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Enzyme
3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme (1.1.1.50) that plays a role in the metabolism of steroids and non-steroidal compounds in humans
3α-Hydroxysteroid dehydrogenase
3α-Hydroxysteroid_dehydrogenase
Class of enzymes
17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B) (EC 1.1.1.51), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which
17β-Hydroxysteroid dehydrogenase
17β-Hydroxysteroid_dehydrogenase
Class of enzymes
11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) enzymes catalyze the conversion of inert 11 keto-products (e.g. cortisone) to active cortisol, or
11β-Hydroxysteroid dehydrogenase
11β-Hydroxysteroid_dehydrogenase
Rare autosomal recessive disorder causing impaired masculinisation
17β-Hydroxysteroid dehydrogenase III deficiency is a rare autosomal recessive disorder of sexual development condition that is a cause of 46,XY disorder
17β-Hydroxysteroid dehydrogenase III deficiency
17β-Hydroxysteroid_dehydrogenase_III_deficiency
Enzyme found in humans
Corticosteroid 11-β-dehydrogenase isozyme 2 also known as 11-β-hydroxysteroid dehydrogenase 2 is an enzyme that in humans is encoded by the HSD11B2 gene
Corticosteroid 11-beta-dehydrogenase isozyme 2
Corticosteroid_11-beta-dehydrogenase_isozyme_2
Mammalian protein found in humans
11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including
11β-Hydroxysteroid dehydrogenase type 1
11β-Hydroxysteroid_dehydrogenase_type_1
Class of enzymes
In enzymology, 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction 17α,20α-dihydroxypregn-4-en-3-one + NADP+
20alpha-hydroxysteroid dehydrogenase
20alpha-hydroxysteroid_dehydrogenase
Protein-coding gene in the species Homo sapiens
C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) or 3α-hydroxysteroid dehydrogenase type 2 (3α-HSD2) is a steroidogenic
AKR1C3
Protein-coding gene in humans
that encodes for 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type II or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
HSD3B2
Protein-coding gene in the species Homo sapiens
More generally, it can function as a 20α-hydroxysteroid dehydrogenase, and a 3α-hydroxysteroid dehydrogenase, among other functions. This gene encodes
AKR1C1
Protein-coding gene in the species Homo sapiens
17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes or reduces the C17 hydroxy/keto
HSD17B1
Protein-coding gene in the species Homo sapiens
17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2
HSD17B2
Protein-coding gene in humans
reading frame 54, also known as HSD-29 (hydroxysteroid 29 dehydrogenase) and HSD-30 (hydroxysteroid 30 dehydrogenase) is a protein coding gene. The accession
C12orf54
Medical condition
enzymes involved in steroid metabolism, like 11β-hydroxylase or 3β-hydroxysteroid dehydrogenase. It has a prevalence between 0.1% and 2% depending on population
Late onset congenital adrenal hyperplasia
Late_onset_congenital_adrenal_hyperplasia
Enzyme
In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical reaction androsterone + NAD(P)+
3alpha-hydroxysteroid dehydrogenase (A-specific)
3alpha-hydroxysteroid_dehydrogenase_(A-specific)
Chemical compound
in the kidneys. This occurs via inhibition of the enzyme 11-β-hydroxysteroid dehydrogenase.[citation needed] As a result, cortisol levels become high
Enoxolone
Endogenous steroid hormone
it can be converted back into DHT via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, bypassing conventional intermediates such
Androsterone
Medical condition
Cortisone reductase deficiency is caused by dysregulation of the 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1), otherwise known as cortisone reductase
Cortisone reductase deficiency
Cortisone_reductase_deficiency
Protein-coding gene in the species Homo sapiens
beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that
