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DLL3

  • DLL3
  • Protein-coding gene in the species Homo sapiens

    Delta-like 3 (Drosophila), also known as DLL3, is a protein which in humans is encoded by the DLL3 gene. Two transcript variants encoding distinct isoforms

    DLL3

    DLL3

    DLL3

  • Tarlatamab
  • Monoclonal antibody

    Govindan R, Boyer M, et al. (June 2023). "Tarlatamab, a First-in-Class DLL3-Targeted Bispecific T-Cell Engager, in Recurrent Small-Cell Lung Cancer:

    Tarlatamab

    Tarlatamab

  • Rovalpituzumab tesirine
  • Experimental antibody-drug conjugate

    (Rova-T) is an experimental antibody-drug conjugate targeting the protein DLL3 on tumor cells. It was originally developed by Stemcentrx and was purchased

    Rovalpituzumab tesirine

    Rovalpituzumab_tesirine

  • Spinal column
  • Bony structure found in vertebrates

    homologues of three genes associated to the mouse segmentation clock, (MESP2, DLL3 and LFNG), have been shown to be mutated in cases of congenital scoliosis

    Spinal column

    Spinal column

    Spinal_column

  • Somite
  • Embryology concept

    clock and wavefront model, forms the boundaries of the somites. DLL1 and DLL3 are Notch ligands, mutations of which cause various defects. Notch regulates

    Somite

    Somite

    Somite

  • Novartis
  • Swiss multinational pharmaceutical corporation

    antigen receptor (CAR-T) therapies, that go after delta-like ligand protein 3 (DLL3) including large cell neuroendocrine carcinoma candidate LB2102 for $100 million

    Novartis

    Novartis

    Novartis

  • GenScript Biotech
  • Biotechnology group

    antigen receptor (CAR-T) therapies, which target delta-like ligand protein 3 (DLL3), including large cell neuroendocrine carcinoma candidate LB2102. Novartis

    GenScript Biotech

    GenScript Biotech

    GenScript_Biotech

  • Merck & Co.
  • American multinational pharmaceutical company

    that is being researched to treat advanced cancer patients associated with DLL3 expression (delta-like ligand 3), an inherent small cell lung cancer (SCLC)

    Merck & Co.

    Merck & Co.

    Merck_&_Co.

  • Kenro Kusumi
  • Genome biologist and professor at Arizona State University

    disorder, spondylocostal dysostosis, caused by mutations in delta-like 3 (DLL3), and he contributed to subsequent research identifying mutations in the

    Kenro Kusumi

    Kenro Kusumi

    Kenro_Kusumi

  • EGF-like domain
  • Protein domain named after the epidermal growth factor protein

    CNTNAP3; CNTNAP4; CNTNAP5; COMP; COX-2; CRB1; CRB2; CSPG3; CUBN; DLK1; DLL1; DLL3; DLL4; DNER; EDIL3; EGF; EGFL11; EGFL7; EGFL8; EGFL9; EGFLAM; EPGN; EREG;

    EGF-like domain

    EGF-like domain

    EGF-like_domain

  • List of therapeutic monoclonal antibodies
  • root plate-specific spondin 3 cancer Rovalpituzumab tesirine mab humanized DLL3 small cell lung cancer Rovelizumab LeukArrest mab humanized CD11, CD18 Y

    List of therapeutic monoclonal antibodies

    List of therapeutic monoclonal antibodies

    List_of_therapeutic_monoclonal_antibodies

  • Spondylocostal dysostosis
  • Axial skeleton growth disorder

    Type OMIM Gene Locus SCDO1 277300 DLL3 19q13.2 SCDO2 608681 MESP2 15q26.1 SCDO3 609813 LFNG 7p22.3 SCDO4 613686 HES7 17p13.1 SCDO5 122600 TBX6 16p11.2

    Spondylocostal dysostosis

    Spondylocostal_dysostosis

  • Notch signaling pathway
  • Series of molecular signals

    coordinate key steps in this process. In mice, mutations in Notch1, Dll1 or Dll3, Lfng, or Hes7 result in abnormal somite formation. Similarly, in humans

    Notch signaling pathway

    Notch signaling pathway

    Notch_signaling_pathway

  • Sally Dunwoodie
  • Australian scientist

    Dunwoodie, D. Henrique, S. M. Harrison, R. S. P. Beddington (1997), "Mouse Dll3: a novel divergent Delta gene which may complement the function of other

    Sally Dunwoodie

    Sally_Dunwoodie

  • List of human protein-coding genes 2
  • HGNC:2907; P80370 4313 DLK2 HGNC:21113; Q6UY11 4314 DLL1 HGNC:2908; O00548 4315 DLL3 HGNC:2909; Q9NYJ7 4316 DLL4 HGNC:2910; Q9NR61 4317 DLST HGNC:2911; P36957

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

  • Kolma N'arrab
  • 2007 studio album by Angham

    منتديات دلع" [Rumour: singer Angham is banned from singing in Kuwait]. vb.dll3.com (in Arabic). Retrieved 31 August 2007.{{cite web}}: CS1 maint: deprecated

    Kolma N'arrab

    Kolma_N'arrab

  • Hepatocyte growth factor receptor
  • Mammalian protein found in Homo sapiens

    The Notch pathway, through transcriptional activation of Delta ligand (see DLL3). MET mediates a complex program known as invasive growth. Activation of

    Hepatocyte growth factor receptor

    Hepatocyte growth factor receptor

    Hepatocyte_growth_factor_receptor

  • List of OMIM disorder codes
  • 609813; LFNG Spondylocostal dysostosis, autosomal recessive, 1; 277300; DLL3 Spondylocostal dystostosis 4, autosomal dominant; 122600; GDF6 Spondyloepimetaphyseal

    List of OMIM disorder codes

    List_of_OMIM_disorder_codes

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Online names & meanings

  • KalaiVanan
  • Boy/Male

    Indian, Tamil

    KalaiVanan

    Gem of Arts

  • Cheyanne
  • Girl/Female

    American, Australian, Chinese, French

    Cheyanne

    Unintelligible Speakers; Similar to Cheyanne; Tribal Name; Little Red Talker

  • Girisha | கீரிஷா
  • Girl/Female

    Tamil

    Girisha | கீரிஷா

    Goddess Parvati

  • Saniksha
  • Girl/Female

    Indian, Tamil

    Saniksha

    Peace

  • Rishan
  • Boy/Male

    Arabic, Indian, Malayalam, Muslim, Tamil

    Rishan

    Good Human Being; Lord Vishnu / Shiva

  • Rashitha
  • Girl/Female

    Hindu

    Rashitha

  • Tulasa
  • Girl/Female

    Hindu

    Tulasa

  • Shiya |
  • Girl/Female

    Muslim

    Shiya |

    Snow at dawn, Death

  • Aar
  • Boy/Male

    Indian

    Aar

    Light bringer

  • Coby
  • Boy/Male

    American, Australian, British, Chinese, English, Scottish

    Coby

    Supplanter; Variant of Coburn

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DLL3

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