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Class of chemical compounds
Thiazides (/ˈθaɪəzaɪd/) are a class of diuretics based on the chemical structure of benzothiadiazine. Thiazides are used in the treatment of hypertension
Thiazide
Diuretic medication
medications as a single pill to increase effectiveness. Hydrochlorothiazide is a thiazide medication which inhibits reabsorption of sodium and chloride ions from
Hydrochlorothiazide
Class of drugs used to treat high blood pressure
different means. Among the most important and most widely used medications are thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors
Antihypertensive
Thiazide-like diuretic drug
Chlortalidone, also known as chlorthalidone, is a thiazide-like diuretic drug used to treat high blood pressure, swelling (such as occurs in heart failure
Chlortalidone
Class of drugs which promote urine production
A thiazide-like diuretic is a sulfonamide diuretic that has similar physiological properties to a thiazide diuretic, but does not have the chemical properties
Thiazide-like_diuretic
Molecular moiety or the drug class that uses it
antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides
Sulfonamide_(medicine)
Substance that promotes the production of urine
weight.[citation needed] The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic effect
Diuretic
Protein-coding gene in the species Homo sapiens
symporter (also known as Na+-Cl− cotransporter, NCC or NCCT, or as the thiazide-sensitive Na+-Cl− cotransporter or TSC) is a cotransporter in the kidney
Sodium-chloride_symporter
Chemical compound
Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart
Metolazone
Condition characterized by large amounts of dilute urine and increased thirst
DI may be treated by addressing the underlying cause or by the use of a thiazide, aspirin or ibuprofen. The number of new cases of diabetes insipidus each
Diabetes_insipidus
Drug used to treat high blood pressure
combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces
Reserpine
Chemical compound
Dytac) is a potassium-sparing diuretic often used in combination with thiazide diuretics for the treatment of high blood pressure or swelling. The combination
Triamterene
Thiazide-like diuretic drug
Indapamide is a thiazide-like diuretic drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with
Indapamide
Chemical compound
Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special
Chlorothiazide
collaboration, World Health Organization, and US guidelines support low-dose thiazide-based diuretic as first-line treatment. The UK guidelines emphasise calcium
Management_of_hypertension
Combination of antihypertensive drugs
An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension (high blood pressure). They are given by mouth. ACE inhibitors
ACE inhibitor and thiazide combination
ACE_inhibitor_and_thiazide_combination
Feature of kidney anatomy
calcium, and pH. On its apical surface (lumen side), cells of the DCT have a thiazide-sensitive Na-Cl cotransporter and are permeable to Ca, via the TRPV5 channel
Distal_convoluted_tubule
Two from different classes: thiazide diuretic, long-acting dihydropyridine CCB, and ACEi or ARB BP ≥130/80: One of: thiazide diuretic, long-acting dihydropyridine
Comparison of international blood pressure guidelines
Comparison_of_international_blood_pressure_guidelines
Symptoms due to excess consumption of calcium and alkali
Other drugs reported to be associated with the development of MAS include thiazide diuretics, which cause increased reabsorption of calcium in the kidneys;
Milk-alkali_syndrome
Genetic kidney disorder
identical to those of patients who are on thiazide diuretics, given that the affected transporter is the target of thiazides. Clinical signs of Gitelman syndrome
Gitelman_syndrome
Pharmaceutical drug classification
Oxprenolol and thiazides C07BA05 Propranolol and thiazides C07BA06 Timolol and thiazides C07BA07 Sotalol and thiazides C07BA12 Nadolol and thiazides C07BA68
ATC_code_C07
Chemical compound
