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Toxicity as observed in the development of an organism
development or behavior. Developmental toxicity is caused by environmental factors, things like drugs, alcohol, diet, toxic chemicals, and physical factors
Developmental_toxicity
Chemical compound
identify: Dermal toxicity Eye irritation Inhalation toxicity Oral toxicity Skin irritation Skin sensitization PBO has a low acute toxicity by oral, inhalation
Piperonyl_butoxide
Hazard associated with chemical substances
fertility as well as causing developmental toxicity in the offspring. Lowered effective fertility related to reproductive toxicity relates to both male and
Reproductive_toxicity
Type of mycotoxin
males and females are not provided yet. Acute toxicity of nivalenol induces bone marrow toxicity and toxicity of lymphoid organs. Long-term exposure may
Nivalenol
Study of substances harmful to living organisms
substance causes cancer and to examine other forms of toxicity. Factors that influence chemical toxicity: Dosage Both large single exposures (acute) and continuous
Toxicology
International standard managed by the United Nations
organ toxicity hazard class are assigned to one of three hazard categories. Substances and mixtures of the repeated exposure target organ toxicity hazard
Globally Harmonized System of Classification and Labelling of Chemicals
Globally_Harmonized_System_of_Classification_and_Labelling_of_Chemicals
Chemical compound
the effects of IAA on humans and toxicity data are limited. No data on human carcinogenic, teratogenic, or developmental effects have been created. IAA
Indole-3-acetic_acid
Set of accepted specifications
TG 453 (Combined Chronic Toxicity/Carcinogenicity) for more on dose ranging. At these high chronic exposure doses, toxicity is likely in some but not
OECD Guidelines for the Testing of Chemicals
OECD_Guidelines_for_the_Testing_of_Chemicals
Polychlorinated dibenzo-p-dioxin, chemical compound
2000, the Expert Group of the World Health Organization considered developmental toxicity as the most pertinent risk of dioxins to human beings. Because people
2,3,7,8-Tetrachlorodibenzodioxin
2,3,7,8-Tetrachlorodibenzodioxin
Poisonous plant
Forsyth, Carol S.; Frank, Anthony A. (July 1993). "Evaluation of developmental toxicity of coniine to rats and rabbits". Teratology. 48 (1): 59–64. doi:10
Conium_maculatum
Standards for evaluating biocompatibility of medical devices
10993-3: 2014. Tests for genotoxicity, carcinogenicity and reproductive toxicity ISO 10993-4: 2017. Selection of tests for interactions with blood ISO 10993-5:
ISO_10993
Mammals of the family Leporidae
Carney, Edward W (2000). "The rabbit as a model for reproductive and developmental toxicity studies". Reproductive Toxicology. 14 (6): 477–493. Bibcode:2000RepTx
Rabbit
Study of developmental anomalies
birth as well as later during early childhood. The related term developmental toxicity includes all manifestations of abnormal development that are caused
Teratology
Condition present at birth regardless of cause
2020 were that 19% of the 1065 chemicals yielded a prediction of developmental toxicity. Probably, the most well-known teratogenic drug is thalidomide.
