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Organic compound
Phthalimide is the organic compound with the formula C6H4(CO)2NH. It is the imide derivative of phthalic anhydride. It is a sublimable white solid that
Phthalimide
Chemical compound
Potassium phthalimide is a chemical compound of formula C8H4KNO2. It is the potassium salt of phthalimide, and usually presents as fluffy, very pale yellow
Potassium_phthalimide
Method for the synthesis of primary amines
halides into primary amines. Traditionally, the reaction uses potassium phthalimide. The reaction is named after the German chemist Siegmund Gabriel. The
Gabriel_synthesis
Chemical compound
Potassium phthalimide is commercially available and is the potassium salt of phthalimide. It may be prepared by adding a hot solution of phthalimide to a solution
Phthalic_anhydride
Class of chemical compounds
bases such as potassium hydroxide. The conjugate base of phthalimide is potassium phthalimide. These anion can be alkylated to give N-alkylimides, which
Imide
Chemical compounds used to kill fungi
and copper salts) vs organic, chemical structures (dithiocarbamates vs phthalimides), and, most successfully, mechanism of action (MOA). These respective
Fungicide
Chemical compound
IUPAC name 3-Iminoisoindol-1-amine Other names Isoindoline-1,3-diimine; Phthalimide diimide Identifiers CAS Number 3468-11-9 3D model (JSmol) Interactive
Diiminoisoindole
Chemical compound
Captan is a general use pesticide (GUP) that belongs to the phthalimide class of fungicides. It is a white solid, although commercial samples appear yellow
Captan
Colorless flammable liquid with an ammonia-like odor
Hydrazine is used to cleave N-alkylated phthalimide derivatives. This scission reaction allows phthalimide anion to be used as amine precursor in the
Hydrazine
Chemical compound
It features the sulfenamide functional group, being a derivative of phthalimide and cyclohexanethiol. In the production of synthetic rubber, CTP impedes
Cyclohexylthiophthalimide
Chemical compound
formula C6H4(CO)2NOH. A white or yellow solid, it is a derivative of phthalimide. The compound is used as a catalyst in the synthesis of other organic
N-Hydroxyphthalimide
Chemical compound
compound with the formula C6H4(CO)2NSCCl3. It is a fungicide derived from phthalimide (C6H4(CO)2N-) and trichloromethylsulfenyl chloride. The compound is white
Folpet
Chemical compound
Sodium cyclamate Steviol glycoside Sugar substitute Sucralose Xylitol Phthalimide "Saccharin". PubChem, US National Library of Medicine. 13 June 2023.
Saccharin
Chemical compound
γ-phthalimido-propylmalonic ester, and published the synthesis of proline from phthalimide propylmalonic ester. The name proline comes from pyrrolidine, one of
Proline
Small molecule (PROTAC)
GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders". ACS Chemical Biology. 13 (3): 553–560. doi:10.1021/acschembio
Proteolysis_targeting_chimera
Chemical compounds and groups containing nitrogen with a lone pair (:N)
Gabriel synthesis, which involves organohalide reacting with potassium phthalimide. Aryl halides are much less reactive toward amines and for that reason
Amine
Immunomodulatory drug which can cause birth defects
chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo. The process
Thalidomide
Chemical compound
is C37H24O6N2 and the molecular weight is 592.61 g/mol. It contains phthalimide and bisphenol A sub-units. The glass transition temperature of PEI is
Polyetherimide
Aromatic organic compound with formula C6H4(COOH)2
Isophthalic acid Terephthalic acid Related compounds Phthalic anhydride Phthalimide Phthalhydrazide Phthaloyl chloride Benzene-1,2- dicarboxaldehyde Except
Phthalic_acid
Chemical compound
a potential replacement for bromide, which is highly corrosive. The phthalimide functions by formation of the oxyl radical. Guanidine inhibits the oxidation
Terephthalic_acid
Organophosphate non-systemic insecticide
Phosmet is a phthalimide-derived, non-systemic, organophosphate insecticide used on plants and animals. It is mainly used on apple trees for control of
Phosmet
Type of chemical reaction
product a diacyl hydrazide. The preparation of anthranilic acid from phthalimide The conversion of Nicotinamide into 3-Aminopyridine A process for chemical
Hofmann_rearrangement
Chemical compound
