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EPILEPTOGENESIS

  • Epileptogenesis
  • Gradual development of epilepsy in the brain

    a pivotal event in the pathogenesis of epileptogenesis. BBB disruption was shown to underlay epileptogenesis by several experimental models. Breakdown

    Epileptogenesis

    Epileptogenesis

  • Epilepsy
  • Group of neurological disorders causing seizures

    understand and prevent epileptogenesis.[citation needed] Animal models are widely used in epilepsy research for studying epileptogenesis, seizure mechanisms

    Epilepsy

    Epilepsy

    Epilepsy

  • Alon Friedman
  • Israeli neuroscientist

    discoveries of the link between blood–brain barrier (BBB) disruption and Epileptogenesis (development of epilepsy) and the mechanisms underlying it, and for

    Alon Friedman

    Alon Friedman

    Alon_Friedman

  • Anticonvulsant
  • Class of medications

    epilepsy. However, no drug has been shown in human trials to prevent epileptogenesis (the development of epilepsy in an individual at risk, such as after

    Anticonvulsant

    Anticonvulsant

  • GAERS
  • Animal model of absence epilepsy

    The GAERS or Genetic Absence Epilepsy Rat from Strasbourg is a recognized animal model of absence epilepsy, a typical childhood form of epilepsy characterized

    GAERS

    GAERS

  • Temporal lobe epilepsy
  • Chronic focal seizure disorder

    uncontrolled neuronal firing, leading to seizures. The secondary epileptogenesis hypothesis is that repetitive seizures lead to interneuron loss, loss

    Temporal lobe epilepsy

    Temporal lobe epilepsy

    Temporal_lobe_epilepsy

  • Seizure
  • Period of symptoms due to excessive or synchronous neuronal brain activity

    changes may lead to the development of epilepsy, in a process called epileptogenesis. The clinical evaluation after a seizure aims to confirm whether the

    Seizure

    Seizure

    Seizure

  • James O. McNamara
  • American Neuroscientist and neurologist

    required for epileptogenesis caused by seizures. Subsequent work elucidated the signaling pathway downstream of TrkB underlying epileptogenesis, namely phospholipase

    James O. McNamara

    James_O._McNamara

  • Inter-ictal spiking
  • Clinical sign in epilepsy

    seizure and origin of onset. Staley, KJ (2006). "Interictal Spikes and Epileptogenesis". Epilepsy Currents. 6 (6): 199–202. doi:10.1111/j.1535-7511.2006.00145

    Inter-ictal spiking

    Inter-ictal_spiking

  • Finasteride
  • Antiandrogen medication

    disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis". Epilepsy & Behavior. 25 (1): 92–97. doi:10.1016/j.yebeh.2012.05.024

    Finasteride

    Finasteride

    Finasteride

  • Post-traumatic epilepsy
  • Medical condition

    biomarkers of epileptogenesis. There is also interest in finding more antiepileptic drugs, with the potential to interfere with epileptogenesis. Some new

    Post-traumatic epilepsy

    Post-traumatic_epilepsy

  • Brain–computer interface
  • Connection between brain and computer

    J, Chrościńska-Krawczyk M, Czuczwar SJ (June 2015). "Prospects of epileptogenesis prevention". Pharmacological Reports. 67 (3): 663–668. doi:10.1016/j

    Brain–computer interface

    Brain–computer interface

    Brain–computer_interface

  • Anaxonic neuron
  • This leads to increased neuronal excitability and susceptibility to epileptogenesis, highlighting the critical role of anaxonic inhibitory neurons in seizure

    Anaxonic neuron

    Anaxonic neuron

    Anaxonic_neuron

  • Paroxysmal depolarizing shift
  • Manifestation of epilepsy in neurons

    potentia l. Failure to terminate a PDS is associated with increased epileptogenesis and may be linked to seizure activity. In general, synaptic PDS could

    Paroxysmal depolarizing shift

    Paroxysmal_depolarizing_shift

  • Ketogenic diet
  • High-fat dietary therapy for epilepsy

    development of seizure susceptibility. The development of epilepsy (epileptogenesis) is a process that is poorly understood. A few anticonvulsants (valproate

    Ketogenic diet

    Ketogenic diet

    Ketogenic_diet

  • Zonisamide
  • Chemical compound

    molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures". Brain Research. Molecular Brain

