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1991 book by Alexander Shulgin and Ann Shulgin
PiHKAL: A Chemical Love Story, also known as Phenethylamines I Have Known and Loved, is a book by Alexander Shulgin and Ann Shulgin published in 1991.
PiHKAL
Scale for reporting subjective effects of psychoactive substances
Pharmacology. It was later described in the Shulgins' popular 1991 book PIHKAL: A Chemical Love Story. MINUS, n. (−) On the quantitative potency scale
Shulgin_Rating_Scale
American chemist and recreational drug explorer (1925–2014)
psychedelics in the scientific literature for decades, before publishing his books PiHKAL: A Chemical Love Story (Phenethylamines I Have Known and Loved) in 1991
Alexander_Shulgin
Class of organic chemical compounds
homologues. "Erowid Online Books : "PIHKAL" - #100 MDA". "Erowid Online Books : "PIHKAL" - #109 MDMA". "Erowid Online Books : "PIHKAL" - #106 MDE". v t e
Phenylacetones
Pharmaceutical compound
benzene ring and hence has a dihydroindene ring system. In his 1991 book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
2C-G-3
Pharmaceutical compound
and DOx families. It is one of the Aleph series of compounds. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph-6's
Aleph-6
1997 book by Alexander Shulgin and Ann Shulgin
is a sequel to PiHKAL: A Chemical Love Story (Phenethylamines I Have Known and Loved) (1991). TiHKAL, much like its predecessor PiHKAL, is divided into
TiHKAL
Pharmaceutical compound
DOx families. It is one of several homologues of Ganesha (G). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
G-4_(drug)
Pharmaceutical compound
(2-MeO-3,4-MDA). MMDA-3b was included as an entry in Alexander Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved). He lists its dose as greater than
MMDA-3b
Psychedelic and entactogen
homologue of MDA, and the N-desmethyl homologue of FLEA (MDMOH). In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin listed the dose
3,4-Methylenedioxy-N-hydroxyamphetamine
3,4-Methylenedioxy-N-hydroxyamphetamine
Pharmaceutical compound
1977 and was documented in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). In his book PiHKAL (Phenethylamines I Have Known and Loved)
2C-E
Chemical compound
(MDA). ALPHA was first synthesized by Alexander Shulgin. In his book PIHKAL on the MDA page, the threshold dosage is listed as 10 mg. At mild threshold
ALPHA_(drug)
Pharmaceutical compound
Shulgin in PiHKAL in 1991. DOx (psychedelics) TWEETIO § DOx compounds EME, MEE, and EEE Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical
EEM_(drug)
Pharmaceutical compound
by Shulgin in PiHKAL in 1991. Scaline 2-Thioisomescaline 4-Thioisomescaline Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love
3-Thioisomescaline
Pharmaceutical compound
4-thioasymbescaline (4-TASB) and 5-thioasymbescaline (5-TASB). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
3-Thioasymbescaline
Psychedelic drug
psychedelics and is one of the most widely used designer drugs. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
2C-B
Pharmaceutical compound
groups on the phenyl ring have been replaced with ethoxy groups. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
Trisescaline
Naturally occurring psychedelic compound
well-tolerated due to side effects like severe nausea and vomiting. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin listed a dose
Mescaline
Psychedelic drug
amphetamine (α-methyl) derivative of 2C-G. The drug is taken orally. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Ganesha's
Ganesha_(psychedelic)
Pharmaceutical compound
homologues, which are known as the 2C-G series of compounds. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists 2C-G's
2C-G
Pharmaceutical compound
and DOx families. It is one of the Aleph series of compounds. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph-4's
Aleph-4
Class of chemical compounds
1021/acsmedchemlett.5c00269 PMID 40529051 "4C-C - PiHKAL·info". Isomer Design. 12 June 2025. Retrieved 1 March 2026. "4C-E - PiHKAL·info". Isomer Design. 12 June 2025
4C_(psychedelics)
Entactogen drug
is a psychedelic and entactogen of the amphetamine family. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MMDA's
MMDA_(drug)
Pharmaceutical compound
2C-G-5 was encountered online as a novel designer drug in 2025. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
2C-G-5
Pharmaceutical compound
Alexander Shulgin in 1963 and was later further described in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). The drug caused a small public
