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Chemical compound
Indoline is an aromatic heterocyclic organic compound with the chemical formulation C8H9N. It has a bicyclic structure, consisting of a six-membered benzene
Indoline
Chemical compound
five-membered nitrogen-containing ring. The compound's structure is similar to indoline except that the nitrogen atom is in the 2 position instead of the 1 position
Isoindoline
Class of pharmaceutical drugs
VEGFR-2 inhibitor, also known as kinase insert domain receptor(KDR) inhibitor, are tyrosine kinase receptor inhibitors that reduce angiogenesis or lymphangiogenesis
VEGFR-2_inhibitor
Antidepressant medication
Bebbington D, Benwell KR, Bickerdike MJ, Davidson JE, et al. (2004). "Indoline derivatives as 5-HT(2C) receptor agonists". Bioorg. Med. Chem. Lett. 14
Trazodone
Chemical class of organic compounds
Phenylethylpyrrolidine (PEP) AC927 (phenylethylpiperidine) Tetrahydroisoquinoline (THIQ) Indoline (dihydroindole) 2-Aminoindane (2-AI) 2-Aminotetralin (2-ATI) 1-Aminomethylindane
Substituted_phenethylamine
Chemical compound
The so-called Wieland-Gumlich aldehyde (6) is an indoline derived by chemical degradation from strychnine. This compound is of some commercial interest
Wieland-Gumlich_aldehyde
Chemical compound
nitrogen-containing ring. Oxindole is a modified indoline with a substituted carbonyl at the second position of the 5-member indoline ring. Classified as a cyclic amide
Oxindole
Chemical compound
building block, construction of the indoline spiroaminal via cautious stepwise oxidations with cyclizations from the indoline, assembly of (Z)-dehydrohistidine
Neoxaline
Chemical compound, food additive and dye
Indigo dye is an organic compound with a distinctive blue color. Indigo is a natural dye obtained from the leaves of some plants of the Indigofera genus
Indigo_dye
Chemical compound
5th position of the benzene ring, structurally belong to the family of indoline derivatives. 5-Hydroxyindoline has shown superior results as a dopamine
5-Hydroxyindoline
Chemical compound
alkyl hydrocarbon tails on each on the nitrogen (Position 1) of the two indoline rings, a conjugated 3-carbon bridge connecting the 2nd positions (Carbon)
DiI
Chemical synthesis
reduced by sodium borohydride to indoline 9, with the C8 hydrogen atom approaching from the least hindered side. Indoline 9 was acetylated to N-acetyl compound
Strychnine_total_synthesis
Experimental drug
Ibutamoren (INNTooltip International Nonproprietary Name; developmental code MK-677, MK-0677, LUM-201, L-163,191; former tentative brand name Oratrope)
Ibutamoren
Photochromic organic chemical compound
length of time of its storage. Another group of spiropyrans which contain indoline or nitrogen heterocycles and the indolinospirothiapyrans found their application
Spiropyran
Reaction impacting chemical bonds
followed again by a retro Diels-Alder in situ, to afford an indoline product. This indoline is a converted into either PDE-I or PDE-II in a few synthetic
Inverse electron-demand Diels–Alder reaction
Inverse_electron-demand_Diels–Alder_reaction
Tar distillation byproduct used as wood preservative
nitrogen-containing heterocycles Pyridines, quinolines, benzoquinolines, acridines, indolines, and carbazoles 3.0–8.0% Sulfur-containing heterocycles Benzothiophenes
Creosote
Reversible chemical transformation by absorption of electromagnetic radiation
(1993). "Comparative photodegradation study between spiro[indoline—oxazine] and spiro[indoline—pyran] derivatives in solution". Journal of Photochemistry
Photochromism
Photons that excite electrons to a higher energy level in an atom
