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HYPERHOMOCYSTEINEMIA

  • Hyperhomocysteinemia
  • Medical condition

    Hyperhomocysteinemia is a medical condition characterized by an abnormally high level of total homocysteine (that is, including homocystine and homocysteine-cysteine

    Hyperhomocysteinemia

    Hyperhomocysteinemia

    Hyperhomocysteinemia

  • Homocysteine
  • Chemical compound

    substrate. However, excessive levels of homocysteine can result in hyperhomocysteinemia, which is regarded as an indicator of cardiovascular disease risk

    Homocysteine

    Homocysteine

    Homocysteine

  • Methylenetetrahydrofolate reductase deficiency
  • Medical condition

    most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important

    Methylenetetrahydrofolate reductase deficiency

    Methylenetetrahydrofolate_reductase_deficiency

  • Foltx
  • Vitamin supplement

    (cyanocobalamin), and folic acid (folacin). It may be used to treat hyperhomocysteinemia, a medical condition. "Foltx, Generic Name: folacin, cyanocobalamin

    Foltx

    Foltx

  • Pinealon
  • Purported geroprotective agent

    Pinealon has been shown to protect rat offspring from prenatal hyperhomocysteinemia and correspondingly improve post natal cognitive function. Pinealon

    Pinealon

    Pinealon

    Pinealon

  • Vitamin B12 deficiency
  • Disorder resulting from low blood levels of vitamin B12

    low vitamin B12 and folate intakes have shown associations with hyperhomocysteinemia, which is associated with cerebrovascular disease, cognitive decline

    Vitamin B12 deficiency

    Vitamin B12 deficiency

    Vitamin_B12_deficiency

  • Methylenetetrahydrofolate reductase
  • Rate-limiting enzyme in the methyl cycle

    citing "Recent meta-analyses have disproven an association between hyperhomocysteinemia and risk for coronary heart disease and between MTHFR polymorphism

    Methylenetetrahydrofolate reductase

    Methylenetetrahydrofolate reductase

    Methylenetetrahydrofolate_reductase

  • Methylenetetrahydrofolate dehydrogenase 1 deficiency
  • Genetic disease

    with or without hyperhomocysteinemia (CIMAH) Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia (CIMAH) - a record

    Methylenetetrahydrofolate dehydrogenase 1 deficiency

    Methylenetetrahydrofolate_dehydrogenase_1_deficiency

  • Pulmonary embolism
  • Blockage of an artery in the lungs

    protein C deficiency, protein S deficiency, antithrombin deficiency, hyperhomocysteinemia and plasminogen/fibrinolysis disorders) Acquired thrombophilia (antiphospholipid

    Pulmonary embolism

    Pulmonary embolism

    Pulmonary_embolism

  • Folate deficiency
  • Abnormally low level of folate (vitamin B9) in the body

    transmethylation reaction, leading to an accumulation of homocysteine (hyperhomocysteinemia) and to impaired metabolism of neurotransmitters (especially the

    Folate deficiency

    Folate deficiency

    Folate_deficiency

  • Thrombosis
  • Formation of blood clots inside the blood vessels

    coagulation Elevated PAI-1 inhibits physiological breakdown of blood clots Hyperhomocysteinemia altered coagulation Elevated factors II, VIII, IX, XI altered coagulation

    Thrombosis

    Thrombosis

    Thrombosis

  • Vegetarianism
  • Abstaining from the consumption of meat

    animal products risks vitamin B12 deficiency, which can lead to hyperhomocysteinemia, a risk factor for several health disorders, including anemia, neurological

    Vegetarianism

    Vegetarianism

    Vegetarianism

  • Mineral (nutrient)
  • Chemical elements essential for life

    seafood, also fermented foods compromised glutathione synthesis / hyperhomocysteinemia Bromine NE (trace); NE (trace) NE; NE Important to basement membrane

    Mineral (nutrient)

    Mineral (nutrient)

    Mineral_(nutrient)

  • Rowena Green Matthews
  • American biochemist emeritus

    and the characterization of the C677T polymorphism associated with hyperhomocysteinemia in humans. The polymorphism can lead to a high amount of homocysteine

