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Thickening of the outermost layer of skin (stratum corneum) due to keratin accumulation
assess minor degrees of hyperkeratosis. It can be caused by vitamin A deficiency or chronic exposure to arsenic. Hyperkeratosis can also be caused by B-Raf
Hyperkeratosis
Medical condition
presents with redness, blisters, erosions, and peeling in a newborn baby. Hyperkeratosis typically develops several months later. Other symptoms include itch
Epidermolytic_hyperkeratosis
Medical condition
dermis and hyperkeratosis (overlying the dilated vessels). Scrotal angiokeratoma; visible large dilated blood vessels and hyperkeratosis Scrotal angiokeratoma
Angiokeratoma
Precancerous white or grey lesion within the mouth
premalignant condition. Although the white color in leukoplakia is a result of hyperkeratosis (or acanthosis), similarly appearing white lesions that are caused by
Leukoplakia
Medical condition
become very itchy. UV irradiation can be utilized after curetting the hyperkeratosis with a combination medication treatment of oral retinoids, psoralen
Kyrle_disease
Medical condition
digitate hyperkeratosis, also known as digitate keratoses, disseminated spiked hyperkeratosis, familial disseminated piliform hyperkeratosis, and minute
Multiple minute digitate hyperkeratosis
Multiple_minute_digitate_hyperkeratosis
Long-term fungal medical condition
culture. It may appear similar to dermatitis, psoriasis, keratoderma, hyperkeratosis and allergic contact dermatitis. Treatment is with long-term systemic
Two_feet-one_hand_syndrome
Medical condition
epidermolytic hyperkeratosis (NPS-2 type) but there is no blistering and the hyperkeratosis is verrucous or spine-like. The hyperkeratosis is brown-grey
Ichthyosis_hystrix
Darkening of the nipple or areola
and breastfeeding or as a side effect of high-dose estrogen therapy. Hyperkeratosis is a condition in which there is a development of a warty thickening
Nipple_pigmentation
Pigmented area on the breast around the nipple
Thomas D.; Kroumpouzos, George (2013-06-01). "Pregnancy-Associated Hyperkeratosis of the Nipple: A Report of 25 Cases". JAMA Dermatology. 149 (6): 722–726
Areola
Medical condition
other symptoms which accompany HHD include acantholysis, erythema and hyperkeratosis. It typically begins in late teenage years or in a person's 30s or 40s
Hailey–Hailey_disease
Medical condition
commonly affects the skin. The skin of the palms and soles may thicken (hyperkeratosis). Nodules ulcerating near joints can cause tissue death. Periostitis
Yaws
Outermost layer of the epidermis
dehydration, infection, direct chemical exposure and mechanical abrasion. Hyperkeratosis and hyperplasia of the stratum corneum, often in response to excessive
Stratum_corneum
Medical condition
Orthokeratosis is hyperkeratosis without parakeratosis. No nucleus is seen in the cells. There is also formation of an anuclear keratin layer, as in the
Orthokeratosis
Medical condition
Keratosis punctata of the palmar creases Other names Hyperkeratosis penetrans, Hyperkeratosis punctata, Keratodermia punctata, Keratosis punctata, Keratotic
Keratosis punctata of the palmar creases
Keratosis_punctata_of_the_palmar_creases
Genetic skin disease
people. There are also rare types of ichthyosis, such as epidermolytic hyperkeratosis, harlequin ichthyosis and so on. Michelin tyre baby syndrome is a rare
Genodermatosis
Medical condition caused by receiving too little or too many nutrients
normal color); broomstick eyelashes; alopecia Skin Dry skin; follicular hyperkeratosis; patchy hyper- and hypopigmentation; erosions; poor wound healing; loose
Malnutrition
Medical condition
Restrictive dermopathy Other names Hyperkeratosis-contracture syndrome, Lethal restrictive dermopathy Restrictive dermopathy is inherited in an autosomal
Restrictive_dermopathy
Medical condition
seen in skin diseases with epidermal hyperplasia and orthokeratotic hyperkeratosis. Skin lesion Skin disease List of skin diseases "Hypergranulosis". v
Hypergranulosis
Genetic skin disease
harlequin-type ichthyosis present with thick, fissured armor-plate hyperkeratosis. Sufferers feature severe cranial and facial deformities. The ears may
