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Amount of drug given to establish desired blood level
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down
Loading_dose
Amount of drug given to keep previously established blood level
One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a loading dose. A loading dose is most useful
Maintenance_dose
Antiplatelet medication
Present for treatment with a myocardial infarction with ST-elevation A loading dose given in advance of percutaneous coronary intervention (PCI), followed
Clopidogrel
Measure of organism response to stimulus
exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time. Dose–response relationships can be described by dose–response
Dose–response_relationship
Toxicity due to paracetamol overdose
140 mg/kg loading dose followed by 70 mg/kg every four hours for 17 more doses, and if the patient vomits within 1 hour of dose, the dose must be repeated
Paracetamol_poisoning
Half maximal inhibitory concentration
measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in
IC50
Chemical compound
taking a lower dose of 3 grams a day for 28 days can also increase total muscle creatine storage to the same amount as the rapid loading dose of 20 g/day
Creatine
Integral of drug concentration in blood plasma over time
useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or
Area under the curve (pharmacokinetics)
Area_under_the_curve_(pharmacokinetics)
Human disorder
daily over two to three months. In another proposed cholecalciferol loading dose guideline for vitamin D-deficient adults, a weekly dosage is given, up
Vitamin_D_deficiency
Medical condition
or low-dose intravenous, subcutaneous or intramuscular (e.g. the "Alberti regime") insulin, potassium supplementation, need for a loading dose of insulin
Diabetic_ketoacidosis
Theoretical drug measure in pharmacology
the drug to exit the intravascular space. One clinical utility is that the dose required D {\displaystyle D} to achieve a target plasma concentration C 0
Volume_of_distribution
Interruption of cardiac blood supply
prasugrel and ticagrelor are given concurrently, also as a loading dose, with the dose depending on whether further surgical management or fibrinolysis
Myocardial_infarction
Vitamin D3, a chemical compound
Patients with severe vitamin D deficiency will require treatment with a loading dose; its magnitude can be calculated based on the actual serum 25-hydroxy-vitamin
Cholecalciferol
Ionic compound (KI)
suppress secretion of thyroxine from the thyroid gland. The dose typically begins with a loading dose, then 1⁄3 mL SSKI (5 drops or 250 mg iodine as iodide)
Potassium_iodide
General term for feeding small quantities of chemicals or medicines
Dosing generally applies to feeding chemicals or medicines when used in small quantities. For medicines the term dose is generally used. In the case of
Dosing
Life-threatening response to infection
with low volume distribution (vancomycin, teicoplanin, colistin), a loading dose is required to achieve an adequate therapeutic level to fight infections
Sepsis
Medication used to prevent formation of blood clots
aggregation was about 70% following three to five days of dosing at 10 mg daily after a 60-mg loading dose. Platelet aggregation gradually returns to baseline
Prasugrel
Time taken for a drug to halve its concentration in blood plasma
with a loading dose to achieve their desired clinical effect more quickly. Many drugs show a biphasic decline in plasma concentration after a dose: a steep
Biological_half-life
Anxiolytic, sedative, and pain medication
doses may cause first-degree or second-degree atrioventricular block. These adverse events usually occur briefly after administering a loading dose of
Dexmedetomidine
Chemical compound
adult dose usually ranges from 12 to 24 grams. When administered in continuous infusion, a loading dose of fosfomycin 8 g followed by a daily dose of 16 g
Fosfomycin
Hormonal antineoplastic drug
500 mg/month by intramuscular injection (and a single additional 500 mg loading dose on day 15 of therapy) in postmenopausal women with advanced breast cancer
Fulvestrant
Plane curve: conic section
practice the curve is generally nearer to a parabola due to the weight of the load (i.e. the road) being much larger than the cables themselves, and in calculations