Birth_defect
Process of testing biological interventions on whole, living organisms
europa.eu. Retrieved 2023-04-11. Toxicity, National Research Council (US) Subcommittee on Reproductive and Developmental (2001). "Experimental Animal and
In_vivo
Latin term meaning outside a natural biological environment
of in vitro toxicity data and physiologically based kinetic modeling to predict dose–response curves for in vivo developmental toxicity of glycol ethers
In_vitro
Chemical compound
lethality studies indicate moderate acute toxicity by mouth and by inhalation (Category II) and low acute toxicity through the skin (Categories IV). It is
Prallethrin
Condition of elevated methemoglobin in the blood
an update on methemoglobinemia occurrence and reproductive and developmental toxicity". Regulatory Toxicology and Pharmacology. 23 (1 Pt 1): 35–43. doi:10
Methemoglobinemia
Chemical compound
H319, H335). Studies show NMP exposure can increase the risk of developmental toxicity, including miscarriage and fetal death. Good ventilation and PPE
N-Methyl-2-pyrrolidone
Chemical compound
670 mg/kg. Exposure to high levels of chlormequat has been linked to developmental toxicity in animal models. Chlormequat has not previously been registered
Chlormequat
Weak acid with formula H3BO3
residents living near boron-rich regions) produced no indicators of developmental toxicity in blood and semen tests. The highest estimated exposure was 5 mg
Boric_acid
Boron compound, a salt of boric acid
low toxicity of borax, as reported in two EPA documents relating to boric acid and borax. EPA has determined that, because they are of low toxicity and
Borax
Chemical compound
products of pymetrozine. Exposure to 3-PCA has been reported to cause developmental toxicity in zebrafish. The annual usage of pymetrozine was at least 4.45
Pymetrozine
Chemical element with atomic number 28 (Ni)
carbonyl [Ni(CO)4] is an extremely toxic gas. The toxicity of metal carbonyls is a function of both the toxicity of the metal and the off-gassing of
Nickel
Substances added to food
subchronic (at least 90 data) and chronic toxicity and carcinogenity; reproductive and developmental toxicity. A subset of food additives, micronutrients
Food_additive
Chemical compound
carcinogenicity, genotoxicity, neurotoxicity, or reproductive and developmental toxicity at the permitted dietary exposures; the European acceptable daily
Ponceau_4R
American scientist and executive
of experimental toxicity findings. Early in Holson's career, while at NCTR, he led studies that assessed the developmental toxicity of FD&C Red No. 2
Joseph_F._Holson
Organic compounds that are resistant to environmental degradation
is highly toxic to aquatic organisms. Human toxicology studies are ongoing, but it shows neuroendocrine disruption and developmental toxicity in animal
Persistent_organic_pollutant
Chemical compound used as colorant
Sunset yellow FCF has no known carcinogenicity, genotoxicity, or developmental toxicity in the amounts at which it is used. It has been claimed since the
Sunset_yellow_FCF
Class of environmentally polluting organic compounds
toxicity, are given a toxicity rating from 0 to 1, where TCDD = 1 (see Dioxins and dioxin-like compounds). This toxicity rating is called the Toxic Equivalence
Polychlorinated dibenzodioxins
Polychlorinated_dibenzodioxins
Brand of hair care products
(August 2004). "Developmental toxicity evaluation of butylparaben in Sprague-Dawley rats". Birth Defects Research Part B: Developmental and Reproductive
Herbal_Essences
Chemical compound
acute toxicity. The toxicity for oral administration and inhalation is of Toxicity Category IV and for the dermal route is the toxicity of Toxicity Category
Novaluron
Chemical compound used in medicines and industry
cosmetic products demonstrates no evidence of a health risk from developmental toxicity". Regulatory Toxicology and Pharmacology. 94. Elsevier BV: 245–251
Salicylic_acid
Chemical compound
had not been dried properly. 2-Ethylhexanol has been linked to developmental toxicity (increased incidence of skeletal malformations in fetuses). This
2-Ethylhexanol
Medical controversy
hexane to perform testing for subchronic toxicity, oncogenicity, reproductive toxicity, developmental toxicity, mutagencity, neurotoxicity, and inhalation
Seed_oil_misinformation
Organic chemical compound
Authority (EFSA), the main toxicity risks of acrylamide are "Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity"
Acrylamide
Effects of cigarettes on the developing human brain
Theodore A.; Spindel, Eliot; Stroud, Laura; Wakschlag, Lauren (2017). "Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for
Effects of nicotine on human brain development
Effects_of_nicotine_on_human_brain_development
Fluorosurfactant and persistent organic pollutant
Boone, J. S.; McGuinn, W. D.; Dewitt, J. C.; Keil, D. E. (2009). "Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane
Perfluorooctanesulfonic_acid
Blue dye derived from indigo
Indigo carmine shows "genotoxicity, developmental toxicity or modifications of haematological parameters in chronic toxicity studies". Only at 17 mg/kg of body
Indigo_carmine
Food made of flour and water
Acrylamide is neurotoxic, has adverse effects on male reproduction and developmental toxicity and is carcinogenic. A study has found that more than 99 percent
Bread
Species of plant
grade safflower concentrate: No evidence for reproduction and early developmental toxicity". Reproductive Toxicology. 104: 155–165. Bibcode:2021RepTx.104.