    Zonisamide

    Zonisamide

    Zonisamide

  • Pyramidal cell
  • Projection neurons in the cerebral cortex and hippocampus

    CA3 Pyramidal Cells: Mechanisms for Epileptic Synchronization and Epileptogenesis", in Schwartzkroin, Philip A. (ed.), Encyclopedia of Basic Epilepsy

    Pyramidal cell

    Pyramidal cell

    Pyramidal_cell

  • Kindling model of epilepsy
  • Model for the development of seizures

    phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. The publication of these results opened a completely

    Kindling model of epilepsy

    Kindling_model_of_epilepsy

  • Kainate receptor
  • Class of ionotropic glutamate receptors

    models. Deletion of either GluK1 or GluK2 does not alter kindling epileptogenesis or the expression of kindled seizures. Recent investigation through

    Kainate receptor

    Kainate receptor

    Kainate_receptor

  • Perforant path
  • Scimemi, A.; Schorge, S; Kullmann, D. M.; Walker, M. C. (2005). "Epileptogenesis is Associated with Enhanced Glutamatergic Transmission in the Perforant

    Perforant path

    Perforant path

    Perforant_path

  • Subiculum
  • Most inferior part of the hippocampal formation

    PMID 18504292. Stafstrom CE (2005). "The role of the subiculum in epilepsy and epileptogenesis". Epilepsy Curr. 5 (4): 121–9. doi:10.1111/j.1535-7511.2005.00049.x

    Subiculum

    Subiculum

    Subiculum

  • AMPA receptor
  • Transmembrane protein family

    in both animal models and humans, emphasizing their contribution to epileptogenesis. Conversely, antagonists targeting AMPARs have demonstrated efficacy

    AMPA receptor

    AMPA receptor

    AMPA_receptor

  • Nicolas Bazan
  • Argentine neuroscientist

    Bazan and his colleagues showed in "in vivo" rodent models of limbic epileptogenesis (LE) that the phospholipid mediator platelet-activating factor (PAF)

    Nicolas Bazan

    Nicolas_Bazan

  • Epilepsy and employment
  • epilepsy Basics Seizure types Aura (warning sign) Postictal state Epileptogenesis Neonatal seizure Epilepsy in children Management Anticonvulsants Investigations

    Epilepsy and employment

    Epilepsy_and_employment

  • Post-traumatic seizure
  • Seizure caused by a traumatic brain injury

    cells produce energy. Late seizures are thought to be the result of epileptogenesis, in which neural networks are restructured in a way that increases

    Post-traumatic seizure

    Post-traumatic_seizure

  • Biological neuron model
  • Mathematical descriptions of the properties of certain cells in the nervous system

    CA3 Pyramidal Cells: Mechanisms for Epileptic Synchronization and Epileptogenesis", in Schwartzkroin, Philip A. (ed.), Encyclopedia of Basic Epilepsy

    Biological neuron model

    Biological neuron model

    Biological_neuron_model

  • Kainic acid
  • Chemical compound

    of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis". The Journal of Neuroscience. 34 (17): 5765–5775. doi:10.1523/JNEUROSCI

    Kainic acid

    Kainic acid

    Kainic_acid

  • Ventromedial nucleus of the hypothalamus
  • Nucleus of the hypothalamus

    1998). "The role of the ventromedial nucleus of the hypothalamus in epileptogenesis". NeuroReport. 9 (16): 3623–9. doi:10.1097/00001756-199811160-00013

    Ventromedial nucleus of the hypothalamus

    Ventromedial nucleus of the hypothalamus

    Ventromedial_nucleus_of_the_hypothalamus

  • Pompilidotoxin
  • Pharmaceutical compound

    important for providing insights into the role of sodium currents in epileptogenesis. Thus, even though pompilidotoxins are not used as drugs and therefore

    Pompilidotoxin

    Pompilidotoxin

  • Racine stages
  • PMID 4981856. Pinel, John P.J.; Rovner, L.I. (1978). "Experimental epileptogenesis: Kindling-induced epilepsy in rats". Experimental Neurology. 58 (2):

    Racine stages

    Racine_stages

  • Animal models of epilepsy
  • understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs

    Animal models of epilepsy

    Animal_models_of_epilepsy

  • SZT2
  • Protein-coding gene in the species Homo sapiens

    that this gene confers low seizure threshold, and may also enhance epileptogenesis. Mutations in this gene have been shown to cause infantile encephalopathy

    SZT2

    SZT2

    SZT2

  • LSP2-9166
  • Chemical compound

    (September 2019). "The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures". Neurobiology of Disease. 129: 13–28. doi:10