Harlequin-type_ichthyosis
Medical condition
characterized by leukonychia along with a lack of onycholysis or subungual hyperkeratosis. Candidal onychomycosis is Candida species invasion of the fingernails
Onychomycosis
Breed of cat
beginning as a dry scale and progressing to crusts and fissures typical of hyperkeratosis. The exact cause remains unclear; it is considered hereditary and incurable
Bengal_cat
Abnormal thickening of skin in the palms or soles
palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in
Palmoplantar_keratoderma
Medical condition
A nail disease or onychosis is a disease or deformity of the nail. Although the nail is a structure produced by the skin and is a skin appendage, nail
Nail_disease
minute digitate hyperkeratosis (digitate keratoses, disseminated spiked hyperkeratosis, familial disseminated piliform hyperkeratosis, minute aggregate
List_of_skin_conditions
Medical condition
thickening of the skin in the palms of the hands and the soles of the feet (hyperkeratosis). This familial disease is associated with a high lifetime risk of esophageal
Howel–Evans_syndrome
Dermatologic drug
for debridement and promotion of normal healing of skin areas with hyperkeratosis, particularly where healing is inhibited by local skin infection, skin
Urea-containing_cream
Structural fibrous protein
of keratin can occur in a variety of conditions including keratosis, hyperkeratosis and keratoderma. Mutations in keratin gene expression can lead to, among
Keratin
Skin peeling
that seen in X-linked ichthyosis, the stratum corneum becomes thicker (hyperkeratosis), imparting a "dry" or scaly appearance to the skin, and instead of
Desquamation
Medical condition
glands. Recent evidence supports that the primary event is follicular hyperkeratosis and obstruction, but the term hidradenitis supperativa has continued
Hidradenitis
Medical condition
acquired plantar keratoderma, is a skin condition characterized by hyperkeratosis of the palms and soles beginning at about the time of menopause. Keratoderma
Keratoderma_climactericum
Medical condition
the middle of areas of hyperkeratosis. As the affected person ages the flaking and blistering should improve. The hyperkeratosis may grow more severe but
Ichthyosis_bullosa_of_Siemens
Medical condition
Arsenical keratosis Chronic scar keratosis Hyperkeratosis lenticularis perstans Hydrocarbon keratosis Hyperkeratosis of the nipple and areola Inverted follicular
Burn_scar_contracture
Medical condition
thinning of the skin become more prominent. In adults, palmoplantar hyperkeratosis can develop and epithelial cancers, such as squamous cell carcinoma
Kindler_syndrome
keratin proteins Defective keratin type Condition(s) 1 Epidermolytic hyperkeratosis Ichthyosis hystrix of Curth–Macklin Diffuse nonepidermolytic palmoplantar
List of cutaneous conditions caused by mutations in keratins
List_of_cutaneous_conditions_caused_by_mutations_in_keratins
Medical condition
points of the palm of the hand and sole of the foot. Palmar hyperkeratosis, Plantar Hyperkeratosis, hyperhidrosis, corneal opacity, corneal ulcers. Type II
Tyrosinemia_type_II
displays: Regular epidermal hyperplasia, elongation of the rete ridges, hyperkeratosis, and parakeratosis. Usually:A superficial perivascular inflammatory
Histopathologic diagnosis of dermatitis
Histopathologic_diagnosis_of_dermatitis
Mode of keratinization characterized by the retention of nuclei in the stratum corneum
age groups and has no established clinical associations. In contrast, hyperkeratosis (pictured) may also show a heterogeneous stratum corneum, but a preserved
Parakeratosis
Medical condition
and distal lifting of the nail plate, often accompanied by subungual hyperkeratosis. Diagnosis is confirmed by demonstrating the absence of fungal elements
Onycholysis
Disease resulting from low vitamin A concentrations in the body
Vitamin A deficiency (VAD) or hypovitaminosis A is a lack of vitamin A in blood and tissues. It is common in poorer countries, especially among children
Vitamin_A_deficiency
British breed of horse
progressive disease that includes symptoms of progressive swelling, hyperkeratosis, and fibrosis of distal limbs. The disease is similar to chronic lymphedema