Cyclopenthiazide (trade name Navidrex) is a thiazide diuretic used in the treatment of heart failure and hypertension. Thiazide diuretics increase the excretion
Cyclopenthiazide
Medical condition
prednisolone), especially when this is in excess of 3 months. The use of thiazide diuretics, and gonadal hormone replacement has also been recommended, with
Steroid-induced_osteoporosis
Medication
diuretic. Amiloride is often used together with another diuretic, such as a thiazide or loop diuretic. It is taken by mouth. Onset of action is about two hours
Amiloride
Increase in parathyroid hormone levels
primary hyperparathyroidism. Additional risk factors include lithium and thiazide diuretics exposure. A number of genetic conditions including multiple endocrine
Hyperparathyroidism
Diuretics that act along the loop of Henle in the kidneys
excrete more water in the urine. Loop diuretics are more effective than thiazide diuretics in patients with impaired kidney function. They get their name
Loop_diuretic
Diuretic drug
Methyclothiazide (trade name Enduron) is a thiazide diuretic. Wirfs MJ (2022). "Hypertension: Primary Essential". APRN and PAS complete guide to prescribing
Methyclothiazide
Chemical compound
losartan, an angiotensin II receptor blocker; and hydrochlorothiazide, a thiazide diuretic. It is taken by mouth. Common side effects include dizziness,
Losartan/hydrochlorothiazide
Antihypertensive diuretic drug
bendrofluazide, trade name Aprinox, is a thiazide diuretic used to treat hypertension. Bendroflumethiazide is a thiazide diuretic which works by inhibiting
Bendroflumethiazide
Combination medication
medication which contains perindopril (an ACE inhibitor) and indapamide (a thiazide-like diuretic) both of which are used for the treatment of essential hypertension
Perindopril/indapamide
Chemical element with atomic number 80 (Hg)
Mercury is still used in some diuretics, although substitutes such as thiazides now exist for most therapeutic uses. In 2003, mercury compounds were found
Mercury_(element)
Long-term high blood pressure in the arteries
treating hypertension. First-line medications for hypertension include thiazide-diuretics, calcium channel blockers, angiotensin converting enzyme inhibitors
Hypertension
Antihypertensive medication
treatment of mild to moderate essential hypertension. It may have a role when thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate
Moxonidine
Severe swelling throughout the body
the way in which the kidney processes urine. Loop diuretics Thiazide diuretics Thiazide-like diuretics Potassium-sparing diuretics The body more efficiently
Anasarca
Formation of mineral deposits in the kidneys
recommended. If fluid intake alone is not effective, medications such as thiazide diuretics, citrate, or allopurinol may be suggested. Soft drinks containing
Kidney_stone_disease
Pharmaceutical drug classification
ATC code C03 Diuretics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed
ATC_code_C03
Chemical compound
available in a fixed-dose combination formulation with hydrochlorothiazide, a thiazide diuretic, to achieve an additive antihypertensive effect. Common side effects
Irbesartan
Typical antipsychotic medication
paradoxical fall in blood pressure. Monoamine oxidase inhibitors (MAOIs) and thiazide diuretics may also accentuate the orthostatic hypotension experienced by
Chlorpromazine
Combination drug
Enalapril/hydrochlorothiazide Combination of Enalapril ACE inhibitor Hydrochlorothiazide Thiazide diuretic Clinical data Trade names Vaseretic, others AHFS/Drugs.com Monograph
Enalapril/hydrochlorothiazide
Industry involved with discovery, development, production and marketing of drugs
millions of victims of hypertension". A 2009 Cochrane review concluded that thiazide antihypertensive drugs reduce the risk of death (RR 0.89), stroke (RR 0
Pharmaceutical_industry
Form of sexual dysfunction in males
beta blockers, antihistamines, alpha-2 adrenergic receptor agonists, thiazides, hormone modulators, and 5α-reductase inhibitors) Neurogenic disorders
Erectile_dysfunction
Form of diabetes mellitus