HSD17B8
246 (11): 3512–7. doi:10.1016/S0021-9258(18)62159-3. PMID 4397102. Hara A, Nakagawa M, Taniguchi H, Sawada H (November 1989). "3(20)α-Hydroxysteroid Dehydrogenase
Indanol_dehydrogenase
Chemical compound
monooxygenases, mainly, 6β-hydroxysteroid dehydrogenase (CYP3A4). 6β-hydroxycortisol is used as a biomarker of 6β-hydroxysteroid dehydrogenase (CYP3A4) activity
6β-Hydroxycortisol
Corticosteroid precursor and metabolite of cortisol
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). Cortisol can also be metabolized back into cortisone by the actions of 11β-hydroxysteroid dehydrogenase 2
Cortisone
Chemical compound
metribolone was identified in 2010 as a potent inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) 1 and 2 (IC50 = 0.02 and 0.16 μM, respectively). On
Metribolone
Chemical compound
estradiol, allowing it to inhibit the activity of aromatase and 3α-hydroxysteroid dehydrogenase. These enzymes are involved in the biosynthesis of steroid hormones
Coumestrol
Medical condition
in the HSD11B2 gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates
Apparent mineralocorticoid excess syndrome
Apparent_mineralocorticoid_excess_syndrome
Chemical compound
cleavage enzyme, 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase, 17α-hydroxylase, 17,20-lyase, 17β-hydroxysteroid dehydrogenase, 21-hydroxylase, and
Danazol
Protein-coding gene in the species Homo sapiens
Aldo-keto reductase family 1 member C4, also known as 3α-Hydroxysteroid dehydrogenase type 1 (3α-HSD1), is an enzyme that in humans is encoded by the AKR1C4
AKR1C4
Protein-coding gene in the species Homo sapiens
17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by
HSD17B10
Chemical compound
11β-Hydroxytestosterone is metabolized by 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) to 11-ketotestosterone (11-KT), a more potent androgen, or by 5α-reductase
11β-Hydroxytestosterone
Protein-coding gene in humans
enzyme that in humans is encoded by the HSD17B7 gene. The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens
HSD17B7
Chemical compound
(respectively) similarly) are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of the potent
Formebolone
Chemical compound
potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP
11α-Hydroxyprogesterone
Chemical compound
Fluoxymesterone has been found to act as a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) (IC50Tooltip Half-maximal inhibitory concentration
Fluoxymesterone
Chemical compound
conversion of inactive cortisone to cortisol by blocking 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-HSD also reversibly catalyzes the conversion of
Carbenoxolone
Chemical compound
(CYP11B1), 18-hydroxylase (aldosterone synthase, CYP11B2), and 3β-hydroxysteroid dehydrogenase (3β-HSD) to a lesser extent. In addition, mitotane has direct
Mitotane
Chemical compound
subsequently claimed by AstraZeneca as an inhibitor of the enzyme 11β-Hydroxysteroid dehydrogenase type 1. No other pharmacological data has been disclosed, though
2-(Ethylamino)-1,2-diphenylethanone
2-(Ethylamino)-1,2-diphenylethanone
Class of enzymes
4-didehydroretinol can act as competitive inhibitor of the 3α-hydroxysteroid dehydrogenase oxidative activity of the enzyme. This can potentially explain
Retinol_dehydrogenase
trisomy 11 beta hydroxylase deficiency 11 beta hydroxysteroid dehydrogenase type 2 deficiency 17 alpha hydroxylase deficiency 17-beta-hydroxysteroid dehydrogenase
List_of_diseases_(0–9)
Protein-coding gene in humans
that encodes for a 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type I or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
HSD3B1
Chemical compound
16α-hydroxyestrone, and finally converted into estriol by 17β-hydroxysteroid dehydrogenase. 15α-Hydroxydehydroepiandrosterone Androstenedione 11β-Hydroxyandrostenedione
