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VAV3

  • VAV3
  • Protein-coding gene in the species Homo sapiens

    Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene. This gene is a member of the VAV gene family. The VAV

    VAV3

    VAV3

    VAV3

  • Amhara people
  • Semitic-speaking ethnic group in Ethiopia

    for involvement in high-altitude adaptation in Ethiopia, including CBARA1, VAV3, ARNT2 and THRB. Although most of these genes have not been identified in

    Amhara people

    Amhara people

    Amhara_people

  • Anaplastic lymphoma kinase
  • Protein found in humans

    Delsol G, et al. (April 2008). "Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas". Oncogene

    Anaplastic lymphoma kinase

    Anaplastic lymphoma kinase

    Anaplastic_lymphoma_kinase

  • Tigrayans
  • Semitic-speaking ethnic group in Ethiopia

    Candidate genes under positive selection in northern highlanders include CBARA1, VAV3, ARNT2, and THRB, all of which are associated with HIF‑1 pathways. Interestingly

    Tigrayans

    Tigrayans

    Tigrayans

  • Chromosome 1
  • Human chromosome

    cutanea tarda) USP1 (1p31) USP48: Ubiquitin carboxyl-terminal hydrolase 48 VAV3 (1p13) VPS13D: Vacuolar protein sorting-associated protein 13D VTCN1 (1p13)

    Chromosome 1

    Chromosome 1

    Chromosome_1

  • SH2 domain
  • Protein domain

    STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4; TXK VAV1; VAV2; VAV3 YES1; ZAP70 Phosphotyrosine-binding domains also bind phosphorylated tyrosines

    SH2 domain

    SH2 domain

    SH2_domain

  • Organisms at high altitude
  • Organisms capable of living at high altitudes

    several other genes appear to be involved in Ethiopians, including CBARA1, VAV3, ARNT2 and THRB, which are known to play a role in HIF genetic functions

    Organisms at high altitude

    Organisms at high altitude

    Organisms_at_high_altitude

  • C1 domain
  • Protein domain

    ROCK1; ROCK2; STAC; STAC2; STAC3; TENC1; UNC13A; UNC13B; UNC13C; VAV1; VAV2; VAV3; Azzi A, Boscoboinik D, Hensey C (1992). "The protein kinase C family". Eur

    C1 domain

    C1 domain

    C1_domain

  • High-altitude adaptation in humans
  • possible explanations for the adaptation of Ethiopians, including CBARA1, VAV3, ARNT2 and THRB. Two of these genes (THRB and ARNT2) are known to play a

    High-altitude adaptation in humans

    High-altitude_adaptation_in_humans

  • RhoGEF domain
  • Protein domain

    PREX1; PREX2; RASGRF1; RASGRF2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3. DOCK1/DOCK180; DOCK2; DOCK3/MOCA; DOCK4; DOCK5; DOCK6/ZIR1; DOCK7/ZIR2;

    RhoGEF domain

    RhoGEF domain

    RhoGEF_domain

  • Pleckstrin homology domain
  • Clinical Significance

    SYNGAP1, TBC1D2, TEC, TIAM1, TRIO, TRIOBP, TYL, URP1, URP2, VAV1, VAV2, VAV3, VEPH1 Pleckstrin The unrelated FYVE domain binds Phosphatidylinositol 3-phosphate

    Pleckstrin homology domain

    Pleckstrin homology domain

    Pleckstrin_homology_domain

  • C13orf38
  • ubiquitin ligase activity; Ring finger proteins 0.559 VAV3 Guanine nucleotide exchange factor VAV3; Exchange factor for GTP-binding proteins RhoA, RhoG

    C13orf38

    C13orf38

    C13orf38

  • Gene redundancy
  • D.; Turner, Martin; Watson, Steve P.; Vigorito, Elena (2004). "Vav1 and Vav3 Have Critical but Redundant Roles in Mediating Platelet Activation by Collagen"