Safflower
Species of spider
(2013). "Old World vs. New World: a preliminary comparison of the developmental toxicity of venom from two tarantula species, Grammostola rosea and Haplopelma
Chilean_rose_tarantula
Scientific analysis
In vitro toxicity testing is the scientific analysis of the toxic effects of chemical substances on cultured bacteria or mammalian cells. In vitro (literally
In_vitro_toxicology
Danish scientist
Board of Health in Denmark. He is known for his research into the developmental toxicity and adverse effects of certain environmental chemicals to which
Philippe Grandjean (professor)
Philippe_Grandjean_(professor)
Chemical compound
Jarry H, Wuttke W, Lichtensteiger W (2004). "Endocrine activity and developmental toxicity of cosmetic UV filters--an update". Toxicology. 205 (1–2): 113–122
Homosalate
Chemicals regulated in the United States
and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductive toxicity" as
California Proposition 65 list of chemicals
California_Proposition_65_list_of_chemicals
Systemic herbicide and crop desiccant
relative acute toxicity of the formulation. Glyphosate has less acute toxicity than 94% of herbicides in USDA data, and less acute toxicity than household
Glyphosate
Chemical compound
be a non-carcinogen with no genotoxicity and in reproductive and developmental toxicity studies using rats and mice, IPBC had no significant effect on fertility
Iodopropynyl_butylcarbamate
Chemical compound
single dose oral toxicity", on the order of tens of grams per kilogram of human body weight when ingested by mouth. Because of its low toxicity, PEO is used
Polyethylene_glycol
Chemical element with atomic number 81 (Tl)
repeated exposure to thallium increases the risk of reproductive toxicity or developmental toxicity. Chronic high level exposure to thallium through inhalation
Thallium
Class of chemical compounds
g. liver toxicity is typical in rabbits. Low doses. Very few signs of toxicity are seen in adult animals after low doses, but developmental effects may
Dioxins and dioxin-like compounds
Dioxins_and_dioxin-like_compounds
United States federal law
long-term toxicity to fish and aquatic species, short-term toxicity to terrestrial organisms and plants, two-generation toxicity study, subchronic toxicity to
Toxic Substances Control Act of 1976
Toxic_Substances_Control_Act_of_1976
Chemical compound
studies of highly exposed female workers have not shown adverse developmental toxicity effects. K. Lascelles, L. G. Morgan, D. Nicholls, D. Beyersmann
Nickel(II)_sulfate
Chemical compound responsible for rotten fish odor
greying of the skin and agitation. Apart from that, reproductive/developmental toxicity has been reported. Some experimental studies suggested that TMA
Trimethylamine
Chemical compound
E.; Schroeder, R. E.; Zwick, L.; Serex, T. (2004). "Inhalation Developmental Toxicity Studies In Rats With Antimony(III) oxide (Sb2O3)". Toxicologist
Antimony_trioxide
Chemical compound
reproductive and developmental toxicity." The NOAELs quoted are actually quite high, indicating the potential for reproductive toxicity is low. The same
Bis(2-ethylhexyl) terephthalate
Bis(2-ethylhexyl)_terephthalate
Chemical compound
Lomash, V; Jatav, PC; Kumar, A; Pant, SC (January 2016). "Prenatal developmental toxicity study of n-heneicosane in Wistar rats". Toxicology and Industrial
Heneicosane
Perfluorinated carboxylic acid
Durda J (April 2019). "Perfluorohexanoic acid toxicity, part II: Application of human health toxicity value for risk characterization". Regulatory Toxicology