    Rowena Green Matthews

    Rowena Green Matthews

    Rowena_Green_Matthews

  • Leukoaraiosis
  • Type of white matter abnormality near the lateral ventricles

    cause of the imaging findings. Hypertension, smoking, diabetes, hyperhomocysteinemia, and heart diseases are all risk factors for leukoaraiosis. Leukoaraiosis

    Leukoaraiosis

    Leukoaraiosis

    Leukoaraiosis

  • Transsulfuration pathway
  • Metabolic pathway involving the transfer of a thiol group

    known as homocystinuria, an outcome of higher homocysteine levels (hyperhomocysteinemia). All four transsulfuration enzymes require vitamin B6 in its active

    Transsulfuration pathway

    Transsulfuration pathway

    Transsulfuration_pathway

  • Osteoporosis
  • Skeletal disorder

    Wagner A, Taban-Shomal O, Widmann T, et al. (2007). "The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis:

    Osteoporosis

    Osteoporosis

    Osteoporosis

  • Cystathionine beta synthase
  • Mammalian protein found in humans

    result in hyperhomocysteinemia with complications in the cardiovascular system leading to early and aggressive arterial disease. Hyperhomocysteinemia also

    Cystathionine beta synthase

    Cystathionine beta synthase

    Cystathionine_beta_synthase

  • Varicose veins
  • Medical condition in which superficial veins become large and twisted

    recurrent varicose veins. Varicose veins could also be caused by hyperhomocysteinemia in the body, which can degrade and inhibit the formation of the three

    Varicose veins

    Varicose veins

    Varicose_veins

  • Levomefolic acid
  • Chemical compound

    metabolism: folate cycle, methionine cycle, trans-sulfuration and hyperhomocysteinemia. 5-MTHF: 5-methyltetrahydrofolate; 5,10-methyltetrahydrofolate; BAX:

    Levomefolic acid

    Levomefolic acid

    Levomefolic_acid

  • Deep vein thrombosis
  • Formation of a blood clot in a deep vein

    free protein S, activated protein C resistance, homocystinuria, hyperhomocysteinemia, high fibrinogen levels, high factor IX levels, and high factor XI

    Deep vein thrombosis

    Deep vein thrombosis

    Deep_vein_thrombosis

  • Chromosome 21
  • Human chromosome

    neuropathy Holocarboxylase synthetase deficiency Homocystinuria Hyperhomocysteinemia Hypotrichosis Immunodeficiency Inflammatory bowel disease Intellectual

    Chromosome 21

    Chromosome 21

    Chromosome_21

  • Peripheral artery disease
  • Abnormal narrowing of arteries other than those that supply the heart or brain

    atherosclerosis risk factor (smoking, dyslipidemia, hypertension, or hyperhomocysteinemia) Individuals with an abnormal lower extremity pulse examination Those

    Peripheral artery disease

    Peripheral artery disease

    Peripheral_artery_disease

  • Methionine synthase
  • Mammalian protein found in humans

    reductase can directly result in elevated levels of homocysteine (hyperhomocysteinemia), which is associated with blindness, neurological symptoms, and

    Methionine synthase

    Methionine synthase

    Methionine_synthase

  • Complications of diabetes
  • Medical condition

    YS, Ouhtit A (July 2012). "Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes". Nutrition. 28

    Complications of diabetes

    Complications_of_diabetes

  • Homocystinuria
  • Disorder of amino acid metabolism

    of Egypt, may have had homocystinuria. Cystinuria DNA methylation Hyperhomocysteinemia Online Mendelian Inheritance in Man (OMIM): 236200 "Homocystinuria"

    Homocystinuria

    Homocystinuria

    Homocystinuria

  • 5,10-Methylenetetrahydrofolate
  • Chemical compound

    metabolism: folate cycle, methionine cycle, trans-sulfuration and hyperhomocysteinemia. 5-MTHF: 5-methyltetrahydrofolate; 5,10-methylenetetrahydrofolate;

