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Protein which binds to a ribosome during translation
In molecular biology, initiation factors are proteins that bind to the small subunit of the ribosome during the initiation of translation, a part of protein
Initiation_factor
Protein that stabilizes the initiation complex for polypeptide translation
A bacterial initiation factor (IF) is a protein that stabilizes the initiation complex for polypeptide translation. Translation initiation is essential
Bacterial_initiation_factor
Cellular process of protein synthesis
binding to the 5' end of mRNA with the help of initiation factors. The ribosome and its associated factors assemble and bind to an mRNA. The first tRNA
Translation_(biology)
Protein in translation of RNA
Eukaryotic Initiation Factor 2 (eIF2) is a eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates
EIF2
Protein involved in gene expression
Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help
Eukaryotic_initiation_factor
Protein-coding gene in the species Homo sapiens
translation initiation factor 4E, also known as eIF4E, is a protein in humans encoded by the EIF4E gene. eIF4E plays a central role in translation initiation and
EIF4E
Multiprotein complex used in gene expression
Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the 5' cap of messenger RNAs (mRNAs) to promote eukaryotic translation
Eukaryotic initiation factor 4F
Eukaryotic_initiation_factor_4F
Protein-coding gene in the species Homo sapiens
translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene. eIF5B is homologous to the bacterial initiation factor 2, sharing
EIF5B
Protein synthesis in prokaryotes
Archaeal initiation factors are proteins that are used during the translation step of protein synthesis in archaea. The principal functions these proteins
Archaeal_initiation_factors
Multiprotein complex that functions during the initiation phase of eukaryotic translation
Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. It is essential
Eukaryotic initiation factor 3
Eukaryotic_initiation_factor_3
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene. The protein encoded by this gene is a component
Eukaryotic translation initiation factor 4 gamma 1
Eukaryotic_translation_initiation_factor_4_gamma_1
Protein needed for initiation of transcription in prokaryotes
factor (σ factor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a bacterial transcription initiation factor
Sigma_factor
Protein family
proteins. This domain is found at the C-terminus of several translation Initiation factors. It was first detected at the very C-termini of the yeast protein
EIF-W2_protein_domain
Chemical compound
proteins (BPs), bind to eukaryotic initiation factor eIF4E, preventing its association with eIF4G, another initiation factor. These two proteins, under unregulated
4EGI-1
Protein family
Bacterial initiation factor 1 is a bacterial initiation factor. IF1 associates with the 30S ribosomal subunit in the A site and prevents an aminoacyl-tRNA
Bacterial_initiation_factor_1
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by the EIF4EBP1 gene. It inhibits
EIF4EBP1
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene. The protein encoded by this gene
EIF2S1
Protein domain
molecular biology, translation initiation factor IF-3 (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria
Translation initiation factor IF-3
Translation_initiation_factor_IF-3
Protein-coding gene in the species Homo sapiens
Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene. GRCh38: Ensembl release 89: ENSG00000156976 – Ensembl, May
EIF4A2
Protein-coding gene in humans
Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene. EIF4B is characterized by a single folded RNA recognition
EIF4B
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene. The eIF2A protein is not to be confused
EIF2A
Protein-coding gene in the species Homo sapiens
Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa
TAF1
Protein-coding gene in humans
Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. It is the only known protein to contain the unusual
EIF5A
Protein-coding gene in humans
translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene. Eukaryotic translation initiation factor 2 (eIF2)
EIF2S3
Protein-coding gene in humans
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene. This gene encodes an essential
EIF1AX
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1. eIF1 interacts
EIF1
Protein domains
TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a part of the transcription initiation factor
TBP-associated_factor
InterPro protein family
Bacterial initiation factor-2 is a bacterial initiation factor. IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound
Bacterial_initiation_factor_2
Single-domain protein
molecular biology, the single-domain protein SUI1 is a translation initiation factor often found in the fungus, Saccharomyces cerevisiae (Baker's yeast)
SUI1
Protein-coding gene in the species Homo sapiens
translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor
EIF3A
Protein family
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the
EIF4A
Protein coding gene in Humans
Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which
EIF4A1
Family of proteins
related to Ded1 plays a part in translation initiation by interacting with eukaryotic initiation factor 2 (eIF2). DDX3X DEAD/DEAH box helicase RNA helicase
DEAD_box
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit C (eIF3c) is a protein that in humans is encoded by the EIF3C gene. EIF3C has been shown to interact
