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Genetic disorder affecting mostly the lungs
as 1595. The name "cystic fibrosis" refers to the characteristic fibrosis and cysts that form within the pancreas. Cystic fibrosis typically manifests
Cystic_fibrosis
Mammalian protein found in humans
Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and anion channel in vertebrates that is encoded by the CFTR gene. Geneticist
Cystic fibrosis transmembrane conductance regulator
Cystic_fibrosis_transmembrane_conductance_regulator
American non-profit organisation
Cystic Fibrosis Foundation (CFF) is a 501(c)(3) non-profit organization in the United States established to provide the means to cure cystic fibrosis
Cystic_Fibrosis_Foundation
American pharmaceutical company
ivacaftor for people with cystic fibrosis ages 12 and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance
Vertex_Pharmaceuticals
American physician and academic (1950–2025)
"Cystic fibrosis detection in high-risk Egyptian children and CFTR mutation analysis", Journal of Cystic Fibrosis, 6 (2), European Cystic Fibrosis Society:
Phyllis Gardner (clinical pharmacologist)
Phyllis_Gardner_(clinical_pharmacologist)
Closed sac growth on the body
appearance of cysts in the pancreas", cystic fibrosis is an example of a genetic disorder whose name is related to fibrosis of the cystic duct (which serves
Cyst
Species of bacterium
nosocomial infections in immunocompromised patients, such as those with cystic fibrosis or chronic granulomatous disease. The quorum sensing systems CepIR
Burkholderia_cenocepacia
Permanent enlargement of the lung airways
disorder cystic fibrosis. Cystic fibrosis eventually results in severe bronchiectasis in nearly all cases. The cause in 10–50% of those without cystic fibrosis
Bronchiectasis
UK charity
The Cystic Fibrosis Trust (stylised as Cystic Fibrosis) is a UK-based national charity founded in 1964, dealing with all aspects of cystic fibrosis (CF)
Cystic_Fibrosis_Trust
Excess connective tissue in healing
Fibrosis, also known as fibrotic scarring, is the development of fibrous connective tissue in response to an injury. Fibrosis can be a normal connective
Fibrosis
Combination cystic fibrosis medication
and Kaftrio, is a fixed-dose combination medication used to treat cystic fibrosis. Elexacaftor/tezacaftor/ivacaftor is composed of a combination of ivacaftor
Elexacaftor/tezacaftor/ivacaftor
Elexacaftor/tezacaftor/ivacaftor
Canadian not-for-profit corporation
Cystic Fibrosis Canada is one of national charitable but not-for-profit corporation established in 1960. Cystic Fibrosis Canada's mandate is to help individuals
Cystic_Fibrosis_Canada
Underrepresented populations, especially Black and Hispanic populations with cystic fibrosis, are often not successfully diagnosed. This is in part due to the minimal
Cystic_fibrosis_and_race
Chemical compound
mammalian cells of the lungs which P. aeruginosa has infected during cystic fibrosis. Since pyocyanin is a zwitterion at blood pH, it is easily able to
Pyocyanin
2019 film by Justin Baldoni
Claire Wineland, who had cystic fibrosis. Haley Lu Richardson and Cole Sprouse play two young patients with cystic fibrosis who try to have a relationship
Five_Feet_Apart
Type of signaling molecule
destruction in cystic fibrosis. With such a strong inflammatory response and an elevated number of immune cells, lungs of cystic fibrosis patients cannot
Inflammatory_cytokine
Species of bacterium
often occurs during existing diseases or conditions – most notably cystic fibrosis and traumatic burns. It generally affects the immunocompromised but
Pseudomonas_aeruginosa
2023 Indian film by Shouryuv
