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Protein domain
A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed
C2_domain
Protein-coding gene in the species Homo sapiens
Multiple C2 domains, transmembrane 2 is a protein that in humans is encoded by the MCTP2 gene. GRCh38: Ensembl release 89: ENSG00000140563 – Ensembl, May
Multiple C2 domains, transmembrane 2
Multiple_C2_domains,_transmembrane_2
Protein family
and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein
Synaptotagmin
Group of human proteins
other double C2 domain proteins, and their role is most similar to that carried out by proteins that exhibit a single C2 domain. The core domain located at
Copine
Large protein superfamily of cell surface and soluble proteins
similar in size to IgC domains. These are called IgC2 domains, while standard IgC domains are called IgC1 domains. IgI: Other Ig domains exist that are called
Immunoglobulin_superfamily
Topics referred to by the same term
mass–energy equivalence formula) C2 (space group), three-dimensional space group number 5 C2 domain, a protein structural domain C2 regulatory sequence for the
C2
Protein domain
Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major protein domain of many blood coagulation factors. Blood coagulation factors
Discoidin_domain
Mammalian protein found in humans
with the plasma. The C domains belong to the phospholipid-binding discoidin domain family (unrelated to C2 domain), and the C2 domain mediates membrane binding
Factor_V
Blood-clotting protein
copper-binding protein ceruloplasmin. The C domains belong to the phospholipid-binding discoidin domain family, and the C2 domain mediate membrane binding. Activation
Factor_VIII
Class of enzymes
C-terminus of the alpha-toxin has been reported as a "C2-like" domain, referencing the C2 domain found in eukaryotes that are involved in signal transduction
Phospholipase_C
Protein family
Ferlins are distinguished by their multiple tandem C2 domains, and sometimes a FerA and a DysF domain. Mutations in ferlins can cause human diseases such
Ferlins
Protein-coding gene in the species Homo sapiens
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene. The protein
PIK3C2B
Class of enzymes
acts as a cofactor in PLD isoforms that contain the C2 domain. Binding of Ca2+ to the C2 domain leads to conformational changes in the enzyme that strengthen
Phospholipase_D
Protein domain
InterPro: IPR003597), C2-set (constant-2; InterPro: IPR008424) and I-set (intermediate; InterPro: IPR013098). Structural studies have shown that these domains share a
Immunoglobulin_C2-set_domain
Two opposing antiparallel beta sheets that commonly occur in proteins
III Repeat). The L-type lectin domain is a variation of the jelly roll fold. The C2 domain in its typical version (PKC-C2) is a β-sandwich composed of 8
Beta-sandwich
protein. The short form of the protein has three C2 domains and a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis
Otoferlin
Protein family
This membrane docking is mediated mostly by lipid-binding domains (e.g. PH domain and C2 domain) that display affinity for different phospholipid components
Phosphoinositide phospholipase C
Phosphoinositide_phospholipase_C
Protein-coding gene in the species Homo sapiens
located on chromosome 20 in humans. ITCH contains a C2 domain, proline-rich region, WW domains, HECT domain, and multiple amino acids that are phosphorylated
ITCH
Protein family
phospholipase B (EC 3.1.1.5) and cytosolic phospholipase A2 which also has a C2 domain InterPro: IPR000008. Phospholipase B enzymes catalyse the release of fatty
Lysophospholipase
Protein-coding gene in the species Homo sapiens
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene. The protein
PIK3C2G
Protein encoded by the DYSF gene in humans
conserved C2 domains (C2A-G) which are conserved across several proteins within the ferlin family, including dysferlin homolog myoferlin. In fact, the C2 domain
Dysferlin
Coiled-coil domain-containing protein 169 is a protein which in humans is encoded by the gene CCDC169 (previously C13orf38). The CCDC169 protein is 139
C13orf38
Protein-coding gene in the species Homo sapiens
Südhof TC, Rizo J (Jan 1997). "Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch". Neuron. 18 (1): 133–42. doi:10
SYT1
Protein-coding gene in the species Homo sapiens
Coiled-coil and C2 domain-containing protein 2A that in humans is encoded by the CC2D2A gene. This gene encodes a coiled-coil and calcium binding domain protein
CC2D2A
Malware strain
command and control (C2) domains in addition to IPS signatures to protect against all exploited vulnerabilities. The C2 domains include cross-compiling
Gayfemboy
Protein-coding gene in the species Homo sapiens
sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy
UVRAG
Protein-coding gene in the species Homo sapiens
Tandem C2 domains nuclear protein is a protein that in humans is encoded by the TC2N gene. ENSG00000165929 GRCh38: Ensembl release 89: ENSG00000276776
TC2N
Protein-coding gene in the species Homo sapiens
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
S100G
Self-stable region of a protein's chain that folds independently from the rest
alone. An example of a superdomain is the protein tyrosine phosphatase–C2 domain pair in PTEN, tensin, auxilin and the membrane protein TPTE2. This superdomain
Protein_domain
Membrane proteins that adhere temporarily to membranes with which they are associated
charybdotoxin, and specific membrane-targeting domains such as some PH domains, C1 domains, and C2 domains.[citation needed] Electrostatic interactions
Peripheral_membrane_protein
Protein-coding gene in the species Homo sapiens
binding domain (C2), 4 WW domains (protein-protein interaction domains) and the carboxyl-terminal HECT domain (ubiquitin ligase domain). The WW domains in
NEDD4L
Protein-coding gene in the species Homo sapiens
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the PIK3C2A gene. The protein
PIK3C2A
Tumor suppressor gene
domain and a C2 domain. The phosphatase domain contains the active site, which carries out the enzymatic function of the protein, while the C2 domain
PTEN_(gene)
Peripheral membrane protein
secreted PLA2 (more than 700 residues). They include a C2 domain and a large catalytic domain. These phospholipases are involved in cell signaling processes
Phospholipase_A2
Protein-coding gene in the species Homo sapiens
WW and C2 domain containing 2 (WWC2) is a protein that in humans is encoded by the WWC2 gene (4q35.1). Though function of WWC2 remains unknown, it has
WWC2
Protein-coding gene in the species Homo sapiens
consisting of an amino-terminal C2 calcium-dependent phospholipid binding domain, 3-4 WW protein-protein interaction domains, and a carboxyl-terminal catalytic
NEDD4
Protein-coding gene in the species Homo sapiens
chain Transmembrane domain – self-association C1 domain – actin-association cytoskeleton Variable domain – syndecan-specific C2 domain – attach to PDZ proteins
Syndecan-4
Protein family
ankyrin, PX, phosphatidylinositol 3- and 4-kinase (INTERPRO), C2 domain, OTU (INTERPRO), DnaJ domain (INTERPRO), RING-finger (INTERPRO) or FYVE-finger (INTERPRO)
Ubiquitin-interacting_motif
Protein-coding gene in the species Homo sapiens
RPGRIP1 is a multi-domain protein containing a coiled-coil domain at the N-terminus, two C2 domains and a C-terminal RPGR-interacting domain (RID). Defects
RPGRIP1
Military exercise of authority by a commanding officer over assigned forces
aspects, uses, and sub-domains of C2. These terms are accompanied by numerous associated abbreviations. For example, in addition to C2, command and control
Command_and_control
Protein-coding gene in the species Homo sapiens
1016/S0006-291X(02)02945-5. PMID 12559952. "Entrez Gene: WWC1 WW and C2 domain containing 1". "dbSNP: rs17070145". Need AC, Attix DK, McEvoy JM, Cirulli
WWC1
Protein-coding gene in humans
proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity. GRCh38:
CPNE6
Protein-coding gene in the species Homo sapiens
adult tissues. RasGAP contains one SH3 domain and two SH2 domains, a PH domain, a C2 domain, and a GAP domain. RAS p21 protein activator 1 has been shown
RAS_p21_protein_activator_1
Protein-coding gene in the species Homo sapiens
Coiled-coil and C2 domain-containing protein 1A is a protein that in humans is encoded by the CC2D1A gene. GRCh38: Ensembl release 89: ENSG00000132024
CC2D1A
Active transport and bulk transport in which a cell transports molecules out of the cell
calcium sensors for exocytosis are EF-hand proteins (e.g., Calmodulin) and C2 domain (e.g., Ferlins, E-synaptotagmin, Doc2b) containing proteins. It is unclear
Exocytosis
Protein-coding gene in humans
calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. GRCh38: Ensembl release
CPNE4
Three-dimensional arrangement of atoms in an amino acid-chain molecule
conservative combination of several domains that occur in different proteins, such as protein tyrosine phosphatase domain and C2 domain pair, was called "a superdomain"
Protein_structure
NATO-centred military coordination organization
the taxonomic and semantic foundation for information exchange in the C2 domain. The goal is to harmonize current information exchange concepts and create
Multilateral Interoperability Programme
Multilateral_Interoperability_Programme
animals, plants and fungi comprise a PTP-C2 superdomain. An integrated PTP domain and C2 domain, the PTP-C2 superdomain came into existence over 1 billion