EIF3C
Protein family
Eukaryotic translation initiation factor 4 G (eIF4G) is a protein involved in eukaryotic translation initiation and is a component of the eIF4F cap-binding
EIF4G
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. The protein encoded by this gene
EIF3CL
Protein-coding gene in the species Homo sapiens
the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding
BRF1_(gene)
List of standard rules to translate DNA encoded information into proteins
methionine—can serve as a start codon and, along with sequences such as an initiation factor, initiates translation. In rare instances, start codons in the standard
DNA_and_RNA_codon_tables
Protein-coding gene in the species Homo sapiens
translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene. Eukaryotic translation initiation factor-3 (eIF3)
EIF3D
expression. Initiation is also regulated by proteins known as initiation factors which provide kinetic assistance to the binding between the initiation codon
Translational_regulation
Protein domain
there are three groups of factors that promote protein synthesis: initiation factors, elongation factors and termination factors. The elongation phase of
Elongation_factor_P
Protein synthesis process in bacteria
of energy, and the three bacterial initiation factors IF1, IF2, and IF3, which help the assembly of the initiation complex. Variations in the mechanism
Bacterial_translation
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a protein that in humans is encoded by the EIF3F gene. EIF3F has been shown to interact
EIF3F
Form of eukaryotic RNA polymerase II
bacterial initiation. In bacteria, the sigma factor recognizes and binds to the promoter sequence. In eukaryotes, the transcription factors perform this
RNA_polymerase_II_holoenzyme
Protein-coding gene in humans
Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene. EIF4EBP2 knockout mice have
EIF4EBP2
Human protein and coding gene
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme
EIF2AK3
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 4E family member 1B is a protein in humans that is encoded by the EIF4E1B gene. GRCh38: Ensembl release 89: ENSG00000175766
EIF4E1B
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene. EIF5 is a GTPase-activating protein. GRCh38: Ensembl
EIF5
Protein-coding gene in the species Homo sapiens
Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene. During the initiation of protein biosynthesis
MTIF2
Antiviral medication
use as a treatment for cancers with elevated eukaryotic translation initiation factor eIF4E, especially acute myeloid leukemia (AML) as well as in head
Ribavirin
Protein-coding gene in the species Homo sapiens
Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene. GRCh38: Ensembl release 89: ENSG00000070785
EIF2B3
Protein-coding gene in humans
involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly
DDX3X
RNA element
allows for translation initiation in a cap-independent manner, as part of the greater process of protein synthesis. Initiation of eukaryotic translation
Internal_ribosome_entry_site
Physical activity that improves health
cardiovascular disease, and physical inactivity is an independent risk factor for the development of coronary artery disease. Low levels of physical exercise
Exercise
Protein-coding gene in the species Homo sapiens
translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene. Eukaryotic translation initiation factor 2 (eIF2)
EIF2S2
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene. This gene encodes a member
EIF4EBP3
Protein-coding gene in the species Homo sapiens
translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene. It belongs to the eukaryotic translation initiation factor 4E
EIF4E2
of eukaryotic translation initiation. The 43S PIC contains the small ribosomal subunit (40S) bound by the initiation factors eIF1, eIF1A, eIF3, and the
43S_preinitiation_complex
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
are stalled translation pre-initiation complexes associated with 40S ribosomal subunits, translation initiation factors, poly(A)+ mRNA and RNA-binding
Stress_granule
Protein-coding gene in humans
Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene. EIF2B1 has been shown to interact with EIF2B5
EIF2B1
Protein-coding gene in the species Homo sapiens
translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene. The ~800 kDa eukaryotic initiation factor 3 (eIF3)
EIF3K
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene. eIF3j has been shown to interact
EIF3J
Rite-of-passage ceremony
Initiation is a rite of passage marking entrance or acceptance into a group or society. It could also be a formal admission to adulthood in a community
Initiation
Protein-coding gene in the species Homo sapiens
translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene. This gene encodes one of the translation initiation factors, which
EIF4H
Protein-coding gene in humans
MCTS1, re-initiation and release factor, otherwise known as MCT-1, is a protein that in humans is encoded by the MCTS1 gene. Eukaryotic translation Eukaryotic
MCT-1
Protein-coding gene in humans
Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene. EIF2B5 has been shown to interact with
EIF2B5
Protein-coding gene in humans
Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene. EIF2AK4 belongs to a family of kinases
EIF2AK4
Protein-coding gene in the species Homo sapiens
Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene. Initiation of transcription by RNA polymerase
TAF9B