Shire_horse
Anti-cancer medication
side effects include papilloma (warts), headache, nausea, vomiting, hyperkeratosis (thickening and toughening of the skin), hair loss, rash, joint pain
Dabrafenib
Mixture of selenium sulfides
Selenium disulfide has been suggested to be effective as a treatment for hyperkeratosis based on a small case series of three treated patients. It has also
Selenium_disulfide
Autoimmune skin condition
has a grey or red colour with a thickened top layer of skin (known as hyperkeratosis), areas where the top layer has worn away (known as erosion), and a
Discoid_lupus_erythematosus
Benign lesion on the side of the tongue due to Epstein-Barr virus
furrowed and shaggy in appearance. The white appearance is created by hyperkeratosis (overproduction of keratin) and epithelial hyperplasia. The causative
Hairy_leukoplakia
Distinctively shaped callus of dead skin
corno), but Catalan uses ull de poll meaning 'chick's eye'. Medically hyperkeratosis (Fr. hyperkératose, Sp. hiperqueratosis, It. ipercheratosi). The hard
Corn_(pathology)
Thickened and hardened area of skin
weightlifting and gymnastics due to the repeated gripping of bars. Callosity Hyperkeratosis "Corns and Calluses: Symptoms, Treatment & Care Tips". Cleveland Clinic
Callus
Dog breed
black points. Spiculosis is a painful condition that causes follicular hyperkeratosis. This condition is only found in the Kerry Blue Terrier. The breed is
Kerry_Blue_Terrier
Projection from mammary glands from which milk flows
cattle. Pseudocowpox Warts caused by bovine papillomavirus Teat-end hyperkeratosis Dermatitis Frostbite Udder sores or necrotic dermatitis Goats are also
Teat
Medical condition
Keratosis punctata palmaris et plantaris Spiny keratoderma Focal acral hyperkeratosis Complex keratodermas Diffuse palmoplantar keratoderma Erythrokeratodermia
Keratoderma
Medical condition
diminished function of the sweat glands, the absence of teeth and hyperkeratosis of the palms and soles. One of the most striking features is the absence
Naegeli–Franceschetti–Jadassohn syndrome
Naegeli–Franceschetti–Jadassohn_syndrome
Chemical acid found in vinegar
80 to 200 ppm at peaks, the principal findings were blackening and hyperkeratosis of the skin of the hands, conjunctivitis (but no corneal damage), bronchitis
Acetic_acid
Protein found in humans
epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on
Keratin_10
Dog breed originating in France
compared to 0.05%. An estimated 5% of dogs may be affected by footpad hyperkeratosis, a thickening of the footpad and sometimes nose. Lesions usually occur
Dogue_de_Bordeaux
Autoimmune diseases of the skin
salmon spots, dryness, thickening of the skin under the nail (subungual hyperkeratosis), loosening and separation of the nail (onycholysis), and crumbling
Psoriasis
Chemical compound
high concentrations. This effect is largely attributed to follicular hyperkeratosis, a process where the compound induces an abnormal accumulation of keratinocytes
Isopropyl_myristate
Genus of flowering plants
scaling, and erythema in the hands, often accompanied by subungual hyperkeratosis (thickening of the skin beneath the nails). It is blamed on exposure
Narcissus_(plant)
Medical condition
linearis circumflexa is a distinctive skin condition of generalized hyperkeratosis and polycyclic and serpiginous erythematous plaques with a characteristic
Ichthyosis linearis circumflexa
Ichthyosis_linearis_circumflexa
Swelling due to a compromised lymphatic system
changes including discoloration, verrucous (wart-like) hyperplasia, hyperkeratosis, papillomatosis, dermal thickening, and ulcers may be seen. Additionally
Lymphedema
Medical condition
appear as loss of nail palate translucency, discoloration, and subungual hyperkeratosis. Complications include pain, distal onycholysis, subungual bleeding
Onychauxis
Medical condition
knowledge. Patients would be taught routinely to inspect their feet for hyperkeratosis, fungal infection, skin lesions and foot deformities. Control of footwear
Diabetic_foot
Medical condition