Tensin
Protein-coding gene in humans
calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. GRCh38: Ensembl release
CPNE8
Protein-coding gene in the species Homo sapiens
secretion. Several conserved domains have been found in UNC13A. These conserved domains include three C2 domains. One C2 domain is centrally located, another
UNC13A
Protein-coding gene in the species Homo sapiens
1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified
OS9_(gene)
Protein-coding gene in the species Homo sapiens
Double C2-like domain-containing protein beta is a protein that in humans is encoded by the DOC2B gene. There are at least two protein isoforms of the
DOC2B
Protein family
Duffy-binding-like (DBL) domain, sometimes a Ca2+-binding C2 domain, and then one or two cysteine-rich interdomain regions (CIDRs). Duffy-binding-like domains are so named
Plasmodium falciparum erythrocyte membrane protein 1
Plasmodium_falciparum_erythrocyte_membrane_protein_1
Protein-coding gene in the species Homo sapiens
"Mapping the site of interaction between annexin VI and the p120GAP C2 domain". FEBS Letters. 460 (1): 166–72. Bibcode:1999FEBSL.460..166C. doi:10
Annexin_A6
Protein-coding gene in the species Homo sapiens
their full-length natures have not been determined. Myoferlin contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting
Myoferlin
Protein domain
these domains are found in eukaryotes and usually contain another lipid-binding domain, typically the GRAM domain and sometimes the C2 domain in plants
VAD1 analog of StAR-related lipid transfer
VAD1_analog_of_StAR-related_lipid_transfer
Complex that catalyzes conversion of prothrombin to thrombin
single-chain procofactor which contains six domains, A1-A2-B-A3-C1-C2. Thrombin activates factor V by cleaving off the B domain. Other proteases also activate factor
Prothrombinase
extracellular structure consists of two Fibronectin type III domains and five Ig-like C2 domains, having structural homology to the neural cell adhesion molecule
Fasciclin_2
Protein found in humans
to the onset of labor. CBR1 has been shown to interact with cortisol, C2 domain, and Flavonoid. GRCh38: Ensembl release 89: ENSG00000159228 – Ensembl
CBR1
Protein-coding gene in humans
Copine-1 protein which has an integrin A domain and two N-terminal type II C2 domains. Where the C2 domains act as calcium dependent phospholipid binding
CPNE1
Protein-coding gene in the species Homo sapiens
Südhof TC, Rizo J (January 1997). "Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch". Neuron. 18 (1): 133–42. doi:10
STX1A
Protein-coding gene in the species Homo sapiens
(Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans"
Extended_synaptotagmin-1
Network time synchronization protocol
ControlNet and PROFINET. A domain is an interacting set of clocks that synchronize to one another using PTP. Clocks are assigned to a domain by virtue of the contents
Precision_Time_Protocol
Protein-coding gene in humans
each exon encoding one of the four domains of CD48: signal peptide, variable (V) domain, constant 2 (C2) domain and the glycophosphatidylinositol anchor
CD48
Gene of the species Homo sapiens
protein that in humans is encoded by the RPH3A gene. It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was
RPH3A
Biological process
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calcium-induced calcium release
Calcium-induced_calcium_release
Protein-coding gene in the species Homo sapiens
(Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans"
Extended_synaptotagmin-2
Calcium-binding protein
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calexcitin
role in many cellular processes. Calcium-binding proteins have specific domains that bind to calcium and are known to be heterogeneous. One of the functions
Calcium-binding_protein
Medical condition
least five domains (figure 1): adaptor-binding domain, a Ras GTPase-binding domain, a PI(3)K-type C2 domain, helical domain, and a kinase domain. Mutations
PASLI_disease
Protein domain
kinase region (1-426), a DH domain (498-691), a PH domain (708-866), a C2 domain (893-1020), and a Rho-GAP (1054-1248) domain. The Protein Data Bank includes
BCR_(gene)
Class of enzymes
of two protein domains: a voltage sensor domain, and a phosphatase domain coupled to a lipid-binding C2 domain. The voltage sensor domain contains four
Voltage_sensitive_phosphatase
Family of enzymes
in atypical PKCs is incapable of binding to DAG or phorbol esters. The C2 domain acts as a Ca2+ sensor and is present in both conventional and novel isoforms
Protein_kinase_C
American neuroscientist
Augustine, George J. (1993). "Inhibition of Neurotransmitter Release by C2-domain Peptides Implicates Synaptotagmin in Exocytosis". Nature. 363 (6425):
