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Amino acid substitutions that mimic a phosphorylated protein
Phosphomimetics are amino acid substitutions that mimic a phosphorylated protein, thereby activating (or deactivating) the protein. Within cells, proteins
Phosphomimetics
Genetic variant
negative charge of the acidic glutamic acid residue causes it to be phosphomimetic. This mimics the phosphorylation of the nearby T599 threonine and S602
V600E
Protein-coding gene in the species Homo sapiens
human skeletal muscle cells, and adult rat cardiomyocytes. Using BNIP3 phosphomimetics in HEK 293 cells, researchers found that phosphorylation of BNIP3's
BNIP3
Scientific discipline
substrates. The development of novel chemical means of incorporating phosphomimetic amino acids into proteins has provided important insight into the effects
Chemical_biology
Peptidomimetic - Small protein-like chains designed to mimic larger peptides. Phosphomimetics - An amino acid substitution or modification which mimic the effect
Protein_mimetic
Imaging technique for in vitro protein
Edwards, Ross A. (2015-05-15). "Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain". ACS Chemical Biology. 10
MRNA_display
InterPro Family
exhibits lower sperm chromatin decondensation efficiency than NPM1, but phosphomimetic mutations at specific N-terminal and C-terminal residues markedly increase
Nucleoplasmin
Protein-coding gene in the species Homo sapiens
PMC 207014. PMID 14517331. Onischenko EA, Crafoord E, Hallberg E (2007). "Phosphomimetic mutation of the mitotically phosphorylated serine 1880 compromises the
Nucleoporin_210kDa
"Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705
Hes3_signaling_axis
Protein-coding gene in the species Homo sapiens
reversed by serum and glucocorticoid kinase 1 (SGK1) or by a corresponding phosphomimetic S1169D mutation on WNK4. The N-terminal segment of WNK4 containing the
WNK4
PHOSPHOMIMETICS
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PHOSPHOMIMETICS
Girl/Female
Indian, Sikh
Attached to God
Boy/Male
Tamil
Lord Vishnu
Girl/Female
Indian
Angle; Gift of God
Boy/Male
Hindu, Indian, Marathi
The Moon; Lord of the Night
Boy/Male
Hindu
Cloud, Disciple
Girl/Female
American, Australian, British, Chinese, Christian, English, Greek, Irish, Jamaican, Swedish
Fortress; Lark; Lovely Flower; Most Beautiful; Variant of Cayley Lovely; Pretty and Beautiful
Girl/Female
German
Noble; Ready for Battle
Boy/Male
Arabic, Australian
Agent
Girl/Female
Arabic
Light.
Boy/Male
Australian, German, Irish
Common in Spain Since the 7th Century; Noble and Ready
PHOSPHOMIMETICS
PHOSPHOMIMETICS
PHOSPHOMIMETICS
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PHOSPHOMIMETICS