorbed by enterocytes in the ileum's cubam receptors. PA is characterised by B12 deficiency caused by the absence of

Pernicious anemia

Pernicious_anemia

Olga Imerslund

Norwegian pediatrician

B12 characteristic of the disease is due to genetic malfunction of the Cubam receptor located in the terminal ileum. Imerslund was born at Vang Municipality

Olga Imerslund

Olga_Imerslund

Cubilin

Mammalian protein found in humans

small intestine and kidneys. A complex of amnionless and cubilin forms the cubam receptor. Mutations in CUBN may play a role in autosomal recessive megaloblastic

Cubilin

Amnionless

Protein-coding gene in the species Homo sapiens

encoded by the AMN gene. A complex of amnionless and cubilin forms the cubam receptor. The protein encoded by this gene is a type I transmembrane protein

Amnionless