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Chemical compound
Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer. It
Flutamide
Any steroid hormone that promotes male characteristics
rats. To further test the role of activated androgen receptors on AHN, flutamide, an antiandrogen drug that competes with testosterone and dihydrotestosterone
Androgen
Antiandrogen medication
clearing of acne with flutamide [62,77]. Flutamide used in combination with an [oral contraceptive], at a dose of 500mg/d, flutamide caused a dramatic decrease
Bicalutamide
and other parameters. Relative to the other first-generation NSAAs, flutamide and nilutamide, bicalutamide shows improved potency, efficacy, tolerability
Comparison of bicalutamide with other antiandrogens
Comparison_of_bicalutamide_with_other_antiandrogens
clearing of acne with flutamide [62,77]. Flutamide used in combination with an [oral contraceptive], at a dose of 500mg/d, flutamide caused a dramatic decrease
Medical_uses_of_bicalutamide
Enlargement of the human male breast
estrogens used for prostate cancer, and antiandrogens such as bicalutamide, flutamide, and spironolactone. Drugs with fair evidence for association with gynecomastia
Gynecomastia
have been reported with flutamide relative to bicalutamide (e.g., 9.8% anemia rate with flutamide plus a GnRH agonist). Flutamide has been associated with
Side_effects_of_bicalutamide
Skin condition characterized by pimples
reported satisfaction with the control of their acne with flutamide. Although effective, flutamide has a risk of serious liver toxicity, and cases of death
Acne
Steroidal antiandrogen and antimineralocorticoid
clinical research has found that flutamide is more effective than spironolactone in the treatment of acne. In one study, flutamide decreased acne scores by 80%
Spironolactone
Class of pharmaceutical drugs
enzalutamide, have largely replaced the earlier nonsteroidal antiandrogens flutamide and nilutamide, which are now little used. The earlier androgen synthesis
Antiandrogen
include ketoconazole, and in female androgenic alopecia spironolactone and flutamide. In June 2022, the FDA authorized baricitinib for the treatment of severe
Management_of_hair_loss
Excessive hair growth on parts of the body where hair is usually minimal
medications: Bicalutamide: A pure antiandrogen. It is effective similarly to flutamide but is much safer as well as better-tolerated. Birth control pills that
Hirsutism
Type of gender-affirming medical treatment
disease. Due to its risks, the use of flutamide in cisgender and transgender women is now limited and discouraged. Flutamide and nilutamide have largely been
Feminizing_hormone_therapy
Chemical compound
modulators) like leuprorelin and degarelix, nonsteroidal antiandrogens like flutamide and bicalutamide, the diuretic and steroidal antiandrogen spironolactone
Cyproterone_acetate
Medical condition
melanin synthesis pathway Kojic acid (2%) OTC Alpha Arbutin 2–5% OTC Flutamide (1%) Chemical peels Microdermabrasion to dermabrasion (light to deep)
Melasma
Antiandrogen medication
randomized controlled trial found that finasteride was less effective than flutamide or an ethinylestradiol/cyproterone acetate birth control pill in the treatment
Finasteride
Skin disease
"Retrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year
Seborrhoeic_dermatitis
Hormonal disorder in women
for symptoms of androgen excess. Anti-androgens such as finasteride and flutamide do not show advantages over COCs for treating hirsutism, but can be an
Polyendocrine metabolic ovarian syndrome
Polyendocrine_metabolic_ovarian_syndrome
Chemical compound
a nonsteroidal antiandrogen (NSAA) and the major active metabolite of flutamide, which is considered to be a prodrug of hydroxyflutamide as the active
Hydroxyflutamide
favourable feature of flutamide therapy has been its lesser effect on libido and sexual potency; fewer than 20% of patients treated with flutamide alone reported
Effects of hormones on sexual motivation
Effects_of_hormones_on_sexual_motivation
Chemical compound
are similar in chemical structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide, all of which are NSAAs similarly. RU-58841
RU-58841
Antiandrogen medication used in treatment of prostate cancer