2,5-Dimethoxy-4-methylamphetamine
2,5-Dimethoxy-4-methylamphetamine
Psychoactive drug, often called ecstasy
- Isomer Design MDMA - PsychonautWiki MDMA - Erowid MDMA - PiHKAL - Erowid MDMA - PiHKAL - Isomer Design A Multi-Site Phase 3 Study of MDMA-Assisted
MDMA
Psychedelic phenthylamine drug
them in 1991, including in Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved). In his book PiHKAL (Phenethylamines I Have Known and Loved)
2C-T-7
Pharmaceutical compound
is a drug. It is the N-cyclopropylmethyl derivative of MDMA. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MDCPM's
Methylenedioxycyclopropylmethylamphetamine
Methylenedioxycyclopropylmethylamphetamine
Pharmaceutical compound
second benzene ring and hence has a 2-naphthalene ring system. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
2C-G-N
Hallucinogenic class of psychoactive drug
well as entactogens in scientific publications and published books such as PiHKAL (1991) and TiHKAL (1997). Notable major examples of these drugs have included
Psychedelic_drug
Pharmaceutical compound
compound was included by Alexander Shulgin as an entry in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). However, Shulgin was unable to
2C-G-4
N-(2C-B)-Fentanyl | PiHKAL · info". isomerdesign.com. "Explore N-(2C-C)-Fentanyl | PiHKAL · info". isomerdesign.com. "Explore N-(2C-D)-Fentanyl | PiHKAL · info".
List_of_designer_drugs
Pharmaceutical compound
Shulgin in PiHKAL in 1991. It is a controlled substance in Canada under phenethylamine blanket-ban language. In Alexander Shulgin's book PiHKAL (Phenethylamines
G-N_(drug)
Psychedelic drug
described in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). Alexander Shulgin listed the dose of DMMDA in his book PiHKAL (Phenethylamines I Have
DMMDA
Group of psychedelic drugs
and tested by Alexander Shulgin and were reported by him in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). All three of the HOT-x drugs produce
HOT-x
Pharmaceutical compound
first described by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). He shared in PiHKAL that he had had Juno on a shelf in his lab
Juno_(psychedelic)
Pharmaceutical compound
literature by Shulgin in PiHKAL in 1991. DOx (psychedelics) MEM § Derivatives Buscaline Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story
MBM_(drug)
Chemical compound
PiHKAL. "Antimicrobial/antifungal compositions". Plant Cell Research Institute, Inc., Dublin, Calif. 1989-10-24. Shulgin A, Shulgin A (1991). Pihkal:
Pseudodillapiole
Species of psychoactive cactus
5281/zenodo.6409376. Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5
Peyote
Pharmaceutical compound
(α-methylated) analogue of mescaline (3,4,5-trimethoxyphenethylamine). In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists TMA's
3,4,5-Trimethoxyamphetamine
Family of phenethylamine psychedelics
Alexander Shulgin in the 1970s and 1980s and were reviewed in his 1991 book PiHKAL (Phenethylamines I Have Known And Loved). 2C-B is the most popular of the
2C_(psychedelics)
Pharmaceutical compound
methylenedioxyphenethylamines. According to Alexander Shulgin in his book «PiHKAL» ( «Phenethylamines I Knew and Loved») GAMMA had a rather unique effect:
GAMMA_(drug)
Pharmaceutical compound
4 position have been replaced with the deuterium isotopes. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
4-D_(psychedelic)
Entactogen drug
phenethylamine, phenylisobutylamine, and MDxx families related to MDMA. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists BDB's
1,3-Benzodioxolylbutanamine
Chemical compound
entactogens such as MDMA ("ecstasy"). According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved), MDPEA was inactive at doses of
3,4-Methylenedioxyphenethylamine
3,4-Methylenedioxyphenethylamine
Pharmaceutical compound
positional isomer of 3,4,5-trimethoxyamphetamine (TMA or TMA-1). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
2,3,5-Trimethoxyamphetamine
Index of chemical compounds with the same name
psychedelic cactus alkaloid mescaline. Some of them are described in the book PiHKAL by Alexander Shulgin and Ann Shulgin. 2,3,4,5-Tetramethoxyphenethylamine
Tetramethoxyphenethylamine
Stimulant drug
substituted benzylamine group. It was reported by Alexander Shulgin in his book PIHKAL as a positional isomer of MDMA. Subsequently, the drug was encountered as
M-ALPHA
Pharmaceutical compound
drug of the phenethylamine, amphetamine, and DOx families. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists DOEF's