2-(1-piperazinyl)pyrimidine (3). Treatment with the phthalimide derivative N-(2-bromoethyl)phthalimide (4) in an alkylation reaction produces (5), which
Adatanserin
Chemical reaction
potential anti-inflammatory agents. It has also been used in the study of phthalimide and saccharin derivatives as mechanism based inhibitors for three enzymes;
Gabriel–Colman_rearrangement
Pharmaceutical compound
or cyclohexane to give crystals of N-[1-(2,5-dimethoxyphenyl)-2-butyl]phthalimide with a melting point of 76–77 °C and an analysis (C20H21NO4) C,H,N. This
4C-I
Synthetic blue pigment from the group of phthalocyanine dyes
observed the formation of traces of phthalocyanine dyes in the synthesis of phthalimide by the reaction of phthalic anhydride and ammonia in the presence of
Copper_phthalocyanine
Group of chemical compounds derived from alkanes containing one or more halogens
Delepine reaction, by undergoing nucleophilic substitution with potassium phthalimide or hexamine respectively, followed by hydrolysis.[citation needed] In
Haloalkane
Chemical compound
+ HOCl → C6H4NH2CO2H + NaCl + CO2 A related method involves treating phthalimide with sodium hypobromite in aqueous sodium hydroxide, followed by neutralization
Anthranilic_acid
Chemical compound
non-dividing tumor cells. 4-Nitro-L-phenylalanine (1) was converted to its phthalimide by heating with phthalic anhydride, and this was converted to its ethyl
Melphalan
Medication used to treat glaucoma and dry mouth
Arndt–Eistert reaction with diazomethane then by treatment with potassium phthalimide and potassium thiocyanate. Pilocarpine is available under several brand
Pilocarpine
Chemical compound
During the reaction of 4-NPI with the sodium salt of bisphenol A, the bis(phthalimide) is formed, which is then hydrolyzed to the tetracarboxylic acid and
Bisphenol A bis(phthalic anhydride)
Bisphenol_A_bis(phthalic_anhydride)
Chemical compound
tautomerism and are therefore simpler to study. The commercially important phthalimide is an isoindole-1,3-dione with two carbonyl groups attached to the heterocyclic
Isoindole
Chemical compound
Maichle-Mössmer, Caecilia (2011-01-01). "Crystal structure of trimethylsulfoxonium phthalimide, [C3H9SO][C8H4NO2]". Zeitschrift für Kristallographie - New Crystal Structures
Trimethylsulfoxonium
Chemical compound
Pomalidomide, sold under the brand name Pomalyst among others, is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related
Pomalidomide
Medication for psoriasis and psoriatic arthritis
substance is found in the urine, and 7% in the feces. Apremilast is a phthalimide derivative. It is a white to pale yellow, nonhygroscopic powder that
Apremilast
Numbers, classes, and proper shipping names allocated to dangerous goods
in use) Phthalimide derivative pesticides, liquid, toxic, flammable (UN No. no longer in use) UN 3008 6.1 (UN No. no longer in use) Phthalimide derivative
List of UN numbers 3001 to 3100
List_of_UN_numbers_3001_to_3100
Chemical compound
of targeted protein degradation. For example, conjugation of JQ1 to phthalimide moieties such as that found in thalidomide recruits the E3 ubiquitin
JQ1
Class of chemical compounds
been discovered from the clinical use of roflumilast. Apremilast, a phthalimide derivative that was approved by the U.S. FDA in March 2014 for use as
PDE4_inhibitor
Numbers, classes, and proper shipping names allocated to dangerous goods
longer in use) Phthalimide derivative pesticides, solid, toxic, n.o.s. (UN No. no longer in use) UN 2774 ? (UN No. no longer in use) Phthalimide derivative
List of UN numbers 2701 to 2800
List_of_UN_numbers_2701_to_2800
Representation method in chemistry
the 1-benzotriazolyl group Im for the 1-imidazolyl group NPhth for the phthalimide-1-yl group Sulfonate esters are often leaving groups in nucleophilic
Skeletal_formula
Drug discovery
amine involved in a phthalimide protection group. Next, a phosgene equivalent is added to form the 2-oxazolidone ring and the phthalimide is removed. The
Discovery and development of direct Xa inhibitors
Discovery_and_development_of_direct_Xa_inhibitors
Food made especially for infants
known to be harmful to humans and bees, and captan, a fungicide of the phthalimide class that has been correlated to cancer. None of the organic baby foods
Baby_food
Chemical compound
Research Division during the 1970s, starting from the initial lead molecule phthalimide. Years later, the molecule was found to exhibit herbicidal activity.
