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FOXM1

  • FOXM1
  • Protein-coding gene in humans

    Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription

    FOXM1

    FOXM1

    FOXM1

  • FOX proteins
  • Family of transcription factors involved in anatomical development

    proteins. FOXM1 is a well-defined transcription factor controlling genes linked to cell cycle development, preserving cellular homeostasis. FOXM1 promotes

    FOX proteins

    FOX proteins

    FOX_proteins

  • Khawla Al-Kuraya
  • Saudi physician and cancer specialist

    the National Cancer Institute. Al-Kuraya has published research on the FOXM1 gene which plays a role in cancer formation. For her cancer research Al-Kuraya

    Khawla Al-Kuraya

    Khawla Al-Kuraya

    Khawla_Al-Kuraya

  • Thiostrepton
  • Chemical compound

    cancer cells through targeting the transcription factor forkhead box M1 (FOXM1), also in 2011. It has also been shown to circumvent acquired cisplatin

    Thiostrepton

    Thiostrepton

    Thiostrepton

  • SMAD3
  • Protein-coding gene in humans

    FOXM1 (forkhead box M1) is a molecule that binds with SMAD3 to sustain activation of the SMAD3/SMAD4 complex in the nucleus. The research over FOXM1 suggested

    SMAD3

    SMAD3

    SMAD3

  • GLI1
  • Protein-coding gene in humans

    for many targets. For example, Gli1 in primary keratinocytes upregulates FOXM1 whereas in mesenchymal C3H10T1/2 cells it has been shown to upregulate platelet-derived

    GLI1

    GLI1

    GLI1

  • Chromosome 21
  • Human chromosome

    with sequence similarity 3 member B FRGCA: producing long non-coding RNA FOXM1-regulated, gastric cancer associated FTCD: encoding enzyme

    Chromosome 21

    Chromosome 21

    Chromosome_21

  • Ovarian cancer
  • Cancer originating in or on the ovary

    homologous recombination DNA repair is dysfunctional, as are the notch and FOXM1 signaling pathways. They also almost always have p53 mutations. Other than

    Ovarian cancer

    Ovarian cancer

    Ovarian_cancer

  • Mezerein
  • Chemical compound

    PMID 23335926. Huynh KM, Soh JW, Dash R, Sarkar D, Fisher PB, Kang D (2010). "FOXM1 Expression Mediates Growth Suppression During Terminal Differentiation of

    Mezerein

    Mezerein

    Mezerein

  • G2 phase
  • Third subphase of interphase

    in response to phosphorylation of transcription factors such as NF-Y, FoxM1 and B-Myb by upstream G1 and G1/S cyclin-CDK complexes. Increased levels

    G2 phase

    G2 phase

    G2_phase

  • Gestational diabetes
  • High blood sugar levels during pregnancy

    pregnancy have been proposed. c-MET may interact with FoxM1, a molecule important in the cell cycle, as FOXM1 levels decrease when c-MET is not present. Additionally

    Gestational diabetes

    Gestational diabetes

    Gestational_diabetes

  • MicroRNA
  • Small non-coding ribonucleic acid molecule

    suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer". The Journal of Pathology. 233 (3): 308–18. doi:10

    MicroRNA

    MicroRNA

    MicroRNA

  • O-GlcNAc
  • Post-translational carbohydrate modification of proteins

    proteasomal degradation of FoxM1, as expression of a FoxM1 mutant lacking a degron rescued the effects of OGT knockdown. FoxM1 was found not to be directly

    O-GlcNAc

    O-GlcNAc

    O-GlcNAc

  • DREAM complex
  • Protein complex

    promote the expression of key G2/M phase genes such as CDK1 and CCNB1. FOXM1 is then recruited in G2 to further promote gene expression (e.g. AURKA)

    DREAM complex

    DREAM_complex

  • BTF3
  • Gene on human chromosome 5

    BTF3 affects the expression of cell cycle elated genes, for example the FOXM1, Ki-67, PCNA, and P27. When BTF3 was suppressed in gastric cancer cells

    BTF3

    BTF3

    BTF3

  • List of human transcription factors
  • ENSG00000183770 Forkhead Known motif – High-throughput in vitro [270] VBGHMAACAH FOXM1 ENSG00000111206 Forkhead Known motif – from protein with 100% identical

    List of human transcription factors

    List_of_human_transcription_factors

  • FRGCA
  • Non-coding RNA in the species Homo sapiens

    FOXM1-regulated, gastric cancer associated is a long non-coding RNA that in humans is encoded by the FRGCA gene. FOXM1 Stomach cancer, also known as gastric

    FRGCA

    FRGCA

    FRGCA

  • NDUFA10
  • Protein-coding gene in the species Homo sapiens

    Leigh's syndrome. Furthermore, reduced NDUFA10 expression levels due to FOXM1-directed hypermethylation are associated with human squamous cell carcinoma

