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Family of cellular adhesion molecules
Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules involved in Ca2+-independent cellular adhesion. Nectins are ubiquitously
Nectin
Mammalian protein found in Homo sapiens
Nectin-3, also known as nectin cell adhesion molecule 3, is a protein that in humans is encoded by the NECTIN3 gene. Nectin-3 belongs to the family of
Nectin-3
Protein-coding gene in the species Homo sapiens
Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein
Poliovirus_receptor-related_2
Medication
antibody-drug conjugate used for the treatment of urothelial cancer. It is a nectin-4-directed antibody and microtubule inhibitor conjugate. Enfortumab refers
Enfortumab_vedotin
Species of virus
cell adhesion molecule Nectin-4. For wild type and vaccine strains, extracellular domains of CD150 (SLAM or SLAMF1) and/or of nectin-4 (also called
Measles_virus
Protein-coding gene in the species Homo sapiens
Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC), is a human protein of the immunoglobulin
Poliovirus_receptor-related_1
Modifying synaptic strength via cell adhesion molecules
ensure stability of synaptic components. SynCAM's (also known as Cadm or nectin-like molecules) are a specific type of synaptic CAM found in vertebrates
Synaptic_stabilization
Protein found in humans
mediates cellular adhesion to other cells bearing its ligands, nectin molecule CD112 and nectin-like protein CD155, that are broadly distributed on normal
CD226
Viral disease affecting humans
and later in the linings of other organs and the respiratory tree via nectin-4 receptors. This causes the cough seen clinically, which aerosolizes the
Measles
Protein found in humans
leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)". Blood. 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144
CD155
Species of virus
receptors include herpesvirus entry mediator (HVEM), nectin-1 and 3-O sulfated heparan sulfate. The nectin receptors usually produce cell-cell adhesion, to
Herpes_simplex_virus
Viral disease caused by herpes simplex viruses
of cases. Virus enters into susceptible cells by entry receptors such as nectin-1, HVEM and 3-O sulfated heparan sulfate. Infected people who show no visible
Herpes
American biotechnology company
ASG-22M6E): product candidate for the treatment of solid tumours (targets Nectin-4 in bladder, breast, lung and pancreatic cancer); developed in 50-50 partnership
Seagen
Protein-coding gene in the species Homo sapiens
"Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500
PARD3
Method of nerve regeneration
and fibronectin, which are natural ECM components, and ProNectin F plus (Pro-F) and ProNectin L (Pro-L), which are artificial ECM components, and poly(ethyleneimine)
Nerve_guidance_conduit
Urinary system cancer that begins in the urinary bladder
ADC enfortumab vedotin ("Padcev", targets tumor cells with the protein nectin-4). Those with genetic alterations that activate the proteins FGFR2 or FGFR3
Bladder_cancer
Protein-coding gene in the species Homo sapiens
related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005). GRCh38: Ensembl release
CADM3
Pharmaceutical drug
including ovarian and pancreatic cancer. The conjugate consists of a human anti-nectin-4 antibody linked to the cytotoxic agent MMAE, which is released after internalization
Sofituzumab_vedotin
Medical condition
It is caused by mutations in the gene PVRL1 (11q23-q24) which encodes nectin-1, the principal receptor used by alpha-herpesviruses to mediate entry into
Rosselli–Gulienetti_syndrome
Enterovirus
PMC 7086627. PMID 19495937. Mueller S, Wimmer E (August 2003). "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155
Poliovirus
Reluctance or refusal of vaccines
PMC 4222184. PMID 25080364. Noyce RS, Richardson CD (September 2012). "Nectin 4 is the epithelial cell receptor for measles virus". Trends in Microbiology
Vaccine_hesitancy
Multiprotein complex that forms a point of contact or adhesion in animal cells
filaments Integrins EC matrix Adherens junctions (Adhesion belt, Focal adhesion) Actin filaments Cadherin / Integrin / Nectins Other cells / EC matrix
Cell_junction
humanized TWEAK receptor cancer etc. Enfortumab vedotin Padcev mab human nectin-4 Y urothelial cancer Enlimomab pegol mab mouse ICAM-1 (CD54) Enoblituzumab
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Cell adhesion molecules in the immunoglobulin superfamily