Perfluorooctanoic_acid
Medication
constipation, mucositis, anorexia, stomatitis, bone marrow toxicity (dose-limiting toxicity; may take 7–21 days to recover after the drug has been discontinued)
Hydroxycarbamide
Study and application of beauty treatment
Donald, J. M; Hooper, K; Hopenhayn-Rich, C (1991). "Reproductive and developmental toxicity of toluene: A review". Environmental Health Perspectives. 94: 237–44
Cosmetology
Chemical compound
Grandjean P, Landrigan PJ (March 2014). "Neurobehavioural effects of developmental toxicity". The Lancet. Neurology. 13 (3): 330–8. doi:10.1016/S1474-4422(13)70278-3
Tetrachloroethylene
Treinen, Kimberley A.; Gray, Tim J. B.; Blazak, William F. (1995). "Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley
Manganese_poisoning
Substance added to a material to make it softer and more flexible
have been classified as potential endocrine disruptors with some developmental toxicity reported. Plasticizers can escape plastics due to migration and
Plasticizer
Chemical compound
1988). "Developmental toxicity of aflatoxin B1 in the rodent embryo in vitro: contribution of exogenous biotransformation systems to toxicity". Teratology
Aflatoxin_B1
Condition in which there are elevated levels of the fluoride ion in the body
Fluoride toxicity is a condition in which there are elevated levels of the fluoride ion in the body. Although fluoride is safe for dental health at low
Fluoride_toxicity
Biomolecule consisting of chains of amino acid residues
Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity, National Academies Press, 2001, retrieved 2024-12-23 Ricard J,
Protein
Chemical compound
D-Glu. Different microcystins have different toxicity profiles, with microcystin-LR found to be the most toxic. Microcystins are small nonribosomal peptides
Microcystin-LR
Species of fly
of emergence, morphological change, and developmental rate, are measured and analyzed to determine toxicity. A great deal of research has been done on
Scathophaga_stercoraria
Organosulfur insecticide
Gao, Bo; Xiao, Peng; Li, Wenhua (May 2023). "Diafenthiuron causes developmental toxicity in zebrafish (Danio rerio)". Chemosphere. 323 138253. Bibcode:2023Chmsp
Diafenthiuron
Chemical compound
by the U.S. EPA (group E). It is not listed for reproductive or developmental toxicity, but is listed on EPA's Tier 1 Screening Order for chemicals to
Imidacloprid
Dental drugs containing fluoride
developmental neurotoxicity than fluoridated water. Fluoride overdose may cause acute toxicity. While the underlying mechanism of fluoride toxicity is
Topical_fluoride
Experimental technique
of in vitro toxicity data and physiologically based kinetic modeling to predict dose–response curves for in vivo developmental toxicity of glycol ethers
In vitro to in vivo extrapolation
In_vitro_to_in_vivo_extrapolation
Uranium with lower content of 235U
PMID 12539863. S2CID 25310165. Domingo JL (2001). "Reproductive and developmental toxicity of natural and depleted uranium: a review". Reproductive Toxicology
Depleted_uranium
Chemical compound
disrupting properties and reproductive toxicity. Although the structural similarity to DEHP raises some concern for toxicity of TBPH, bromination alters the
Bis(2-ethylhexyl)tetrabromophthalate
Bis(2-ethylhexyl)tetrabromophthalate
Benzodiazepine medication
Wada H, Kerata Y (1972). "Chronic Toxicity of 1-Methyl-7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Nimetazepam)in Rats". Chronic Toxicity.