Parabola
Biochemical analysis procedure
ED50, LD50, TD50) Therapeutic index Affinity Pharmacokinetics Metrics Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological
Structural Dynamics Response Assay
Structural_Dynamics_Response_Assay
Drug discovery by identifying protein targets
ED50, LD50, TD50) Therapeutic index Affinity Pharmacokinetics Metrics Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological
Reverse_pharmacology
Serotonin modulator antidepressant
vortioxetine (area-under-the-curve levels after a single dose versus at steady state) is 5 to 6. A loading dose given intravenously has been found to achieve steady-state
Vortioxetine
Drug class of antiplatelet agents
clopidogrel. The clinically approved dose of prasugrel is a 60-mg loading dose PO and a 10-mg a day maintenance dose PO. Ticagrelor is a much more potent
Adenosine diphosphate receptor inhibitor
Adenosine_diphosphate_receptor_inhibitor
Drug discovery by phenotypic screening
ED50, LD50, TD50) Therapeutic index Affinity Pharmacokinetics Metrics Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological
Classical_pharmacology
Bacterial infection of the prostate gland
Standard doses of all antibiotics were employed in these studies, with minocycline being administered orally or IV as a 200 mg loading dose followed by
Chronic_bacterial_prostatitis
Species of fungus
voriconazole, and amphotericin B failed; caspofungin 50 mg/day after a loading dose of 70 mg intravenously was also unsuccessful. Amphotericin B, introduced
Coccidioides_immitis
Anti-seizure medication
oral loading dose. Consider using decreased maintenance dose. Kidney disease: Do not use oral loading dose. Can begin with standard maintenance dose and
Phenytoin
Medical stent implanted into coronary arteries
not already given prior), commonly in the form of an immediate oral loading dose of aspirin in combination with another anti-platelet agent, typically
Coronary_stent
Anticoagulant medication
co-factor), so reduces degradation of factor Va and factor VIIIa. Although loading doses of warfarin over 5 mg also produce a precipitous decline in factor VII
Warfarin
Topical Antibiotic
administered mono-therapy with a high loading dose is under development in the United States. A different oral dosing regimen, based on the compound's
Fusidic_acid
Chemical to treat bacterial infections
community-acquired, lower respiratory tract infections, sparfloxacin (200 or 400 mg loading dose then 100 or 200 mg daily; i.e. 200/100 mg and 400/200 mg) had a similar
Sparfloxacin
Movement of drug through the body
order to obtain a required concentration of the drug in the organism ('loading dose): D c = V d . C p D a . B {\displaystyle Dc={\frac {Vd.Cp}{Da.B}}} This
Distribution_(pharmacology)
Type of drug side effect
May be provoked by increased heart rate. Exercise stress tests after loading. Dose dependent. Follow bradycardia, prolonged QT closely. Roden DM (August
Proarrhythmia
Medical intervention
beta-lactams and vancomycin infusion, it is advisable to administer a loading dose in order to reduce time to reach target concentrations Chapman, A. L
Outpatient parenteral antibiotic therapy
Outpatient_parenteral_antibiotic_therapy
Machine that washes clothes
in most front-loaders. Compactness: True front-loading machines may be installed underneath counter-height work surfaces. A front-loading washing machine
Washing_machine
Field of study
ED50, LD50, TD50) Therapeutic index Affinity Pharmacokinetics Metrics Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological
Pharmacoepigenetics
Fungal infection of the lungs
mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad trial)". Clinical Infectious Diseases. 44 (10): 1289–1297
Aspergillosis
Biochemical analysis procedure
Artifacts can be avoided by maintaining plate uniformity by applying the same dose of the specific medium in each well, in addition to maintaining atmospheric
Ligand_binding_assay
Medication
mg (n = 72) or placebo (n = 36) for 24 weeks (three loading doses followed by five maintenance doses). The participants were approximately 43% female; 57%
Tofersen
Medical condition
