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BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC). It is an antibody to EpCAM (epithelial cell
BerEp4
Most common type of skin cancer
usually well differentiated. In uncertain cases, immunohistochemistry using BerEP4 can be used, having a high sensitivity and specificity in detecting only
Basal-cell_carcinoma
Transmembrane glycoprotein
such conditions can therefore be assisted by immunohistochemistry using BerEp4, which is an antibody to EpCAM. A problem in EpCAM can indirectly cause
Epithelial cell adhesion molecule
Epithelial_cell_adhesion_molecule
Protein-coding gene in humans
effusion specimens, it has also been found to have a superior performance to BerEp4 staining. GRCh38: Ensembl release 89: ENSG00000189143 – Ensembl, May 2017
CLDN4
Biochemistry concept
in combination with other immunohistochemistry tests, such as those for BerEp4, WT1, and calretinin. For cancers that highly express CEA, targeting CEA
Carcinoembryonic_antigen
Medical condition
cytokeratins, WT1, D2-40, and calretinin. They are negative for MOC31, BerEP4, and vascular markers (CD31 or CD34). BAP1 expression is retained. L1 cell
Adenomatoid_tumor
large B-cell lymphoma leg type Bcl-6 Primary cutaneous follicular lymphoma BerEp4 Desmoplastic trichoepithelioma Basal cell carcinoma Brown–Brenn Eumycotic
List of histologic stains that aid in diagnosis of cutaneous conditions
List_of_histologic_stains_that_aid_in_diagnosis_of_cutaneous_conditions
Medical condition
(11 of 14 cases), and epithelial cell adhesion molecule as detected by BerEp4 staining (8 of 14 cases). A study on one to a few patients reported that
Porocarcinoma
Medical condition
adhesion molecule as detected by immunohistochemical analyses using the BerEp4 antibody. The tumor tissues of trichoepithelioma-like CCS tumors may also
CYLD_cutaneous_syndrome
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