Hesham Abdul Wahab. The plot follows six-year-old Mahi, a girl battling cystic fibrosis, who lives with her loving father, Viraj. Her quest to learn about
Hi_Nanna
Epithelial cell lining of the pancreatic duct
for pancreas regeneration. Cystic fibrosis affects pancreatic ducts as well as many other secretory epithelia. Cystic fibrosis transmembrane conductance
Pancreatic_ductal_cell
Protein found in mice and rats
to help breakdown food as a part of saliva composition. People with cystic fibrosis (CF) have an 85% chance of additionally experiencing the effects of
Lingual_lipase
Medical condition
for the condition. Current therapies for PCD are extrapolated from Cystic Fibrosis and patients with non-CF bronchiectasis and lack validation for PCD-specific
Primary_ciliary_dyskinesia
Noncancerous growths within the nose or sinuses
sinuses. They occur more commonly among people who have allergies, cystic fibrosis, aspirin sensitivity, or certain infections. The polyp itself represents
Nasal_polyp
Disease that causes scarring of the lungs
sound in idiopathic pulmonary fibrosis velcro crackles on auscultation in a person with idiopathic pulmonary fibrosis Problems playing this file? See
Pulmonary_fibrosis
Inflammation of the alveoli of the lungs
healthcare-associated pneumonia. Risk factors for pneumonia include cystic fibrosis, chronic obstructive pulmonary disease (COPD), sickle cell disease
Pneumonia
Cystic fibrosis treatment drug
Ivacaftor is a medication used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)
Ivacaftor
2026 film by Leah McKendrick
She regularly relates her life to her sister Isabelle, a longtime cystic fibrosis patient who lives back home in Austin, over the phone. After Isabelle's
Voicemails_for_Isabelle
Impact investment used for philanthropy
the Bethesda-based Cystic Fibrosis Foundation (CFF), wanting to take more direct action toward finding treatments for cystic fibrosis (CF) beyond its traditional
Venture_philanthropy
American television personality & football player (born 1992)
founded the Colton Underwood Legacy Foundation to raise money for cystic fibrosis research and medical equipment. Brown-Underwood started the foundation
Colton_Underwood
Chemical compound
Tezacaftor is a medication used for the treatment of cystic fibrosis. It is available in fixed-dose combination medications. The combination of tezacaftor
Tezacaftor
American actress (born 1989)
competitions. Rosman is an active supporter of fundraising for the Cystic Fibrosis Foundation and wishes to educate the public about the need for organ
Mackenzie_Rosman
The following notable people have or had cystic fibrosis. "'Real World: San Diego' Alum Frankie Abernathy Dead At 25". MTV. June 12, 2007. Archived from
List of people diagnosed with cystic fibrosis
List_of_people_diagnosed_with_cystic_fibrosis
American activist and author (1997–2018)
Foundation, she provided support to children and families affected by cystic fibrosis (CF). She died from a blood clot one week after receiving a double
Claire_Wineland
Disorders of the pancreas
digestive juices, and mucus. The name cystic fibrosis refers to the characteristic 'fibrosis' (tissue scarring) and cyst formation within the pancreas, causing
Pancreatic_disease
Earliest feces of a mammalian infant
meconium ileus. Meconium ileus is often the first sign of cystic fibrosis. In cystic fibrosis, the meconium can form a bituminous black-green mechanical
Meconium
Israeli geneticist (born 1955)
causing cystic fibrosis (CF). She later established the Israel National Center for CF Genetic Research. She discovered the most prevalent cystic fibrosis-causing
Batsheva_Kerem
Antibiotic
for cystic fibrosis". Eur Respir J. 24 (5): 834–8. doi:10.1183/09031936.04.00084304. PMID 15516680. S2CID 17778741. "Azithromycin and cystic fibrosis".