    LSP2-9166

    LSP2-9166

    LSP2-9166

  • Sunil Pradhan
  • Indian neurologist

    His studies revealed that patients are likely to suffer from chronic epileptogenesis with poor seizure outcome if gliosis is present around their lesions

    Sunil Pradhan

    Sunil_Pradhan

  • Juan Lerma Gómez
  • Spanish neuroscientist and research professor

    KAR's fundamental role in controlling neuronal tissue excitability and epileptogenesis, demonstrating that KARs have a dual mechanism of signaling. Nowadays

    Juan Lerma Gómez

    Juan_Lerma_Gómez

  • Reflex seizure
  • Medical condition

    and reflex epilepsies: old models for understanding mechanisms of epileptogenesis". Epilepsy Research. 100 (1–2): 1–11. doi:10.1016/j.eplepsyres.2012

    Reflex seizure

    Reflex_seizure

  • Adenosine kinase
  • Enzyme

    PMID 17942368. Boison D (March 2008). "The adenosine kinase hypothesis of epileptogenesis". Progress in Neurobiology. 84 (3): 249–62. doi:10.1016/j.pneurobio

    Adenosine kinase

    Adenosine kinase

    Adenosine_kinase

  • Ephaptic coupling
  • Form of nervous system communication

    Rash JE (November 1998). "'Non-synaptic' mechanisms in seizures and epileptogenesis". Cell Biol. Int. 22 (11–12): 793–805. doi:10.1006/cbir.1999.0397.

    Ephaptic coupling

    Ephaptic_coupling

  • James Rutka
  • Canadian neurosurgeon (born 1956)

    colleagues have used magnetoencephalography (MEG) to identify regions of epileptogenesis amenable to neurosurgical resection. Over the course of his research

    James Rutka

    James Rutka

    James_Rutka

  • Long-term video-EEG monitoring
  • Beamer, E; Sexton, A; Crutison, J; Thippeswamy, T (2015). "Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence

    Long-term video-EEG monitoring

    Long-term_video-EEG_monitoring

  • Granule cell dispersion
  • 2009). "Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the

    Granule cell dispersion

    Granule_cell_dispersion

  • LGI1
  • Protein-coding gene in the species Homo sapiens

    Finocchiaro G, Steinlein OK (May 2005). "LGI1: a gene involved in epileptogenesis and glioma progression?". Neurogenetics. 6 (2): 59–66. doi:10.1007/s10048-005-0216-5

    LGI1

    LGI1

    LGI1

  • Granule cell
  • Type of neuron with a very small cell body

    that result in the hippocampal network plasticity associated with epileptogenesis. Patients with Alzheimer's have shorter granule cell dendrites. Furthermore

    Granule cell

    Granule cell

    Granule_cell

  • Raymond Dingledine
  • American pharmacologist, neurobiologist (born 1948)

    Alon; Dingledine, Raymond J. (June 2013). "The role of inflammation in epileptogenesis". Neuropharmacology. 69: 16–24. doi:10.1016/j.neuropharm.2012.04.004

    Raymond Dingledine

    Raymond Dingledine

    Raymond_Dingledine

  • Galanin receptor
  • InterPro Family

    Shin D, Langel U, Sankar R (August 2006). "Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of

    Galanin receptor

    Galanin_receptor

  • Daniel H. Lowenstein (physician)
  • American neurologist

    fundamental mechanisms of neuronal network remodeling that occur during epileptogenesis, the process in which a normal network transforms into a hyperexcitable

    Daniel H. Lowenstein (physician)

    Daniel_H._Lowenstein_(physician)

  • Gene therapy for epilepsy
  • Medical treatment research

    seizures are triggered, potentially resulting in the development of epileptogenesis. Studies have shown that ADK overexpression results from astrogliosis

    Gene therapy for epilepsy

    Gene_therapy_for_epilepsy

  • Nervous system of gastropods
  • the decision. Neurons of Helix, Helix aspersa, are used for study of epileptogenesis, because they are sensitive to epileptogenic drugs including pentylenetetrazol

    Nervous system of gastropods

    Nervous system of gastropods

    Nervous_system_of_gastropods

  • National Brain Research Centre
  • Indian neuroscience research institute

    Centre for Excellence for Epilepsy/MEG facility: This center studies epileptogenesis, better diagnosis, and localization of epileptogenic foci and new therapeutic