(JAM), BT-IgSF, Coxsackie virus and adenovirus receptor (CAR), VSIG, ESAM Nectins and related proteins, including CADM1 and other Synaptic Cell Adhesion
IgSF_CAM
Protein found in humans
Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (May 1999). "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based
Afadin
PMID 2538245. S2CID 44296539. Mueller, S.; Wimmer, E. (2003). "Recruitment of Nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155
Eckard_Wimmer
American virologist
in aid of viral entry" (2001) "Striking similarity of murine nectin-1alpha to human nectin-1alpha (HveC) in sequence and activity as a glycoprotein D receptor
Deepak_Shukla
American virologist
mediator (HVEM), two members of the immunoglobulin superfamily called Nectin-1 and Nectin-2, and For 16 years, Spear served as chair of the department of microbiology
Patricia_G._Spear
Protein-coding gene in the species Homo sapiens
PLEKHA7 or PDZD11, the amount of nectin-3 and nectin-4 detected at junctions is decreased, as well as total nectin levels, through proteasome-mediated
PLEKHA7
associated with forms of anemia, myelofibrosis and thrombocythemia. CD111 Nectin-1 or Herpesvirus entry mediator C (HveC), encoded by the PVRL1 (Poliovirus
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Overview of and topical guide to immunology
family CTX Junctional adhesion molecule BT-IGSF CAR VSIG ESAM Nectins PVRL1 PVRL2 PVRL3 Nectin-4 CADM1 CADM3 NECL3 NECL4 NECL5 CD2 family CD2 CD58 Signaling
Outline_of_immunology
Protein found in humans
A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology
CD96
Protein-coding gene in the species Homo sapiens
"Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals". The Journal of Infectious
Herpesvirus_entry_mediator
Research method in neuroscience
cell to attach to it and are then endocytosed. For example, HSV uses the nectin receptor and is then endocytosed. After endocytosis, the low pH inside the
Anterograde_tracing
Swiss neurobiologist
proteins myelin-associated glycoprotein, peripheral myelin protein 22kD, and nectin like 4. As an example, without MAL the paranodel loops lose contact with
Nicole_Schaeren-Wiemers
Protein involved in attachment of cells
also associated with Autistic spectrum disorder. Cell adhesion molecule Nectin GRCh38: Ensembl release 89: ENSG00000182985 – Ensembl, May 2017 GRCm38:
Cell_adhesion_molecule_1
m. Nectin listed in the Annals of Ulster as dying in 693 along with Bruide m. Bili (i.e., Bridei III of the Picts). It is possible that this Nectin is
Elfin_of_Alt_Clut
German biochemist
tibtech.2009.02.002. Epub 2009 Mar 25. Review. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Mühlebach MD, Mateo M, Sinn
Klaus_Cichutek
Index of articles on biophysics
channel NMDA receptor Nanobiomechanics Nanodisc Nav1.1 Nav1.2 Nav1.4 Nav1.5 Nectin Neurophysins Nicolas Rashevsky Nicotinic acetylcholine receptor Niosome
Index_of_biophysics_articles
Protein-coding gene in the species Homo sapiens
T, Takai Y (Oct 1999). "Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption
SORBS1
Geneticist from occupied Palestine
controls ciliary body morphogenesis and secretion by directly regulating nectin protein expression." Cell Reports, vol. 34, no. 2, Jan. 2021, p. 108603
Ruth_Ashery-Padan
Protein-coding gene in the species Homo sapiens
addition to catenins and cadherins, PTPmu dephosphorylates PIPKIγ90 and nectin-3 (PVRL3) to stabilize E-cadherin-based adherens junctions. PTPmu also dephosphorylates
PTPRM
Italian virologist
acquiring HIV with HSV-2 Herpesviruses Campadelli-Fiume's discovered that nectin is the host cell receptor for HSV. She also discovered the triggering activity
Gabriella_Campadelli-Fiume
RNA family
mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers". Oncogene. 29 (31): 4436–48. doi:10.1038/onc.2010
Mir-661 microRNA precursor family
Mir-661_microRNA_precursor_family
NECTIN
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NECTIN
NECTIN
Male
Italian
Italian form of Latin Anatolius, ANATOLIO means "east" and "sunrise."
Boy/Male
Hindu, Indian, Marathi
Lord Shiva
Boy/Male
Hindu, Indian
From Earth; Friendly
Girl/Female
Tamil
Simple, Straight forward
Boy/Male
Muslim/Islamic
Singing
Girl/Female
Tamil
Prajnya | பà¯à®°à®œà®¨à¯à®¯à®¾Â
Boy/Male
Arabic, Hindu, Indian, Marathi, Muslim, Nigerian
Friend; Dear; Beloved; Respected; Precious
Male
Japanese
(ä¹éƒŽ) Japanese name KUROU means "ninth son."
Boy/Male
American, British, English
A Form of Devon; Variant of the English County Name Devon
Boy/Male
Hindu
Good seizer
NECTIN
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NECTIN