Nimetazepam
Chemical compound
one-carbon moieties in 2-methoxyethanol and 2-methoxyacetic acid-induced developmental toxicity". Toxicology and Applied Pharmacology. 99 (1): 98–109. Bibcode:1989ToxAP
Methoxyacetic_acid
Measured quantity of a medicine, nutrient, or pathogen which is delivered as a unit
Integration of Toxicity and Exposure Information". 2001: 3 – via National Research Council (US) Subcommittee on Reproductive and Developmental Toxicity. {{cite
Dose_(biochemistry)
Chemical compound
2012). "Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency"
Diisobutyl_phthalate
Wakefulness medication
studies, administration of tasimelteon during pregnancy resulted in developmental toxicity (embryofetal mortality, neurobehavioral impairment, and decreased
Tasimelteon
uranium is a toxic metal that can disrupt normal functioning of the kidney, brain, liver, heart, and numerous other systems. Chemical toxicity can cause
Uranium_in_the_environment
Delayed development in children
Global developmental delay is an umbrella term used when children are significantly delayed in two or more areas of development. It can be diagnosed when
Global_developmental_delay
Chemical compound
acute toxicity by dermal or oral contact. However, an increasing number of studies have linked exposure to TPhP with reproductive and developmental toxicity
Triphenyl_phosphate
Chemical compound
hormones and animal studies have demonstrated its reproductive and developmental toxicity, especially among males. A number of studies have documented that
Endosulfan
Chemical compound
Reproduction : phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalate ଝ (Vol. 16) NTP - CERHR. (2003). NTP-CERHR
Benzyl_butyl_phthalate
Scientific discipline
Treinen, Kimberley A.; Gray, Tim J. B.; Blazak, William F. (1995). "Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley
Nutritional_neuroscience
Weed control herbicide
Gwonhwa; Lim, Whasun (1 January 2023). "Ethalfluralin induces developmental toxicity in zebrafish via oxidative stress and inflammation". Science of
Ethalfluralin
Species of fish
"Automated Morphological Feature Assessment for Zebrafish Embryo Developmental Toxicity Screens". Toxicological Sciences. 167 (2): 438–449. doi:10.1093/toxsci/kfy250
Zebrafish
Chemical compound
Zhang T, Zhao J, Huang L, Peng S (April 2014). "T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos". Journal of Environmental Sciences
T-2_mycotoxin
Discarded electronic devices (E-Waste)
{{cite journal}}: CS1 maint: DOI inactive as of January 2026 (link) "Lead Toxicity: What Are U.S. Standards for Lead Levels?". Agency for Toxicology Substances
Electronic_waste
Chemical compound
(1996). "Quantitative Structure-Activity Relationships for the Developmental Toxicity of Haloacetic Acids in Mammalian Whole Embryo Culture". Teratology
Iodoacetic_acid
Chemical compound
the mouse central nervous system. In mice gambogic acid causes developmental toxicity in a dose-dependent manner, including low birth weight and inhibitory
Gambogic_acid
Replacing a material or process with a lower risk alternative
carcinogenicity, mutagenicity, reproductive and developmental toxicity, endocrine disruption, acute and chronic toxicity, dermal and eye irritation, and dermal
Hazard_substitution
Biology software
biological and biomedical research fields, including developmental biology, developmental toxicity, cancer biology, toxicology, immunology, and tissue
CompuCell3D
Chemical compound
and Mutagenesis 11:1-10. Faustman, E., et al. (1989). In Vitro Developmental Toxicity of Five Direct-Acting Alkylating Agents in Rodent Embryos: Structure-Activity
N-Nitroso-N-methylurea
Chemical compound
affected. This may ultimately lead to nephrotoxicity, reproductive and developmental toxicity due to tissue damage, necrosis and inflammation. Mustafa, S.; Murtaza
Chromium(III)_phosphate
Chinese-American biostatistician
inference, machine learning in biomedical big data, and applications in developmental toxicity including the study of fetal alcohol spectrum disorder and the risks
Ronghui_Xu
Chemical compound
"Characterization of Maternal Influence on Teratogenicity: An Assessment of Developmental Toxicity Studies for the Herbicide Cyanazine1,2," Regul. Toxicol. Pharmacol
