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Protein playing a major role in the formation of coated vesicles
Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. It forms a triskelion
Clathrin
Process by which cells absorb materials
Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and
Receptor-mediated_endocytosis
Cellular process
cytosolic protein clathrin. Clathrin-coated vesicles (CCVs) are found in virtually all cells and form domains of the plasma membrane termed clathrin-coated pits
Endocytosis
Prevalent tubulovesicular membranes
Clathrin-independent endocytosis refers to the cellular process by which cells internalize extracellular molecules and particles through mechanisms that
Clathrin-independent endocytosis
Clathrin-independent_endocytosis
Links clathrin to receptors in coated vesicles
Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. The association between adaptins
Clathrin_adaptor_protein
Viral pulmonary disease of humans
micropinocytosis, clathrin-independent receptor-mediated endocytosis and cholesterol- or caveolae-dependent endocytosis. Old World hantaviruses use clathrin-dependent
Hantavirus_pulmonary_syndrome
Prevalent tubulovesicular membranes
Clathrin-independent carriers (CLICs) are prevalent tubulovesicular membranes responsible for non-clathrin mediated endocytic events. They appear to endocytose
Clathrin-independent_carrier
multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable complex of four adaptins which give
AP2_adaptor_complex
Genus of viruses
micropinocytosis, clathrin-independent receptor-mediated endocytosis and cholesterol- or caveolae-dependent endocytosis. Old World hantaviruses use clathrin-dependent
Hantavirus
Protein
in clathrin-mediated endocytosis of synaptic vesicles. It is capable of simultaneously binding both membrane lipids (via an ANTH domain) and clathrin and
Ap180
Genus of viruses
attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus
Lyssavirus
Protein-coding gene in humans
Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene. Clathrin is a major protein component of the cytoplasmic face of intracellular
CLTC
Protein found in humans
adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two
Adaptor-related protein complex 2, alpha 1
Adaptor-related_protein_complex_2,_alpha_1
Biological suffix denoting cellular transport processes or abnormal cell counts
the cell. The particles are absorbed through the use of clathrin-coated pits. These clathrin-coated pits are short lived and serve only to form a vesicle
Cytosis
Mammalian protein found in humans
2001). "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen
Cytotoxic T-lymphocyte associated protein 4
Cytotoxic_T-lymphocyte_associated_protein_4
eukaryotes there are several conserved motifs such as the clathrin-binding motifs which bind clathrin heavy chain, these motifs flank a cluster of up to eight
Epsin
Genus of viruses
attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus
Sigmavirus
Mode of endocytosis to bring small particles into a cell
The clathrin coats are lost almost immediately, and the membrane is subsequently recycled to the cell surface. Macropinocytosis is a clathrin-independent
Pinocytosis
Protein-coding gene in the species Homo sapiens
interactor HIPPI. HIP1’s non-pathological activity includes clathrin assembly via interaction with clathrin light chains. HIP1 is the human homologue of Sla2p
Huntingtin-interacting protein 1
Huntingtin-interacting_protein_1
Genus of viruses
attachment of the viral envelope protein E to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the positive-strand RNA virus
Orthohepacivirus
Protein-coding gene in the species Homo sapiens
located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic
AP1B1
Protein-coding gene in the species Homo sapiens
clathrin-coated vesicles during endocytosis. The clathrin-binding domain gathers clathrin into baskets. At pH 7 GAK allows Hsc70 to uncoat clathrin baskets
GAK_(protein)
Protein-coding gene in the species Homo sapiens
Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene. PICALM has been
PICALM
Genus of viruses
hosts of novel bocaparvoviruses. Bovine bocaviruses utilise endocytosis in clathrin-coated vesicles to enter cells; they are dependent upon acidification,
Bocaparvovirus
Protein-coding gene in the species Homo sapiens
extracellular region endoplasmic reticulum clathrin-coated pit nucleus clathrin-coated vesicle membrane clathrin-coated endocytic vesicle Biological process
CEMIP
Mammalian protein found in Homo sapiens
including a signal sequence important for localizing the receptors to clathrin-coated pits and for triggering receptor-mediated endocytosis after binding