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene. EIF3B has been shown to interact
EIF3B
First codon of a messenger RNA translated by a ribosome
a 1.26-kb DNA fragment containing the structural gene for E.coli initiation factor IF3: Presence of an AUU initiator codon". The EMBO Journal. 1 (3):
Start_codon
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit I (eIF3i) is a protein that in humans is encoded by the EIF3I gene. eIF3i has been shown to interact
EIF3I
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions
EIF4G3
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene. EIF3G has been shown to interact
EIF3G
response to nutrient deprivation. GCN2 is the only known eukaryotic initiation factor 2α kinase (eIF2α) in Saccharomyces cerevisiae. It inactivates eIF2α
Gcn2
Topics referred to by the same term
Immunofluorescence, a form of labeling substances with fluorescent antibodies Initiation factor, an important component in protein synthesis Intermediate filament
If
Sequence of nucleotides
Translation initiation is the most highly regulated step of protein synthesis in prokaryotes. The rate of translation depends on two factors: the rate at
Ribosome-binding_site
Topics referred to by the same term
secondary reactions Initiation, the process of beginning gene transcription Initiation as beginning of gene translation Initiation factor, proteins that bind
Initiation_(disambiguation)
Protein complex
from eukaryotic translation initiation factor 4E (eIF4E). eIF4E is now free to join the eukaryotic translation initiation factor 4G (eIF4G) and the eukaryotic
MTORC1
Protein-coding gene in the species Homo sapiens
Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene. TATA-binding protein associated factors (TAFs) participate
TAF4B
Protein-coding gene in the species Homo sapiens
translation activator activity translation initiation factor binding protein binding eukaryotic initiation factor 4E binding mRNA 3'-UTR binding mRNA 5'-UTR
LARP1
Organic compounds containing amine and carboxylic groups
component of the connective tissue collagen. Hypusine in the translation initiation factor EIF5A, contains a modification of lysine. Some non-proteinogenic amino
Amino_acid
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene. eIF3h has been shown to interact
EIF3H
Mammalian protein found in Homo sapiens
phosphorylation, transcription initiation does not occur. It has been suggested that the general transcription factor TFIIH could act as the kinase for
Transcription_factor_II_B
Protein-coding gene in the species Homo sapiens
RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene. RRN3 has been shown to interact
RRN3
Protein-coding gene in the species Homo sapiens
Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene. GRCh38: Ensembl release 89: ENSG00000115211
EIF2B4
Class of enzymes
Protein-synthesizing GTPases (EC 3.6.5.3, elongation factor (EF), initiation factor (IF), peptide-release or termination factor) are enzymes involved in mRNA translation
Protein-synthesizing_GTPase
Protein-coding gene in the species Homo sapiens
triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the
MED7
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene. Like its X-chromosomal counterpart
EIF1AY
Prolonged resting phase in oogenesis
which results in that initiation factors of translation can not bind to that site. Two such molecules, that impedes initiation factors, are CPEB and maskin
Dictyate
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit L (eIF3l), less commonly known as EIF3EIP, is a protein that in humans is encoded by the EIF3L gene
EIF3EIP
Protein-coding gene in the species Homo sapiens
Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene. Eukaryotic initiation factor-2B (EIF2B) is
EIF2B2
Indian academic, researcher
Therapy. Batool, A.; Aashaq, S.; Andrabi, K. I. (2019). "Eukaryotic initiation factor 4E (eIF4E): A recap of the cap binding protein". Journal of Cellular
Khurshid_Iqbal_Andrabi
Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a protein that in humans is encoded by the EIF3E gene. EIF3S6 has been shown to interact
EIF3S6
Class of protein transcription factors
transcription factors are necessary for transcription to occur. In bacteria, transcription initiation requires an RNA polymerase and a single GTF: sigma factor. In
General_transcription_factor
Protein family
In molecular biology, the eukaryotic translation initiation factor 4E family (eIF-4E) is a family of proteins that bind to the cap structure of eukaryotic
Eukaryotic translation initiation factor 4E family
Eukaryotic_translation_initiation_factor_4E_family
RNA family
initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F. Fernández-Miragall O, Martínez-Salas E (November 2003). "Structural
Aphthovirus internal ribosome entry site (IRES)
Aphthovirus_internal_ribosome_entry_site_(IRES)
Protein-coding gene in the species Homo sapiens
translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene. Translation initiation is
EIF4G2
carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein
CTDP1
Multiprotein complex
Translation can be regulated at the initiation step by: preventing the binding of the eukaryotic translation initiation factor (eIF) to the 5' cap. It has been
RNA-induced_silencing_complex
Addition of adenylic acids to 3' end of mature mRNA
recruit, several proteins that affect translation, one of these is initiation factor-4G, which in turn recruits the 40S ribosomal subunit. However, a poly(A)
Polyadenylation
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