Imazaquin
Protein in humans
Souza A, Dhe-Paganon S, Bradner JE (2015-06-19). "DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation". Science
Cereblon
Chemical compound
2-Amino-7-chloro-1,8-naphthyridine [15944-33-9] (2) with leads to the corresponding phthalimide. Selective reduction of one of the imide carbonyl groups give the corresponding
Pagoclone
Chemical compound
opening of the protected lactone (1), derived from erythrose with sodium phthalimide gives the acid 2; hydrazinolysis (cf Gabriel synthesis) then leads to
Eritadenine
Protein-coding gene in the species Homo sapiens
further analogs (see 3d model) Chromone-3-phenylcarboxamides Isatins Phthalimides 8-Benzyloxycaffeines and CSC analogs (E,E)-8-(4-phenylbutadien-1-yl)caffeines
Monoamine_oxidase_B
Chemical compound
citraconamic acid (HO2CCH2CH(CH3)C(O)NH2 and HO2CCH(CH3)CH2C(O)NH2), and phthalimide gives phthalamidic acid (HO2CC6H4C(O)NH2). Hood, David K. (2024). "Maleic
Maleamic_acid
Group of atoms introduced into a compound to prevent subsequent reactions
allyloxycarbonyl compounds. Other, more exotic amine protectors are the phthalimides, which admit reductive cleavage, and the trifluoroacetamides, which hydrolyze
Protecting_group
Class of pharmaceutical drugs
profile of a nonsteroidal antiandrogen N-(3,5-dimethyl-4-isoxazolylmethyl)phthalimide (DIMP)". Acta Endocrinologica. 72 (3): 604–614. doi:10.1530/acta.0.0720604
Antiandrogen
Chemical compound
β-lactams, indoles, heterocyclic compounds, N-substituted aromatic imides, phthalimides, and other similar compounds. Caesium carbonate and copper(II) chloride
Caesium_carbonate
Cancer cell line used in research
PAULO MICHEL; et al. (2015). "Cytotoxic and toxicological effects of phthalimide derivatives on tumor and normal murine cells" (PDF). Annals of the Brazilian
S180
Chemical compound
3-(1-piperidinylmethyl)phenol (3). Williamson ether synthesis with N-(3-bromopropyl)phthalimide (4) gives the intermediate 5. Deprotection with hydrazine yields
Roxatidine_acetate
Chemical compound
including phthalonitrile, diiminoisoindole, phthalic anhydride, and phthalimides. Alternatively, heating phthalic anhydride in the presence of urea yields
Phthalocyanine
Chemical compound
Phthalimidopropiophenone is a chemical intermediate used in the synthesis of cathinone. It has been found to be sold on the illicit market as a controlled
Phthalimidopropiophenone
Chemical compound
2-amino-7-chloro-1,8-naphthyridine with phthalic anhydride leads to the corresponding phthalimide. Selective reduction of one of the imide carbonyl groups in essence converts
Pazinaclone
Protein
Souza, Amanda; Dhe-Paganon, Sirano; Bradner, James E. (2015-06-19). "Phthalimide conjugation as a strategy for in vivo target protein degradation". Science
Ubiquitin_ligase
Index of chemical compounds with the same molecular formula
6-quinone, a chemical present in the browning reaction of fruits Isatin Phthalimide This set index page lists chemical structure articles associated with
C8H5NO2
Chemical compound
converted to an amino group via a Gabriel synthesis (with potassium phthalimide) followed by hydrazinolysis (Ing–Manske procedure). The final step is
Leonurine
Class of immunomodulatory drugs
"Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators". Bioorganic & Medicinal Chemistry. 14 (20):
Cereblon_E3_ligase_modulator
Withdrawn NSAID drug
2-(4-aminophenyl)propionic acid (2). Reaction with phthalic anhydride then gives the phthalimide (4). Treatment with zinc in acetic acid yields indoprofen after reduction
Indoprofen
Month of 1924
transforms primary alkyl halides into primary amines, using potassium phthalimide Walter Humphreys Sr., 74, English cricketer and umpire Sir William Macewen
March_1924
C8H5NOS benzoyl isothiocyanate 532-55-8 C8H5NO2 isatin 91-56-5 C8H5NO2 phthalimide 85-41-6 C8H5NO3 isatoic anhydride 118-48-9 C8H5N3 pyridinium dicyanomethylide
List of compounds with carbon number 8
List_of_compounds_with_carbon_number_8
Antimalarial drug
sidechain to give [106635-87-4 ] (9). Wolff-Kishner reduction of the phthalimide to the primary amine completed the synthesis of tafenoquine (10). Tafenoquine
Tafenoquine
Chemical compound
Naltalimide (INN; development code TRK-130, formerly TAK 363) is a novel, centrally-acting opioid drug which is under development by Takeda and Toray for
Naltalimide
German chemist (1851–1924)