Orthokeratotic hyperkeratosis is characterised by hyperkeratosis with non-nucleated cells. Parakeratotic hyperkeratosis is characterised by hyperkeratosis with
Inflammatory linear verrucous epidermal nevus
Inflammatory_linear_verrucous_epidermal_nevus
Medical condition
characterized by progressive corneal opacification, either mild generalized hyperkeratosis or discrete erythematous plaques, and neurosensory deafness. It is caused
Keratitis–ichthyosis–deafness syndrome
Keratitis–ichthyosis–deafness_syndrome
Chemical compound
drug causes it to accumulate, in turn producing side effects such as hyperkeratosis, particularly of the palms and soles. Desmosterolosis Triparanol X-linked
Azacosterol
Medical condition
gray-brown. Due to prolonged scratching, lesions often show marked hyperkeratosis, excoriation, central umbilication (crater-like depression), fresh excoriations
Prurigo_nodularis
Medical condition
Ichthyosis vulgaris AR Congenital ichthyosiform erythroderma: Epidermolytic hyperkeratosis Lamellar ichthyosis Harlequin-type ichthyosis Netherton syndrome CHIME
Gerodermia_osteodysplastica
Group of genetic conditions affecting the embryonic ectoderm
in individuals with ED is frequently dry and thin, and may display hyperkeratosis, especially on the palms and soles. This dryness is largely due to reduced
Ectodermal_dysplasia
Group of illnesses affecting canines
include the whole body. The paw pads can be affected, causing marked hyperkeratosis (thickening of the pads with scale). Other autoimmune diseases include
Dog_skin_disorders
Austrian pathologist and dermatologist
Kyrle disease, being also known as "hyperkeratosis penetrans". In 1916 Kyrle referred to this condition as hyperkeratosis follicularis et parafollicularis
Josef_Kyrle
Topics referred to by the same term
hair Traumatic anserine folliculosis, a gooseflesh-like follicular hyperkeratosis Traumatic bone cyst, a condition of the jaws Traumatic neuroma, a type
Trauma
Skin condition characterized by small bumps caused by overproduction of keratin
Schwartz RA (September 2008). "Keratosis pilaris: a common follicular hyperkeratosis". Cutis. 82 (3): 177–80. PMID 18856156. "Keratosis pilaris ("chicken
Keratosis_pilaris
Dog breed
that occur later on include crusting, papules, pustules, erythema, hyperkeratosis, and colour dilution. The condition manifests within the first few weeks
Bull_Terrier
Class of chemical compounds
improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis". Cutis. 61 (6): 347–50. PMID 9640557. The strength
Alpha_hydroxycarboxylic_acid
Dog breed
that occur later on include crusting, papules, pustules, erythema, hyperkeratosis, and colour dilution. The condition manifests within the first few weeks
Miniature_Bull_Terrier
Damage to skin or biological tissue from radiation exposure
plaques, often whitish or yellowish, with telangiectasia, sometimes with hyperkeratosis. Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy
Radiation_burn
keratoacanthoma Occurs in the setting of immunosuppression or with epidermolytic hyperkeratosis; May erupt in the setting of systemic lupus erythematosus Gottron's
List of verrucous carcinoma subtypes
List_of_verrucous_carcinoma_subtypes
Medical condition
keratinocytes. One type is characterized by generalized, persistent, brown hyperkeratosis with accentuated skin markings, while a second type is localized, with
Erythrokeratodermia variabilis
Erythrokeratodermia_variabilis
Medical condition
is diagnosed based on clinical and histological signs. Epidermolytic hyperkeratosis is the main characteristic of epidermolytic acanthoma. Treatment isn't
Epidermolytic_acanthoma
Any medical condition that affects the integumentary system
Granuloma Livedo Purpura Erythema (redness) Horn (a cell type) Poikiloderma Hyperkeratosis Parakeratosis Hypergranulosis Acanthosis Papillomatosis Dyskeratosis
Skin_condition
Medical condition
and persistent. The appearance is variable. White lesions indicate hyperkeratosis. Red, erosive or ulcerative lesions indicate atrophy, loss of epithelium
Actinic_cheilitis
Human disease
Author Year Major features Plewig & Steger 1989 Initial hyperkeratosis of the follicular infundibulum. Bacterial super-infection and follicle rupture.