Azithromycin
Bravely "Cystic Fibrosis Continuity of Care - Connecting and Creating Solutions". cfcoc.org. Retrieved 2016-07-22. Cystic-L Cystic Fibrosis Canada Cystic Fibrosis
List of cystic fibrosis organizations
List_of_cystic_fibrosis_organizations
International collegiate sorority
volunteer training initiatives. The Cystic Fibrosis Foundation aids those with the genetic disease cystic fibrosis (CF) through research, grants, and awareness
Delta_Phi_Epsilon_(social)
Medical condition
Cystic fibrosis–related diabetes (CFRD) is diabetes specifically caused by cystic fibrosis, a genetic condition. Cystic fibrosis related diabetes mellitus
Cystic fibrosis–related diabetes
Cystic_fibrosis–related_diabetes
English actress (born 1952)
son. She supports several charitable causes, mostly ones related to cystic fibrosis, a condition from which her niece suffers, and for her service to those
Jenny_Agutter
Fibrosis of lungs due to unknown causes
Idiopathic pulmonary fibrosis (IPF), formerly known as cryptogenic fibrosing alveolitis, is a rare, progressive illness of the respiratory system, characterized
Idiopathic_pulmonary_fibrosis
Partial collapse of a lung causing reduced gas exchange
manifestations that result from the mucus plugging of the airways as seen in cystic fibrosis and pneumonia, mucoactive agents such as acetylcysteine (NAC) is used
Atelectasis
Inherited genetic variation
PMID 20949031. "Cystic Fibrosis Canada". www.cysticfibrosis.ca. Retrieved 2017-11-30. O'Sullivan BP, Freedman SD (May 2009). "Cystic fibrosis". Lancet. 373
Germline_mutation
Species of bacterium
especially in patients with cystic fibrosis. In 2013, the complete genome of an A. xylosoxidans strain from a patient with cystic fibrosis was sequenced. A. xylosoxidans
Achromobacter_xylosoxidans
Canadian service organization
Since 1964, Kin Canada has supported Cystic Fibrosis Canada, often raising over CAD $1 million a year for cystic fibrosis (CF) research and treatment. To date
Kin_Canada
Type of modifier gene
recycling were characterized such as by Blau et al. in 1993. Research on cystic fibrosis (CF) exhibits a progression from genetic to molecular characterization
Human_disease_modifier_gene
Medical intervention
with a lung transplant include COPD, cystic fibrosis, pulmonary hypertension and idiopathic pulmonary fibrosis. Methods for the preservation of donor
Lung_surgery
Mammalian protein found in Homo sapiens
decreased lactoferrin activity is observed in patients with cystic fibrosis. In cystic fibrosis, antibiotic susceptibility may be modified by lactoferrin
Lactoferrin
Diseases of the space or tissue between the alveoli of the lungs
disease eventually develop pulmonary fibrosis which has a median survival of 2.5-3.5 years. Idiopathic pulmonary fibrosis is interstitial lung disease for
Interstitial_lung_disease
Chemical compound
first-in-class medication. Brensocatib is indicated for the treatment of non-cystic fibrosis bronchiectasis in people aged twelve years of age and older. Bresocatib
Brensocatib
Medical textbook edited by John D. Lloyd-Still
Textbook of Cystic Fibrosis is a medical textbook, published in 1983 by John Wright-PSG. It was edited John D. Lloyd-Still and had 27 contributors in
Textbook_of_Cystic_Fibrosis
Chemical compound
environment of cystic fibrosis patients' weakened respiratory immune system against bacterial infection. Symptoms of cystic fibrosis include an inability
Hypothiocyanite
Medical diagnostic method
for cystic fibrosis (CF). Due to defective chloride channels (CFTR), the concentration of chloride in sweat is elevated in individuals with CF. Cystic fibrosis
Sweat_test
Mutation that shifts codon alignment
prevents the protein from being responsive. Cystic fibrosis (CF) is a disease based on mutations in the Cystic fibrosis transmembrane conductance regulator gene
Frameshift_mutation
Fungal infection of the lungs
It generally occurs in people with lung diseases such as asthma, cystic fibrosis or tuberculosis, or those who are immunocompromised such as those who
Aspergillosis
Medical condition
intestinal content and occurs in about 20% of mainly adult individuals with cystic fibrosis. DIOS was previously known as meconium ileus equivalent, a name which
Distal intestinal obstruction syndrome
Distal_intestinal_obstruction_syndrome
American biotechnology company
Cystic Fibrosis Foundation, with Prime Medicine receiving $15 million in funding towards the development of prime editing-based therapies for cystic fibrosis
Prime_Medicine
Medical condition