large loading doses at the start of treatment. Warfarin necrosis usually occurs three to five days after drug therapy is begun, and a high initial dose increases
Warfarin_necrosis
Pharmaceutical drug
infarction (STEMI), streptokinase is administered as an intravenous loading dose, followed by an continuous intravenous infusion. As streptokinase is
Streptokinase
HIV prevention strategy using preventative medication for HIV-negative individuals
later, as a loading dose. People who use cabotegravir receive the initial dose followed by a second dose one month later; thereafter dosing is every two
Pre-exposure prophylaxis for HIV prevention
Pre-exposure_prophylaxis_for_HIV_prevention
Anesthetic technique
is called the volume of distribution at a stable state. In case the loading dose was administered after the CRI, the time period of which will keep the
Balanced_anesthesia
Medical intervention
directly after the stenting procedure, commonly in the form of an immediate loading dose of the potent anticoagulant (blood thinner) Plavix administered as a
Percutaneous coronary intervention
Percutaneous_coronary_intervention
ED50, LD50, TD50) Therapeutic index Affinity Pharmacokinetics Metrics Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological
Pharmacomicrobiomics
Vitamin, dietary supplement, and yellow food dye
24-hour urine collection. Beyond a load dose of 1.1 mg, urinary excretion increased rapidly, so that with a dose of 2.5 mg, urinary output was 800 micrograms
Riboflavin
1996 studio album by Metallica
solo on "Bleeding Me" as a summation of all his influences, "with a good dose of my own style". "Mama Said" "Mama Said" is a country rock and Southern
Load_(album)
Chemical compound
temocillin as a continuous intravenous infusion in severe disease a single loading dose of 2 g is given intravenously followed by a 4-g or 6-g infusion over
Temocillin
American physician and academic
Annual Scientific Meeting, Boca Raton, FL, 2005. Impact of Avoiding Loading Dose of Sirolimus on Wound Complication After Kidney Transplant. A Single
Robert_Provenzano
American biochemist
development of therapeutic regimens involving a high initial loading dose followed by small doses to maintain effective atabrine levels in plasma. In addition
Bernard_Beryl_Brodie
Antibiotic medication
Standard doses of all antibiotics were employed in these studies, with minocycline being administered orally or IV as a 200 mg loading dose followed by
Minocycline
Antiarrythmic drug
of the loading dose: LD = Vss(l/kg) × IBW(kg) × Cp(mg/L) / ( S x F) The daily empiric oral dose can be calculated by the next formula: Daily dose = (Css)ave
Acecainide
Hybrid bridge
loading experienced by the external cables, and their subsequent treatment by design codes. Unlike a bridge's near-constant dead load, its live load can
Extradosed_bridge
Species of bacterium
small study, oral supplementation with O. formigenes HC-1 along with a loading dose of oxalate resulted in reduced oxalate excretion during the 6 h immediately
Oxalobacter_formigenes
Medical intervention
clopidogrel is recommended. Lower doses need days to achieve full antiplatelet effect; therefore, a loading dose is necessary for patients who are not
Management of acute coronary syndrome
Management_of_acute_coronary_syndrome
Chemical compound
month is a cautious but sensible choice. A standard dose is 30 mg weekly, but 60 mg loading doses can reduce pregnancy rates by 38%. It has a failure
Ormeloxifene
Pharmaceutical drug
exhibits a long half-life of 45-70 hours, allowing for once-daily dosing after loading doses. Although teicoplanin is primarily approved for intravenous and
Teicoplanin
Use of Iodine by organisms
hormone from iodine and tyrosine, but assuming it is not, a short-term loading dose of one or two weeks at the tolerable upper intake level may quickly restore
Iodine_in_biology
NSAID analgesic and anti-inflammatory drug
increase the rate at which the diflunisal plasma levels become steady, a loading dose is usually used. It is primarily used to treat symptoms of arthritis
Diflunisal
Chemical compound
irreversible. Within 48 hours of noted acetylcholine excess administer: Initial loading dose of Atropine: 2 mg intravenous (IV) infusion, repeating as needed for
Cholinesterase_reactivator
British rapper (born 1998)