16α-Hydroxyandrostenedione
Chemical compound
5β-androstanediol (via 3β-hydroxysteroid dehydrogenase), and 3β,5β-androstanediol to epietiocholanolone (via 17β-hydroxysteroid dehydrogenase). Epietiocholanolone
Epietiocholanolone
Substituted amphetamine derivative
bupropion via reduction of the ketone group primarily by 11β-hydroxysteroid dehydrogenase-1 and to a minor extent by aldo-keto reductases. It can also
Erythrohydrobupropion
Chemical compound
steroids androstanediol via 17β-hydroxysteroid dehydrogenase or from androstanedione via 3β-hydroxysteroid dehydrogenase. Epiandrosterone is used as a precursor
Epiandrosterone
Chemical compound
11β-hydroxyprogesterone, 11-ketoprogesterone is reported to act as an inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase. It has also been found
11-Ketoprogesterone
Protein-coding gene in the species Homo sapiens
Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology
HSD17B11
Mammalian pheromone also found in truffles
3β-hydroxysteroid dehydrogenase (androstadienol to androstadienone), 5α-reductase (androstadienone to androstenone), and 3α-hydroxysteroid dehydrogenase
Androstenol
17)a-hydroxysteroid dehydrogenase - 3110001I22Rik - 3alpha-hydroxyglycyrrhetinate dehydrogenase - 4932414N04Rik - 3alpha-hydroxysteroid dehydrogenase (A-specific)
Index of molecular biology articles
Index_of_molecular_biology_articles
Chemical compound
(1998). "Cortisol, hypertension and obesity: the role of 11 beta-hydroxysteroid dehydrogenase". J R Coll Physicians Lond. 32 (2): 154–9. PMC 9663025. PMID 9597634
11-Deoxycortisol
Chemical compound
act as an inhibitor of 17β-hydroxysteroid dehydrogenases. 16-Ketoestrone can be converted by 16α-hydroxysteroid dehydrogenase into estriol in the body.
16-Ketoestrone
Chemical compound
the human 11beta-hydroxysteroid dehydrogenase type 1". J. Steroid Biochem. Mol. Biol. 105 (1–5): 159–65. doi:10.1016/j.jsbmb.2006.11.021. PMID 17624766
7α-Hydroxyepiandrosterone
Cortisol synthesis inhibitor
specifically acts as a centrally penetrant inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and thereby inhibits the synthesis of the glucocorticoid
Emestedastat
Chemical compound
inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). As a result of this action, trilostane blocks the conversion of Δ5-3β-hydroxysteroids, including pregnenolone
Trilostane
Chemical compound
17α-dihydroxyprogesterone) and is reversibly formed from it by 11β-hydroxysteroid dehydrogenase, analogously to the reversible formation of cortisone from cortisol
21-Deoxycortisone
Chemical compound
glucocorticosteroids and androstenedione through the activity of 3α-hydroxysteroid dehydrogenase. Measurements of 17α-hydroxypregnenolone are useful in the diagnosis
17α-Hydroxypregnenolone
Protein-coding gene in the species Homo sapiens
Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene. The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12)
HSD17B12
Chemical compound
11β-hydroxyprogesterone are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of the potent
Roxibolone
Enzyme family
skin of reductive 17β-hydroxysteroid dehydrogenase, oxidative 3α-hydroxysteroid dehydrogenase, and 3β-hydroxysteroid dehydrogenase enzymes. Gynecomastia
5α-Reductase
Layer of adrenal cortex
further converted in the adrenal cortex if the cells lack 17β-Hydroxysteroid dehydrogenase. Instead, they are released into the blood stream and taken up
Zona_reticularis
Androgen and anabolic steroid
(as it is already 5α-reduced) and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic
Oxymetholone
Chemical compound
"The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation". Toxicol. Sci. 126 (2):
Oxofluoxymesterone
Chemical compound
Okinaga S, Arai K (June 1989). "Inhibition of rat ovarian 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17 alpha-hydroxylase and 17,20 lyase by progestins
