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GR 159897

• GR-159897

Chemical compound

GR-159897 is a potent and selective NK2 receptor antagonist drug. It has anxiolytic effects in animal models, and also inhibits bronchoconstriction of

GR-159897



GR-159897

• Elinzanetant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Elinzanetant



Elinzanetant

• Tradipitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Tradipitant



Tradipitant

• Fezolinetant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Fezolinetant



Fezolinetant

• Aprepitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Aprepitant



Aprepitant

• Substance P

Chemical compound (polypeptide neurotransmitter)

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Substance P



Substance_P

• NK1 receptor antagonist

Chemical compound class

that led to the discovery of aprepitant. GR-205171 (figure 4) was developed by Glaxo and was based on CP-99994. GR-205171 had a tetrazole ring in position

NK1 receptor antagonist

NK1_receptor_antagonist

• Rolapitant

Pharmaceutical drug

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Rolapitant



Rolapitant

• Lanepitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Lanepitant



Lanepitant

• Neurokinin A

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Neurokinin A



Neurokinin_A

• Neurokinin B

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Neurokinin B



Neurokinin_B

• Maropitant

Veterinary medication

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Maropitant



Maropitant

• Fosaprepitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Fosaprepitant



Fosaprepitant

• Saredutant

Chemical compound

among which was saredutant for the treatment of major depressive disorder. GR-159,897 Ibodutant Nepadutant Hopkins CR (October 2010). "ACS chemical neuroscience

Saredutant



Saredutant

• Tachykinin receptor

InterPro Family

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Tachykinin receptor

Tachykinin_receptor

• Netupitant/palonosetron

Pharmaceutical drug

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Netupitant/palonosetron

Netupitant/palonosetron

• Talnetant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Talnetant



Talnetant

• Vestipitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Vestipitant



Vestipitant

• Tachykinin receptor 2

Protein-coding gene in the species Homo sapiens

negative Phase 3 trial results in 2009, and abandoned by Sanofi-Aventis GR-159897 Nepadutant MEN-10376 - potent and selective antagonist, 7-amino acid polypeptide

Tachykinin receptor 2



Tachykinin_receptor_2

• Vofopitant

Chemical compound

(October 2009). "Anxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear-potentiated startle model

Vofopitant



Vofopitant

• Ezlopitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Ezlopitant



Ezlopitant

• Pavinetant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Pavinetant



Pavinetant

• Tachykinin receptor 3

Protein-coding gene in the species Homo sapiens

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Tachykinin receptor 3



Tachykinin_receptor_3

• Tachykinin receptor 1

Protein-coding gene in the species Homo sapiens

now available, several of which have gone into clinical use as antiemetics. GR-73632 - potent and selective agonist, EC50 2nM, 5-amino acid polypeptide chain

Tachykinin receptor 1



Tachykinin_receptor_1

• Osanetant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Osanetant



Osanetant

• 5-Fluoro-DMT

Chemical compound

Analogue Act if intended for human consumption. Substituted tryptamine GR-159897 5-Fluoro-AMT Puigseslloses P, Nadal-Gratacós N, Fumàs B, Modenutti CP

5-Fluoro-DMT



5-Fluoro-DMT

• Ibodutant

Chemical compound

as of 2015 because of low response and negative results of study NAK-06. GR-159,897 Nepadutant Saredutant "Clinical Trials Database". Menarini Group.

Ibodutant



Ibodutant

• Netupitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Netupitant



Netupitant

• Casopitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Casopitant



Casopitant

• Nepadutant

Chemical compound

functional gastrointestinal disorders and asthma but was never marketed. GR-159,897 Ibodutant Saredutant Annual Reports in Medicinal Chemistry. Academic

Nepadutant



Nepadutant

• L-733,060

Chemical compound

Aprepitant Casopitant Fosaprepitant Maropitant Vestipitant Vofopitant Seabrook GR, Shepheard SL, Williamson DJ, Tyrer P, Rigby M, Cascieri MA, et al. (December

L-733,060



L-733,060

• Serlopitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Serlopitant



Serlopitant

• Orvepitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Orvepitant



Orvepitant

• Burapitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Burapitant



Burapitant

• Befetupitant

Chemical compound

Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant Otilonium bromide NK3 Agonists: Neurokinin

Befetupitant



Befetupitant

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GR 159897

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GR 159897

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GR 159897

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GR 159897

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GR 159897

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GR 159897

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GR 159897

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GR 159897