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NOVA1

NOVA1

Protein-coding gene in the species Homo sapiens

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene. This gene encodes a neuron-specific RNA-binding protein, a member

NOVA1

Evolution of the brain

Overview of animal and human brain evolution

created with stem cells into which they reintroduced the archaic gene variant NOVA1 present in Neanderthals and Denisovans via CRISPR-Cas9 shows that it has

Evolution of the brain

Evolution_of_the_brain

KH domain

Protein domain

revealed a beta-alpha-alpha-beta-beta-alpha structure. Autoantibodies to NOVA1, a KH domain protein, cause paraneoplastic opsoclonus ataxia. The KH domain

KH domain

KH_domain

List of human protein-coding genes 5

Q99466 10685 NOTO HGNC:31839; A8MTQ0 10686 NOTUM HGNC:27106; Q6P988 10687 NOVA1 HGNC:7886; P51513 10688 NOVA2 HGNC:7887; Q9UNW9 10689 NOX1 HGNC:7889; Q9Y5S8

List of human protein-coding genes 5

List_of_human_protein-coding_genes_5

CRISPR gene editing

Gene editing method

Madrigal AA, et al. (February 2021). "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment". Science. 371 (6530) eaax2537

CRISPR gene editing

CRISPR_gene_editing

Brain size

Topic of study

than in anatomically-modern humans. When the neanderthal version of the NOVA1 gene is inserted into stem cells it creates neurons with fewer synapses

Brain size

Brain_size

January–March 2021 in science

created with stem cells into which they reintroduced the archaic gene variant NOVA1 present in Neanderthals and Denisovans via CRISPR-Cas9 shows that it has

January–March 2021 in science

January–March_2021_in_science

HITS-CLIP

interaction maps for the neuron-specific RNA-binding protein and splicing factor NOVA1 and NOVA2; since then a number of other splicing factor maps have been generated

HITS-CLIP

Cross-linking immunoprecipitation

Method used in molecular biology

interactions between the neuron-specific RNA-binding protein and splicing factors NOVA1 and NOVA2 in the mouse brain, identifying RNA binding sites that contained

Cross-linking immunoprecipitation

Cross-linking_immunoprecipitation

Poison exon

Biological phenomenon

neuronal RBPs NOVA1/2 are translocated from the nucleus to the cytoplasm during pilocarpine-induced seizure in mice, and it was found that NOVA1/2 regulates

Poison exon

Poison_exon

RNA-binding protein

Type of protein

binding proteins such as neuronal specific RNA-binding proteins, namely NOVA1, control the alternative splicing of a subset of hnRNA by recognizing and

RNA-binding protein

RNA-binding_protein

HNRNPK

Human protein and coding gene

IGF2BP3; KHDRBS1; KHDRBS2; KHDRBS3; KHSRP; KRR1; MEX3A; MEX3B; MEX3C; MEX3D; NOVA1; NOVA2; PCBP1; PCBP2; PCBP3; PCBP4; PNO1; PNPT1; QKI; SF1; TDRKH; GRCh38:

HNRNPK

MiR-324-5p

Type of microRNA

Ibrahim EC (August 2016). "MicroRNA screening identifies a link between NOVA1 expression and a low level of IKAP in familial dysautonomia". Disease Models

MiR-324-5p