with the single "Loading", released on 22 October 2020. The music videos for the three tracks were released by GRM Daily. "Loading" and February 2021's
Central_Cee
Oral dosing drug regimen
Phase 2 study comparing the efficacy and safety of an oral fusidic acid loading-dose regimen to oral linezolid in the treatment of acute bacterial skin and
Taksta
Treatment of cancer using drugs that inhibit cell division or kill cells
whether dose reduction is required. Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be
Chemotherapy
1986 nuclear accident in the Soviet Union
ingested dose was largely from iodine and, unlike the other fission products, rapidly found its way from dairy farms to human ingestion. Similarly in dose reconstruction
Chernobyl_disaster
Amount of virus found in host tissue
environment but a minuscule infectious dose is required to produce infection in humans: less than 100 viral particles. Viral load is often expressed as viral particles
Viral_load
Type of vaccine for humans
encapsulated in lipid nanoparticles. Initial guidance recommended a two-dose regimen, given 21 days apart; this interval was subsequently extended to
Pfizer–BioNTech COVID-19 vaccine
Pfizer–BioNTech_COVID-19_vaccine
Atypical antipsychotic medication
48-year-old male patient with bipolar affective disorder received two 234 mg loading doses of paliperidone palmitate (Invega Sustenna) one week apart. Two days
Paliperidone_palmitate
Medication against high blood pressure
unclear. When used by people with liver problems, and in elderly individuals, doses should be reduced. Amlodipine works partly by vasodilation (relaxing the
Amlodipine
Drug mixture used mainly to treat ADHD and narcolepsy
Adderall is the brand name of a fixed-dose combination medication used for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy
Adderall
Electronic oscillator circuit
voltage, load impedance, magnetic fields, electric fields (in case of cuts that are sensitive to them, e.g., SC cuts), the presence and absorbed dose of γ-particles
Crystal_oscillator
Device that delivers medication to the lungs in the form of a dry powder
inhalers commonly called metered-dose inhalers (or MDIs). DPIs may require some procedure to allow a measured dose of powder to be ready for the patient
Dry-powder_inhaler
dose equivalent data (radiation weighting factor). In relation to the body, the relevant dose term is the Organ Equivalent Dose (formerly "Organ Dose")
History of radiation protection
History_of_radiation_protection
with a median lethal dose for acute oral toxicity of not more than 300 mg/kg. Dermal toxicity. A material with a median lethal dose for acute dermal toxicity
HAZMAT Class 6 Toxic and infectious substances
HAZMAT_Class_6_Toxic_and_infectious_substances
Romanian biophysicist
(1981). "Glucose oxidation in relation to the size of the oral glucose loading dose". Metabolism. 30 (1): 143–49. doi:10.1016/0026-0495(81)90033-0. PMID 6796801
Florentina_Mosora
Boosting the number of red blood cells in the bloodstream
concentration is greater than 10 μg/L after at least 10 days of administration. The dose, which increases the red blood cell production to approximately 16%-21%,
Blood_doping
Indian actress and model (born 1994)
Urvashi appeared in Yo Yo Honey Singh's international video album Love Dose, which was released in October 2014. Soon after, she ventured into the Kannada
Urvashi_Rautela
Central nervous system stimulant
exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic loading into an addict. Volkow
Amphetamine
Accumulation of nutrients in water
Cook GD (June 1982). "Control of Lake Phosphorus with Aluminum Sulfate: Dose Determination and Application Techniques". Journal of the American Water
Eutrophication
The concept of a minimal infective dose (MID), also known as the infectious dose, has traditionally been used for infectious microorganisms that contaminate
Minimal_infective_dose
Uncontrolled nuclear fission chain reaction
plutonium. Criticality accidents can release potentially fatal radiation doses if they occur in an unprotected environment. Under normal circumstances
Criticality_accident
Drug combination for HIV/AIDS prophylaxis and treatment
(FTC/TDF), sold under the brand name Truvada among others, is a fixed-dose combination antiretroviral medication used to treat and prevent HIV/AIDS