George_J._Augustine
Chemical compound
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Inositol_trisphosphate
Protein domain
immunoglobulin E-set domains. This domain is present in the following proteins: Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which
ML_domain
Protein-coding gene in the species Homo sapiens
allosteric regulation is mediated by binding PI(3,4)P2 to the C2 domain. Furthermore, binding PDB domain to C-terminus of SHIP1 is regulated by Y915 and Y1022
INPP5D
Class of enzymes
function. The distinct feature of Class II PI3Ks is the C-terminal C2 domain. This domain lacks critical Asp residues to coordinate binding of Ca2+, which
Phosphoinositide_3-kinase
Mammalian protein found in Homo sapiens
distinct domains that include an N-terminal C2 domain, two to three WW domains containing tryptophan residues, and an HECT domain. The C2 domain plays a
SMURF1
Mammalian protein found in humans
extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The
CD33
Protein-coding gene in the species Homo sapiens
Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene. There are at least two protein isoforms of the
DOC2A
LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256
Intracellular calcium-sensing proteins
Intracellular_calcium-sensing_proteins
Protein found in humans
troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions
Calretinin
Protein-coding gene in the species Homo sapiens
DD (January 1996). "Calcium-dependent binding of S100C to the N-terminal domain of annexin I". The Journal of Biological Chemistry. 271 (2): 719–725. doi:10
Annexin_A1
Messenger protein
kDa). The protein has two approximately symmetrical globular domains (the N- and C- domains) each containing a pair of EF hand motifs separated by a flexible
Calmodulin
Other names in common use include type II phosphoinositide 3-kinase, C2-domain-containing phosphoinositide 3-kinase, and phosphoinositide 3-kinase. This
Phosphatidylinositol-4-phosphate 3-kinase
Phosphatidylinositol-4-phosphate_3-kinase
Calcium-binding protein
for its high-capacity to bind Ca2+. In addition, the hydrophobic core of domain II appears to be necessary for CASQ2's function, because a single amino
Calsequestrin
Protein-coding gene in the species Homo sapiens
"Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical
Adhesion G protein-coupled receptor B1
Adhesion_G_protein-coupled_receptor_B1
Mammalian protein found in Homo sapiens
first identified as a calcium-binding protein. Because osteocalcin has gla domains, its synthesis is vitamin K2-dependent. In humans, osteocalcin is encoded
Osteocalcin
Protein-coding gene in the species Homo sapiens
Johnson JL, Ruedi JM, Thon V, Babior BM (June 2001). "JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase". The Journal
SYTL1
Mammalian protein found in Homo sapiens
broken into 4 domains: 1) a Ca2+ binding domain near the glutamic acid-rich region at the amino terminus (domain I), 2) a cysteine-rich domain (II), 3) a
Osteonectin
Protein that stabilizes the initiation complex for polypeptide translation
protein has many domains, including an N-terminal domain, a GTPase domain, a linker region, C1, C2, and C-terminal domains. The GTPase domain encompasses the
Bacterial_initiation_factor
Intracellular communication process
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calcium_signaling
Protein-coding gene in the species Homo sapiens
the position of the C2, pseudosubstrate, and C1 domains; various second messengers in different combinations can act on the C1 domain to direct subcellular
PRKCE
Family of vertebrate proteins involved in cell division and inflammation
Chin (2014-08-01). "Structural Insights into Calcium-Bound S100P and the V Domain of the RAGE Complex". PLOS ONE. 9 (8) e103947. Bibcode:2014PLoSO...9j3947P
S100_protein
Protein-coding gene in the species Homo sapiens
fluorescence microscope. Annexin A5 has been shown to interact with Kinase insert domain receptor and Integrin, beta 5. GRCh38: Ensembl release 89: ENSG00000164111
Annexin_A5
Class of intracellular transport proteins
receptors, approximately 80% of the mass, are present in the cytosolic domain, which accounts for the many regulatory interactions. The cytosolic portion
Ryanodine_receptor
Mammalian protein found in Homo sapiens
repeats are related in structure (but barely in sequence) to the ADF-H domain, forming a superfamily (InterPro: IPR029006). The family appears to have
Gelsolin
Antiporter membrane protein that removes calcium from cells
transmembrane domain. Inserted between the pseudo-symmetric halves is a cytoplasmic loop containing regulatory domains. These regulatory domains have C2 domain like
Sodium-calcium_exchanger
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