LDL_receptor
Protein family
continuously between the plasma membrane and endosomal compartments in a clathrin-dependent manner. The mannose receptor is a type I transmembrane protein
Mannose_receptor
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
β2-adrenoreceptors acts as an adaptor for binding with clathrin, and with the beta-subunit of AP2 (clathrin adaptor molecules); thus, the arrestin here acts
G_protein-coupled_receptor
Genus of viruses
the virus via receptor-mediated endocytosis involving the formation of clathrin-coated pits. Mammalian orthoreoviruses The only orthoreovirus to not produce
Orthoreovirus
Protein complex secreted by the bacterium Vibrio cholerae
endocytic pathways, including: Clathrin-dependent (e.g., clathrin-coated pits) Clathrin-independent (e.g., caveolae, clathrin-independent carriers (CLICs)
Cholera_toxin
Polyhedron resembling a soccerball
Fat Man atomic bombs. Its structure can also be found in the protein of clathrin. The truncated icosahedron was known to Archimedes, who classified the
Truncated_icosahedron
Endocytic pathway found in eukaryotic cells
require clathrin. Instead, FEME is a clathrin-independent endocytic pathway that requires the activity of endophilins and dynamins. In Clathrin-dependent
Fast endophilin-mediated endocytosis
Fast_endophilin-mediated_endocytosis
concentration of molecules within a vesicle. Examples include: Archain ARFs Clathrin Caveolin Dynamin and related proteins, such as the EHD protein family Rab
Vesicular_transport_protein
Protein-coding gene in the species Homo sapiens
endosome perinuclear region of cytoplasm lysosome extracellular exosome clathrin-coated vesicle membrane phagocytic vesicle membrane azurophil granule membrane
Vesicle-associated membrane protein 8
Vesicle-associated_membrane_protein_8
Genus of viruses
integrin entry receptors mediates internalization into the host cell by clathrin-mediated endocytosis of the virus and fiber shedding. Some serotypes also
Mastadenovirus
Protein-coding gene in the species Homo sapiens
of external side of plasma membrane extracellular region brush border clathrin-coated vesicle ER to Golgi transport vesicle membrane anchored component
Folate_receptor_1
Heterodimeric receptor
internalized through endocytosis in response to agonism through clathrin-dependent and clathrin-independent mechanisms. IFNAR subunits can be differentially
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Gene and protein involved in Huntington's disease
protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin-binding protein, to mediate endocytosis, the trafficking of materials into
Huntingtin
Protein-coding gene in the species Homo sapiens
phosphorylation positive regulation of Notch signaling pathway regulation of clathrin-dependent endocytosis regulation of endocytosis Sources:Amigo / QuickGO
BMP2K
Group of clinically similar illnesses caused by species of hantaviruses
micropinocytosis, clathrin-independent receptor-mediated endocytosis and cholesterol- or caveolae-dependent endocytosis. Old World hantaviruses use clathrin-dependent
Hantavirus hemorrhagic fever with renal syndrome
Hantavirus_hemorrhagic_fever_with_renal_syndrome
Any small, fluid-filled, spherical organelle enclosed by a membrane
vesicle coats: clathrin, COPI and COPII. The various types of coat proteins help with sorting of vesicles to their final destination. Clathrin coats are found
Vesicle (biology and chemistry)
Vesicle_(biology_and_chemistry)
Protein-coding gene in the species Homo sapiens
"Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7
AP2M1
are a group of related proteins (three in humans) that act as monomeric clathrin adaptor proteins in various important membrane vesicle traffickings, but
Vesicular transport adaptor protein
Vesicular_transport_adaptor_protein
Family of viruses
attachment of the viral envelope protein E to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the positive-stranded RNA virus
Flaviviridae
Protein-coding gene in the species Homo sapiens
binds to the terminal domain of the clathrin heavy chain and stimulates clathrin cage vesicle assembly. Clathrin coated vesicles enable neurotransmitter
CLINT1
Protein-coding gene in the species Homo sapiens
Lundmark R, Carlsson SR (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J
DNM2
Protein kinase found in humans
homodimerization activity signaling receptor complex adaptor activity clathrin binding co-receptor binding transferase activity GTPase activator activity
LRRK2
Protein-coding gene in the species Homo sapiens
class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking". Mol. Cell. 7 (2): 443–449.