absorbing a photon. For example, the BIPS molecule(2H-l-benzopyran-2,2-indolines) can convert from trans to cis and back by absorbing a photon. The different
Photoexcitation
(the quinuclidonium salt and a reference amine such as diethylamine or indoline) are introduced into a mass spectrometer. The relative basicity is then
Quinuclidone
Dopamine agonist medication
Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). It
Ropinirole
Chemical compound
1937–1943. doi:10.1055/s-0034-1380517. Wei, W.T. (2018). "Synthesis of Indoline-2,3-diones by Radical Coupling of Indolin-2-ones with tert-Butyl Hydroperoxide"
Isatin
Chemical compound
6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide (CEPC) is a drug which acts as a potent and selective antagonist for the serotonin 5-HT2C receptor
6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
Act of the Parliament of the United Kingdom
structurally derived from 1-benzofuran, 2,3-dihydro-1-benzofuran, 1H-indole, indoline, 1H-indene, or indane by certain modifications. 2. Any stereoisomeric form
Misuse_of_Drugs_Act_1971
Class of indoles
flipped (isotryptamines) and/or replaced with related cores such as indene, indoline, indazole, indolizine, benzothiophene, or benzofuran. Like tryptamines
Substituted_tryptamine
Chemical reaction
Zhou, Y. G. (2011). "An Enantioselective Approach to 2,3-Disubstituted Indolines through Consecutive Brønsted Acid/Pd-Complex-Promoted Tandem Reactions"
Asymmetric_hydrogenation
Chemical compound
Indoles are susceptible to hydrogenation of the imine subunit to give indolines. Indole-3-butyric acid Indole test Isoindole Isoindoline Skatole (3-methylindole)
Indole
Organic compound with a –C≡N functional group
Potential o -Quinone Catalyst Enabling Aerobic Dehydrogenation of Tertiary Indolines in Pharmaceutical Intermediates", Organic Letters, 21 (4): 1176–1181,
Nitrile
Type of organic compounds
(January 2011). "X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase". Journal of the American
Histamine_liberators
Chemical compound
(+)-(3S)-3-(2-chlorophenyl)-1-[2-(diethylamino)ethyl]-3-hydroxo-2-oxo-4-(trifluoromethyl)indoline-6-carboxamide CAS Number 259666-71-2 Y PubChem CID 9890863 ChemSpider 7980503 Y
SM-130686
Chemical compound
Iprazochrome is an antimigraine agent used for prophylaxis of the attacks. It is also indicated for diabetic retinopathy (both treatment and prevention
Iprazochrome
Group of stereoisomers
Amedalin (UK-3540-1) is an antidepressant which was synthesized in the early 1970s but was never marketed. It is a selective norepinephrine reuptake inhibitor
Amedalin
Topics referred to by the same term
Culinary Federation (ACF) certification 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide, a pharmaceutical Circular Electron Positron Collider, a
CEPC
Medical condition
8a-hexahydropyrrolo-[2,3-b]-indole-2-carboxylic acid (peak C) and 2-(2-hydroxy indoline)-tryptophan (peak FF). These were characterized using accurate mass LC–MS
Eosinophilia–myalgia_syndrome
Chemical compound
Oxyphenisatine (or oxyphenisatin) is a laxative. It is closely related to bisacodyl, sodium picosulfate, and phenolphthalein. Long-term use is associated
Oxyphenisatine
Pharmaceutical compound
relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines". Journal of Medicinal Chemistry. 41 (10): 1598–1612. doi:10.1021/jm970741j
SB-221284
Index of chemical compounds with the same molecular formula
formula C8H9N (molar mass: 119.167 g/mol) may refer to: 4,7-Dihydroisoindole Indoline Isoindoline Azonine 2,3-Cyclopentapyridine 3,4-Cyclopentapyridine This
C8H9N
Chemical compound
2',3,10-tetraoxo-spiro[4,5,6,7-tetrahydropyrido[1,2-f]pteridine-8,3'-indoline]-7-carboxylate. It is insoluble in organic solvents and has very low solubility