as an antiandrogen relative to so-called "first-generation" NSAAs like flutamide and bicalutamide. The drug has only 2-fold lower affinity for the AR than
Enzalutamide
Pharmaceutical compound
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
PP405
Body hair removal
their DNA. Antiandrogens, including spironolactone, cyproterone acetate, flutamide, bicalutamide, and finasteride, can be used to reduce or eliminate unwanted
Hair_removal
Chemical compound
and analogue of the NSAA flutamide, and shows greater in vivo antiandrogenic potency than does flutamide. Similarly to flutamide, AA560 is a selective antagonist
AA560
Physiological molecule and therapeutic drug
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Hyaluronic_acid
Drug class affecting sex hormones
estramustine phosphate; antiandrogens such as nonsteroidal antiandrogens like flutamide, nilutamide, and bicalutamide; and androgen synthesis inhibitors such
Gonadotropin-releasing hormone agonist
Gonadotropin-releasing_hormone_agonist
Chemical compound
second-generation NSAA enzalutamide but unlike first-generation NSAAs like flutamide and bicalutamide, elevated liver enzymes and hepatotoxicity have not been
Apalutamide
Chemical compound
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Zinc_pyrithione
Chemical compound
topical potency of the medication was greater than that of progesterone, flutamide, and finasteride and was equivalent to that of cyproterone acetate. Likewise
Clascoterone
Immunosuppressive drug
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Tacrolimus
Antiseptic solution
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Povidone-iodine
Investigational hair loss drugs
(androgen receptor antagonists) (e.g., spironolactone, cyproterone acetate, flutamide, bicalutamide) Oral estrogens (e.g., ethinylestradiol, estradiol) Topical
List of investigational hair loss drugs
List_of_investigational_hair_loss_drugs
Chemical compound
to 62% in the case of flutamide. The risk of hepatotoxicity with nilutamide has been described as far less than with flutamide. Fulminant hepatic failure
Nilutamide
Pharmaceutical compound
AR, bicalutamide has shown 0.29 to 6.4%, hydroxyflutamide 0.20 to 1%, flutamide <0.0057%, nilutamide 0.9%, and cyproterone acetate 2.2 to 7.8% of that
Pharmacology_of_bicalutamide
Chemical compound
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Hydroquinone
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Magnesium sulfate (medication)
Magnesium_sulfate_(medication)
Chemical compound
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Calcium_gluconate
Hormonal treatment for prostate cancer
the androgen receptor. The main antiandrogens are cyproterone acetate, flutamide, nilutamide, bicalutamide, and enzalutamide which are all administered
Androgen_deprivation_therapy
Drug used to treat allergic diseases
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Dupilumab
Chemical compound
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Monobenzone
Hormone replacement medication
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Dutasteride
Mechanisms of action
spironolactone is significantly or near-significantly inferior to 500 mg/day flutamide in improving symptoms of acne and hirsutism. One study compared placebo
Pharmacodynamics of spironolactone
Pharmacodynamics_of_spironolactone
Group of antibiotics derived from fungi
Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane
Penicillin
comparison of 750 mg/day flutamide and 150 mg/day oral CPA; the rates of hepatotoxicity were 15.3% (19 of 124) for flutamide and 9.5% (10 of 105) for
Side effects of cyproterone acetate
Side_effects_of_cyproterone_acetate
Chemical compound
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Drostanolone_propionate
only SAAs also acting as AR antagonists. First-generation Bicalutamide Flutamide Nilutamide Second-generation Apalutamide Darolutamide Enzalutamide Proxalutamide
List_of_antiandrogens
Antiandrogen with a nonsteroidal chemical structure
actions of androgens at the level of their biological target, the AR. Flutamide (Eulexin): Marketed for the treatment of prostate cancer and also used
Nonsteroidal_antiandrogen
Class of pharmaceutical drugs