2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine
2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine
Pharmaceutical compound
DOx families. It is one of several homologues of Ganesha (G). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
G-3_(drug)
Pharmaceutical compound
, 4-substituted-2,5-dimethoxyamphetamine) series of drugs. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists TMA-2's
2,4,5-Trimethoxyamphetamine
Pharmaceutical compound
positional isomers, the other being 4-thiomescaline (4-TM). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
3-Thiomescaline
Chemical compound
been encountered as a novel designer drug. Alexander Shulgin reported in PiHKAL (Phenethylamines I Have Known and Loved) and other publications that lophophine
Lophophine
Pharmaceutical compound
replaced with an ethoxy group. According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CI-2-EtO's
2CI-2-EtO
Psychoactive drug
is also more distantly related to methylone (β-keto-MDMA). In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists BOH's
BOH_(drug)
Pharmaceutical compound
replaced with an ethoxy group. According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT-2-EtO's
2CT-2-EtO
Pharmaceutical compound
became a controlled substance in the United States in 2012. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
2C-D
Pharmaceutical compound
MDxx families. It is the N-methoxyethyl derivative of MDA. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MDMEOET's
Methylenedioxymethoxyethylamphetamine
Methylenedioxymethoxyethylamphetamine
Pharmaceutical compound
and 5 positions have been replaced with methylthio groups. In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
Bis-TOM
Pharmaceutical compound
group at the 5 position has been replaced with an ethoxy group. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MME's
MME_(drug)
Class of chemical compounds
methylenedioxyphenethylamines Substituted phenethylamines Substituted tryptamines PiHKAL The Shulgin Index Daniel Trachsel; David Lehmann & Christoph Enzensperger
DOx
Drug-like effect from proximity to drug users
a person who has inhaled secondhand smoke. In Alexander Shulgin's book PiHKAL, under the 2C-I entry, a notable reaction was observed in a participant
Contact_high
Pharmaceutical compound
N-isopropyl analogue of 3,4-methylenedioxyamphetamine (MDA). In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MDIP's
3,4-Methylenedioxy-N-isopropylamphetamine
3,4-Methylenedioxy-N-isopropylamphetamine
Pharmaceutical compound
Shulgin in PiHKAL in 1991. DOx (psychedelics) TWEETIO § DOx compounds EEM, MEE, and EEE Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical
EME_(drug)
Pharmaceutical compound
TMA with an ethyl group at the α position of the side chain. In his book PiHKAL, Alexander Shulgin lists AEM's dose as greater than 220 mg orally and its
Α-Ethylmescaline
Chemical compound
it was described in greater detail by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). DOI has been encountered as a
2,5-Dimethoxy-4-iodoamphetamine
2,5-Dimethoxy-4-iodoamphetamine
Pharmaceutical compound
literature by Shulgin in PiHKAL in 1991. DOx (psychedelics) MEM § Derivatives DOAM Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story
MAM_(drug)
Pharmaceutical compound
groups on the phenyl ring have been replaced with ethoxy groups. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists EEE's
EEE_(drug)
American author (1931–2022)
and the wife of chemist Alexander Shulgin, with whom she wrote the books PiHKAL (Phenethylamines I Have Known and Loved) and TiHKAL (Tryptamines I Have
Ann_Shulgin
Pharmaceutical compound
by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved) in 1991. In his book PiHKAL (Phenethylamines I Have Known and Loved)
2C-P
Pharmaceutical compound
positional isomer of 3,4,5-trimethoxyamphetamine (TMA or TMA-1). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
2,3,4-Trimethoxyamphetamine
Pharmaceutical compound
drug is also the α-methyl or amphetamine analogue of 2C-O-7. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MPM's
MPM_(drug)
Pharmaceutical compound
Shulgin and was described in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). In his book PiHKAL (Phenethylamines I Have Known and Loved)
2C-N
Chemical compound
Administration. Retrieved 2024-04-12. MDE (MDEA) - Isomer Design MDEA - PsychonautWiki MDE - Erowid MDE - PiHKAL - Erowid MDE - PiHKAL - Isomer Design
3,4-Methylenedioxy-N-ethylamphetamine
3,4-Methylenedioxy-N-ethylamphetamine
Pharmaceutical compound