    5,10-Methylenetetrahydrofolate

    5,10-Methylenetetrahydrofolate

    5,10-Methylenetetrahydrofolate

  • Neurotoxin
  • Toxin harmful to nervous tissue

    doi:10.4049/jimmunol.175.10.6893. PMID 16272348. Bleich, S (2003). "Hyperhomocysteinemia as a New Risk Factor for Brain Shrinkage in Patients with Alcoholism"

    Neurotoxin

    Neurotoxin

    Neurotoxin

  • Metanx
  • Pharmaceutical compound

    Endothelial dysfunction associated with diabetic peripheral neuropathy, Hyperhomocysteinemia. Metanx package insert, 2014 Smith HS, Pappagallo M (2012). "Metanx:

    Metanx

    Metanx

  • Iniencephaly
  • Rare neural tube defect characterised by fusion of the occiput with the spine

    nutrition, low parity, and lack of folic acid supplementation, and/or hyperhomocysteinemia have shown to be at larger risk. Animal studies have shown that administration

    Iniencephaly

    Iniencephaly

    Iniencephaly

  • Azaribine
  • Chemical compound

    severe functional deficiency of pyridoxal phosphate and the resultant hyperhomocysteinemia. However, it continues to be researched as a potential agent for

    Azaribine

    Azaribine

    Azaribine

  • Lanthionine
  • Chemical compound

    chronic kidney failure and uremic patiens. It likely contributes to hyperhomocysteinemia and impaired hydrogen sulfide biosynthesis. Lanthionine retention

    Lanthionine

    Lanthionine

    Lanthionine

  • Methylmalonic acid
  • Chemical compound

    ISSN 1432-1459. Isber S (2007). The role of poor nutritional status and hyperhomocysteinemia in complicated pregnancy in Syria (PDF) (doctoralThesis). doi:10

    Methylmalonic acid

    Methylmalonic acid

    Methylmalonic_acid

  • Antifolate
  • Class of antimetabolite medications

    acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during long-term, low-dose methotrexate therapy for rheumatoid arthritis:

    Antifolate

    Antifolate

    Antifolate

  • Adenosine kinase
  • Enzyme

    Koning, A. B.; Werstuck, G. H.; Zhou, J.; Austin, R. C. (2003). "Hyperhomocysteinemia and its role in the development of atherosclerosis". Clinical Biochemistry

    Adenosine kinase

    Adenosine kinase

    Adenosine_kinase

  • Maitree Bhattacharyya
  • Indian physicist

    Maitree (2015). "Association of MTHFR 677C>T genetic polymorphism with hyperhomocysteinemia in type 2 diabetes patients". Cogent Medicine. 2. doi:10.1080/2331205X

    Maitree Bhattacharyya

    Maitree_Bhattacharyya

  • DNA methylation
  • Biological process

    this global hypomethylation is elevated homocysteine levels causing hyperhomocysteinemia, a known risk factor for cardiovascular disease. High plasma levels

    DNA methylation

    DNA methylation

    DNA_methylation

  • Venous thrombosis
  • Blood clot (thrombus) that forms within a vein

    protein S Activated protein C resistance High factor VIII levels Hyperhomocysteinemia High fibrinogen levels High factor IX levels High factor XI levels

    Venous thrombosis

    Venous thrombosis

    Venous_thrombosis

  • Long-term effects of alcohol
  • Health effects of long-term alcohol consumption

    S2CID 20270541. Bleich S, Bandelow B, Javaheripour K, et al. (January 2003). "Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism"

    Long-term effects of alcohol

    Long-term_effects_of_alcohol

  • Hypercoagulability in pregnancy
  • Medical condition

    heredity in a first-degree relative Age > 40 years Pre-eclampsia Hyperhomocysteinemia 2 points Intermediate risk factors Protein S or protein C deficiency

    Hypercoagulability in pregnancy

    Hypercoagulability_in_pregnancy

  • Neuroscience of aging
  • Field of study

    risk factors for dementia include diabetes, hypertension, smoking, hyperhomocysteinemia, hypercholesterolemia, and obesity (which are usually associated

