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DEAF1

  • DEAF1

    • Protein/gene that regulates mTORC1 expression

    The DEAF1 transcription factor (HGNC:14677) (or "deformed epidermal autoregulatory factor 1) is a protein coded by the gene DEAF1 in humans. It is a member

    DEAF1

    DEAF1

    DEAF1

  • List of human transcription factors

    • ENSG00000175197 bZIP Known motif – In vivo/Misc source [140] RVVKATTGCANNB DEAF1 ENSG00000177030 SAND Inferred motif from similar protein – In vivo/Misc

    List of human transcription factors

    List_of_human_transcription_factors

  • SAND DNA-binding protein domain

    • Protein family

    and AIRE-1 (Autoimmune regulator 1) proteins. Sp100 nuclear antigen AIRE DEAF1 GMEB1 GMEB2 Wojciak JM, Clubb RT (2001). "Finding the function buried in

    SAND DNA-binding protein domain

    SAND DNA-binding protein domain

    SAND_DNA-binding_protein_domain

  • Sp100 nuclear antigen

    • similar to two interferon-inducible nuclear phosphoproteins, suppressin and DEAF1. This defines a novel protein motif, the HNPP-box. Another class of variants

    Sp100 nuclear antigen

    Sp100 nuclear antigen

    Sp100_nuclear_antigen

  • MTORC1

    • Protein complex

    damaged proteins, which compromises muscle functions. Transcription factor DEAF1 is a gene that drives this dysregulation, switching on overactivity in the

    MTORC1

    MTORC1

    MTORC1

  • Peripheral tolerance

    • Removal of autoreactive T and B cells outside of the primary lymphoid organs

    regulator, and the production of autoantigens depends on transcription factor Deaf1. LECs express PD-L1 to engage PD-1 on CD8 T cells to restrict self-reactivity

    Peripheral tolerance

    Peripheral_tolerance

  • Deubiquitinating enzyme

    • Protein family

    ubiquitin-specific protease (ZnF-UBP) domain; zinc-finger myeloid, nervy and DEAF1 (ZnF-MYND) domain; ubiquitin-associated (UBA) domain; CHORD-SGT1 (CS) domain;

    Deubiquitinating enzyme

    Deubiquitinating enzyme

    Deubiquitinating_enzyme

  • C. Garrison Fathman

    • American medical doctor and academic

    L, Su L, Sheng D, Chang P, Atkinson M…. Fathman CG, Creusot RJ. (2009) Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens

    C. Garrison Fathman

    C._Garrison_Fathman

  • List of human protein-coding genes 2

    • Q5T1V6 4106 DDX60 HGNC:25942; Q8IY21 4107 DDX60L HGNC:26429; Q5H9U9 4108 DEAF1 HGNC:14677; O75398 4109 DECR1 HGNC:2753; Q16698 4110 DECR2 HGNC:2754; Q9NUI1

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

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