Emtricitabine/tenofovir
Medical condition resulting from overconsumption of bromine (Br)
to excessive accumulation. Doses of 0.5 to 1 gram per day of bromide can lead to bromism. Historically, the therapeutic dose of bromide is about 3 to 5 grams
Bromism
Medical condition
contrast-induced nephropathy are:[citation needed] Adjustment of the radiocontrast dose Treating or mitigating risk factors Using no intravenous contrast for the
Contrast-induced_nephropathy
Determinants Agent Biofilm Germ theory of disease Infectivity Infectious dose Pathogenesis Pathogenicity Attack rate Quorum sensing Virulence Endotoxin
Infectious disease on cruise ships
Infectious_disease_on_cruise_ships
Medical injection device
to young children or animals, or milk to small young animals, because the dose can be measured accurately and it is easier to squirt the medicine into the
Syringe
Form of execution involving injection of chemicals into the bloodstream
induction dose is 0.35 grams. Loss of consciousness is induced within 30–45 seconds at the typical dose, while a 5 gram dose (14 times the normal dose) is likely
Lethal_injection
Form of electromagnetic radiation
equivalent dose, and also of effective dose. For X-rays the "equivalent dose" is numerically equal to a Gray (Gy). 1 Sv = 1 Gy. For the "effective dose" of X-rays
X-ray
CNS stimulant and isomer of amphetamine
exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic loading into an addict. Volkow
Dextroamphetamine
British television crime drama
fake nurse into the courier's hospital room to administer him with a lethal dose of heroin. Meanwhile, Taylor's buyer starts putting pressure on him to secure
The_Knock
Argentine footballer (born 1987)
directors spoke of their admiration for Messi – in order to secure 50,000 doses of Sinovac's COVID-19 vaccine, CoronaVac, in the hope of vaccinating all
Lionel_Messi
Nuclear power station under construction in England
Reference Group investigated the doses to the public and workers and concluded that 'the individual and collective doses derived were below the de minimis
Hinkley Point C nuclear power station
Hinkley_Point_C_nuclear_power_station
Nuclear research reactor in Oak Ridge, Tennessee
(called rabbits) between the capsule loading station and the flux trap in the reactor core. The capsule loading station is in the storage pool adjacent
High_Flux_Isotope_Reactor
Codes used for on-board diagnostics
{\displaystyle {\frac {256C+D}{1000}}} A5 165 4 Commanded Diesel Exhaust Fluid Dosing 0 127.5 % [A0]= 1:Supported; 0:Unsupported B 2 {\displaystyle {\frac {B}{2}}}
OBD-II_PIDs
Chemical compound and chemical warfare nerve agent
a lethal dose due to suffocation from respiratory paralysis, unless antidotes are quickly administered. Those who absorb a non-lethal dose and do not
Sarin
impose a high cation load at performance-relevant doses. Magnesium L-lactate and combined salt blends – used to reduce the load of any single cation.
Exogenous_lactate
Collection of character sketches
hope, of thought, of learning, and humanity? It has ended in swallowing doses of oblivion and in writing paragraphs in the Courier.—Such, and so little
The_Spirit_of_the_Age
Central nervous system stimulant
exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic loading into an addict. Volkow
Methamphetamine
LOADING DOSE
LOADING DOSE
Surname or Lastname
English
English : from the late Old English personal name Golding, in form a patronymic from Golda (see Gold 4).German : patronymic from a short form of a Germanic personal name formed with gold, guld ‘gold’, ‘bright’.Jewish (from Latvia and Lithuania) : habitational name from Golding, the German and Yiddish name of the city of Kuldīga in Latvia.
Surname or Lastname
English
English : from a Middle English personal name Lyfing, Old English Lēofing, based on lēof ‘dear’.Swedish : apparently an ornamental name formed from the place-name element lov-, meaning unknown, + the suffix -ing (see Arning).
Surname or Lastname
English
English : variant of Gooding.German (Göding) : variant of Godding.
Surname or Lastname
English (Somerset)
English (Somerset) : unexplained.
Surname or Lastname
English
English : ethnic name from Old French Lohereng ‘man from Lorraine’ (see Lorraine).
