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Protein in humans
Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the
Cereblon
Class of immunomodulatory drugs
Cereblon E3 ligase modulators, also known as immunomodulatory imide drugs (IMiDs) or CELMoDs, are a class of immunomodulatory drugs (drugs that adjust
Cereblon_E3_ligase_modulator
Chemical compound
Mezigdomide is a cereblon E3 ligase modulator developed by Bristol Myers Squibb to treat multiple myeloma. Richardson, Paul G.; Trudel, Suzanne; Quach
Mezigdomide
Pair of enantiomers
belongs to a class of drugs known as immunomodulatory imide drugs (IMiDs) or Cereblon E3 ligase modulators, which includes thalidomide and its analogs. In lymphocytes
Lenalidomide
Chemical compound
Iberdomide (CC-220) is an experimental thalidomide analog that works as an cereblon E3 ligase modulator; it has a higher binding affinity than lenalidomide
Iberdomide
Immunomodulatory drug which can cause birth defects
in both their anti-cancer and teratogenic effects is now known to be as cereblon E3 ligase modulators. Thalidomide also binds to and acts as an antagonist
Thalidomide
Chemical compound
Avadomide (CC-122) is an experimental cereblon E3 ligase modulator, or thalidomide analog (molecular glue) that was discovered and studied by Celgene to
Avadomide
Class of pharmaceutical drug
Duncan AD, Mirza NQ, Jacques V, Dewitt S, Iyer SP (2022). "SP-3164, a Novel Cereblon-Binding Protein Degrader, Shows Activity in Preclinical Lymphoma Models"
Deuterated_drug
Class of chemical compounds
states. One example is lenalidomide (an immunomodulatory drug), which binds cereblon (CRBN) and reprograms it to degrade transcription factors like IKZF1/IKZF3
Molecular_glue
Birth defects linked to thalidomide use
2010-03-21. As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide "Thalidomide: The Fifty Year Fight
Thalidomide_scandal
Organic compound, core structure of many drugs
in several drugs. Derivatives like thalidomide and lenalidomide bind to cereblon (CRBN), an E3 ubiquitin ligase adaptor, promoting protein degradation and
Glutarimide
Small molecule (PROTAC)
Wang J, Raina K, et al. (June 2015). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10
Proteolysis_targeting_chimera
Human chromosome
alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) CRBN: Cereblon protein DCLK3: Doublecortin like kinase 3 DLEC1: encoding protein Deleted
Chromosome_3
Chemical compound
not inhibit myeloma cell growth or angiogenesis. Pomalidomide works as a cereblon E3 ligase modulator. The parent compound of pomalidomide, thalidomide,
Pomalidomide
Protein-coding gene in humans
CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide. Human CUL4B is 913
CUL4B
Protein-coding gene in humans
pathogenesis of certain viruses including HIV. A component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide
CUL4A
Transcription factor
anti-retrovirals (e.g. HIV-1). Thalidomide analogs, in combination with the E3 ligase Cereblon (CRBN), represent a new class of potential therapeutics for selectively
Zinc finger transcription factor
Zinc_finger_transcription_factor
Small structural protein motif found mostly in transcriptional proteins
the Zincore complex, which is involved in transcription activation, or Cereblon (CRBN), which, together with thalidomide analogs, can degrade C2H2-containing
Zinc_finger
Class of biopharmaceutical drugs
described a KIF11-directed degrader–antibody conjugate (DAC), in which a cereblon-recruiting degrader was used as the payload to induce antigen-dependent
Antibody–drug_conjugate
Protein-coding gene in the species Homo sapiens
CTBP1, HDAC1, HDAC7A, Histone deacetylase 5, IKZF2, IKZF3, IKZF4, SIN3A, Cereblon SIN3B. GATA2 GRCh38: Ensembl release 89: ENSG00000185811 – Ensembl, May
IKZF1
Chemical compound
moieties such as that found in thalidomide recruits the E3 ubiquitin ligase cereblon (CRBN) to effect proteasomal degradation of BRD4. Monovalent degraders
JQ1
Protein
Kevin; Crews, Craig M. (2015-06-18). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10
Ubiquitin_ligase
Class of protein inhibiting drugs
bioavailability. While early examples, such as thalidomide analogs recruiting cereblon, were discovered by accident, mechanistic and structural insights are now
Targeted_protein_degradation
Greek chemist and physician (born 1954)
epigenetics; inhibitors of histone-modifying enzymes; immunomodulatory drugs and cereblon ligands; PROTAC-related concepts; nucleoside analogues; and the synthesis
Athanassios_Giannis
American chemist and inventor
Vincent; DeWitt, Sheila; Iyer, Swami P. (2022-11-15). "SP-3164, a Novel Cereblon-Binding Protein Degrader, Shows Activity in Preclinical Lymphoma Models"
Sheila_DeWitt
Protein-coding gene in the species Homo sapiens
colleagues reported in the Journal of Clinical Oncology the development of a cereblon (CRBN)-recruiting KIF11 degrader as part of a KIF11 degrader-antibody conjugate
Kinesin-like_protein_KIF11
CEREBLON
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Boy/Male
English
From the Priest's dwelling.
Boy/Male
Gujarati, Indian
Apocalypse
Boy/Male
Tamil
Lord of wealth
Girl/Female
American, English
A Good Fruit Name
Surname or Lastname
English
English : habitational name from any of various places called Harlow. One in West Yorkshire is probably named from Old English hær ‘rock’, ‘heap of stones’ + hlÄw ‘mound’, ‘hill’; those in Essex and Northumberland have Old English here ‘army’ as the first element, perhaps in the sense ‘host’, ‘assembly’.English : There is also a record of this name as a variant of Cornish Penhollow.
Boy/Male
Tamil
Name of a sage
Boy/Male
Hebrew
God is my judge.
Boy/Male
Japanese
Lawful; manages affairs of state.
Surname or Lastname
English
English : unexplained; perhaps a habitational name from a lost or unidentified place. In England it occurs mainly in Bedfordshire, Cambridgeshire, and Norfolk.French : unexplained; possibly a habitational name for someone from a lost or unidentified place.
Boy/Male
Indian, Punjabi, Sikh
Glorious Victory
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