PIK3C2A
Protein-coding gene in humans
plasma membrane membrane raft extracellular exosome cytoplasmic vesicle clathrin-coated vesicle nucleoplasm cytosol focal adhesion actin cytoskeleton brush
ABCB4
Protein-coding gene in the species Homo sapiens
an enzyme that in humans is encoded by the AAK1 gene and is involved in clathrin mediated endocytosis. Alternatively spliced transcript variants have been
AAK1
Protein family
enveloped by the cell and transported inside either through clathrin-dependent endocytosis or clathrin-independent endocytosis. For the cholera toxin, the principal
AB5_toxin
Protein-coding gene in the species Homo sapiens
membrane cytosol clathrin-sculpted monoamine transport vesicle membrane membrane secretory granule membrane plasma membrane clathrin-sculpted gamma-aminobutyric
VAMP2
Protein-coding gene in humans
stable complex with p200 and synergin gamma. It contains a clathrin box with two known clathrin-binding sequence motifs, is involved in vesicle trafficking
AFTPH
Family of proteins
links the receptor to elements of the internalization machinery, clathrin and clathrin adaptor AP2, which promotes receptor internalization via coated
Arrestin
Cyclic oligosaccharide with 6 to 8 glucose units
"Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles". Molecular Biology of the Cell. 10 (4): 961–974
Cyclodextrin
Topics referred to by the same term
examiner, common official title of a coroner Continuing medical education Clathrin-mediated endocytosis, another name for receptor-mediated endocytosis (RME)
CME
Protein-coding gene in the species Homo sapiens
membrane early endosome extrinsic component of plasma membrane nucleus clathrin-coated vesicle cytoplasmic vesicle glutamatergic synapse Biological process
NUMB_(gene)
American biologist, academic, and researcher
the molecular mechanisms of cytoskeletal dynamics, actin assembly, and clathrin‑mediated endocytosis using both genetically tractable model organisms and
David_G._Drubin
Protein-coding gene in the species Homo sapiens
perinuclear region of cytoplasm neuron projection terminus cytoplasmic vesicle clathrin-coated vesicle trans-Golgi network membrane ER to Golgi transport vesicle
VTI1A
Biological molecular machines
polymerization using GTP. Dynamin is responsible for the separation of clathrin buds from the plasma membrane. GTP is used. Rotary motors: FoF1-ATP synthase
Molecular_motor
Protein-coding gene in the species Homo sapiens
Cellular component integral component of membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane endosome Golgi apparatus trans-Golgi
HLA-DPB1
Protein-coding gene in the species Homo sapiens
a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". The Journal of Biological Chemistry. 278 (52): 52865–52872. doi:10.1074/jbc
APLP1
Genus of viruses
is achieved by attachment to host receptors, and is probably driven by clathrin-mediated endocytosis. Replication follows the rolling-hairpin model. DNA-templated
Aveparvovirus
Human protein and coding gene
plasma membrane synapse axon soma dendrite neuron projection microtubule clathrin-coated vesicle presynapse dendritic spine postsynaptic density cytoplasmic
DVL1
Protein family
mammalian cells. LDLR binds cholesterol-carrying LDL, associates with clathrin-coated pits, and is internalized into acidic endosomes where it separates
YWTD_repeat
Type of viral hemorrhagic fever
this position.[citation needed] Unlike most enveloped viruses which use clathrin coated pits for cellular entry and bind to their receptors in a pH dependent
Lassa_virus
Protein found in humans
chemical signals. Studies have implicated cortactin in both clathrin-mediated endocytosis and clathrin-independent endocytosis. In both kinds of endocytosis
Cortactin
Family of viruses
attachment of the viral GP glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus
Bornaviridae
Proteins performing more than one function
Iron homeostasis ATF2 H. sapiens Transcription factor DNA damage response Clathrin H. sapiens Membrane traffic Mitotic spindle stability Crystallins Various
Protein_moonlighting
Topics referred to by the same term
Bakersfield, California Calmodulin (CaM), calcium-modulated protein CALM2 CALM3 Clathrin-assembly lymphoid myeloid leukaemia protein, see Ap180 Communications,
