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Protein-coding gene in the species Homo sapiens
Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene. GRCh38: Ensembl release 89: ENSG00000185008 – Ensembl, May 2017 GRCm38:
ROBO2
Protein family
have three Robo receptors: Robo1, Robo2, and Robo3. In vertebrates, four Robo receptors have been identified: Robo1, Robo2, Robo3/Rig-1, and Robo4/Magic Roundabout
Roundabout_family
In vertebrates, there are four different Robos and three Slits: Robo1, Robo2, Robo3/Rig-1, and Robo4, and Slit1, Slit2, Slit3. There are three Robos
Slit-Robo
length (bases) Longest Intron length (bases) Number of introns in the gene ROBO2 1,743,269 1,160,411 104 KCNIP4 1,220,183 1,097,903 76 ASIC2 1,161,877 1
Split_gene_theory
Protein-coding gene in the species Homo sapiens
cell signaling, cell migration, and axon guidance. ROBO2 was found to interact with LRRC24. ROBO2 is a member of the Roundabout gene family, which are
LRRC24
Protein domain
PAPLN, PDGFRA, PRODH2, PTK7, PTPRD, PTPRF, PTPRS, PTPsigma, PUNC, ROBO1, ROBO2, ROBO3, ROBO4, ROR1, ROR2, SDK1, SDK2, SIGLEC1, SIGLEC6, SPEG, TRIO, TTN
Immunoglobulin_I-set_domain
Protein domain
PTPRM; PTPRO; PTPRS; PTPRT; PTPRU; PTPRZ1; PTPsigma; PUNC; RIMBP2; ROBO1; ROBO2; ROBO3; ROBO4; ROS1; SDK1; SDK2; SNED1; SORL1; SPEG; TEK; TIE1; TNC; TNN;
Fibronectin_type_III_domain
Type of cell within the eye
PMID 21521613. Thompson H, Andrews W, Parnavelas JG, Erskine L (November 2009). "Robo2 is required for Slit-mediated intraretinal axon guidance". Developmental
Retinal_ganglion_cell
DNA sequence that binds activators to increase the likelihood of gene transcription
(December 2022). "Characterization of enhancer fragments in Drosophila robo2". Fly. 16 (1): 312–346. bioRxiv 10.1101/2022.08.01.502399. doi:10.1080/19336934
Enhancer_(genetics)
Biological process
mice, the cortex exhibited decreased immunoreactivity. Nrp1, Robo1, and Robo2 have also been shown to be present and important in the development of interneurons
Development of the cerebral cortex
Development_of_the_cerebral_cortex
Protein-coding gene in the species Homo sapiens
with the ROBO3/Rig-1 receptor. It can also bind with ROBO2 under acidic conditions, where ROBO2 undergoes proteolytic cleavage. NELL2 expression has been
NELL2
French researcher (born 1967)
Eichmann, Anne; Chédotal, Alain (2015). "Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization". Nature Medicine. 21 (5): 483–491
Alain_Chédotal
Protein-coding gene in the species Homo sapiens
PMC 139241. PMID 12477932. Hivert B, Liu Z, Chuang CY, et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth". Mol. Cell
ROBO1
Q15287 13939 RO60 HGNC:11313; P10155 13940 ROBO1 HGNC:10249; Q9Y6N7 13941 ROBO2 HGNC:10250; Q9HCK4 13942 ROBO3 HGNC:13433; Q96MS0 13943 ROBO4 HGNC:17985;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Vertical talus, congenital; 192950; HOXD10 Vesicoureteral reflux 2; 610878; ROBO2 VEXAS; 301054; UBA1 Vitamin D-dependent rickets, type I; 264700; CYP27B1
List_of_OMIM_disorder_codes
, Roesener, A. P., Mendonca, P. R., & Mastick, G. S. (2011). Robo1 and Robo2 have distinct roles in pioneer longitudinal axon guidance. Dev Biol, 358(1)
Pioneer_axon
has two isoforms, 3.1 and 3.2, and these isoforms interact with Robo1 and Robo2 (Robo1/2) through cis interactions at the leading edge of the growth cone
Tropic cues involved in growth cone guidance
Tropic_cues_involved_in_growth_cone_guidance
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