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NEUROPHYSIN II

  • Neurophysin II
  • Cleavage product of the arginine vasopressin gene

    Neurophysin II is a carrier protein with a size of 19,687.3 Da and is made up of a dimer of two virtually identical chains of amino acids. Neurophysin

    Neurophysin II

    Neurophysin II

    Neurophysin_II

  • Neurophysins
  • Carrier protein for oxytocin and vasopressin

    neurosecretory granules, the analogous neurophysin I and II form stabilizing complexes via covalent interactions. Stabilizing neurophysin-hormone complexes that are

    Neurophysins

    Neurophysins

  • Neurophysin I
  • Cleavage product of the coding protein of OXT gene

    Neurophysin I is a carrier protein with a size of 10 KDa and contains 90 to 97 amino acids. It is a cleavage product (formed by splitting of a compound

    Neurophysin I

    Neurophysin_I

  • Herring bodies
  • Structures in the pituitary gland

    contains ATP and a type of neurophysin. Neurophysins are binding proteins, of which there are two types: neurophysin I and neurophysin II, which bind to oxytocin

    Herring bodies

    Herring_bodies

  • Oxytocin
  • Peptide hormone and neuropeptide

    "Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20". Molecular

    Oxytocin

    Oxytocin

    Oxytocin

  • Copeptin
  • Protein fragment in Homo sapiens

    derived from the C-terminus of pre-pro-hormone of arginine vasopressin, neurophysin II and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic

    Copeptin

    Copeptin

  • Vasopressin
  • Mammalian hormone released from the pituitary gland

    calcium channels in neurohypophyseal nerve terminals in rats. Angiotensin II stimulates AVP secretion, in keeping with its general pressor and pro-volumic

    Vasopressin

    Vasopressin

    Vasopressin

  • AVP gene
  • Gene

    to produce vasopressin (also known as antidiuretic hormone or ADH), neurophysin II, and a glycoprotein called copeptin. AVP and other AVP-like peptides

    AVP gene

    AVP gene

    AVP_gene

  • Neurotransmitter
  • Chemical substance that enables neurotransmission

    type II synapses are flattened. The material on the presynaptic and post-synaptic membranes is denser in a Type I synapse than it is in a Type II, and

    Neurotransmitter

    Neurotransmitter

    Neurotransmitter

  • Vasotocin
  • Chemical compound

    synthesized as a preprohormone that includes a second peptide, neurophysin VT (neurophysins are carrier proteins that are secreted along with their passenger

    Vasotocin

    Vasotocin

    Vasotocin

  • NP-1031
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    NP-1031

    NP-1031

  • Lactation
  • Release of milk from the mammary glands

    hypothalamo-neurohypophyseal tract with the help of the carrier protein, neurophysin I, to the pars nervosa of the posterior pituitary, and then stored in

    Lactation

    Lactation

    Lactation

  • CA7 (drug)
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    CA7 (drug)

    CA7 (drug)

    CA7_(drug)

  • Conivaptan
  • Chemical compound

    Omeclamox, and Ethyol. Hepatoren, Boxban, Vasculan, and currently in phase II clinical trials. Protaban, Methotrexate, and Totect are waiting for pre-approval

    Conivaptan

    Conivaptan

    Conivaptan

  • Demoxytocin
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Demoxytocin

    Demoxytocin

    Demoxytocin

  • Howard Sachs (scientist)
  • American biochemist

    Biology. Through his research, Sachs discovered the relationship between neurophysin, an intracellular chaperone protein and vasopressin, the neurohormone

    Howard Sachs (scientist)

    Howard_Sachs_(scientist)

  • Merotocin
  • Chemical compound

    mothers with lactation failure requiring lactation support, and is in phase II clinical trials for this indication. Merotocin is potent (EC50 < 0.1 nM) and

    Merotocin

    Merotocin

    Merotocin

  • TGOT
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    TGOT

    TGOT

  • Vasopressin receptor 1B
  • Protein-coding gene in the species Homo sapiens

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Vasopressin receptor 1B

    Vasopressin receptor 1B

    Vasopressin_receptor_1B

  • Retosiban
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Retosiban

    Retosiban

    Retosiban

  • Relcovaptan
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Relcovaptan

    Relcovaptan

    Relcovaptan

  • Felypressin
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Felypressin

    Felypressin

    Felypressin

  • Epelsiban
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Epelsiban

    Epelsiban

    Epelsiban

  • SRX246
  • Chemical compound

    derivative, and was developed from LY-307174 as a lead compound. A Phase II activity trial of the drug in the treatment of adults with intermittent explosive

    SRX246

    SRX246

    SRX246

  • Oxytocin receptor agonist
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Oxytocin receptor agonist

    Oxytocin receptor agonist

    Oxytocin_receptor_agonist

  • Desmopressin
  • Medication

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Desmopressin

    Desmopressin

    Desmopressin

  • Tocinoic acid
  • Oxytocin receptor antagonist

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Tocinoic acid

    Tocinoic acid

    Tocinoic_acid

  • Vasopressin receptor
  • G protein-coupled receptor

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Vasopressin receptor

    Vasopressin_receptor

  • Lithium carbonate
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Lithium carbonate

    Lithium carbonate

    Lithium_carbonate

  • Vasopressin receptor 2
  • Protein-coding gene in the species Homo sapiens

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Vasopressin receptor 2

    Vasopressin receptor 2

    Vasopressin_receptor_2

  • L-368,899
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    L-368,899

    L-368,899

    L-368,899

  • Ethinylestradiol
  • Estrogen medication

    Robinson AG (May 1981). "Oxytocin in human plasma: correlation with neurophysin and stimulation with estrogen". J Clin Endocrinol Metab. 52 (5): 988–993