    NDUFA10

    NDUFA10

    NDUFA10

  • C6orf136
  • Protein-coding gene in the species Homo sapiens

    currently unknown, C6orf136 has been shown to be hypermethylated in response to FOXM1 expression in Head Neck Squamous Cell Carcinoma (HNSCC) tissue cells. Additionally

    C6orf136

    C6orf136

    C6orf136

  • Cadherin-1
  • Human protein-coding gene

    shown to interact with CBLL1, CDC27, CDH3, C-Met, CTNND1, CTNNB1, CTNNA1 FOXM1, HDAC1, HDAC2, IQGAP1, FYN, NEDD9, Plakoglobin, Vinculin, PTPmu(PTPRM) PTPrho(PTPRT)

    Cadherin-1

    Cadherin-1

    Cadherin-1

  • Breast cancer classification
  • Medical classification system

    luminal A but: TP53 inactivation Rb inactivation Myc-related transcription FOXM1-related transcription HER2 amplicon and corresponding signaling pathway

    Breast cancer classification

    Breast cancer classification

    Breast_cancer_classification

  • Cyclin-dependent kinase 4
  • Human protein

    phosphorylate transcription factors and co-regulators like Smad3, MYC, FOXM1, and MEP50 to regulate the cell cycle, survival and senescence. Interestingly

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • Ectoderm specification
  • Stage in embryonic development

    , and Knochel, W. (2005). The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development. Int J Dev Biol 49, 53-58. Matsuo-Takasaki

    Ectoderm specification

    Ectoderm specification

    Ectoderm_specification

  • Benita Katzenellenbogen
  • American professor of physiology and cell biology

    endocrine resistance in breast cancer: Interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis". Breast Cancer Research.

    Benita Katzenellenbogen

    Benita_Katzenellenbogen

  • Cruciform DNA
  • DNA structure

    to cancer cells by a cruciform DNA nanostructure composed of AS1411 and FOXM1 aptamers". Expert Opinion on Drug Delivery. 15 (11): 1045–1052. doi:10.1080/17425247

    Cruciform DNA

    Cruciform DNA

    Cruciform_DNA

  • Cyclin D
  • Member of the cyclin protein family

    et al. (November 2011). "A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells". Cancer Cell

    Cyclin D

    Cyclin D

    Cyclin_D

  • List of human protein-coding genes 3
  • 5819 FOXL2NB HGNC:34428; Q6ZUU3 5820 FOXL3 HGNC:54201; A0A1W2PRP0 5821 FOXM1 HGNC:3818; Q08050 5822 FOXN1 HGNC:12765; O15353 5823 FOXN2 HGNC:5281; P32314

    List of human protein-coding genes 3

    List_of_human_protein-coding_genes_3

  • ATP5SL
  • Protein-coding gene in the species Homo sapiens

    miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer, Tan et al (Jan 2016). DMAC2 NCBI Reference

    ATP5SL

    ATP5SL

    ATP5SL

  • MicroRNA 4521
  • Non-coding RNA in the species Homo sapiens

    suppresses gastric carcinoma progression through regulation of IGF2 and FOXM1". Molecular Cancer. 20 (1): 9. doi:10.1186/s12943-020-01295-2. PMC 7786912

    MicroRNA 4521

    MicroRNA 4521

    MicroRNA_4521

  • CENPF
  • Centromere- and microtubule-associated protein

    MR, Brás A, Kauw J, Kerkhoven RM, Morrison A, et al. (February 2005). "FoxM1 is required for execution of the mitotic programme and chromosome stability"

    CENPF

    CENPF

    CENPF

  • Jeffrey Hill
  • British Scientist

    Ding, Ling-Wen (2021-03-01). "MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma". Oncogene. 40 (10): 1851–1867. doi:10

    Jeffrey Hill

    Jeffrey_Hill

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Online names & meanings

  • Alyque
  • Boy/Male

    Indian

    Alyque

    Sweet; Flower; Kind to All

  • Proma
  • Girl/Female

    Hindu, Indian

    Proma

    Truth

  • Himadyuti
  • Boy/Male

    Hindu, Indian, Marathi, Sanskrit

    Himadyuti

    Of Cool Radiance; The Moon

  • Neron
  • Boy/Male

    Australian, Spanish

    Neron

    Strong

  • Zukhruf
  • Girl/Female

    Arabic, Muslim

    Zukhruf

    Pure Gold

  • Adron
  • Boy/Male

    American, Australian, British, English, Latin

    Adron

    From Adria

  • Eustace
  • Boy/Male

    Greek

    Eustace

    Fruitful, productive. Famous bearer: St Eustace (Eustachins) was a martyred 2nd century Roman...

  • Jehovah
  • Biblical

    Jehovah

    self-subsisting,I am; the eternal living one,to be, exist,to be, to become; I am who am, hath sent me; I am who am with you,

  • Brondolf
  • Boy/Male

    Norse

    Brondolf

    Son of Naddodd.

  • Hemanshu
  • Boy/Male

    Hindu

    Hemanshu

    The Moon

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FOXM1

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