Calm
Gene which maintains basic cellular functions
ANXA6 Annexin 6 ANXA7 Annexin 7 AP1B1 Coated vesicles CLTA Clathrin A (vesicles) CLTB Clathrin B (vesicles) CLTC MTX2 AP2S1 CD81 GPAA1 LGALS9 MGAT2 MGAT4B
Housekeeping_gene
Transport protein
cell surface perinuclear region of cytoplasm membrane raft sarcolemma clathrin-coated pit trans-Golgi network transport vesicle extracellular exosome
GLUT4
Protein-coding gene in the species Homo sapiens
Cellular component integral component of membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane endosome Golgi apparatus trans-Golgi
HLA-DQB2
Protein-coding gene in humans
Bergson C (June 2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis". The Journal of Biological Chemistry
CALY
Protein-coding gene in humans
expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7
SLAMF6
Subfamily of viruses in the family Coronaviridae
She G, Wu T, Xue C, Cao Y (February 2020). "PEDV enters cells through clathrin-, caveolae-, and lipid raft-mediated endocytosis and traffics via the endo-/lysosome
Coronavirus
Species of virus
enters the cell through partially clathrin-coated vesicles; virus-containing vesicles contain more clathrin and clathrin adaptor than conventional vesicles
Indiana_vesiculovirus
Protein-coding gene in the species Homo sapiens
extracellular vesicle endosome clathrin-sculpted monoamine transport vesicle membrane membrane synaptic vesicle plasma membrane clathrin-sculpted gamma-aminobutyric
RAB3A
Protein-coding gene in the species Homo sapiens
integral component of membrane membrane synaptic vesicle plasma membrane clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane synapse inhibitory
Vesicular inhibitory amino acid transporter
Vesicular_inhibitory_amino_acid_transporter
Human retrovirus, cause of AIDS
membrane. More recently, however, productive infection by pH-independent, clathrin-mediated endocytosis of HIV-1 has also been reported and was recently suggested
HIV
Symbol with three-fold rotational symmetry
point group of triskelion-shaped molecules is C3h. The endocytic protein, clathrin, is triskelion-shaped, as well as the Ediacaran organism Tribrachidium
Triskelion
Topics referred to by the same term
family, including: SNAP23 SNAP25 SNAP29 SNAP91, the genetic that codes for clathrin coat assembly protein AP180 HT-2157, formerly SNAP-37889, a pharmacological
Snap
Protein-coding gene in the species Homo sapiens
Gene ontology Molecular function calcium-dependent phospholipid binding clathrin binding calcium ion binding neurexin family protein binding syntaxin binding
SYTL1
Type of toxic lectin
membrane invaginations. The holotoxin can be taken up by clathrin-coated pits, as well as by clathrin-independent pathways including caveolae and macropinocytosis
Ricin
Genus of viruses
competent vector organism. Viral entry proceeds by receptor-mediated (clathrin-dependent) endocytosis, but which receptors unknown. Although, Heparan
Orthobunyavirus
Small particle, often in plants
Insulin granules bud from the trans golgi network and are further sorted via clathrin-coated vesicle transport. After budding, insulin secretory granules are
Granule_(cell_biology)
Protein-coding gene in the species Homo sapiens
binding calcium ion binding inositol 1,3,4,5 tetrakisphosphate binding clathrin binding syntaxin binding protein binding calcium-dependent phospholipid
SYT2
Technique in molecular biology
support for ultrasound application inducing calcium-mediated uncoating of clathrin-coated pits seen in traditional endocytosis pathways. Other work reported
Sonoporation
Mammalian protein found in Homo sapiens
cell-cell adhesion negative regulation of protein homodimerization activity clathrin-dependent extracellular exosome endocytosis cell adhesion receptor clustering
Integrin_alpha_4
Form of neural negative feedback
usually involves clathrin-coated vesicles, though non-clathrin-coated vesicles may also be used. After the endocytic vesicles lose their clathrin coat, however
Short-term synaptic depression
Short-term_synaptic_depression
Protein-coding gene in the species Homo sapiens
Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/s0092-8674(01)00299-9.