    Ethinylestradiol

    Ethinylestradiol

    Ethinylestradiol

  • Demeclocycline
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Demeclocycline

    Demeclocycline

    Demeclocycline

  • Nelivaptan
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Nelivaptan

    Nelivaptan

    Nelivaptan

  • NMRA-511
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    NMRA-511

    NMRA-511

  • Vasopressin receptor antagonist
  • Agent that interferes with action at the vasopressin receptors

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Vasopressin receptor antagonist

    Vasopressin_receptor_antagonist

  • LIT-001
  • Small-molecule oxytocin receptor agonist

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    LIT-001

    LIT-001

    LIT-001

  • Selepressin
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Selepressin

    Selepressin

    Selepressin

  • SRX251
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    SRX251

    SRX251

    SRX251

  • List of MeSH codes (D12.776.157)
  • 125.825.249 – synaptotagmin i MeSH D12.776.157.125.825.500 – synaptotagmin ii MeSH D12.776.157.325.150.200 – peptide elongation factor g MeSH D12.776.157

    List of MeSH codes (D12.776.157)

    List_of_MeSH_codes_(D12.776.157)

  • NTX-1472
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    NTX-1472

    NTX-1472

  • Carbetocin
  • Medication used for preventing postpartum bleeding

    "Neurohypofyzární peptidy v lékařství z pražských a švédských laboratoří. Část II: desmopressin, terlipressin, carbetocin – farmakologie a klinické aplikace"

    Carbetocin

    Carbetocin

    Carbetocin

  • LIT-002
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    LIT-002

    LIT-002

    LIT-002

  • Nolasiban
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Nolasiban

    Nolasiban

    Nolasiban

  • Atosiban
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Atosiban

    Atosiban

    Atosiban

  • TC OT 39
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    TC OT 39

    TC OT 39

    TC_OT_39

  • Tolvaptan
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Tolvaptan

    Tolvaptan

    Tolvaptan

  • PF-06655075
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    PF-06655075

    PF-06655075

  • Vasopressin (medication)
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Vasopressin (medication)

    Vasopressin (medication)

    Vasopressin_(medication)

  • Oxytocin (medication)
  • Medication made from the peptide oxytocin

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Oxytocin (medication)

    Oxytocin (medication)

    Oxytocin_(medication)

  • RG7713
  • Vasopressin V1A receptor antagonist

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    RG7713

    RG7713

    RG7713

  • Cligosiban
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Cligosiban

    Cligosiban

    Cligosiban

  • KNX-101
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    KNX-101

    KNX-101

  • OT-12
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    OT-12

    OT-12

  • KNX-100
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    KNX-100

    KNX-100

    KNX-100

  • Terlipressin
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Terlipressin

    Terlipressin

    Terlipressin

  • Uterotonic
  • Medication causing uterine contraction

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Uterotonic

    Uterotonic

  • Vasopressin receptor 1A
  • Protein-coding gene in the species Homo sapiens

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Vasopressin receptor 1A

    Vasopressin receptor 1A

    Vasopressin_receptor_1A

  • WAY-267464
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    WAY-267464

    WAY-267464

    WAY-267464

  • Oxytocin receptor
  • Genes on human chromosome 3

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Oxytocin receptor

    Oxytocin receptor

    Oxytocin_receptor

  • Satavaptan
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Satavaptan

    Satavaptan

    Satavaptan

  • PF-184563
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    PF-184563

    PF-184563

    PF-184563

  • Brezivaptan
  • Chemical compound

    treatment of major depressive disorder. As of November 2022, it is in phase II clinical trials for this indication. ABT-436 Balovaptan List of investigational

    Brezivaptan

    Brezivaptan

    Brezivaptan

  • WJ0679
  • Pharmaceutical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    WJ0679

    WJ0679

    WJ0679

  • Mozavaptan
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Mozavaptan

    Mozavaptan

    Mozavaptan

  • Lixivaptan
  • Chemical compound

    hyponatremia indications is no longer ongoing. Palladio conducted the ELiSA Phase II study with lixivaptan in 31 ADPKD patients. In this study, the proportion

    Lixivaptan

    Lixivaptan

    Lixivaptan

  • Lipo-oxytocin-1
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Lipo-oxytocin-1

    Lipo-oxytocin-1

    Lipo-oxytocin-1

  • Ornipressin
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Ornipressin

    Ornipressin

    Ornipressin

  • Balovaptan
  • Chemical compound

    disorder (PTSD). It was in a phase III clinical trial for adults and a phase II clinical trial for children for post-traumatic stress disorder. In January

    Balovaptan

    Balovaptan

    Balovaptan

  • L-371,257
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    L-371,257

    L-371,257

    L-371,257

  • ABT-436
  • Chemical compound

    anxiety disorders, and alcoholism but was discontinued. It reached phase II clinical trials prior to the discontinuation of its development. Balovaptan

    ABT-436

    ABT-436

  • Barusiban
  • Chemical compound

    RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate) Others Carrier proteins: Neurophysin (I, II)

    Barusiban

    Barusiban

    Barusiban

  • List of MeSH codes (D12.776.641)
  • 641.650.070.075 – angiotensin i MeSH D12.776.641.650.070.078 – angiotensin ii MeSH D12.776.641.650.070.080 – angiotensin iii MeSH D12.776.641.650.340.500

    List of MeSH codes (D12.776.641)

    List_of_MeSH_codes_(D12.776.641)

  • List of MeSH codes (D12.644)
  • hormone MeSH D12.644.400.500 – neuropeptide y MeSH D12.644.400.525 – neurophysins MeSH D12.644.400.550 – neurotensin MeSH D12.644.400.575 – opioid peptides

    List of MeSH codes (D12.644)

    List_of_MeSH_codes_(D12.644)

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