    Neuroscience of aging

    Neuroscience_of_aging

  • Kamineni Institute of Medical Sciences
  • Private medical college in Telangana, India

    Suneetha, N.; Mohanty, Shruti; Rao, Pragna (2008). "Association of hyperhomocysteinemia to alcohol withdrawal in chronic alcoholics". Indian Journal of Clinical

    Kamineni Institute of Medical Sciences

    Kamineni Institute of Medical Sciences

    Kamineni_Institute_of_Medical_Sciences

  • Glutamate receptor
  • Neuron membrane protein

    tremor Glaucoma Hepatic encephalopathy Hydroxybutyric aminoaciduria Hyperhomocysteinemia and homocysteinuria Hyperprolinemia Lead encephalopathy Leber's disease

    Glutamate receptor

    Glutamate receptor

    Glutamate_receptor

  • Asymmetric dimethylarginine
  • Chemical compound

    2005.12.007. PMID 16414052. Dayal S, Lentz SR (2005). "ADMA and hyperhomocysteinemia". Vasc Med. 10 Suppl 1 (2): S27–33. doi:10.1191/1358863x05vm599oa

    Asymmetric dimethylarginine

    Asymmetric dimethylarginine

    Asymmetric_dimethylarginine

  • List of MeSH codes (C18)
  • 066.477 – hyperglycinemia, nonketotic MeSH C18.452.648.066.480 – hyperhomocysteinemia MeSH C18.452.648.066.544 – hyperlysinemias MeSH C18.452.648.066.608

    List of MeSH codes (C18)

    List_of_MeSH_codes_(C18)

  • Ischemic preconditioning
  • Experimental medical technique

    hypercholesterolemia, hyperglycemia, hypertension, cardiac hypertrophy, and hyperhomocysteinemia. [citation needed] Animal research and one single human case also

    Ischemic preconditioning

    Ischemic_preconditioning

  • Histone-modifying enzymes
  • Type of enzymes

    PC, Chandel S (April 2019). "Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among

    Histone-modifying enzymes

    Histone-modifying enzymes

    Histone-modifying_enzymes

  • Congenital disorders of amino acid metabolism
  • Medical condition

    Carbamoyl-phosphate synthase I deficiency disease Citrullinemia Hyperargininemia Hyperhomocysteinemia Hypermethioninemia Hyperlysinemias Nonketotic hyperglycinemia Propionic

    Congenital disorders of amino acid metabolism

    Congenital disorders of amino acid metabolism

    Congenital_disorders_of_amino_acid_metabolism

  • Haptocorrin
  • Protein-coding gene in the species Homo sapiens

    (Nov 2003). "The role of genetic factors in the development of hyperhomocysteinemia". Clinical Chemistry and Laboratory Medicine. 41 (11): 1427–1434

    Haptocorrin

    Haptocorrin

    Haptocorrin

  • MTRR (gene)
  • Protein-coding gene in the species Homo sapiens

    premature coronary artery disease (CAD) independent of hyperhomocysteinemia. Hyperhomocysteinemia is associated with cerebral, coronary and peripheral atherosclerotic

    MTRR (gene)

    MTRR (gene)

    MTRR_(gene)

  • List of diseases (H)
  • Hypergonadotropic ovarian failure, familial or sporadic Hyperhidrosis Hyperhomocysteinemia Hyper-IgD syndrome Hyperimidodipeptiduria Hyperimmunoglobinemia D

    List of diseases (H)

    List_of_diseases_(H)

  • Prevention of dementia
  • Possible prevention methods of dementia

    PMID 24959550. Ansari R, Mahta A, Mallack E, Luo JJ (October 2014). "Hyperhomocysteinemia and neurologic disorders: a review". Journal of Clinical Neurology

    Prevention of dementia

    Prevention_of_dementia

  • PHLDA1
  • Protein-coding gene in the species Homo sapiens

    Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia". J. Biol. Chem. 278 (32): 30317–27. doi:10.1074/jbc.M212897200.