predispose to diabetes. Some of the medications include: glucocorticoids, thiazides, beta blockers, atypical antipsychotics, and statins. Those who have previously
Type_2_diabetes
Combination drug
as the besilate, a calcium channel blocker, and hydrochlorothiazide, a thiazide diuretic. It is taken by mouth. "AusPAR: Olmesartan medoxomil / Amlodipine
Olmesartan/amlodipine/hydrochlorothiazide
Olmesartan/amlodipine/hydrochlorothiazide
Medication
antagonist and potassium-sparing diuretic; and hydrochlorothiazide, a thiazide diuretic and antihypertensive. Spironolactone/hydrochlorothiazide was approved
Spironolactone/hydrochlorothiazide
Spironolactone/hydrochlorothiazide
Difference between systolic and diastolic blood pressure
Among classes of drugs currently on the market, a 2020 review stated that thiazide diuretics and long‐acting nitrates are the two most effective at lowering
Pulse_pressure
Medical condition
drugs, such as estrogen, corticosteroids, retinoids, protease inhibitors, thiazide diuretics, and beta-blockers, may cause hypertriglyceridemia. Obesity increases
Combined_hyperlipidemia
Organomercury compound once used diuretic
diuretic. It is only rarely used as a drug, having been superseded by thiazides and loop diuretics that are less toxic because they do not contain mercury
Mersalyl
2024 American medical drama TV series
rescuing a woman. Avery discovers Kelly's collapse was caused by her taking Thiazide. Tristan and Avery kiss while Max watches from afar. Sam, a promiscuous
Doctor_Odyssey
American multinational pharmaceutical company
companies to ensure a reliable supply of the antibiotic. In the 1950s, thiazide diuretics were developed by Merck scientists Karl H. Beyer, James M. Sprague
Merck_&_Co.
Nonsteroidal anti-inflammatory medication
exacerbation of hypertension may occur (NSAIDs may impair response to thiazide or loop diuretics), and may contribute to cardiovascular events; monitor
Celecoxib
Pharmaceutical drug classification
ATC code C02 Antihypertensives is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed
ATC_code_C02
Blood pressure medication
(>900 mg/24 hours). Although evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (due
Losartan
Uncontrolled hypertension
antihypertensive agents of different classes. Agents used include a long-acting thiazide-like diuretic (such as chlorthalidone) and spironolactone. Refractory hypertension
Refractory_hypertension
Medication used to treat low blood sugar and high blood pressure
pulmonary hypertension and heart failure. It is chemically similar to thiazide diuretics. It works by decreasing insulin release from the pancreas and
Diazoxide
Abnormally elevated levels of lipids or lipoproteins in the blood
of acquired hyperlipidemia are: Diabetes mellitus Use of drugs such as thiazide diuretics, beta blockers, and estrogens Other conditions leading to acquired
Hyperlipidemia
Failure of the heart to provide sufficient blood flow throughout the body
include diuretics classes such as loop diuretics (such as furosemide), thiazide-like diuretics, and potassium-sparing diuretics. Although widely used,
Heart_failure
Pharmaceutical drug
as the besylate, a calcium channel blocker; and hydrochlorothiazide, a thiazide diuretic. It is taken by mouth. It was approved for medical use in the
Aliskiren/amlodipine/hydrochlorothiazide
Aliskiren/amlodipine/hydrochlorothiazide
Plant-derived medication
arrhythmias when given with thiazides and loop diuretics. This is because co-administration of digoxin with drugs such as thiazides and loop diuretics which
Digoxin
Disorder of the inner ear
suppressant in patients with Ménière's disease. Diuretics, such as the thiazide-like diuretic chlortalidone, are widely used to manage MD on the theory
Ménière's_disease
Angiotensin II receptor antagonist
is available in a fixed-combination formulation with a low dose of the thiazide diuretic hydrochlorothiazide (HCT). Candesartan/HCT combination preparations
Candesartan
Chemical compound
piperidine diuretic. Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the
Clopamide
Type of cells of the immunological system
