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Protein-coding gene in the species Homo sapiens
Crossover junction endonuclease EME1 is an enzyme that is encoded by the EME1 gene in humans. It forms a complex with MUS81 which resolves Holliday junctions
EME1
Protein-coding gene in the species Homo sapiens
endonuclease shares redundancy with the EME1/MUS81 protein complex for DNA damage repair in mammalian cells. GEN1 and EME1/MUS81, in mice, have redundant functions
GEN1, Holliday junction 5' flap endonuclease
GEN1,_Holliday_junction_5'_flap_endonuclease
Enzymes which cleave a nucleotide chain
stage of crosslink repair involves production of double-strand breaks. MUS81/EME1 is a structure specific endonuclease involved in converting interstrand crosslinks
Endonuclease
Protein-coding gene in the species Homo sapiens
West SC (Jul 2003). "Identification and characterization of the human mus81-eme1 endonuclease". The Journal of Biological Chemistry. 278 (27): 25172–8. doi:10
MUS81
open the unfinished DNA using enzyme nucleases such as SLX1-SLX4 and MUS81-EME1. Typically, these nucleases will work as the cell transitions from the G2
Mitotic_DNA_Synthesis
British biochemist and molecular biologist
processing in human cells involving BLM-topoIIIα-RMI1-RMI2 (BTR), SLX1-SLX4-MUS81-EME1-ERCC1-XPF (SMX) and GEN1. His laboratory discovered that the Holliday junction
Stephen_C._West
HGNC:27609; Q5UCC4 4919 EMCN HGNC:16041; Q9ULC0 4920 EMD HGNC:3331; P50402 4921 EME1 HGNC:24965; Q96AY2 4922 EME2 HGNC:27289; A4GXA9 4923 EMG1 HGNC:16912; Q92979
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
Protein family
bacteriophages (T7 endonuclease I), bacteria (RuvC), fungi (GEN1) and humans (hMus81-Eme1) have revealed that the enzymes function in dimers, and part of the resolution
Crossover junction endodeoxyribonuclease
Crossover_junction_endodeoxyribonuclease
Protein-coding gene in the species Homo sapiens
comprising two subunits. Such nucleases include, for example, the MUS81-EME1 nuclease. The ERCC1–XPF complex is a structure-specific endonuclease. ERCC1-XPF
ERCC4
Protein-coding gene in humans
comprising two subunits. Such nucleases include, for example, the MUS81-EME1 nuclease. The ERCC1–XPF complex is a structure-specific endonuclease. ERCC1-XPF
ERCC1
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