Aspergillus terrus .It occurs most often in people with asthma or cystic fibrosis. Aspergillus spores are ubiquitous in soil and are commonly found in
Allergic bronchopulmonary aspergillosis
Allergic_bronchopulmonary_aspergillosis
American actor (1989–2016)
California in the fall of 2007 to study film. Yelchin was born with cystic fibrosis, though the details of his medical condition were revealed posthumously
Anton_Yelchin
Inflammation of the sinus' membranes
infection. Recurrent episodes are more likely in people with asthma, cystic fibrosis, and immunodeficiency. A diagnosis of sinusitis is based on the symptoms
Sinusitis
Reduction in the size and function of the testicles
1177/1756287218783900. PMC 6088496. PMID 30116303. "About Cystic Fibrosis | Cystic Fibrosis Foundation". Cystic Fibrosis Foundation. Retrieved 1 August 2022. Profka
Testicular_atrophy
Organic chemist and the founder of Vertex Pharmaceuticals
inhibitor for treatment of hepatitis C; and Kalydeco, for the treatment of cystic fibrosis. In 2003, Vertex was listed as one of forty worldwide Technology Pioneers
Joshua_Boger
CEO of biotechnology company
and Trikafta – the first medicines to treat the underlying cause of cystic fibrosis. The FDA approved Trikafta on October 21, 2019. In 2015 Leiden established
Jeffrey_Leiden
American biopharmaceutical company
2014). "Cystic Fibrosis Foundation Sells Drug's Rights for $3.3 Billion". Wall Street Journal – via www.wsj.com. "Deal by Cystic Fibrosis Foundation
Royalty_Pharma
paired with water to thin the mucus of the airway lumen when the active Cystic Fibrosis Transport Receptor moves chloride ions into the airway. The minimum
Sodium_in_biology
1983 book and 1986 film
biography and film about the life and death of Alexandra Deford from cystic fibrosis. After her death in 1980 at the age of eight, her father, Frank Deford
Alex:_The_Life_of_a_Child
Study of respiratory diseases
general review focusing on: hereditary diseases affecting the lungs (cystic fibrosis, alpha 1-antitrypsin deficiency) exposure to toxicants (tobacco smoke
Pulmonology
American physician
to identify the basic defect in cystic fibrosis.[citation needed] Littlewood, James. "The history of Cyctic Fibrosis". cfmedicine. Archived from the original
Paul_di_Sant'Agnese
Medical condition
dysfunction, skeletal and cardiac abnormalities and short stature. After cystic fibrosis (CF), it is the second most common cause of exocrine pancreatic insufficiency
Shwachman–Diamond_syndrome
Chemist
senior vice president at Vertex Pharmaceuticals. She works at Vertex's cystic fibrosis research center in San Diego. She was awarded the Breakthrough Prize
Sabine_Hadida
Regulatory class of pharmaceutical drug
treatment for cystic fibrosis patients by significantly improving their quality of life and extending their life expectancies. Now, cystic fibrosis patients
Orphan_drug
University of Washington, he became a specialist in the genetics of cystic fibrosis, and one of the founders of the Human Genome Project. During his years
Maynard_Olson
American pulmonologist
Negulescu, for their work that uncovered the physiological defects in cystic fibrosis and developed effective medications. He also received the 2025 Lasker
Michael_J._Welsh_(biologist)
Cystic fibrosis medication
Elexacaftor is a medication that acts as cystic fibrosis transmembrane conductance regulator (CFTR) corrector, which means that it helps the CFTR protein
Elexacaftor
doi:10.1192/bjp.178.41.s134. PMID 11388952. Wood Klinger, K. (1983). "Cystic fibrosis in the Ohio Amish: Gene frequency and founder effect". Human Genetics
Health_among_the_Amish
American writer, poet, musician, performance artist, and comic
artist and writer known for his work on sadomasochism and living with cystic fibrosis. Flanagan was born in New York City on December 26, 1952, and grew
Bob Flanagan (performance artist)
Bob_Flanagan_(performance_artist)
Species of bacterium
immunocompromised individuals with underlying lung disease (such as cystic fibrosis or chronic granulomatous disease). Patients with sickle-cell haemoglobinopathies
Burkholderia_cepacia_complex
Inflammation of the membranes lining the chest cavity (pleurae)
Inflammatory bowel disease Lung cancer and lymphoma Other lung diseases like cystic fibrosis, sarcoidosis, asbestosis, lymphangioleiomyomatosis, and mesothelioma
Pleurisy
Health problem from genome abnormalities
disorder are albinism, medium-chain acyl-CoA dehydrogenase deficiency, cystic fibrosis, sickle cell disease, Tay–Sachs disease, Niemann–Pick disease, spinal
Genetic_disorder
Type of mutation in a DNA sequence