    Gene redundancy

    Gene redundancy

    Gene_redundancy

  • Calponin homology domain
  • Protein domain

    SPTBN4, SPTBN5, SYNE1, SYNE2, TAGLN, TAGLN2, TAGLN3, UTRN, and VAV1, VAV2, VAV3 PDB: 2RR8​; Umemoto R, Nishida N, Ogino S, Shimada I (September 2010). "NMR

    Calponin homology domain

    Calponin homology domain

    Calponin_homology_domain

  • Vav (protein)
  • Proteins involved in cell signalling

    bound pathogens or cells. In humans there are three Vav proteins: Vav1 Vav2 Vav3 Bustelo, X. R. (March 2000). "Regulatory and Signaling Properties of the

    Vav (protein)

    Vav_(protein)

  • RhoG
  • Protein-coding gene in the species Homo sapiens

    migration). Other GEFs reported to interact with RhoG include Dbs, ECT2, VAV2 and VAV3. There have been very few interactions reported between RhoG and negative

    RhoG

    RhoG

    RhoG

  • ROS1
  • Protein-coding gene in the species Homo sapiens

    Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, et al. (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity

    ROS1

    ROS1

    ROS1

  • Neurotrophin-4
  • Protein-coding gene in the species Homo sapiens

    Thomas R, Chakrabarti S (October 2010). "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure

    Neurotrophin-4

    Neurotrophin-4

    Neurotrophin-4

  • GRB2
  • Protein-coding gene in the species Homo sapiens

    proto-oncogene, SH2B1, SH3KBP1, SHC1, SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich syndrome protein. MAPK/ERK pathway GRCh38: Ensembl release

    GRB2

    GRB2

    GRB2

  • SH2B2
  • Protein-coding gene in the species Homo sapiens

    NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene. 21 (50): 7720–9. doi:10.1038/sj.onc

    SH2B2

    SH2B2

    SH2B2

  • Sarah Tishkoff
  • American geneticist (born 1965)

    different gene candidates underlying adaptation to high altitude (CBARA1, VAV3, ARNT2, and THRB). This study demonstrates another example of convergent

    Sarah Tishkoff

    Sarah_Tishkoff

  • List of human protein-coding genes 9
  • Q9HCJ6 18079 VAV1 HGNC:12657; P15498 18080 VAV2 HGNC:12658; P52735 18081 VAV3 HGNC:12659; Q9UKW4 18082 VAX1 HGNC:12660; Q5SQQ9 18083 VAX2 HGNC:12661; Q9UIW0

    List of human protein-coding genes 9

    List_of_human_protein-coding_genes_9

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Online names & meanings

  • Gavrel
  • Boy/Male

    Russian

    Gavrel

    Worships God.

  • Ratnapriya | ரத்ந்ப்ரீயா
  • Girl/Female

    Tamil

    Ratnapriya | ரத்ந்ப்ரீயா

    Adorned, Loved by jewels

  • Fiyanshu
  • Girl/Female

    Hindu, Indian

    Fiyanshu

    Great Angel

  • Hemlata
  • Girl/Female

    Indian

    Hemlata

    Golden creeper

  • Adriane
  • Girl/Female

    American, Australian, British, Chinese, Christian, Danish, English, French, German, Latin

    Adriane

    From Hadria; Dark

  • Birger
  • Boy/Male

    Norse Scandinavian Swedish

    Birger

    Rescue.

  • Sukthi
  • Girl/Female

    Hindu, Indian, Kannada, Marathi, Telugu

    Sukthi

    Shining

  • Bindiya
  • Girl/Female

    Indian

    Bindiya

    A dot on the forehead. the one which indian women who put down the same in between two eyebrows, Drop, Point

  • ŁUKASZ
  • Male

    Polish

    ŁUKASZ

    Polish form of Greek Loukas, ŁUKASZ means "from Lucania."

  • Dhanushri
  • Girl/Female

    Indian

    Dhanushri

    The bow or name of a Hindu Rashi sagittarius

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