mixed agonist/antagonists were nonsteroidal AR antiandrogens such as flutamide, nilutamide, bicalutamide. These antagonists work by binding to the AR
Selective androgen receptor modulator
Selective_androgen_receptor_modulator
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
List of 5α-reductase inhibitors
List_of_5α-reductase_inhibitors
Loss of hair from the head or body
modulators (oral contraceptives or antiandrogens such as spironolactone and flutamide) can be used for female-pattern hair loss associated with hyperandrogenemia
Hair_loss
Anabolic steroid
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Trenbolone
Chemical compound
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Cromoglicic_acid
Chemical compound
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
4-Aminobenzoic_acid
Mosaic genetic disorder affecting the bone, skin and endocrine systems
boys, these should be combined with drugs such as spironolactone and flutamide to treat androgen excess. Periodic ultrasounds of testicular lesions should
McCune–Albright_syndrome
Drug or agent applied to the skin to control seborrhea or seborrheic dermatitis
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Anti-seborrheic
Class of medications
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
5α-Reductase_inhibitor
Gonadotropin secreted by the adenohypophysis
antagonists (via disinhibition of the HPG axis): Antiandrogens (e.g., flutamide, bicalutamide, enzalutamide) Antiestrogens/SERMsTooltip Selective estrogen
Luteinizing_hormone
Androgen and anabolic steroid
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Metandienone
Androgen and anabolic steroid
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Oxandrolone
Nonsteroidal anti-inflammatory drug
Hormonal Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone ASC-J9 Estrogens Estradiol Ethinylestradiol Retinoids Adapalene
Aspirin
Formulary by the World Health Organization
Alternatives are 4th level ATC chemical subgroup (L02BG Aromatase inhibitors) Flutamide and nilutamide are alternatives Goserelin and triptorelin are alternatives
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Bile acid
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Deoxycholic_acid
Explosive chemical compound
Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane
RDX
Chemical compound
Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane
Γ-Hydroxybutyric_acid
Third-generation topical retinoid
Hormonal Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone ASC-J9 Estrogens Estradiol Ethinylestradiol Retinoids Adapalene
Adapalene
Antibiotic
Hormonal Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone ASC-J9 Estrogens Estradiol Ethinylestradiol Retinoids Adapalene
Clindamycin
Monoclonal antibody
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Nemolizumab
Medication
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Atinvicitinib
Psychological or sexual drive or energy
hypothyroidism, the effect of certain prescription medications (for example flutamide), and the attractiveness and biological fitness of one's partner, among
Libido
Drug class
inhibitors like anastrozole, and, only in men, pure antiandrogens such as flutamide, bicalutamide, enzalutamide, and apalutamide. Cole, H. H. (1975). "Studies
Progonadotropin
Androgenic Anabolic steroid
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Nandrolone
Medication for parasite infestations
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Ivermectin
Hormone for the maternal recognition of pregnancy
antagonists (via disinhibition of the HPG axis): Antiandrogens (e.g., flutamide, bicalutamide, enzalutamide) Antiestrogens/SERMsTooltip Selective estrogen
Human_chorionic_gonadotropin
Chemical compound
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Testosterone_cypionate
Antibiotic
Hormonal Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone ASC-J9 Estrogens Estradiol Ethinylestradiol Retinoids Adapalene
Tetracycline
Organic chemical compound
Hormonal Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone ASC-J9 Estrogens Estradiol Ethinylestradiol Retinoids Adapalene
Azelaic_acid
Chemical compound
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Boldenone_undecylenate
Chemical compound
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Testosterone_enanthate