antidepressant-like effects and improved safety relative to MDMA in 2026. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MDDMA's
MDDMA
Pharmaceutical compound
the 4 position has been replaced with a phenylethoxy group. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists phenescaline's
Phenescaline
Pharmaceutical compound
DOx families. It is one of several homologues of Ganesha (G). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
G-5_(drug)
Pharmaceutical compound
2C-T-17 in greater detail in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). In his book PiHKAL (Phenethylamines I Have Known and Loved)
2C-T-4
Pharmaceutical compound
3-thioasymbescaline (3-TASB) and 4-thioasymbescaline (4-TASB). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
5-Thioasymbescaline
Pharmaceutical compound
4-thiometaescaline (4-TME) and 5-thiometaescaline (5-TME). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
3-Thiometaescaline
Pharmaceutical compound
positional isomers, the other being 3-thiomescaline (3-TM). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
4-Thiomescaline
Pharmaceutical compound
of the MDxx psychedelic and entactogen MMDA (5-methoxy-MDA). In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MEDA's
MEDA
Amphetamine drug
Shulgin in PiHKAL in 1991. DOx (psychedelics) TWEETIO § DOx compounds EEM, EME, and EEE Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical
MEE_(drug)
Pharmaceutical compound
positional isomers, the other being 3-thioescaline (3-TE). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
4-Thioescaline
Pharmaceutical compound
by Shulgin in PiHKAL in 1991. Scaline 3-Thiometaescaline 4-Thiometaescaline Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love
5-Thiometaescaline
Pharmaceutical compound
and DOx families. It is one of the Aleph series of compounds. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph's
Aleph_(psychedelic)
Pharmaceutical compound
Shulgin in PiHKAL in 1991. DOx (psychedelics) TWEETIO § DOx compounds MEM and MME Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical
EMM_(drug)
Pharmaceutical compound
Subsequent, it was further described by Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) in 1991. Substituted methoxyphenethylamine
MAPEA
Chemical class of organic compounds
(September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. 2C-O-4 Entry in PiHKAL Custodio RJ
Substituted_phenethylamine
Pharmaceutical compound
a psychoactive drug of the phenethylamine and 2C families. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists 2C-T-15's
2C-T-15
Pharmaceutical compound
group at the 5 position has been replaced with an ethoxy group. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Iris's
Iris_(drug)
Pharmaceutical compound
was encountered as a novel designer drug in Europe in 2023. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph-2's
Aleph-2
Pharmaceutical compound
80 mg orally and its duration as 10 to 16 hours in Alexander Shulgin's book PiHKAL (Phenethylamines I Have Known and Loved). A higher dose of 100 mg was also
MMDA-3a
Pharmaceutical compound
N-propargyl-MDA, is a lesser-known drug and a substituted amphetamine. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MDPL's
3,4-Methylenedioxy-N-propargylamphetamine
3,4-Methylenedioxy-N-propargylamphetamine
Pharmaceutical compound
lesser-known psychoactive drug and a substituted amphetamine. In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MDPR's
3,4-Methylenedioxy-N-propylamphetamine
3,4-Methylenedioxy-N-propylamphetamine
Drug that increases alertness
is now called microdosing.144 Alexander T. Shulgin, Ann Shulgin (1991). PiHKAL: A Chemical Love Story (1st ed.). Berkeley, CA: Transform Press. ISBN 978-0-9630096-0-9
Stimulant
Pharmaceutical compound
replaced with a sulfur atom. According to Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved), a 4T-MMDA-2 dose of 25 mg orally
4T-MMDA-2
Pharmaceutical compound
other being 3-thiotrisescaline (3-T-TRIS; 3-thiotrescaline). In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander
4-Thiotrisescaline
Pharmaceutical compound
2C-T-17 in greater detail in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). In his book PiHKAL (Phenethylamines I Have Known and Loved)
2C-T-17
Chemical compound
described the effects of DOB in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). In his book PiHKAL (Phenethylamines I Have Known and Loved)
2,5-Dimethoxy-4-bromoamphetamine
2,5-Dimethoxy-4-bromoamphetamine
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