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PRDM16

  • PRDM16
  • Protein-coding gene in the species Homo sapiens

    PR domain containing 16, also known as PRDM16, is a protein which in humans is encoded by the PRDM16 gene. PRDM16 acts as a transcription coregulator that

    PRDM16

    PRDM16

    PRDM16

  • Brown adipose tissue
  • Type of adipose tissue

    cultured with the transcription factor PRDM16 were converted into brown fat cells, and brown fat cells without PRDM16 were converted into muscle cells. Brown

    Brown adipose tissue

    Brown adipose tissue

    Brown_adipose_tissue

  • List of human transcription factors
  • ENSG00000141956 C2H2 ZF Known motif – In vivo/Misc source [734] DTGGAAHTCCMA PRDM16 ENSG00000142611 C2H2 ZF Inferred motif from similar protein – In vivo/Misc

    List of human transcription factors

    List_of_human_transcription_factors

  • Adipose tissue
  • Loose connective tissue composed mostly by adipocytes

    These include peroxisome proliferator-activated receptor gamma (PPARγ), PRDM16, peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α)

    Adipose tissue

    Adipose tissue

    Adipose_tissue

  • Adipocyte
  • Cells that primarily compose adipose tissue, specialized in storing energy as fat

    subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16". Nature Communications. 7 11533. Bibcode:2016NatCo...711533D. doi:10.1038/ncomms11533

    Adipocyte

    Adipocyte

    Adipocyte

  • TMED5
  • Protein-coding gene in the species Homo sapiens

    , & Arrowsmith, C. H. (2019). Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids

    TMED5

    TMED5

    TMED5

  • Gene therapy
  • Medical technology

    disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1". Nature Medicine. 12 (4): 401–409. doi:10.1038/nm1393. PMID 16582916

    Gene therapy

    Gene therapy

    Gene_therapy

  • SETBP1
  • Protein-coding gene in the species Homo sapiens

    disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1". Nature Medicine. 12 (4): 401–9. doi:10.1038/nm1393. PMID 16582916

    SETBP1

    SETBP1

    SETBP1

  • Corey Harwell
  • American neuroscientist

    Christopher A.; Harwell, Corey C. (July 11, 2018). "The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position". Neuron

    Corey Harwell

    Corey_Harwell

  • Wiskott–Aldrich syndrome
  • Medical condition

    "Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16". Leukemia. 22 (8): 1519–1528. doi:10.1038/leu.2008.118. PMID 18496560.

    Wiskott–Aldrich syndrome

    Wiskott–Aldrich syndrome

    Wiskott–Aldrich_syndrome

  • Chronic granulomatous disease
  • Hereditary disease group

    disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1". Nature Medicine. 12 (4): 401–9. doi:10.1038/nm1393. PMID 16582916

    Chronic granulomatous disease

    Chronic granulomatous disease

    Chronic_granulomatous_disease

  • List of human protein-coding genes 6
  • Q9H4Q3 12776 PRDM14 HGNC:14001; Q9GZV8 12777 PRDM15 HGNC:13999; P57071 12778 PRDM16 HGNC:14000; Q9HAZ2 12779 PRDX1 HGNC:9352; Q06830 12780 PRDX2 HGNC:9353;

    List of human protein-coding genes 6

    List_of_human_protein-coding_genes_6

  • Bruce M. Spiegelman
  • American biochemist and cell biologist

    cells to produce brown fat. Spiegelman and colleagues later identified PRDM16 as a crucial factor in brown fat development and the browning of white fat

    Bruce M. Spiegelman

    Bruce_M._Spiegelman

  • Mir-133 microRNA precursor family
  • RNA family

    miR-133a is down regulated in diabetic cardiomyopathy. miR-133 suppresses Prdm16 expression in skeletal muscle stem cells (satellite cells), which controls

    Mir-133 microRNA precursor family

    Mir-133 microRNA precursor family

    Mir-133_microRNA_precursor_family

  • CTBP2
  • Protein-coding gene in the species Homo sapiens

    been found to be important in fat biology, binding to key proteins such as PRDM16, NRIP, and FOG2. The full functional roles of CtBP proteins in mammals have

    CTBP2

    CTBP2

    CTBP2

  • SMIM23
  • Protein-coding gene in the species Homo sapiens

    type XVII, alpha 1. This may play a role in overall protein structure. PRDM16 binds to DNA and acts as a transcriptional regulator. It functions in the

    SMIM23

    SMIM23

  • Super-enhancer
  • Region of a genome which regulates expression of genes related to cell identity

    MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, et al. (April 2014). "Prdm16 is required for the maintenance of brown adipocyte identity and function

    Super-enhancer

    Super-enhancer

    Super-enhancer

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