    National Brain Research Centre

    National Brain Research Centre

    National_Brain_Research_Centre

  • Nencki Institute of Experimental Biology of the Polish Academy of Sciences
  • conditions. We study the effects of stroke and neurodegenerative diseases, epileptogenesis and the consequences of re-innervation, as well as emotional disturbances

    Nencki Institute of Experimental Biology of the Polish Academy of Sciences

    Nencki_Institute_of_Experimental_Biology_of_the_Polish_Academy_of_Sciences

  • Low-threshold spikes
  • Marco (2012). "Voltage-Gated Ca2+ Channel Mediated Ca2+ Influx in Epileptogenesis". In Islam, Md. Shahidul (ed.). Calcium Signaling. Advances in Experimental

    Low-threshold spikes

    Low-threshold_spikes

  • Fabrice Bartolomei
  • French neurophysiologist

    involved in animal research studies dealing with stress influence on epileptogenesis He is the co-inventor of the “Epileptogenicity Index, a method for

    Fabrice Bartolomei

    Fabrice Bartolomei

    Fabrice_Bartolomei

  • Apical dendrite
  • Type of dendrite found at the apex of cortical pyramidal cell pathways

    pyramidal cells and interneurons has been related to CA1 roles in epileptogenesis. CA1 is hyperexcitable when the CA3 region is damaged. Reduction of

    Apical dendrite

    Apical_dendrite

  • Oleg Krishtal
  • Ukrainian neurophysiologist (born 1945)

    (plasmalemma and nuclear envelope); molecular mechanisms of epilepsy and epileptogenesis and pharmacological agents with antiseizure properties; the role of

    Oleg Krishtal

    Oleg Krishtal

    Oleg_Krishtal

  • GABRB3
  • Protein-coding gene in the species Homo sapiens

    4001011. PMID 11920158. DeLorey TM, Olsen RW (September 1999). "GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with Angelman syndrome in man"

    GABRB3

    GABRB3

    GABRB3

  • MiR-324-5p
  • Type of microRNA

    epilepsy is seizure-suppressive. Changes in miRNA expression are seen in epileptogenesis and in other disease pathologies. In epilepsy, miR-324-5p expression

    MiR-324-5p

    MiR-324-5p

  • Annalisa Scimemi
  • American neuroscientist

    Stephanie; Kullmann, Dimitri M.; Walker, Matthew C. (February 2006). "Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant

    Annalisa Scimemi

    Annalisa Scimemi

    Annalisa_Scimemi

  • Nonsynaptic plasticity
  • Form of neuroplasticity

    pyramidal excitability and NMDA conductance can explain posttraumatic epileptogenesis without disinhibition: a model". Journal of Neurophysiology. 82 (4):

    Nonsynaptic plasticity

    Nonsynaptic plasticity

    Nonsynaptic_plasticity

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Online names & meanings

  • Mahiraj
  • Boy/Male

    Gujarati, Hindu, Indian, Marathi

    Mahiraj

    Ruler of the World

  • Harmalah
  • Boy/Male

    Arabic, Muslim

    Harmalah

    A Plant; An Egyptian Disciple of Shafaee had this Name; He was Ibn Yahya

  • Yusayrah
  • Girl/Female

    Arabic, Muslim

    Yusayrah

    Easy; One of the First Two Swear Allegiance (Bayah) to the Prophet (SAW) Among the Ansar

  • Chardae
  • Girl/Female

    French

    Chardae

    Feminine of Charles meaning manly.

  • Hanfa
  • Girl/Female

    Arabic, Muslim, Sindhi

    Hanfa

    Name of the Wife of Sayyidina Ismail

  • Nur-al-Huda
  • Girl/Female

    Arabic, Muslim

    Nur-al-Huda

    Light of the Faith

  • Umar
  • Boy/Male

    African, American, Arabic, Gujarati, Hindu, Indian, Indonesian, Jamaican, Kannada, Malaysian, Muslim, Pashtun, Sindhi, Swahili, Tamil

    Umar

    Second Khalifah; A Long Individual Life; Who has Long Live; Flourishing; Blossoming; Long-lived; Prosper; Variant of Omar; Longevity; Age; Usman; Populous

  • Bhagavan
  • Boy/Male

    Assamese, Hindu, Indian, Kannada, Sanskrit, Telugu

    Bhagavan

    Of Great Fortune; King; Lord

  • Igor
  • Boy/Male

    Christian & English(British/American/Australian)

    Igor

    Heroic Warrior

  • Prameela
  • Girl/Female

    Indian, Telugu

    Prameela

    Godeess; Honey

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EPILEPTOGENESIS

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