ARF1
French-German biochemist (born 1966)
reorganization acts as a driving force for endocytic pit construction in clathrin-independent endocytosis. He also aims at exploiting his discoveries in
Ludger_Johannes
zone the membrane proteins are sequestered and are endocytosed forming a clathrin coated vesicle. (6) The vesicle is then filled with neurotransmitter and
Active_zone
Protein-coding gene in the species Homo sapiens
thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles". Cellular Signalling. 10 (8): 553–9. doi:10.1016/S0898-6568(97)00190-3
Thyrotropin-releasing hormone receptor
Thyrotropin-releasing_hormone_receptor
Cell structure involved in protein transport
Sec13/31 complexes to form a cuboctahedron with a broader lattice than its Clathrin vesicle analog. The formation of the cuboctahedron deforms the ER membrane
COPII
Protein-coding gene in the species Homo sapiens
revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation". Biosci. Biotechnol. Biochem. 71 (7): 1764–8
FCHO1
American geneticist
Zhou Y, Meinertzhagen IA, Bellen HJ (2002). "Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release". Cell. 109 (1):
Hugo_J._Bellen
Blood vessel lining
total mass of pinocytic vesicles and lysosomes, and contain twice as many clathrin-coated pits per membrane unit, compared with two other major liver cells
Liver sinusoidal endothelial cell
Liver_sinusoidal_endothelial_cell
Type of affinity in biochemistry
polymers. If clustered proteins form an organized matrix, such as the clathrin-coat, the interaction is described as a matricity.[citation needed] Avidity
Avidity
Protein-coding gene in the species Homo sapiens
BioGPS More reference expression data Gene ontology Molecular function clathrin binding calcium ion binding syntaxin binding protein binding metal ion
SYT11
CLATHRIN
CLATHRIN
CLATHRIN
CLATHRIN
Boy/Male
Australian, British, English, French, German, Turkish
Letters Patent; Authorization Letter
Boy/Male
Indian
Name of a companion of the prophet
Biblical
a man excelling others
Boy/Male
British, English
A Fisher King
Boy/Male
Tamil
Lord Vishnu
Boy/Male
Hindu, Indian, Traditional
Mirror
Girl/Female
Arabic, Australian
Mark; Sign; Proof
Boy/Male
Indian
Powerful
Surname or Lastname
German
German : variant of Buss.North German (Büsse) : metonymic occupational name for a maker of boxes and containers or for a gunsmith, from Middle Low German büsse, busse ‘box’, ‘gun’, ‘rifle’.English : variant spelling of Buss.
Girl/Female
Hindu, Indian, Marathi
The Best Voice; Melody
CLATHRIN
CLATHRIN
CLATHRIN
CLATHRIN
CLATHRIN