    PHLDA1

    PHLDA1

    PHLDA1

  • Exposure science
  • For example, exposure to vitamin B12 deficient diets can cause hyperhomocysteinemia, which increases oxidative stress within the body leading to the

    Exposure science

    Exposure_science

  • Methylenetetrahydrofolate dehydrogenase (NADP+)
  • combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia (CIMAH). The systematic name of this enzyme class is 5

    Methylenetetrahydrofolate dehydrogenase (NADP+)

    Methylenetetrahydrofolate dehydrogenase (NADP+)

    Methylenetetrahydrofolate_dehydrogenase_(NADP+)

  • MTHFD1
  • combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia (CIMAH). GRCm38: Ensembl release 89: ENSMUSG00000021048 – Ensembl

    MTHFD1

    MTHFD1

    MTHFD1

  • Dimethylargininase
  • Class of enzymes

    stress such as oxidized LDL-cholesterol, inflammatory cytokines, hyperhomocysteinemia, hyperglycemia and infectious agents. Each of these insults attenuates

    Dimethylargininase

    Dimethylargininase

    Dimethylargininase

  • Shantanu Sengupta
  • 1 (1): 45. doi:10.4103/2395-5414.157568. Mendelian randomization Hyperhomocysteinemia India portal Biology portal Medicine portal Please see Selected bibliography

    Shantanu Sengupta

    Shantanu_Sengupta

  • Renal vein thrombosis
  • Medical condition

    antithrombin. Hypercoagulability can be inherited and/or acquired. Hyperhomocysteinemia, a condition known to promote clots, can be caused by a combination

    Renal vein thrombosis

    Renal vein thrombosis

    Renal_vein_thrombosis

  • Epigenetics of autism
  • Field of study

    as folate hydrolase 1 and hydroxymethyltransferase 1 along with hyperhomocysteinemia were used as factors contributing to autism to develop an artificial

    Epigenetics of autism

    Epigenetics_of_autism

  • List of MeSH codes (C16)
  • 066.477 – hyperglycinemia, nonketotic MeSH C16.320.565.066.480 – hyperhomocysteinemia MeSH C16.320.565.066.544 – hyperlysinemias MeSH C16.320.565.066.608

    List of MeSH codes (C16)

    List_of_MeSH_codes_(C16)

  • Gluten-sensitive enteropathy–associated conditions
  • Medical conditions

    1080/003655298750026651. PMID 9867122. Wilcox GM, Mattia AR (2006). "Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants". J. Clin. Gastroenterol. 40 (7): 596–601

    Gluten-sensitive enteropathy–associated conditions

    Gluten-sensitive_enteropathy–associated_conditions

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Online names & meanings

  • Indal
  • Boy/Male

    Indian

    Indal

    Different

  • Dezso
  • Boy/Male

    Australian, Latin

    Dezso

    Desired

  • Rupsha | روپشا
  • Girl/Female

    Muslim

    Rupsha | روپشا

    Beautiful, River in bangladesh, Alternatively, Impeccable beauty

  • Giulia
  • Girl/Female

    Australian, Danish, French, German, Italian, Latin

    Giulia

    Italian Form of Julia; Youthful

  • Sarvayoni | ஸர்வயோநீ
  • Boy/Male

    Tamil

    Sarvayoni | ஸர்வயோநீ

    Source of everything

  • Usha
  • Girl/Female

    Hindi Indian Sanskrit

    Usha

    A princess.

  • Inder
  • Boy/Male

    Sikh

    Inder

    Ruler of all that is wild and untamed., Born of tooth and fang

  • Suhavi | ஸுஹாவீ
  • Girl/Female

    Tamil

    Suhavi | ஸுஹாவீ

    Beautiful

  • Pete
  • Boy/Male

    American, Australian, British, Christian, Danish, English, Finnish, German, Greek

    Pete

    Rock; Form of Peter; Stone

  • Palani Kumar
  • Boy/Male

    Hindu

    Palani Kumar

    Another name of Lord Murugan

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HYPERHOMOCYSTEINEMIA

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