medications, anticonvulsants, quinine, quinidine, indometacin, procainamide, thiazides Radiation Toxins – alcohol, benzenes Intrinsic disorders – Fanconi's,
White_blood_cell
Abnormally low levels of chloride in the blood
therapy – Thiazide diuretics and loop diuretics like furosemide inhibit chloride reabsorption causing hypochloremia and metabolic alkalosis. Thiazides block
Hypochloremia
Chemical compound
swelling of distal limbs and general bruising. As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body. Trichlormethiazide
Trichlormethiazide
Inflammation of the pancreas
such as furosemide have a direct toxic effect on the pancreas. Meanwhile, thiazide diuretics cause hypertriglyceridemia and hypercalcemia, where the latter
Pancreatitis
Combination drug used to treat high blood pressure
hydrochlorothiazide (bottom) Combination of Lisinopril ACE inhibitor Hydrochlorothiazide Thiazide diuretic Clinical data Trade names Zestoretic, Prinzide, others Other names
Lisinopril/hydrochlorothiazide
Lisinopril/hydrochlorothiazide
Steroid acid in the bile of animals
PMID 27571266. Chiarugi S, Margheriti F, Garau G (2025). "NAPE-PLD is target of thiazide diuretics". Cell Chem Biol. 32 (3): 449–462. doi:10.1016/j.chembiol.2025
Bile_acid
Chemical compound
Tensodiural, Valmiran), sometimes abbreviated CTZ, is a benzothiadiazide (thiazide) diuretic and antihypertensive that was originally introduced in the United
Cyclothiazide
Excretion of potassium in human urine
(/ˌkeɪl(j)ʊəˈriːsɪs, ˌkæl-/) is the condition of excreting potassium in the urine. Thiazide diuretics are used to treat patients with heart failure. Their goal is
Kaliuresis
Chemical compound
Polythiazide is a thiazide diuretic. O'Brien ET, MacKinnon J (October 1972). "Propranolol and polythiazide in treatment of hypertension". British Heart
Polythiazide
Medical treatment using approved pharmaceutical products
calcium channel blocker (CCB) or a Thiazide-like diuretic to the previous therapy, i.e., ACEi or ARBs with a CCB or a thiazide-like diuretic. Every patient
Pharmacotherapy
Class of chemical compounds
widely used, they have largely been superseded by safer diuretics such as thiazides, and are now rarely used. Inorganic mercury compounds, such as mercury(I)chloride
Mercurial_diuretic
Too much blood sugar, usually because of diabetes
hyperglycemia, including: corticosteroids, octreotide, beta blockers, epinephrine, thiazide diuretics, niacin, pentamidine, protease inhibitors, L-asparaginase, statins
Hyperglycemia
order to perform the normal functions of the kidney. Loop diuretics and thiazide diuretics decrease filtration fraction. Catecholamines (norepinephrine
Filtration_fraction
Cluster of diseases occurring with obesity
cardiovascular and diabetes guidelines. Blood pressure: First-line agents include thiazide-type diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor
Metabolic_syndrome
Calcium channel blocker medication
diuretics and ACE inhibitors, although calcium channel antagonists, along with thiazide diuretics, are still favoured as primary treatment for patients over 55
Nifedipine
Group of similar medications
Benzodiazepine Cannabinoid Cardiac glycoside Fibrate Gabapentinoid Steroid Thiazide diuretic Triptan β-lactam antibiotic This type of categorisation is from
Drug_class
Part of experimental design
medication rather than the new medication. For example in the ALLHAT trial, Thiazide diuretics were demonstrated to be superior to calcium channel blockers
Treatment_and_control_groups
Excess potassium in the blood
disorder caused by defective modulators of salt transporters, including the thiazide-sensitive Na-Cl cotransporter. Metabolic acidosis can cause hyperkalemia
Hyperkalemia
Combination medication
Co-tenidone Combination of Atenolol Beta blocker Chlortalidone Thiazide diuretic Clinical data Routes of administration Oral Legal status Legal status
Co-tenidone
Chemical compound
the gut and inhibit or delay their absorption. Such substances include: thiazide diuretics, furosemide gemfibrozil benzylpenicillin, tetracycline digoxin