synthesizes pure primary amines, involving the reaction of potassium phthalimide with an alkyl halide, followed by hydrolysis. The Gabriel Synthesis was
Siegmund_Gabriel
Type of DNA damage
isomers. A large variety of photosensitizers, such as benzophenones, phthalimides or fluoroquinolones, have been tested in order to study the requirements
Pyrimidine_dimer
Chemical compound
N',N′-Ethylenebis(tetrabromophthalimide) is a brominated flame retardant used as an additive in plastics and synthetic rubbers, including polyolefins,
N,N′-Ethylenebis(tetrabromophthalimide)
N,N′-Ethylenebis(tetrabromophthalimide)
Chemical reaction
"Tscherniac-Einhorn reaction. I. Equilibria in solutions of N-(hydroxymethyl)phthalimide in strong sulfuric acid", The Journal of Organic Chemistry, vol. 34,
Tscherniak-Einhorn_reaction
Chemical compound
Bavdegalutamide is an experimental proteolysis targeting chimera that functions as a androgen receptor degrader. It is being developed to treat metastatic
Bavdegalutamide
Chemical compound
Phthalimidoperoxycaproic acid (ε- or 6-(phthalimido)peroxyhexanoic acid, abbreviated as PAP) is a synthetic organic peroxy acid derived from caprolactam
Phthalimidoperoxycaproic_acid
Pharmaceutical compound
Press. ISBN 0-9630096-0-5. OCLC 25627628. "The treatment of the 2C-B phthalimide described above, with cuprous cyanide rather than cuprous chloride, gave
2C-CN
Scottish researcher
Pablo, J.J. Structural, Ionic, and Electronic Properties of Solid-State Phthalimide-Containing Polymers for All-Organic Batteries J. Am. Chem. Soc. Au 2024
Stuart_Rowan
Topics referred to by the same term
of sarin gas DIMP (antiandrogen) (N-(3,5-dimethyl-4-isoxazolylmethyl)phthalimide), a nonsteroidal antiandrogen Deoxyinosine monophosphate (dIMP) This
DIMP
Chemical compound
(developmental code name Ro 7-8117), or N-(3,5-dimethyl-4-isoxazolylmethyl)phthalimide, is a nonsteroidal antiandrogen (NSAA) structurally related to thalidomide
DIMP_(antiandrogen)
English crystallographer (1944–2014)
"Crystal and molecular structure of thalidomide, N-(α-glutarimido)-phthalimide". J. Chem. Soc. B: 1073–1079. "RCSB PDB Advisory Committee". RCSB PDB
Frank_Allen_(chemist)
nonahydrate) KladnoiteH (Y: 1942) 10.CA.25 [361] [362] [363] (IUPAC: phthalimide) Klajite (IMA2010-004) 8.CE.30 [364] [no] [no] (IUPAC: manganese tetracopper
List of minerals recognized by the International Mineralogical Association (K)
List_of_minerals_recognized_by_the_International_Mineralogical_Association_(K)
Pharmaceutical compound
Zelebrudomide (NX-2127) is an investigational new drug that is being evaluated by Nurix Therapeutics for the treatment of relapsed or refractory B-cell
Zelebrudomide
phthalocyanine was discovered by Scottish Dyes at Grangemouth, when investigating phthalimide. Its chemical structure was found in 1934 by Sir Patrick Linstead. These
Chemical industry in the United Kingdom
Chemical_industry_in_the_United_Kingdom
Chemical compound
ML-SA1 is a chemical compound which acts as an "agonist" (i.e. channel opener) of the TRPML family of calcium channels. It has mainly been studied for
ML-SA1
Chemical compound
NAN-190 is a drug and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT1A receptor antagonist
NAN-190
MeSH D02.241.223.805.800 – phthalic anhydrides MeSH D02.241.223.805.810 – phthalimides MeSH D02.241.223.805.810.800 – thalidomide MeSH D02.241.511.085 – benzilates
List_of_MeSH_codes_(D02)
Chemical compound
Dialifor (Torak) is an organophosphate pesticide. It is extremely poisonous. "Document Display | NEPIS | US EPA". nepis.epa.gov. Retrieved 26 August 2023
Dialifor
PHTHALIMIDE
PHTHALIMIDE
PHTHALIMIDE
PHTHALIMIDE
Boy/Male
Indian, Tamil
Strength of Lord Rama
Girl/Female
Gujarati, Hindu, Indian, Kannada, Marathi, Telugu
Beautiful
Boy/Male
Bengali, Hindu, Indian
Power; Energy; Goodness
Boy/Male
Hindu, Indian
Na Jalne Wala
Boy/Male
Christian & English(British/American/Australian)
Gardener
Boy/Male
Tamil
An ancient indian city
Girl/Female
Arabic
Of Silk
Boy/Male
Hindu
The Moon
Girl/Female
Greek American French Latin Irish English
Form of the Greek Catherine meaning 'pure'.
Boy/Male
Hindu
Leader of the devoted, Lord of devotees
PHTHALIMIDE
PHTHALIMIDE
PHTHALIMIDE
PHTHALIMIDE
PHTHALIMIDE
n.
An imido derivative of phthalic acid, obtained as a white crystalline substance, C6H4.(CO)2NH, which has itself (like succinimide) acid properties, and forms a series of salts. Cf. Imido acid, under Imido.