Gestrinone
Chemical compound
by 3β-hydroxysteroid dehydrogenase type I into androstenedione, and androstenedione is aromatized into estrone. Then, placental 17β-hydroxysteroid dehydrogenase
Estriol
Medical condition
of all steroid hormones from cholesterol [citation needed] 3β-Hydroxysteroid dehydrogenase 2 deficiency: impairs progestogen and androgen metabolism; prevents
Inborn errors of steroid metabolism
Inborn_errors_of_steroid_metabolism
Chemical compound
activity. Medrogestone has been found to be an inhibitor of 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase in vitro, preventing conversion of pregnenolone
Medrogestone
Chemical compound
Cholesterol side-chain cleavage enzyme (P450scc, CYP11A1) and 3α-hydroxysteroid dehydrogenase (3α-HSD). Leung-Gurung, Lucie; Escalante Cobb, Priscilla; Mourad
HPTE
Chemical compound
BAN) (developmental code name WIN-32729) is an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) that was developed as a contraceptive, abortifacient
Epostane
Class of medications
skin of reductive 17β-hydroxysteroid dehydrogenase, and oxidative 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid dehydrogenase enzymes. In BPH, DHT
5α-Reductase_inhibitor
Chemical compound
humans. The compound is synthesized from androstadienol by 3β-hydroxysteroid dehydrogenase, and can be converted into androstenone (a more potent and odorous
Androstadienone
glucose-6-phosphate dehydrogenase (NADP+) EC 1.1.1.50: 3α-hydroxysteroid 3-dehydrogenase (Si-specific) EC 1.1.1.51: 3(or 17)β-hydroxysteroid dehydrogenase EC 1.1.1
List_of_EC_numbers_(EC_1)
Chemical compound
W. (October 1975). "Enzymatic transformation of morphine by hydroxysteroid dehydrogenase from Pseudomonas testosteroni". Applied Microbiology. 30 (4):
14-Hydroxymorphine
Chemical compound
can be further metabolized into 3α,5α-tetrahydrocortisol by 3α-hydroxysteroid dehydrogenase. "Hydrallostane". Azzouni F, Godoy A, Li Y, Mohler J (2012).
5α-Dihydrocortisol
Nuclear receptor that mediates the effects of the mineralocorticoid hormone Aldosterone
co-localization of an enzyme, corticosteroid 11-beta-dehydrogenase isozyme 2 (a.k.a. 11β-hydroxysteroid dehydrogenase 2; 11β-HSD2), that converts cortisol to
Mineralocorticoid_receptor
to 3β-hydroxysteroid dehydrogenase deficiency 5α-Reductase deficiency Androgen insensitivity syndrome Ovotesticular disorder 17β-Hydroxysteroid dehydrogenase
Testosterone regulations in women's athletics
Testosterone_regulations_in_women's_athletics
Chemical compound
acts as a potent, selective, and irreversible inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme that is responsible for the conversion of
Cyanoketone
Chemical compound
androgen receptor (AR), and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD), CYP11B1 (steroid 11β-hydroxylase), CYP21A2 (Steroid
Abiraterone_acetate
Chemical compound
formed from androstenedione by 5α-reductase and from DHT by 17β-hydroxysteroid dehydrogenase. It has some androgenic activity. In female genital skin, the
Androstanedione
Chemical compound
a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic
Drostanolone_propionate
Substance that quells or blunts the libido
Studies have demonstrated that some of these products inhibit 17β-hydroxysteroid dehydrogenase and 17,20-lyase, which catalyzes the conversion of 17α-hydroxyprogesterone
Anaphrodisiac
Investigational drug under development for treatment of endometriosis
Linustedastat (developmental code names FOR-6219 and OG-6219) is a 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1; HSD17B1) inhibitor which is under development for
Linustedastat
Chemical compound
potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). The steroid 11β-OHP has been known since 1987 to occur
11β-Hydroxyprogesterone
Chemical compound