Colestipol
Blood test assessing vital organ health
diseases of the parathyroid gland or kidneys. Calcium salts, lithium, thiazide diuretics, thyroxine, and vitamin D can all increase levels and may interfere
Comprehensive_metabolic_panel
Antihypertensive drug of the ACE inhibitor class
particularly other blood pressure lowering classes of medications like thiazide diuretics to maximize its effectiveness. In vivo, when alacepril undergoes
Alacepril
Noncancerous increase in size of the prostate gland
relaxation. Diuretic medications such as loop diuretics (e.g., furosemide) or thiazides (e.g., chlorthalidone) can cause or worsen urinary frequency and nighttime
Benign_prostatic_hyperplasia
Chemical compound
Altizide is a thiazide diuretic. In combination with spironolactone it is sold under the brand name of Aldactacine and Aldactazine by Pfizer and other
Altizide
Topical antibiotic
This reaction is known from other sulfonamides including antibacterials, thiazide diuretics, and sulfonylurea antidiabetics; but data on the likelihood of
Silver_sulfadiazine
Medical condition
whereas Gitelman syndrome causes hypocalciuria and is due to an abnormal thiazide-sensitive transporter in the distal segment. Pseudo-Bartter's syndrome
Bartter_syndrome
High sodium concentration in the blood
experience in treatment of electrolyte imbalance. Specific treatments such as thiazide diuretics (e.g., chlorthalidone) in congestive heart failure or corticosteroids
Hypernatremia
Medical condition
angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs and thiazide diuretics. The diagnosis is generally based on symptoms and supported by
Lithium_toxicity
Study of the physiology of the kidney
passive transport reabsorption in response to PTH and ↑ reabsorption with Thiazide Diuretics. – Magnesium Calcium and magnesium compete, and an excess of
Renal_physiology
Insufficient potassium in the blood
Blood pressure medications such as loop diuretics (e.g. furosemide) and thiazide diuretics (e.g., hydrochlorothiazide) commonly cause hypokalemia. Other
Hypokalemia
Abnormal amount of lipids in the blood
higher risk. Some medications that may contribute to dyslipidemia are thiazide diuretics, beta blockers, oral contraceptives, atypical antipsychotics
Dyslipidemia
High calcium (Ca2+) level in the blood serum
Hyperthyroidism Multiple myeloma Prolonged immobilisation Paget's disease Thiazide use Vitamin A intoxication Tertiary hyperparathyroidism Aluminium intoxication
Hypercalcaemia
Loop diuretic medication
Glutamate metabolism/transport modulators v t e Symporter inhibitors Na+-Cl− Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide
Furosemide
Medical condition
infarction, sepsis) Certain medications (glucocorticoids, beta-blockers, thiazide diuretics, calcium channel blockers, and phenytoin) HHS is usually precipitated
Hyperosmolar hyperglycemic state
Hyperosmolar_hyperglycemic_state
When dysfunction of the kidneys or heart induces dysfunction in the other
typically involves fluid removal, primarily through loop diuretics, with thiazides as adjuncts for diuretic resistant cases. Ultrafiltration is reserved
Cardiorenal_syndrome
Burning of the skin by the sun's radiation
phenothiazines, psoralens, retinoids, sulfonamides, sulfonylureas, tetracyclines, thiazides, and vinblastine. Photoallergic reactions: Uncommon immunological response
Sunburn
Pharmaceutical drug
diabetes drugs Penicillin G Phenobarbital Spironolactone Tetracycline Thiazide-type diuretic pills Thyroid medication Warfarin Leflunomide Most interactions
Colestyramine
Medication
besilate salt, a dihydropyridine calcium channel blocker; and indapamide, a thiazide-like diuretic. The combination telmisartan/amlodipine/indapamide was approved
Telmisartan/amlodipine/indapamide
Telmisartan/amlodipine/indapamide
Endocrine disorder of a lack of the hormone aldosterone
can prove a problem in these patients, so often a diuretic (such as the thiazide diuretic, bendrofluazide, or a loop diuretic, such as furosemide) is used
Hypoaldosteronism
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