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See searches and references containing POLYCYSTIN 2!POLYCYSTIN 2
Protein and coding gene in humans
Polycystin-2 (PC2) is a protein that in humans is encoded by the PKD2 gene. The gene PKD2 also known as TRPP2, encodes a member of the polycystin protein
Polycystin_2
Topics referred to by the same term
Polycystin refers to one of the following proteins: Polycystin-1 (PKD1) Polycystin-2 (PKD2) Polycystine This disambiguation page lists articles associated
Polycystin
Family of transport proteins
Polycystin 1 (PC1) is a protein that in humans is encoded by the PKD1 gene. Mutations of PKD1 are associated with most cases of autosomal dominant polycystic
Polycystin_1
Group of membrane proteins that passively export cations out of a cell
The Polycystin Cation Channel (PCC) Family (TC# 1.A.5) consists of several transporters ranging in size from 500 to over 4000 amino acyl residues (aas)
Polycystin cation channel family
Polycystin_cation_channel_family
American biologist and academic (born 1952)
membrane ion channels. Recent research investigates the function of polycystin-2, the inositol trisphosphate receptor, and the ryanodine receptor. Ehrlich
Barbara_E._Ehrlich
Mammalian protein
cilia of epithelial cells and co-localizes with the Pkd2 gene product polycystin-2 (PC2), suggesting that these two proteins may function in a common molecular
Fibrocystin
Congenital disorder of urinary system
formation are tied to abnormal cilia-mediated signaling. The polycystin-1 and polycystin-2 proteins appear to be involved in both autosomal dominant and
Polycystic_kidney_disease
Protein-coding gene in the species Homo sapiens
that in humans is encoded by the PKD2L1 gene. TRPP2 is a member of the polycystin protein family. TRPP2 contains multiple transmembrane domains, and cytoplasmic
PKD2L1
Pluripotent stem cell generated directly from a somatic cell
JL, Iatrino R, Su X, Koon SJ, et al. (October 2013). "Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients
Induced_pluripotent_stem_cell
Chemical compound
putative target proteins of triptolide have been reported, including polycystin-2, ADAM10, DCTPP1, TAB1, and XPB. Multiple triptolide-resistant mutations
Triptolide
Medical condition
suggested to lead to cystogenesis include a germline mutation in one of the polycystin gene alleles, a somatic second hit that leads to the loss of the normal
Autosomal dominant polycystic kidney disease
Autosomal_dominant_polycystic_kidney_disease
Family of transport proteins
disease 1 (PKD1)-like, contains polycystin-1 (Previously known as TRPP1), PKDREJ, PKD1L1, PKD1L2, and PKD1L3. Polycystin-1 contains numerous N-terminal
TRPP
Protein-coding gene in the species Homo sapiens
"Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5): 637–43
CNTRL
Runping; Lin, Fang; Huang, Chou-Long (August 2022). "Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic
Jianjie_Ma
Shibazaki, Sekiya; Somlo, Stefan (1 April 2006). "Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif". Journal
RVxP_motif
Lebanese physician
caused by a primary defect in vascular polycystin-1. In collaborative studies, he also showed that polycystin-2, the other gene product defective in ADPKD
M._Amin_Arnaout
Protein
adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2". J. Biol. Chem. 275 (42): 32888–93. doi:10.1074/jbc
CD2AP
Protein-coding gene in humans
"Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". The Journal of Cell Biology
PCNT
Protein-coding gene in the species Homo sapiens
"Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5): 637–43
IFT20
Protein domain
domain was first identified in the polycystic kidney disease protein, polycystin-1 (PKD1 gene), and contains an Ig-like fold consisting of a beta-sandwich
PKD_domain
Precursor microRNA family
EM, Wessely O (2010). "The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity". Development. 137 (7):
Mir-17 microRNA precursor family
Mir-17_microRNA_precursor_family
Protein-coding gene in the species Homo sapiens
PY, Wu G, Chen XZ (Jan 2003). "Polycystin-2 interacts with troponin I, an angiogenesis inhibitor". Biochemistry. 42 (2): 450–7. doi:10.1021/bi0267792
Troponin I, fast skeletal muscle
Troponin_I,_fast_skeletal_muscle
Protein
C5orf28 [8] TimeTree Data on Date of Divergence Valentine, Megan Smith, "Polycystin-2 (PKD2), Eccentric (XNTA), and Meckelin (MKS3) in the Ciliated Model Organism
TMEM267
Protein-coding gene in the species Homo sapiens
Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS
TRPP3
Protein-coding gene in the species Homo sapiens
Hussain Z, et al. (November 2006). "Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin". Human Molecular Genetics
KIF3B
Protein-coding gene in humans
novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699
Protein_chibby_homolog_1
Protein family
K (2005). "Cellular and molecular function of mucolipins (TRPML) and polycystin 2 (TRPP2)". Pflügers Arch. 451 (1): 277–85. doi:10.1007/s00424-005-1469-4
TRPML
German-American molecular biologist and academic
Clinic Shillingford, Jonathan M. (2006). "The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney
Thomas_Weimbs
Human chromosome
tyrosine-(Y)-phosphorylation regulated kinase 1A EPCIP: encoding exosomal polycystin-1-interacting protein ERG: encoding protein transcriptional regulator
Chromosome_21
Type of ion channel transmembrane protein
5-triphosphate receptor Ca2+ channels, transient receptor potential Ca2+ channels, polycystin cation channels, glutamate-gated ion channels, calcium-dependent chloride
Voltage-gated_ion_channel
Protein family
Hofmann K, Bork P (August 1999). "A latrophilin/CL-1-like GPS domain in polycystin-1". Curr. Biol. 9 (16): R585–8. doi:10.1016/S0960-9822(99)80379-0. PMID 10469603
Zinc-dependent phospholipase C
Zinc-dependent_phospholipase_C
Pore-forming membrane protein
homology: classical (TRPC), vanilloid receptors (TRPV), melastatin (TRPM), polycystins (TRPP), mucolipins (TRPML), and ankyrin transmembrane protein 1 (TRPA)
Ion_channel
Class of transport proteins
Mendes S, Gühmann M, et al. (December 2018). "Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance". eLife
Transient receptor potential channel
Transient_receptor_potential_channel
Genetic disease resulting in abnormal formation or function of cilia
is ADPKD, which is caused by mutations in PKD1 and PKD2, encoding polycystin-1 and -2, respectively. These proteins are essential for the mechanosensory
Ciliopathy
Agent that interferes with action at the vasopressin receptors
reduction in portal pressure and a decreased risk of variceal bleeding. Polycystin defects increase intracellular cAMP, secondary messenger for vasopressin
Vasopressin receptor antagonist
Vasopressin_receptor_antagonist
Medical condition
collecting ducts and cholangiocytes of bile ducts, and show similarity to polycystins and several other ciliopathy proteins. FPC is also found to be expressed
Autosomal recessive polycystic kidney disease
Autosomal_recessive_polycystic_kidney_disease
Calcium-dependent cell adhesion molecule
hdl:1765/56571. PMID 10931041. S2CID 3083613. Wilson PD (April 2001). "Polycystin: new aspects of structure, function, and regulation" (PDF). Journal of
Cadherin
Classification of membrane proteins including ion channels
channel family 1.A.4 Transient receptor potential Ca2+ channel family 1.A.5 Polycystin cation channel family 1.A.6 Epithelial Na+ channel family 1.A.7 ATP-gated
Transporter Classification Database
Transporter_Classification_Database
Protein domain
032. PMID 19439262. S2CID 17409821. Drickamer K (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol. Progress in
C-type_lectin
Human protein-coding gene
doi:10.1016/S0959-8049(00)00158-1. PMID 10959047. Wilson PD (April 2001). "Polycystin: new aspects of structure, function, and regulation". Journal of the American
Cadherin-1
Type of membrane proteins
superfamily: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), TRPA (ankyrin), and TRPN (NOMPC-like). TRP proteins
Mechanosensitive_channels
Mammalian protein found in humans
Communications. 268 (2): 243–248. Bibcode:2000BBRC..268..243K. doi:10.1006/bbrc.1999.1860. PMID 10679188. Wilson PD (April 2001). "Polycystin: new aspects of
Catenin_beta-1
Protein-coding gene
regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway". Human Molecular Genetics. 18 (1): 151–63. doi:10
Folliculin
Protein-coding gene in the species Homo sapiens
gene encodes a highly conserved protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting
LOXHD1
Protein-coding gene in the species Homo sapiens
Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96
RGS7
Protein-coding gene in the species Homo sapiens
Exosomal polycystin-1-interacting protein is a protein that, in humans, is encoded by the EPCIP gene. EPCIP is found on human chromosome 21, and it is
EPCIP_(gene)
Protein-coding gene in the species Homo sapiens
are the obligate site of action for proteins such as Hedgehog, and the polycystins: by influencing ciliary stability, NEDD9 is positioned to affect these
NEDD9
Mammalian protein found in Homo sapiens
doi:10.1016/S0959-8049(00)00158-1. PMID 10959047. Wilson PD (April 2001). "Polycystin: new aspects of structure, function, and regulation". Journal of the American
Plakoglobin
Protein-coding gene in the species Homo sapiens
conserved signal and GTPase complex are required for the ciliary transport of polycystin-1". Molecular Biology of the Cell. 22 (18): 3289–3305. doi:10.1091/mbc
ARF4
Protein family
nonmechanoreceptor potential C (nonpC), and the more distant cousins, the polycystins and mucolipins. A representative list of members belonging to the TRP-CC
Transient receptor potential calcium channel family
Transient_receptor_potential_calcium_channel_family
Protein-coding gene in the species Homo sapiens
as: LRR_8 (leucine-rich repeat), LRR_RI (ribonuclease inhibitor), PCC (polycystin cation channel protein) Super family, and Ig (immunoglobulin). The predicted
ISLR
British botanist and artist (1799–1872)
photographs of her drawings were included in Figures of Remarkable Forms of Polycystins, or Allied Organisms, in the Barbados Chalk deposit in 1860–1861, followed
Priscilla_Susan_Bury
POLYCYSTIN 2
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