that these mutations can cause are Duchenne muscular dystrophy (DMD), cystic fibrosis (CF), spinal muscular atrophy (SMA), cancers, metabolic diseases, and
Nonsense_mutation
Deuterated cystic fibrosis drug (ivacaftor analogue)
is a fixed-dose combination medication used for the treatment of cystic fibrosis. It is a combination of deutivacaftor, a CFTR potentiator; tezacaftor;
Vanzacaftor/tezacaftor/deutivacaftor
Vanzacaftor/tezacaftor/deutivacaftor
American author and cystic fibrosis advocate
author and cystic fibrosis advocate. Smith was born to Mark Smith and Diane Shader Smith on October 12, 1992, and diagnosed with cystic fibrosis, a "progressive
Mallory_Smith
Species of bacterium
belongs to the Burkholderia cepacia complex, which was isolated from cystic fibrosis patients in Argentina. Burkholderia acidipaludis can cause biliary
Burkholderia_contaminans
Disease caused by lack of dietary vitamin E
result from malabsorption disorders (such as abetalipoproteinemia, cystic fibrosis, or Crohn's disease), or impaired lipid transport. As a potent antioxidant
Vitamin_E_deficiency
Different genetic causes for the same disease
same disease. For example, multiple mutations in the CFTR gene cause cystic fibrosis. Locus heterogeneity arises when mutations in different genes cause
Genetic_heterogeneity
New Brunswick) is a Canadian biochemist, noted for his research into cystic fibrosis. After acquiring his bachelor's degree in 1966 from the University
John_R._Riordan
1997 film by Kirby Dick
performance artist, comic, and BDSM celebrity, who had and later died of cystic fibrosis. The film premiered at the 1997 Sundance Film Festival, where it was
Sick: The Life and Death of Bob Flanagan, Supermasochist
Sick:_The_Life_and_Death_of_Bob_Flanagan,_Supermasochist
Salt water for medical purposes
Hypertonic saline is currently recommended by the Cystic Fibrosis Foundation as a primary part of a cystic fibrosis treatment regimen. An 11% solution of xylitol
Saline_(medicine)
Case in which having two different versions of a gene provides an advantage
fitness it grants, rather than the degree of suffering alleviation. Cystic fibrosis (CF) is an autosomal recessive hereditary monogenic disease of the
Heterozygote_advantage
Canadian actor (born 1970)
niece was born with the genetic disorder cystic fibrosis, and he has long been a champion of the Cystic Fibrosis Foundation. In an interview with MTV News
JR_Bourne
American pediatrician (1927–2016)
research and treatment of cystic fibrosis. When she began her 40-year career in the 1950s, those diagnosed with cystic fibrosis rarely reached puberty;
Carolyn_Denning
American cell biologist
with Michael J. Welsh, for their work that uncovered the etiology of cystic fibrosis and developed effective medications. Negulescu was born in San Francisco
Paul_Negulescu
Deformity of the finger or toe nails
idiopathic pulmonary fibrosis Complicated tuberculosis Suppurative lung disease: lung abscess, empyema, bronchiectasis, cystic fibrosis Mesothelioma of the
Nail_clubbing
Species of bacterium
pathogen associated with opportunistic infections in patients with cystic fibrosis, cancer, and HIV/AIDS. Adherence of this organism to abiotic surfaces
Stenotrophomonas_maltophilia
Techniques to clear the respiratory airways
techniques (ACTs) in a number of respiratory disorders including, cystic fibrosis, bronchitis, bronchiectasis, and chronic obstructive pulmonary disease
Airway_clearance_therapy
Canadian molecular biologist
cloned the CFTR gene, which when mutated, is responsible for causing cystic fibrosis (CF). She later discovered the gene responsible for Shwachman-Diamond
Johanna_Rommens
Abnormal collection of air in the pleural space
breathlessness in someone with chronic obstructive pulmonary disease (COPD), cystic fibrosis, or other serious lung diseases should therefore prompt investigations
Pneumothorax
Birth defect of the male sex organ
azoospermia in postpubertal males with cystic fibrosis. Strikingly, CAVD is one of the most consistent features of cystic fibrosis as it affects 98-99% of individuals
Congenital absence of the vas deferens
Congenital_absence_of_the_vas_deferens
Subspecies of bacterium
human to human. This phenomenon has been observed in hospitals with cystic fibrosis patients. Mycobacterium avium subsp. hominissuis is a non-tuberculosis
Mycobacterium avium subsp. hominissuis
Mycobacterium_avium_subsp._hominissuis
Inflammation of the pancreas
calcium, some medications, and certain genetic disorders, such as cystic fibrosis, among others. Smoking increases the risk of both acute and chronic
Pancreatitis
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