Hidradenitis_suppurativa
Medical condition
indicated. Nicotinic stomatitis is whitening of the hard palate by hyperkeratosis caused by the heat from smoking or from drinking hot liquids. This irritation
Salivary_gland_disease
Medical condition
density of collagen fibers and fibroblasts. Acanthosis, basket weave hyperkeratosis, elevated basal pigmentation, and obliteration with focal rete ridge
Nevus lipomatosus superficialis
Nevus_lipomatosus_superficialis
Long-term inflammatory arthritis
discolored (e.g., "oil spots"). There may be subungual (under the nail) hyperkeratosis. The nail may separate from the nail bed, which is termed onycholysis
Psoriatic_arthritis
Medical condition
epidermal perivascular infiltrate of eosinophils and lymphocytes, and hyperkeratosis, can confirm the diagnosis if clinical suspicion is high. Some characteristics
Psoriatic_erythroderma
Itchy skin rash usually affecting the genitals
genital LSc), easier bruising, cracking, tearing and peeling, as well as hyperkeratosis, are common symptoms in both men and women. In women, the condition
Lichen_sclerosus
Rough skin induced by UV exposure
confined to the epidermis; they include: Hypertrophic: Notable for marked hyperkeratosis, often with evident parakeratosis. Keratinocytes in the stratum malphigii
Actinic_keratosis
Species of mite
pinnipeds such as northern fur seals and is associated with causing hyperkeratosis, alopecia and puritis, with topical amitraz showing to be an effective
Demodex_zalophi
Disorder of the cells lining the inside of a hair follicle
times, and strongly at others. Very often it cannot be felt at all. Hyperkeratosis Lomholt, H. B.; Kilian, M (2010). "Population genetic analysis of Propionibacterium
Hyperkeratinization
Skin lesion on the legs due to Graves' disease
lower- dermis. There is no increase in fibroblasts. Over time, secondary hyperkeratosis may occur, which may become verruciform. Many of these patients may
Pretibial_myxedema
Japanese-South Korean-American animated superhero film
(from In Darkness Dwells) Christopher Drake 3:00 14. "Epidermolytic Hyperkeratosis" (from In Darkness Dwells) Christopher Drake 0:43 15. "Killer
Batman:_Gotham_Knight
Medical condition
paraspinal ligament, sclerosis of the sacroiliac joint, and punctate hyperkeratosis (affecting the soles and palms). Some people with the condition are
Ankylosing vertebral hyperostosis with tylosis
Ankylosing_vertebral_hyperostosis_with_tylosis
involvement of hair follicles. Frequently eosinophils Lichen sclerosus Hyperkeratosis, atrophic epidermis, sclerosis of dermis and dermal lymphocytes. Erythema
Vacuolar_interface_dermatitis
Medical condition
leukokeratosis Cysts, including steatocystoma multiplex Follicular hyperkeratosis Natal or prenatal teeth Blisters Excessive sweating of the palms and
Pachyonychia_congenita
Outermost of the three layers that make up the skin
squamous downgrowths with no significant cytologic atypia. In contrast, hyperkeratosis is a thickening of the stratum corneum, and is not necessarily due to
Epidermis
Medical condition
acanthosis nigricans. Other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual deficit, disturbances of skin pigmentation
Lelis_syndrome
Viral disease affecting some mammals
infections), interstitial pneumonia, encephalitis with demyelination, and hyperkeratosis of the nose and foot pads. The virus first appears in bronchial lymph
Canine_distemper
Small, rough growth resembling a cauliflower or a solid blister
under the microscope. They have thickening of the stratum corneum (hyperkeratosis), thickening of the stratum spinosum (acanthosis), thickening of the
Wart
Medical condition
Keratin Epidermolysis bullosa simplex skin KRT5, KRT14 Epidermolytic hyperkeratosis skin KRT1, KRT10 Ichthyosis bullosa of Siemens skin KRT2A Palmoplantar
Keratin_disease
DC Comics character
explains that he was born with a condition resembling epidermolytic hyperkeratosis, a disfiguring skin disorder. However, it is actually a form of regressive
Killer_Croc
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