and 3β-hydroxysteroid dehydrogenase) and, from them, respectively, etiocholanolone and epietiocholanolone (by 17β-hydroxysteroid dehydrogenase). Unlike
5β-Dihydrotestosterone
Topical glucocorticoid drug
topically because the skin lacks the necessary activating enzyme 11β-Hydroxysteroid dehydrogenase. Systemically, this agent's activity on glucocorticoid receptors
Chloroprednisone
Endogenous weak androgen
subsequent conversion of DHEA to androstenedione via the enzyme 3β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17α-hydroxyprogesterone
Androstenedione
Metabolite of bupropion
formed from bupropion via reduction of the ketone group by 11β-hydroxysteroid dehydrogenase-1 and aldo-keto reductases. It can also be formed from bupropion
Threohydrobupropion
Chemical compound
[citation needed] Umbelliferone is a potent inhibitor of type 3 17β-hydroxysteroid dehydrogenase, the primary enzyme responsible for the conversion of 4-androstene-3
Umbelliferone
Prohormone of an anabolic-androgenic steroid
2022. Lommer D, Dorfman RI, Forchelli E. Reversal of the 3 -hydroxysteroid dehydrogenase-isomerase reactions in rat adrenals. Steroidologia. 1970;1(3):175-82
Androgen_prohormone
Protein-coding gene in the species Homo sapiens
retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is a homodimer composed of 2 chi subunits
ADH5
Chemical compound
was never marketed. It acts as a competitive inhibitor of 3β-hydroxysteroid dehydrogenase (IC50 = 1 μM), and thereby inhibiting the formation of progesterone
Azastene
Injectable form of birth control
MPA has been found to act as a competitive inhibitor of rat 3α-hydroxysteroid dehydrogenase (3α-HSD). This enzyme is essential for the transformation of
Medroxyprogesterone_acetate
Group of corticosteroids
glucocorticoids. This enzyme, 11-beta hydroxysteroid dehydrogenase type II (Protein:HSD11B2), catalyzes the deactivation of glucocorticoids to 11-dehydro metabolites
Mineralocorticoid
Chemical compound
"Troglitazone". Diabetes Monitor. March 28, 2000. Archived from the original on August 11, 2001. "Troglitazone". RxList. Archived from the original on April 5, 2004
Troglitazone
Genetic disorders of the adrenal gland
in an apparent vulva. Ambiguous genitalia in XY males with 3β-hydroxysteroid dehydrogenase deficiency (3β-HSD2D). In females, hypogonadism can cause sexual
Congenital adrenal hyperplasia
Congenital_adrenal_hyperplasia
Chemical compound
progesterone, formed by the 20α-hydroxysteroid dehydrogenases (20α-HSDs) AKR1C1, AKR1C2, and AKR1C3 and the 17β-hydroxysteroid dehydrogenase (17β-HSD) HSD17B1. 20α-DHP
20α-Dihydroprogesterone
Anti-inflammatory drug
80–90% (rectal) Protein binding 99% Metabolism Liver Elimination half-life 2.6-11.2 hours (adults), 12-28 hours (infants) Excretion Kidney (60%), fecal (33%)
Indometacin
Chemical compound
deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA
Tetrahydrodeoxycorticosterone
Catechin (polyphenol) in tea
and individual variability". Cancer Epidemiology, Biomarkers & Prevention. 11 (10 Pt 1): 1025–1032. PMID 12376503. Manach, C; Williamson, G; Morand, C;
Epigallocatechin_gallate
Chemical compound
can inhibit enzymes related to steroid metabolism, such as 11β-hydroxysteroid dehydrogenase, although this effect is still under further investigation. Because
Masticadienonic_acid
Chemical compound
synthesized from progesterone via the enzymes 5β-reductase and 3α-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone occurring as a metabolic intermediate
Pregnanolone
Vertebrate natural glucocorticoid hormone
to cortisone by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: 11-beta HSD1 and 11-beta HSD2. The metabolism
Cortisol
Chemical compound
2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 2020 (11) CD013516. doi:10.1002/14651858.CD013516.pub2. PMC 8092670. PMID 33210751
Pioglitazone
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