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CPSF6

  • CPSF6
  • Protein-coding gene in humans

    specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene. The protein encoded by this gene is one subunit of a cleavage factor

    CPSF6

    CPSF6

    CPSF6

  • Paraspeckle
  • Cell compartment found in the nucleus's interchromatin space

    Dispensable Yes CELF6 n.d.(e) No CIRBP Dispensable No CPSF5 Dispensable No CPSF6 Dispensable No CPSF7 Important No DAZAP1 Essential Yes DLX3 n.d. Yes EWSR1

    Paraspeckle

    Paraspeckle

    Paraspeckle

  • HIV integration
  • HIV-1 preference for highly spliced genes depends on another host factor CPSF6, a poly adenylation factor. Cancer genes with high number of introns are

    HIV integration

    HIV integration

    HIV_integration

  • Cleavage and polyadenylation specificity factor
  • polyadenylation are tightly coupled processes. CPSF1, CPSF2, CPSF3, CPSF4, NUDT21, CPSF6, CPSF7, FIP1L1 Alternative polyadenylation (APA) is a regulatory mechanism

    Cleavage and polyadenylation specificity factor

    Cleavage_and_polyadenylation_specificity_factor

  • Cleavage factor
  • Two proteins involved in gene transcription

    kDa, respectively: CFIm25 (or CPSF5/NUDT21) CFIm59 (or CPSF7) CFIm68 (or CPSF6) CFIm25 and CFIm68 are sufficient for the activity of the complex, proving

    Cleavage factor

    Cleavage_factor

  • Fibroblast growth factor receptor 1
  • Protein found in humans

    notation gene locus notation gene locus notation MYO18A 17q11 t(8;17)(p11;q11) CPSF6 12q15 t(8;12)(p11;q15) TPR 1q25 t(1;8)(q25p11;; HERV-K 10q13 t(8;13)(p11-q13)

    Fibroblast growth factor receptor 1

    Fibroblast growth factor receptor 1

    Fibroblast_growth_factor_receptor_1

  • Stress granule
  • Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

    CPSF3 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 CPSF6 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 CPSF7 CPSF7

    Stress granule

    Stress granule

    Stress_granule

  • CPSF7
  • Protein-coding gene in humans

    factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6). GRCh38: Ensembl release 89: ENSG00000149532 – Ensembl, May 2017 GRCm38:

    CPSF7

    CPSF7

    CPSF7

  • Phospholipid scramblase 1
  • Protein-coding gene in the species Homo sapiens

    is encoded by the PLSCR1 gene. PLSCR1 has been shown to interact with: CPSF6, Epidermal growth factor receptor, NEU4, SHC1, SLPI, and TFG. Scramblase

    Phospholipid scramblase 1

    Phospholipid scramblase 1

    Phospholipid_scramblase_1

  • Clonal hypereosinophilia
  • Group of blood-based disorders

    TRIP11, CCDC88C TP53BP1, NDE1, SPECC1, NDEL1, MYO18A, BIN2, COL1A1, DTD1 CPSF6, RABEP1, MPRIP, SPTBN1, WDR48, GOLGB1, DIAPH1, TNIP1, or SART3 gene create

    Clonal hypereosinophilia

    Clonal_hypereosinophilia

  • WWP1
  • Protein-coding gene in the species Homo sapiens

    nerve cells into the cortical plate. WWP1 has been shown to interact with: CPSF6, KLF2, and Reticulon 4 GRCh38: Ensembl release 89: ENSG00000123124 – Ensembl

    WWP1

    WWP1

    WWP1

  • Chromosome 12 open reading frame 71
  • Protein encoded in humans by c12orf71 gene

    family SPRYD4 Spry domain-containing protein 4; SPRY domain containing 4 CPSF6 Cleavage and polyadenylation specificity factor subunit 6; Component of

    Chromosome 12 open reading frame 71

    Chromosome 12 open reading frame 71

    Chromosome_12_open_reading_frame_71

  • PDGFRB
  • Protein-coding gene in humans

    t(5;12)(q32;q13) COL1A1 17q22 t(5;17)q32;q22) DTD1 20p11 t(5;20)(q32;p11) CPSF6 12q15 t(5;12)(q32;q15) RABEP1 17p13 t(5;17)(q32;p13) MPRIP 17p11 t(5;17)(q32;p11)

    PDGFRB

    PDGFRB

    PDGFRB

  • List of human protein-coding genes 2
  • Q9UKF6 3510 CPSF4 HGNC:2327; O95639 3511 CPSF4L HGNC:33632; A6NMK7 3512 CPSF6 HGNC:13871; Q16630 3513 CPSF7 HGNC:30098; Q8N684 3514 CPT1A HGNC:2328; P50416

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

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