Cyanazine
Economic theory
(2004). "NTP-CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Methanol". Reproductive Toxicology. 18 (3): 303–390. Bibcode:2004RepTx
Methanol_economy
Medication
and showed no embryo-fetal developmental toxicity up to 300 mg/kg/day. Similar data was found in rabbits. Maternal toxicity was observed when doses exceeded
Vibegron
Chemical compound
neurodevelopmental toxicity due to reactive oxygen species formation inhibiting the PI3K/AKT/mTOR pathway. DCBQ does not only have high toxic potency but is
2,6-Dichloro-1,4-benzoquinone
DEVELOPMENTAL TOXICITY
DEVELOPMENTAL TOXICITY
Boy/Male
Hindu
Development, Expanding
Girl/Female
Hindu, Indian
Development
Boy/Male
Arabic, Muslim, Sindhi
Dignity; Development
Boy/Male
Hindu
Development or expanding
Boy/Male
Bengali, Indian
Development; Brightness
Boy/Male
Hindu, Indian
Development
Boy/Male
Indian, Sanskrit
Development; Expansion
Boy/Male
Indian
Altitude, Height, High, Development
Boy/Male
Hindu
Development, Prosper
Boy/Male
Tamil
Development, Prosper
Boy/Male
Hindu
Development, Prosper
Girl/Female
Assamese, Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Sanskrit, Sindhi, Tamil, Telugu
Progress; Development; Improvement
Boy/Male
Tamil
Development, Prosper
Boy/Male
Muslim
Altitude, Height, High, Development
Boy/Male
Tamil
Development or expanding
Girl/Female
Muslim
Altitude, Height, High, Development
Girl/Female
Indian
Altitude, Height, High, Development
Boy/Male
Bengali, Indian
Development of God
Girl/Female
Hindu, Indian
Development; Improvement; Progress
Boy/Male
Tamil
Development, Expanding
DEVELOPMENTAL TOXICITY
DEVELOPMENTAL TOXICITY
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Lord of Water
Boy/Male
Arabic
Wish
Girl/Female
Arabic, Muslim
Sun; Sunshine
Girl/Female
Gujarati, Indian, Kannada
Wondering; Wonderment
Girl/Female
Latin
Fertile.
Surname or Lastname
English
English : unexplained. In part at least, the name appears to be of Dutch or French (possibly Huguenot) origin, perhaps a translation of Papier, a metonymic occupational name for a clerk or scribe, or perhaps a respelling of Pape.Swiss German : variant spelling of Papper, probably from baby talk. Compare Paben.
Boy/Male
Biblical
This mouth or mouthful, falsehood.
Girl/Female
Muslim
Clean
Girl/Female
Hindu, Indian, Kannada, Telugu
Sun Ray
Boy/Male
Hindu, Indian, Punjabi, Sikh, Traditional
Victory in the Shelter of God
DEVELOPMENTAL TOXICITY
DEVELOPMENTAL TOXICITY
DEVELOPMENTAL TOXICITY
DEVELOPMENTAL TOXICITY
DEVELOPMENTAL TOXICITY
n.
The origin and development of blood.
n.
Plot; action; construction; manner of development.
n.
Failure or lack of development.
n.
The equivalent expression into which another has been developed.
n.
The act of developing or disclosing that which is unknown; a gradual unfolding process by which anything is developed, as a plan or method, or an image upon a photographic plate; gradual advancement or growth through a series of progressive changes; also, the result of developing, or a developed state.
a.
Having two modes of embryonic development.
n.
The elaboration of a theme or subject; the unfolding of a musical idea; the evolution of a whole piece or movement from a leading theme or motive.
n .
Cell production or development; cytogenesis.
n.
Life development generally.
n.
The development of the spermatozoids.
n.
Growth or development of new material; neoplasty.
n.
Development of cells in animal and vegetable organisms. See Gemmation, Budding, Karyokinesis; also Cell development, under Cell.
n.
That which promotes development or growth.
n.
Indistinctness; want of development.
n.
The act or process of changing or expanding an expression into another of equivalent value or meaning.
n.
A growth or development inward.
n.
Development; disclosure; discovery.
a.
Pertaining to, or characteristic of, the process of development; as, the developmental power of a germ.
n.
The series of changes which animal and vegetable organisms undergo in their passage from the embryonic state to maturity, from a lower to a higher state of organization.
n.
The development of cartilage.