Nonsteroidal anti-inflammatory drug
Hormonal Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone ASC-J9 Estrogens Estradiol Ethinylestradiol Retinoids Adapalene
Ibuprofen
Method to synthesize amides from amines and acid chlorides
reaction is widely used in organic chemistry. The industrial synthesis of flutamide, a nonsteroidal antiandrogen pharmaceutical drug, serves as a good example
Schotten–Baumann_reaction
GABA receptor antagonist drug and benzodiazepine antidote
Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane
Flumazenil
Fluoroquinolone antibiotic
Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane
Ciprofloxacin
Chemical compound with uses in industry and acne treatment
Hormonal Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone ASC-J9 Estrogens Estradiol Ethinylestradiol Retinoids Adapalene
Benzoyl_peroxide
Immunomodulatory drug which can cause birth defects
metabolite p,p’-DDE) Dieldrin DIMP Endosulfan Enzalutamide EPI-001 Fenarimol Flutamide Hydroxyflutamide Inocoterone Inocoterone acetate Ketoconazole Ketodarolutamide
Thalidomide
Hormone therapy used to treat symptoms of menopause
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Hormone_replacement_therapy
Class of drugs
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Anabolic_steroid
Anabolic steroid
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Nandrolone_phenylpropionate
Chemical compound
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Metenolone_enanthate
Nonsteroidal anti-inflammatory drug
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Diclofenac
Chemical compound
Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane
Γ-Butyrolactone
Antibiotic
Nonsteroidal antiandrogens (e.g., apalutamide, bicalutamide, enzalutamide, flutamide, nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane
Levofloxacin
Discontinued steroid for heart treatment
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Stanozolol
Chemical compound
ISBN 978-1-4160-6911-9. Knuth UA, Hano R, Nieschlag E (November 1984). "Effect of flutamide or cyproterone acetate on pituitary and testicular hormones in normal
Dienogest
Medication used to treat hair loss
(D11) Anti-seborrheics Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide)
Minoxidil
Chemical compound
RU-22930 is a nonsteroidal antiandrogen (NSAA) related to the NSAAs flutamide and nilutamide (RU-23908) and was developed by Roussel Uclaf but was never
RU-22930
Surgical procedure to perform a prostatectomy
reduced by pre-treatment with an anti-androgen such as finasteride or flutamide.[citation needed] Clot retention and clot colic. The blood released from
Transurethral resection of the prostate
Transurethral_resection_of_the_prostate
Gender-affirming medical treatment
Nonsteroidal: Apalutamide Bicalutamide Cimetidine Darolutamide Enzalutamide Flutamide Ketoconazole Nilutamide Seviteronel† Topilutamide (fluridil) Steroidogenesis
Gender-affirming hormone therapy
Gender-affirming_hormone_therapy
cyproterone and created cyproterone acetate. In the 1970s, the antiandrogen flutamide was discovered. In 1989 the United States Food and Drug Administration
Discovery and development of antiandrogens
Discovery_and_development_of_antiandrogens
Mammalian protein found in humans
acetate, spironolactone, oxendolone) Nonsteroidal antiandrogens (e.g., flutamide, nilutamide, bicalutamide, enzalutamide, apalutamide, RU-58841) N-Terminal
Androgen_receptor
FLUTAMIDE
FLUTAMIDE
FLUTAMIDE
FLUTAMIDE
Boy/Male
Shakespearean
Measure for Measure' An ancient Lord. 'The Tragedy of Romeo And Juliet' Prince of Verona.
Girl/Female
Indian
Wife of the Moon (Wife of the Moon)
Girl/Female
Tamil
Kirtmalini | கிரà¯à®¤à®®à®¾à®²à®¿à®¨à¯€
Garlanded with fame
Girl/Female
Biblical
Punishment, correction.
Boy/Male
English French
fifth.' Surname.
Girl/Female
German American Greek French
Male
Greek
(ἈÏτεμίσιος) Greek name derived from the name of the goddess Artemis, ARTEMISIOS means "safe and sound."
Girl/Female
African, American, Australian, British, Christian, English, French, Greek
God's Appearance; Manifestation of God
Girl/Female
Arabic, Muslim, Sindhi
Auspicious; Fortunate
Girl/Female
Hindu
Crown of hair
FLUTAMIDE
FLUTAMIDE
FLUTAMIDE
FLUTAMIDE
FLUTAMIDE