Surname or Lastname
English
English : patronymic from Good.
Surname or Lastname
English
English : topographic name for someone who lived at a place where wood was cut, Middle English wo(o)ding.
Boy/Male
German
Renowned Warrior's Son
Surname or Lastname
English
English : variant of Leeming.
Surname or Lastname
English (Hampshire and the Isle of Wight)
English (Hampshire and the Isle of Wight) : habitational name from a place on the Isle of Wight named Brading, from Old English brerd ‘hillside’ + -ingas ‘dwellers at’, i.e. ‘(settlement of) the dwellers on the hillside’.
Boy/Male
American, Anglo, British, English
Son of the Red-haired
Surname or Lastname
English
English : unexplained.
Surname or Lastname
English and German
English and German : patronymic from Bold as a personal name.Danish : habitational name from a place so named in Jutland.
Surname or Lastname
English
English : habitational name from the county seat of Berkshire, which gets its name from Old English Rēadingas ‘people of Rēad(a)’, a byname meaning ‘red’.English : topographic name for someone who lived in a clearing, an unattested Old English ryding.
Surname or Lastname
Danish
Danish : probably a habitational name from Kolding. This was originally the name of a river, from kaldr ‘cold’ + a derivational suffix -ung, hence ‘the cold river’.English : perhaps a spelling variant of Golding.
Surname or Lastname
English
English : variant of Holden.
Boy/Male
English
Son Of Gold.
Surname or Lastname
English
English : variant of Dowden.
Boy/Male
British, English
Son of Gold; Little Golden One
Boy/Male
English
Son of Reed.
LOADING DOSE
LOADING DOSE
Girl/Female
American, Australian, British, Chinese, Christian, Danish, Dutch, English, French, German, Italian, Latin, Portuguese, Swedish
Little and Womanly; Joy; Song of Happiness; Feminine Variant of Charles; Manly
Male
Yiddish
(יוּדֶעל) Yiddish form of Hebrew Yehuwdah, YUDEL means "praised," or Yehuwdiy, meaning "Jew."Â
Boy/Male
Hindu, Indian
Stars
Girl/Female
Australian, Irish
Island
Boy/Male
Tamil
Nirajit | நிராஜித
Illuminated
Surname or Lastname
English
English : patronymic from Ellis.Scottish : habitational name from the lands of Elliston, near Bowden, in Roxburghshire.
Male
French
French form of Latin Milon, MILUN means "little soldier."Â
Surname or Lastname
English
English : variant spelling of Sneed.
Girl/Female
Arthurian Legend
Faithful or abused wife.
Boy/Male
English
From the raven farm.
LOADING DOSE
LOADING DOSE
LOADING DOSE
LOADING DOSE
LOADING DOSE
a.
Free or lose from the usual attachment; as, the floating ribs in man and some other animals.
p. pr. & vb. n.
of Load
n.
That which lades or constitutes a load or cargo; freight; burden; as, the lading of a ship.
n.
The planking or boarding of a shaft, cofferdam, etc.
n.
Freight; loading; cargo.
n.
A place for landing, as from a ship, a carriage. etc.
n.
The act, or state, of inclining; inclination; tendency; as, a leaning towards Calvinism.
n.
A coat or covering; a layer of any substance, as a cover or protection; as, the coating of a retort or vial.
n.
A load; cargo; burden.
a.
Guiding; directing; controlling; foremost; as, a leading motive; a leading man; a leading example.
n.
Floating threads. See Floating threads, above.
n.
The beads or bead-forming quality of certain liquors; as, the beading of a brand of whisky.
n.
That which stands at the head; title; as, the heading of a paper.
a.
Buoyed upon or in a fluid; a, the floating timbers of a wreck; floating motes in the air.
a.
Not funded; not fixed, invested, or determined; as, floating capital; a floating debt.
n.
The act of putting a load on or into.
n.
The act of loading.
a.
Receiving its charge through the muzzle; as, a muzzle-loading rifle.
n.
A little lord; a lordling; a lord, in contempt or ridicule.