Surugatoxin
Chemical catalyst
under similar conditions but using N-tosyl indoles. Syn-hyrdoborylated indolines are obtained. Borylation of S-H bonds in thiols by a dehydrogenative process
Frustrated_Lewis_pair
Serotonergic drug
Bebbington D, Benwell KR, Bickerdike MJ, Davidson JE, et al. (May 2004). "Indoline derivatives as 5-HT(2C) receptor agonists". Bioorganic & Medicinal Chemistry
Meta-Chlorophenylpiperazine
New Zealand-Australian chemist
4-diene-1-carboxylic Acid as an Approach to the C-Ring of the Binary Indole-Indoline Alkaloid Vinblastine". Aust. J. Chem. 58 (1): 14–17. doi:10.1071/CH04185
Martin_Banwell
Chemical compound
Semaxanib (INN, codenamed SU5416) is a tyrosine-kinase inhibitor drug designed by SUGEN as a cancer therapeutic. It is an experimental stage drug, not
Semaxanib
Pharmaceutical compound
7-Hydroxyropinirole (developmental code name SK&F-89124 or SKF-89124) is a dopamine receptor agonist and active metabolite of the antiparkinsonian agent
7-Hydroxyropinirole
Chemical compound
1-(3-hydroxypropyl)-5-[(2R)-({2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carboxamide CAS Number 160970-54-7 N PubChem CID 5312125 IUPHAR/BPS 493
Silodosin
Chemical compound
serotonin 5-hydroxytryptamine 2B receptor. Structurally it belongs to the indolines. Substituted tryptamine § Related compounds Glennon, R. A.; Jacyno, J
2,3-Dihydro-DMT
Organic chemical reaction
proton-transfer catalyst. Cyclization of arylvinyl- or diarylamines provides indolines and carbazoles, respectively. In one interesting example, the use of circularly
Mallory_reaction
Chemical compound
Conofoline is an alkaloid of the vinca alkaloid class which is closely related to conophylline. It is found in the leaves of some species in the genus
Conofoline
Chemical compound
8a,9-tetrahydrospiro[5a,9a-(epiminomethano)cyclopenta[f]indolizine-7,2'-indoline]-3',5,10(1H,6H,8H)-trione Brevianamide B: (2′S,5aR,8aS,9aR)-8,8-Dimethyl-2
Brevianamide
Pharmaceutical compound
Boudreau MW, Hergenrother PJ (June 2022). "Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity". RSC
ErSO
Chemical compound
Motesanib (AMG 706) is an experimental drug candidate originally developed by Amgen but later investigated by the Takeda Pharmaceutical Company. It is
Motesanib
Organic chemistry reaction
Arylboration of Indoles: Regioselective Synthesis of C2- and C3-Borylated Indolines". Journal of the American Chemical Society. 143 (40): 16502–16511. doi:10
Carboboration
Chemical compound
Aszonalenin is an alkaloid which is produced by Neosartorya and Aspergillus species. Aszonalenin is a neurotoxin. "Aszonalenin". PubChem. Whittall, John;
Aszonalenin
Chemical compound
IUPAC name 6-chloro-5-methyl-N-{6-[(2-methylpyridin-3-yl)oxy]pyridin-3-yl}indoline-1-carboxamide CAS Number 181632-25-7 PubChem CID 3644637 IUPHAR/BPS 193
SB-242084
Molecule with ability to reversibly switch states
(1993). "Comparative photodegradation study between spiro[indoline—oxazine] and spiro[indoline—pyran] derivatives in solution". Journal of Photochemistry
Molecular_switch
Chemical compound
Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of
Linopirdine
Pharmaceutical compound
4 (2): 98–101. doi:10.1021/op9900941. ISSN 1083-6160. The spirocyclic indoline 21 is a key intermediate in the preparation of SB-245570 3, a 5HT1B autoreceptor
SB-245570
Chemical compound
conophylline and conophyllidine in 2011. Their strategy was to couple two indoline-containing fragments using a type of Polonovski reaction. The synthesis
Conophylline
Chemical compound
Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood
Carbazochrome
Chemical compound
relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines". Journal of Medicinal Chemistry. 41 (10): 1598–612. doi:10.1021/jm970741j
SB-206553
Chemical compound
VER-3323 is a drug which acts as a selective agonist for both the 5-HT2B and 5-HT2C serotonin receptor subtypes, with moderate selectivity for 5-HT2C,
VER-3323
Species of bacterium
Seto, Haruo; Yoo, Ick-Dong (March 1997). "Benzastatins E, F, and G: New indoline alkaloids with neuronal cell protecting activity from Streptomyces nitrosporeus"
Streptomyces_nitrosporeus
Chemical compound
S32212 is a drug which is under preclinical investigation as a potential antidepressant medicine. It behaves as a selective, combined 5-HT2C receptor inverse
S32212
Chemical compound
SB-215505 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with good selectivity over the related 5-HT2A and
SB-215505
Chemical compound
5-methyl-N-(6-[(2-methylpyridin-3-yl)oxy]pyridin-3-yl)-6-(trifluoromethyl)indoline-1-carboxamide CAS Number 200940-23-4 PubChem CID 443391 ChemSpider 391620
SB-243213
Photochemical technique
Cells: Remarkable Enhancement in Performance through Molecular Design of Indoline Sensitizers". Angewandte Chemie International Edition. 47 (10): 1923–1927
Photochemical_action_plots
Method of separating enantiomers in a racemic mixture by reaction rate
below. A similar protocol was developed for the kinetic resolution of indolines. The Sharpless epoxidation, developed by K. Barry Sharpless in 1980, has
Kinetic_resolution
Chemical compound
Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed. It is a selective
Daledalin
Pharmaceutical compound
Jones J, et al. (August 2000). "1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists". Bioorganic
SB-247853
Chemical compound
2-Indolinethione is an organic compound with the formula C8H6(S)(NH). It is a derivative of dihydroindole containing a thione group. The compound is a
2-Indolinethione
Chemical compound
Methisazone (USAN) or metisazone (INN) is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. During trials
Metisazone
Chemical compound
Vat Blue 36 is a vat dye that is chemically related to indigo. It is produced by condensation of 4-methyl-5-chloro-7-methoxy-3-indolinone and 5,7–dich
Vat_Blue_36
Chemical compound
Doliracetam is a nootropic drug (cognition enhancer) from the racetam family used in treatment of epilepsy. According to the Hoechst patent title, it has
Doliracetam
INDOLINE
INDOLINE
INDOLINE
INDOLINE
Surname or Lastname
English, French, German, Italian (Venetian), Polish, Czech and Slovak (Fabián), and Hungarian (Fábián)
English, French, German, Italian (Venetian), Polish, Czech and Slovak (Fabián), and Hungarian (Fábián) : from a personal name, Latin Fabianus, a derivative of the Roman family name Fabius. The personal name achieved considerable popularity in Europe in the Middle Ages, having been borne by a 3rd-century pope and saint.Americanized or Italianized spelling of Slovenian Fabjan or Fabijan (see 1).Jewish : adoption of the non-Jewish surname under the influence of the Yiddish personal name Fayvish.
Boy/Male
Hindu, Indian
Powerful; Brave; Thick Necked Lion
Male
French
French form of Latin Clement, CLÉMENT means "gentle and merciful."
Boy/Male
Hindu, Indian, Sanskrit, Telugu
Sky; Soul
Male
English
 Contracted form of Old High German Hrodwulf, ROLF means "famous wolf." This name came into Middle English use via the Normans. Compare with other forms of Rolf.
Boy/Male
Tamil
Beautiful
Girl/Female
Hindu
Joy, Devoted to God
Boy/Male
British, English, Swedish
High-born; Brilliant; Noble; Bright; Famous
Boy/Male
Hindu, Indian
Shiva's Ansh; Part of Lord Shiva
Girl/Female
Indian
Soul, Gods blessing, A mosque
INDOLINE
INDOLINE
INDOLINE
INDOLINE
INDOLINE